Page last updated: 2024-08-23

lovastatin and Pregnancy

lovastatin has been researched along with Pregnancy in 23 studies

Research

Studies (23)

TimeframeStudies, this research(%)All Research%
pre-19904 (17.39)18.7374
1990's7 (30.43)18.2507
2000's9 (39.13)29.6817
2010's3 (13.04)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Paintlia, AS; Paintlia, MK; Singh, AK; Singh, I1
Barszczyk, A; Charlton, MP; Feng, ZP; Quan, Y; Sun, HS; Zheng, W1
Chen, F; Han, ZC; Ma, FX; Ren, Q1
Hoe, CM; Lankas, GR; Stoffregen, DA; Wise, LD1
Chang, TY; Chou, CK; Chow, NH; Leu, TH; Liu, HS; Tsai, WJ1
Cukierski, MA; Lankas, GR; Wise, LD1
Gibb, H; Scialli, AR1
Edison, RJ; Muenke, M1
Burnett, DM; Cunningham, ML; Osborne, MJ; Pollack, PS; Shields, KE; Stepanavage, ME1
Brown, MS; Engelking, LJ; Evers, BM; Goldstein, JL; Liang, G; Richardson, JA1
Pickering, TG1
Hatton, J; Middleton, B; White, DA1
Bokelman, DL; MacDonald, JS; Minsker, DH; Robertson, RT1
Durham, SK; Flint, OP; Gregg, RE; Masters, BA; Palmoski, MJ; Wang-Iverson, D1
Desager, JP; Horsmans, Y1
Durham, SK; Flint, OP; Gregg, RE; Masters, BA2
Camarillo, IG; Rillema, JA1
Löwik, C; Papapoulos, S; van beek, E; van der Pluijm, G1
Getz, B; Ingle, JN; Karpeisky, MY; Mikhailov, SN; Padyukova, NSh; Reinholz, GG; Sanders, ES; Spelsberg, TC1
Yeatman, E1
Reimers, TJ; Ullmann, MB1

Reviews

2 review(s) available for lovastatin and Pregnancy

ArticleYear
Recommendations for treatment of hyperlipidemia in adults. A joint statement of the Nutrition Committee and the Council on Arteriosclerosis.
    Circulation, 1984, Volume: 69, Issue:5

    Topics: Cholesterol; Clofibrate; Coronary Disease; Female; Gemfibrozil; Humans; Hypercholesterolemia; Hyperlipidemias; Hyperlipoproteinemia Type IV; Hyperlipoproteinemias; Lactation; Lipoproteins; Lovastatin; Naphthalenes; Niacin; Pentanoic Acids; Pregnancy; Pregnancy Complications; Probucol; Tangier Disease; Triglycerides

1984
Clinical pharmacokinetics of 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors.
    Clinical pharmacokinetics, 1996, Volume: 31, Issue:5

    Topics: Aged; Cholesterol; Drug Interactions; Fatty Acids, Monounsaturated; Female; Fluvastatin; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Lipoproteins; Lovastatin; Male; Pravastatin; Pregnancy; Simvastatin

1996

Other Studies

21 other study(ies) available for lovastatin and Pregnancy

ArticleYear
Modulation of Rho-Rock signaling pathway protects oligodendrocytes against cytokine toxicity via PPAR-α-dependent mechanism.
    Glia, 2013, Volume: 61, Issue:9

    Topics: Analysis of Variance; Animals; Animals, Newborn; Cell Survival; Cells, Cultured; Cerebral Cortex; Cytokines; Enzyme Inhibitors; Female; Galactosides; Glutathione; Hydroxymethylglutaryl-CoA Reductase Inhibitors; L-Lactate Dehydrogenase; Lovastatin; Membrane Potential, Mitochondrial; Mice; Mice, Knockout; Neurons; Oligodendroglia; PPAR alpha; Pregnancy; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; rho GTP-Binding Proteins; rho-Associated Kinases; Signal Transduction; Transfection

2013
Differential roles of the mevalonate pathway in the development and survival of mouse Purkinje cells in culture.
    Molecular neurobiology, 2015, Volume: 51, Issue:3

    Topics: Animals; Cell Differentiation; Cell Survival; Cells, Cultured; Female; Lovastatin; Mevalonic Acid; Mice; Pregnancy; Purkinje Cells; Signal Transduction

2015
Lovastatin restores the function of endothelial progenitor cells damaged by oxLDL.
    Acta pharmacologica Sinica, 2009, Volume: 30, Issue:5

    Topics: Antigens, CD34; Apoptosis; Cell Adhesion; Cell Movement; Cells, Cultured; Down-Regulation; Female; Hematopoietic Stem Cells; Humans; Lipoproteins, LDL; Lovastatin; Nitric Oxide Synthase Type III; Phosphorylation; Pregnancy; Proto-Oncogene Proteins c-akt; Signal Transduction

