Page last updated: 2024-08-23

lovastatin and Innate Inflammatory Response

lovastatin has been researched along with Innate Inflammatory Response in 37 studies

Research

Studies (37)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's3 (8.11)18.2507
2000's14 (37.84)29.6817
2010's19 (51.35)24.3611
2020's1 (2.70)2.80

Authors

AuthorsStudies
Baumann, K; Camenisch, G; Meingassner, JG; Schmutz, S; Ullrich, T; Weitz-Schmidt, G; Welzenbach, K1
Edwards, BS; Graves, SW; Saunders, MJ; Sklar, LA; Zhu, J1
Du, T; Du, XJ; Huang, YP; Li, P; Wang, S1
Braga, L; Celsi, F; Crovella, S; Gratton, R; Tricarico, PM1
Choi, HW; Choi, WS; Kang, MJ; Kim, GD; Kong, WS; Lee, JH; Oh, MJ; Seo, YB; Shin, PG1
Feng, WW; Kuang, SY; Liu, TS; Ma, ZJ; Pang, JY; Tu, C; Wang, JB; Wang, YH; Xiao, XH; Zang, QC; Zhao, YL1
Aa, JY; Feng, D; Ge, C; Sun, JG; Tan, ZY; Wang, GJ; Xie, Y; Yan, CX; Yao, L1
Guo, L; Huang, H; Liang, L; Shao, W; Shu, T; Sun, P; Xu, S; Zhang, Y; Zhou, Y1
English, H; Frey, T; Llewellyn, T; Monteferante, K; Swade, K; Vogt, E; Zwecker, L1
Kurup, GM; Renju, GL; Saritha Kumari, CH1
Bleedorn, JA; Kalscheur, V; Lu, Y; Markel, MD; Nemke, B; Sullivan, R1
Fraemohs, L; Hackeng, TM; Koenen, RR; Schmitt, MM; Weber, C1
Crovella, S; Kleiner, G; Marcuzzi, A; Monasta, L; Piscianz, E; Tricarico, PM1
Canavese, M; Crisanti, A1
Dokmeci, MR; Ferreira, L; Khademhosseini, A; Leijten, J; Miscuglio, M; Nissan, X; Pitrez, PR; Ribas, J; Rouwkema, J; Zhang, YS1
Almonacid, L; Ardavín, C; Barber, DF; Goya, I; Jiménez-Baranda, S; León, B; Mañes, S; Márquez, G; Martínez-A, C; Mira, E; Stein, JV; Zaballos, A1
Bode, C; Diehl, P; Goetz, L; Heinke, J; Helbing, T; Moser, M; Patterson, C; Rothweiler, R; Zirlik, A1
Croze, R; Levy, BD; Pfeffer, MA; Planagumà, A; Rubin, G; Serhan, CN; Uddin, M1
Fritz, G; Grösch, S; Henninger, C; Huelsenbeck, J; Huelsenbeck, S; Kaina, B; Lackner, KJ; Schad, A1
Hollis, BW; Paintlia, AS; Paintlia, MK; Singh, AK; Singh, I1
Li, X; Ning, Y; Qiu, Y; Tian, D; Wang, X; Yin, L; Zhan, Y; Zhi, X1
Assis, EF; Bozza, FA; Bozza, PT; Castro-Faria-Neto, HC; d'Avila, JC; da Silva, TI; Estato, V; Reis, PA; Siqueira, LD; Tibiriça, EV; Zimmerman, GA1
Alber, HF; Ares, MP; Dichtl, W; Dulak, J; Frick, M; Nilsson, J; Pachinger, O; Schwarzacher, SP; Weidinger, F1
Fei, J; Hänsch, GM; Kamimura, M; Katus, HA; Kreuzer, J; Shen, W; Viedt, C1
Fang, CH; Li, JJ1
Contreras, MA; Haq, E; Khan, M; Paintlia, AS; Paintlia, MK; Singh, AK; Singh, I; Stanislaus, R1
Chen, CC; Chen, SF; Huang, YN; Hung, TH; Lin, KH; Tsai, HC; Wang, JY1
Paintlia, AS; Paintlia, MK; Singh, AK; Singh, I1
Arima, J; Chiba, Y; Misawa, M; Sakai, H1
Albrecht, C; Borm, PJ; Haberzettl, P; Höhr, D; Schins, RP; Wilhelmi, V1
Lee, CL; Pan, TM; Wang, JJ1
Bateman, TM; Conn, RD; Lavie, CJ; O'Keefe, JH1
Rosenson, RS; Tangney, CC1
Rosenson, RS1
Davignon, J; Mabile, L1
Garrett, IR; Gutierrez, G; Mundy, GR1
Farmer, JA; Gotto, AM1

