loxapine has been researched along with Neuroleptic Malignant Syndrome in 14 studies
Loxapine: An antipsychotic agent used in SCHIZOPHRENIA.
Neuroleptic Malignant Syndrome: A potentially fatal syndrome associated primarily with the use of neuroleptic agents (see ANTIPSYCHOTIC AGENTS) which are in turn associated with dopaminergic receptor blockade (see RECEPTORS, DOPAMINE) in the BASAL GANGLIA and HYPOTHALAMUS, and sympathetic dysregulation. Clinical features include diffuse MUSCLE RIGIDITY; TREMOR; high FEVER; diaphoresis; labile blood pressure; cognitive dysfunction; and autonomic disturbances. Serum CPK level elevation and a leukocytosis may also be present. (From Adams et al., Principles of Neurology, 6th ed, p1199; Psychiatr Serv 1998 Sep;49(9):1163-72)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Haloperidol was stopped and intravenous clonazepam 5mg/kg was begun." | 5.36 | [Catatonia in a 14 year-old girl: treatment with clorazepam and carbamazepine, a 10-year follow-up]. ( Askenazy, F; Benoit, M; Dor, E; Dupuis, G; Myquel, M; Seddiki, Y; Serret, S, 2010) |
| "Loxapine was introduced to the British market two years ago although it has been used in North America for eight years." | 5.28 | Neuroleptic malignant syndrome secondary to loxapine. ( Abbott, PM; Chong, LS, 1991) |
| "Neuroleptic malignant syndrome (NMS) is a rare but severe adverse effect of antipsychotic drugs." | 1.46 | Pharmacist intervention to detect drug adverse events on admission to the emergency department: Two case reports of neuroleptic malignant syndrome. ( Breuker, C; Castet-Nicolas, A; Giraud, I; Gourhant, V; Leenhardt, F; Perier, D; Pinzani, V; Villiet, M, 2017) |
| "Haloperidol was stopped and intravenous clonazepam 5mg/kg was begun." | 1.36 | [Catatonia in a 14 year-old girl: treatment with clorazepam and carbamazepine, a 10-year follow-up]. ( Askenazy, F; Benoit, M; Dor, E; Dupuis, G; Myquel, M; Seddiki, Y; Serret, S, 2010) |
| " The syndrome often develops after a sudden increase in dosage of the neuroleptic medication or in states of dehydration." | 1.32 | Neuroleptic malignant syndrome: case report and discussion. ( Chandran, GJ; Keegan, DL; Mikler, JR, 2003) |
| "Loxapine was introduced to the British market two years ago although it has been used in North America for eight years." | 1.28 | Neuroleptic malignant syndrome secondary to loxapine. ( Abbott, PM; Chong, LS, 1991) |
| "The authors report a case of unequivocal Neuroleptic Malignant Syndrome, in which the patient was successfully rechallenged with a different potent neuroleptic in substantial dosage during the recovery phase." | 1.28 | Use of neuroleptics after an episode of neuroleptic malignant syndrome. ( Lipman, E; Padgett, R, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (21.43) | 18.7374 |
| 1990's | 4 (28.57) | 18.2507 |
| 2000's | 2 (14.29) | 29.6817 |
| 2010's | 4 (28.57) | 24.3611 |
| 2020's | 1 (7.14) | 2.80 |
| Authors | Studies |
|---|---|
| Fernandez, A | 1 |
| Pendaries, G | 1 |
| Dor, E | 2 |
| Askenazy, F | 2 |
| Thümmler, S | 1 |
| Leenhardt, F | 1 |
| Perier, D | 1 |
| Pinzani, V | 1 |
| Giraud, I | 1 |
| Villiet, M | 1 |
| Castet-Nicolas, A | 1 |
| Gourhant, V | 1 |
| Breuker, C | 1 |
| Descoeur, J | 1 |
| Philibert, L | 1 |
| Chalard, K | 1 |
| Attal, J | 1 |
| Petit, P | 1 |
| Klouche, K | 1 |
| Olivier, M | 1 |
| Benoit, M | 1 |
| Dupuis, G | 1 |
| Serret, S | 1 |
| Myquel, M | 1 |
| Seddiki, Y | 1 |
| Eiden, C | 1 |
| Capdevielle, D | 1 |
| Deddouche, C | 1 |
| Boulenger, JP | 1 |
| Blayac, JP | 1 |
| Peyrière, H | 1 |
| Chandran, GJ | 1 |
| Mikler, JR | 1 |
| Keegan, DL | 1 |
| Irwin, GE | 1 |
| Simon, JE | 1 |
| Karagianis, J | 1 |
| Phillips, L | 1 |
| Hogan, K | 1 |
| LeDrew, K | 1 |
| Chong, LS | 1 |
| Abbott, PM | 1 |
| Neuzil, KM | 1 |
| Morgan, HJ | 1 |
| Goeke, JE | 1 |
| Hagan, DS | 1 |
| Goelzer, SL | 1 |
| Coursin, DB | 1 |
| Keepers, GA | 1 |
| Padgett, R | 1 |
| Lipman, E | 1 |
| Blue, MG | 1 |
| Schneider, SM | 1 |
| Noro, S | 1 |
| Fraley, DS | 1 |
14 other studies available for loxapine and Neuroleptic Malignant Syndrome
| Article | Year |
|---|---|
[Malignant neuroleptic syndrome: An atypical case in an adolescent affected by bipolar I disorder associated with catatonic syndrome].