2009
Juvenile toxicity assessment of open-acid lovastatin in rats.
    Birth defects research. Part B, Developmental and reproductive toxicology, 2011, Volume: 92, Issue:4

    Topics: Abnormalities, Drug-Induced; Animals; Anticholesteremic Agents; Behavior, Animal; Body Weight; Brain; Female; Lovastatin; Male; Motor Activity; Nervous System Diseases; Pregnancy; Rats; Rats, Sprague-Dawley

2011
Identifying the factors and signal pathways necessary for anchorage-independent growth of Ha-ras oncogene-transformed NIH/3T3 cells.
    Life sciences, 2003, Jul-25, Volume: 73, Issue:10

    Topics: 3T3 Cells; Animals; Antibodies, Blocking; Cattle; Cell Adhesion; Cell Line, Transformed; Colostrum; Dose-Response Relationship, Drug; Female; Gene Expression Regulation; Genes, ras; Insulin-Like Growth Factor I; Lovastatin; Mice; NF-kappa B; Phosphatidylinositol 3-Kinases; Pregnancy; Proto-Oncogene Proteins p21(ras); Receptor, IGF Type 1; Signal Transduction; Transgenes

2003
The role of maternal toxicity in lovastatin-induced developmental toxicity.
    Birth defects research. Part B, Developmental and reproductive toxicology, 2004, Volume: 71, Issue:3

    Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Animals; Area Under Curve; Body Weight; Bone and Bones; Dose-Response Relationship, Drug; Drug-Related Side Effects and Adverse Reactions; Embryo, Mammalian; Female; Fetal Weight; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Liver; Lovastatin; Maternal Exposure; Organ Size; Pregnancy; Pregnancy, Animal; Rats; Teratogens; Time Factors; Weight Loss

2004
Statin drugs and congenital anomalies.
    American journal of medical genetics. Part A, 2005, Jun-01, Volume: 135, Issue:2

    Topics: Abnormalities, Drug-Induced; Atorvastatin; Female; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Infant, Newborn; Lovastatin; Pregnancy; Pregnancy Outcome; Pyrroles; Simvastatin

2005
Gestational exposure to lovastatin followed by cardiac malformation misclassified as holoprosencephaly.
    The New England journal of medicine, 2005, Jun-30, Volume: 352, Issue:26

    Topics: Abnormalities, Drug-Induced; Central Nervous System; Female; Heart Defects, Congenital; Holoprosencephaly; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Infant, Newborn; Lovastatin; Pregnancy; Pregnancy Trimester, First

2005
Pregnancy outcomes after maternal exposure to simvastatin and lovastatin.
    Birth defects research. Part A, Clinical and molecular teratology, 2005, Volume: 73, Issue:11

    Topics: Abnormalities, Drug-Induced; Abortion, Spontaneous; Adult; Anticholesteremic Agents; Female; Fetal Death; Humans; Lovastatin; Maternal-Fetal Exchange; Pregnancy; Pregnancy Outcome; Prospective Studies; Retrospective Studies; Simvastatin

2005
Severe facial clefting in Insig-deficient mouse embryos caused by sterol accumulation and reversed by lovastatin.
    The Journal of clinical investigation, 2006, Volume: 116, Issue:9

    Topics: Animals; Bone and Bones; Female; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Membrane Proteins; Mice; Mice, Knockout; Mouth Abnormalities; Pregnancy; Sterols

2006
The Food and Drug Administration and over-the-counter statins: an opportunity lost?
    Journal of clinical hypertension (Greenwich, Conn.), 2008, Volume: 10, Issue:3

    Topics: Adult; Aged; Cardiovascular Diseases; Contraindications; Drug Approval; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lipoproteins, LDL; Lovastatin; Male; Middle Aged; Nonprescription Drugs; Pravastatin; Pregnancy; Self Administration; United States; United States Food and Drug Administration

2008
A mevalonate requirement for maintenance of fatty acid and protein synthesis during hormonally stimulated development of mammary gland in vitro.
    The Journal of biological chemistry, 1984, Aug-25, Volume: 259, Issue:16

    Topics: Acetates; Acetic Acid; Animals; Carbon Radioisotopes; Fatty Acids; Female; Hydroxymethylglutaryl CoA Reductases; Insulin; Leucine; Lovastatin; Mammary Glands, Animal; Mevalonic Acid; Microsomes; Naphthalenes; Organ Culture Techniques; Pregnancy; Prolactin; Protein Biosynthesis; Rabbits; Tritium