Reviews

6 review(s) available for lovastatin and Innate Inflammatory Response

ArticleYear
The new paradigm for coronary artery disease: altering risk factors, atherosclerotic plaques, and clinical prognosis.
    Mayo Clinic proceedings, 1996, Volume: 71, Issue:10

    Topics: Adrenergic beta-Antagonists; Angiotensin-Converting Enzyme Inhibitors; Anticholesteremic Agents; Antioxidants; Coronary Angiography; Coronary Artery Disease; Endothelium, Vascular; Exercise Test; Humans; Hypercholesterolemia; Inflammation; Lovastatin; Platelet Aggregation Inhibitors; Prognosis; Randomized Controlled Trials as Topic; Risk Factors; Simvastatin

1996
Antiatherothrombotic properties of statins: implications for cardiovascular event reduction.
    JAMA, 1998, May-27, Volume: 279, Issue:20

    Topics: Animals; Antithrombins; Cardiovascular Diseases; Cholesterol, LDL; Clinical Trials as Topic; Coronary Disease; Endothelium, Vascular; Fibrinogen; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypolipidemic Agents; Inflammation; Lovastatin; Muscle, Smooth, Vascular; Platelet Aggregation; Pravastatin; Simvastatin; Thromboplastin; Thrombosis

1998
Non-lipid-lowering effects of statins on atherosclerosis.
    Current cardiology reports, 1999, Volume: 1, Issue:3

    Topics: Anticholesteremic Agents; Arteriosclerosis; Blood Coagulation; Cytokines; Endothelin-1; Endothelium, Vascular; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inflammation; Lovastatin; Nitric Oxide; Plasminogen Activator Inhibitor 1

1999
[Mechanisms of action of statins and their pleiotropic effects].
    Annales d'endocrinologie, 2001, Volume: 62, Issue:1 Pt 2

    Topics: Arteriosclerosis; Cell Division; Endothelium, Vascular; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inflammation; Lovastatin; Neoplasms; Osteoporosis

2001
Statins and bone formation.
    Current pharmaceutical design, 2001, Volume: 7, Issue:8

    Topics: Animals; Bone Development; Endothelium, Vascular; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inflammation; Lovastatin; Neoplasms; Nitric Oxide Synthase; Pyridines; Simvastatin

2001
Pleiotropic effects of statins: do they matter?
    Current opinion in lipidology, 2001, Volume: 12, Issue:4

    Topics: Animals; Cardiovascular Diseases; Cholesterol, LDL; Endothelium, Vascular; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inflammation; Lovastatin; Thrombosis

2001

Other Studies

31 other study(ies) available for lovastatin and Innate Inflammatory Response

ArticleYear
Statin-derived 1,3-oxazinan-2-ones as submicromolar inhibitors of LFA-1/ICAM-1 interaction: stabilization of the metabolically labile vanillyl side chain.
    Bioorganic & medicinal chemistry letters, 2004, May-17, Volume: 14, Issue:10

    Topics: Animals; Anti-Inflammatory Agents; Dose-Response Relationship, Drug; Drug Stability; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inflammation; Inhibitory Concentration 50; Intercellular Adhesion Molecule-1; Lovastatin; Lymphocyte Function-Associated Antigen-1; Microsomes, Liver; Protein Binding; Rats; Structure-Activity Relationship

2004
Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
    Current protocols in cytometry, 2010, Volume: Chapter 13

    Topics: Animals; Biotinylation; Flow Cytometry; Fluorescence Resonance Energy Transfer; Green Fluorescent Proteins; High-Throughput Screening Assays; Humans; Inflammation; Kinetics; Microspheres; Peptide Hydrolases; Peptides; Reproducibility of Results; Temperature

2010
Protective effect and mechanism of Monascus-fermented red yeast rice against colitis caused by Salmonella enterica serotype Typhimurium ATCC 14028.
    Food & function, 2020, Jul-22, Volume: 11, Issue:7

    Topics: Animals; Biological Products; Cholesterol; Citrinin; Colitis; Disease Models, Animal; Dysbiosis; Feces; Female; Fermentation; Fermented Foods; Gastrointestinal Microbiome; Gene Expression; Inflammation; Intestines; Lactobacillus; Lipids; Lovastatin; Mice; Mice, Inbred BALB C; Monascus; NF-kappa B; Protective Agents; Salmonella typhimurium; Serogroup