Topics: Adolescent; Antipsychotic Agents; Bipolar Disorder; Catatonia; Electroencephalography; Humans; Hypno | 2020 |
Pharmacist intervention to detect drug adverse events on admission to the emergency department: Two case reports of neuroleptic malignant syndrome.
Topics: Aged; Antipsychotic Agents; Clozapine; Emergency Service, Hospital; Fatal Outcome; Humans; Loxapine; | 2017 |
Success of tardive electroconvulsive therapy sessions after loxapine-induced malignant syndrome in the context of very poor metabolisation.
Topics: Antipsychotic Agents; Chromatography, Liquid; Cytochrome P-450 CYP1A2; Electroconvulsive Therapy; Fe | 2017 |
[Catatonia in a 14 year-old girl: treatment with clorazepam and carbamazepine, a 10-year follow-up].
Topics: Acute Disease; Adolescent; Adult; Anticonvulsants; Antipsychotic Agents; Carbamazepine; Cataplexy; C | 2010 |
Neuroleptic malignant syndrome-like reaction precipitated by antipsychotics in a patient with gamma-butyrolactone withdrawal.
Topics: 4-Butyrolactone; Adult; Antipsychotic Agents; Clonazepam; Diagnosis, Differential; Drug Evaluation, | 2011 |
Neuroleptic malignant syndrome: case report and discussion.
Topics: Aged; Aged, 80 and over; Antipsychotic Agents; Humans; Loxapine; Male; Neuroleptic Malignant Syndrom | 2003 |
Neuroleptic malignant syndrome.
Topics: Basal Ganglia Diseases; Chronic Disease; Diagnosis, Differential; Dibenzoxazepines; Dose-Response Re | 1984 |
Re: Neuroleptic malignant syndrome associated with quetiapine.
Topics: Antipsychotic Agents; Dibenzothiazepines; Drug Therapy, Combination; Humans; Loxapine; Neuroleptic M | 2001 |
Neuroleptic malignant syndrome secondary to loxapine.
Topics: Adult; Female; Humans; Loxapine; Neuroleptic Malignant Syndrome; Neurologic Examination; Schizophren | 1991 |
Stiff neck and fever in a nursing home patient.
Topics: Aged; Female; Fever; Humans; Loxapine; Muscle Rigidity; Neck Muscles; Neuroleptic Malignant Syndrome | 1991 |
Lethal catatonia complicated by the development of neuroleptic malignant syndrome in a middle-aged female.
Topics: Adult; Catatonia; Diagnosis, Differential; Electroconvulsive Therapy; Female; Humans; Loxapine; Neur | 1991 |
Neuroleptic malignant syndrome associated with withdrawal from carbamazepine.
Topics: Adult; Carbamazepine; Humans; Loxapine; Male; Neuroleptic Malignant Syndrome; Psychotic Disorders; S | 1990 |
Use of neuroleptics after an episode of neuroleptic malignant syndrome.
Topics: Adolescent; Dibenzoxazepines; Drug Therapy, Combination; Humans; Loxapine; Male; Methotrimeprazine; | 1989 |
Successful treatment of neuroleptic malignant syndrome with sodium nitroprusside.
Topics: Combined Modality Therapy; Female; Ferricyanides; Fluphenazine; Humans; Loxapine; Middle Aged; Neuro | 1986 |