1984
Mevalonate supplementation in pregnant rats suppresses the teratogenicity of mevinolinic acid, an inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme a reductase.
    Teratology, 1983, Volume: 28, Issue:3

    Topics: Abnormalities, Drug-Induced; Animals; Cholesterol; Female; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Naphthalenes; Pregnancy; Rats; Rats, Inbred Strains

1983
In vitro myotoxicity of the 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors, pravastatin, lovastatin, and simvastatin, using neonatal rat skeletal myocytes.
    Toxicology and applied pharmacology, 1995, Volume: 131, Issue:1

    Topics: Animals; Anticholesteremic Agents; Blood Proteins; Cells, Cultured; Cholesterol; Drug Stability; Female; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Liver; Lovastatin; Mevalonic Acid; Muscle, Skeletal; Pravastatin; Pregnancy; Protein Binding; Rats; Rats, Sprague-Dawley; Simvastatin

1995
Inhibition of cholesterol synthesis by squalene synthase inhibitors does not induce myotoxicity in vitro.
    Toxicology and applied pharmacology, 1997, Volume: 145, Issue:1

    Topics: Analysis of Variance; Animals; Animals, Newborn; Anticholesteremic Agents; Butylamines; Cells, Cultured; Cholesterol; Diterpenes; Enzyme Inhibitors; Farnesol; Farnesyl-Diphosphate Farnesyltransferase; Female; Hydroxymethylglutaryl-CoA Reductase Inhibitors; L-Lactate Dehydrogenase; Lovastatin; Mevalonic Acid; Muscle, Skeletal; Pravastatin; Pregnancy; Prodrugs; Protein Biosynthesis; Rats; Rats, Sprague-Dawley; Squalene; Sulfonic Acids

1997
HMG CoA reductase inhibitor-induced myotoxicity: pravastatin and lovastatin inhibit the geranylgeranylation of low-molecular-weight proteins in neonatal rat muscle cell culture.
    Toxicology and applied pharmacology, 1997, Volume: 145, Issue:1

    Topics: Animals; Animals, Newborn; Anticholesteremic Agents; Autoradiography; Cells, Cultured; Cholesterol; Densitometry; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Female; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Isotope Labeling; Lovastatin; Mevalonic Acid; Molecular Weight; Muscle Proteins; Muscle, Skeletal; Polyisoprenyl Phosphates; Pravastatin; Pregnancy; Protein Processing, Post-Translational; Rats; Rats, Sprague-Dawley; Scintillation Counting; Sesquiterpenes; Tritium

1997
Lovastatin inhibits prolactin-induced Nb2 cell mitogenesis and milk product synthesis in mouse mammary gland explants.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1997, Volume: 216, Issue:1

    Topics: Animals; Cell Division; Female; Lactose; Lovastatin; Mammary Glands, Animal; Mice; Pregnancy; Prolactin; Protein Prenylation; Proto-Oncogene Proteins p21(ras)

1997
The role of geranylgeranylation in bone resorption and its suppression by bisphosphonates in fetal bone explants in vitro: A clue to the mechanism of action of nitrogen-containing bisphosphonates.
    Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 1999, Volume: 14, Issue:5

    Topics: Animals; Bone and Bones; Bone Resorption; Culture Techniques; Diphosphonates; Dose-Response Relationship, Drug; Female; Ibandronic Acid; Lovastatin; Mevalonic Acid; Mice; Models, Chemical; Nitrogen; Pregnancy; Protein Prenylation

1999
Distinct mechanisms of bisphosphonate action between osteoblasts and breast cancer cells: identity of a potent new bisphosphonate analogue.
    Breast cancer research and treatment, 2002, Volume: 71, Issue:3

    Topics: Bone and Bones; Breast Neoplasms; Cell Differentiation; Diphosphonates; Dose-Response Relationship, Drug; Etidronic Acid; Female; Humans; Imidazoles; Lovastatin; Mevalonic Acid; Osteoblasts; Pregnancy; Structure-Activity Relationship; Tumor Cells, Cultured; Zoledronic Acid

2002
Simvastatin.
    The Australian nurses' journal. Royal Australian Nursing Federation, 1991, Volume: 21, Issue:1

    Topics: Anticholesteremic Agents; Contraindications; Drug Interactions; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Lovastatin; Pregnancy; Simvastatin

1991
Progesterone production by binucleate trophoblastic cells of cows.
    Journal of reproduction and fertility. Supplement, 1989, Volume: 37

    Topics: Aminoglutethimide; Animals; Calcimycin; Calcium; Calmodulin; Cattle; Cells, Cultured; Cholesterol, HDL; Cholesterol, LDL; Female; Lovastatin; Pregnancy; Pregnancy, Animal; Progesterone; Sterols; Trifluoperazine; Trophoblasts

1989