2020
25-Hydroxycholesterol and inflammation in Lovastatin-deregulated mevalonate pathway.
    The international journal of biochemistry & cell biology, 2017, Volume: 92

    Topics: Apoptosis; Autophagy; Cell Line, Tumor; Humans; Hydroxycholesterols; Inflammation; Interleukin-1beta; Lovastatin; Mevalonic Acid; Protein Prenylation; Signal Transduction

2017
Anti-inflammatory effect of lovastatin is mediated via the modulation of NF-κB and inhibition of HDAC1 and the PI3K/Akt/mTOR pathway in RAW264.7 macrophages.
    International journal of molecular medicine, 2018, Volume: 41, Issue:2

    Topics: Animals; Anti-Inflammatory Agents; Gene Expression Regulation; Histone Deacetylase 1; Humans; Inflammation; Lipopolysaccharides; Lovastatin; Macrophages; Mice; NF-kappa B; Nitric Oxide Synthase Type II; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; RAW 264.7 Cells; TOR Serine-Threonine Kinases; Tumor Necrosis Factor-alpha

2018
Natural products berberine and curcumin exhibited better ameliorative effects on rats with non-alcohol fatty liver disease than lovastatin.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2018, Volume: 99

    Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Berberine; Biological Products; Blood Glucose; Body Weight; Curcumin; Gene Expression Regulation; Inflammation; Insulin; Intra-Abdominal Fat; Lipid Metabolism; Lipids; Lipopolysaccharides; Liver; Lovastatin; Male; Non-alcoholic Fatty Liver Disease; Organ Size; Oxidative Stress; Rats, Sprague-Dawley

2018
Isoflavones enhance pharmacokinetic exposure of active lovastatin acid via the upregulation of carboxylesterase in high-fat diet mice after oral administration of Xuezhikang capsules.
    Acta pharmacologica Sinica, 2018, Volume: 39, Issue:11

    Topics: Administration, Oral; Animals; Carboxylesterase; Cell Line, Tumor; Down-Regulation; Drugs, Chinese Herbal; Humans; Hyperlipidemias; Inflammation; Isoflavones; Lovastatin; Male; Mice, Inbred C57BL; Pregnane X Receptor; Up-Regulation

2018
Xuezhikang improves the outcomes of cardiopulmonary resuscitation in rats by suppressing the inflammation response through TLR4/NF-κB pathway.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2019, Volume: 114

    Topics: Animals; Cardiopulmonary Resuscitation; Drugs, Chinese Herbal; Heart Arrest; Hippocampus; Inflammation; Interleukin-1beta; Interleukin-6; Lovastatin; Male; NF-kappa B; Rats; Rats, Sprague-Dawley; Signal Transduction; Survival Rate; Toll-Like Receptor 4; Tumor Necrosis Factor-alpha

2019
Monocyte Production of IFN-γ Is Interleukin-12 Dependent in a Model of Mevalonate Kinase Deficiency.
    Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research, 2019, Volume: 39, Issue:6

    Topics: Healthy Volunteers; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inflammation; Interferon-gamma; Interleukin-12; Lipopolysaccharides; Lovastatin; Mevalonate Kinase Deficiency; Monocytes; THP-1 Cells

2019
Effect of lycopene from Chlorella marina on high cholesterol-induced oxidative damage and inflammation in rats.
    Inflammopharmacology, 2014, Volume: 22, Issue:1

    Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Carotenoids; Chlorella; Cholesterol; Inflammation; Lovastatin; Lycopene; Male; Oxidative Stress; Rats; Rats, Sprague-Dawley; Triglycerides

2014
Percutaneous lovastatin accelerates bone healing but is associated with periosseous soft tissue inflammation in a canine tibial osteotomy model.
    Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 2014, Volume: 32, Issue:2

    Topics: Animals; Dogs; Female; Fracture Fixation; Fracture Healing; Inflammation; Injections, Subcutaneous; Lovastatin; Osteotomy; Radiography; Tibia

2014
Atherogenic mononuclear cell recruitment is facilitated by oxidized lipoprotein-induced endothelial junctional adhesion molecule-A redistribution.
    Atherosclerosis, 2014, Volume: 234, Issue:2

    Topics: Animals; Anti-Inflammatory Agents; Apolipoproteins E; Atherosclerosis; Cell Adhesion Molecules; Cells, Cultured; Coculture Techniques; Endothelial Cells; Humans; Inflammation; Inflammation Mediators; Leukocyte Rolling; Leukocytes, Mononuclear; Lipoproteins, LDL; Lovastatin; Mice; Mice, Knockout; Permeability; Pioglitazone; Protein Transport; Receptors, Cell Surface; RNA Interference; Signal Transduction; Thiazolidinediones; Transendothelial and Transepithelial Migration; Transfection

2014
Microglia activation and interaction with neuronal cells in a biochemical model of mevalonate kinase deficiency.
    Apoptosis : an international journal on programmed cell death, 2015, Volume: 20, Issue:8

    Topics: Animals; Apoptosis; Cell Line; Coculture Techniques; Cytokines; Disease Models, Animal; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inflammation; Lipopolysaccharides; Lovastatin; Membrane Potential, Mitochondrial; Mevalonate Kinase Deficiency; Mevalonic Acid; Mice; Microglia; Neurons

2015
Vascular endothelial growth factor (VEGF) and lovastatin suppress the inflammatory response to Plasmodium berghei infection and protect against experimental cerebral malaria.
    Pathogens and global health, 2015, Volume: 109, Issue:6

    Topics: Animals; Antimalarials; Cytokines; Disease Models, Animal; Drug Synergism; Female; Heme Oxygenase-1; Inflammation; Lovastatin; Malaria, Cerebral; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Oxidative Stress; Plasmodium berghei; Vascular Endothelial Growth Factor A

2015
Biomechanical Strain Exacerbates Inflammation on a Progeria-on-a-Chip Model.
    Small (Weinheim an der Bergstrasse, Germany), 2017, Volume: 13, Issue:15

    Topics: Angiotensin II; Biomechanical Phenomena; Blood Vessels; Cytoskeleton; Disease Progression; Humans; Induced Pluripotent Stem Cells; Inflammation; Lab-On-A-Chip Devices; Lovastatin; Microfluidics; Myocytes, Smooth Muscle; Phenotype; Progeria

2017
Statins induce regulatory T cell recruitment via a CCL1 dependent pathway.
    Journal of immunology (Baltimore, Md. : 1950), 2008, Sep-01, Volume: 181, Issue:5

    Topics: Animals; Candida albicans; Chemokine CCL1; Chemotaxis, Leukocyte; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypersensitivity; Inflammation; Lovastatin; Mice; Mice, Knockout; T-Lymphocyte Subsets; T-Lymphocytes, Regulatory; Th2 Cells; Up-Regulation

2008
BMPER is upregulated by statins and modulates endothelial inflammation by intercellular adhesion molecule-1.
    Arteriosclerosis, thrombosis, and vascular biology, 2010, Volume: 30, Issue:3

    Topics: Actins; Animals; Bone Morphogenetic Protein 4; Carrier Proteins; Cells, Cultured; Down-Regulation; Endothelium, Vascular; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inflammation; Intercellular Adhesion Molecule-1; Lovastatin; Mice; Mice, Inbred C57BL; Models, Animal; rho-Associated Kinases; rhoA GTP-Binding Protein; Signal Transduction; Up-Regulation

2010
Lovastatin decreases acute mucosal inflammation via 15-epi-lipoxin A4.
    Mucosal immunology, 2010, Volume: 3, Issue:3

    Topics: 8,11,14-Eicosatrienoic Acid; Acute Disease; Animals; Anticholesteremic Agents; Cell Line; Disease Models, Animal; Female; Humans; Hypercholesterolemia; Inflammation; Inflammation Mediators; Lipoxins; Lovastatin; Male; Mice; Neutrophils; Pneumonia; Respiratory Mucosa

2010
The lipid lowering drug lovastatin protects against doxorubicin-induced hepatotoxicity.
    Toxicology and applied pharmacology, 2012, May-15, Volume: 261, Issue:1

    Topics: Animals; Antibiotics, Antineoplastic; Chemical and Drug Induced Liver Injury; Connective Tissue Growth Factor; DNA Damage; Dose-Response Relationship, Drug; Doxorubicin; Epirubicin; Gene Expression Regulation; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inflammation; Liver Cirrhosis; Lovastatin; Mice; Mice, Inbred BALB C; Oxidative Stress; RNA, Messenger

2012
Interference with RhoA-ROCK signaling mechanism in autoreactive CD4+ T cells enhances the bioavailability of 1,25-dihydroxyvitamin D3 in experimental autoimmune encephalomyelitis.
    The American journal of pathology, 2012, Volume: 181, Issue:3

    Topics: 25-Hydroxyvitamin D3 1-alpha-Hydroxylase; Animals; Biological Availability; Biosynthetic Pathways; Calcitriol; CD4-Positive T-Lymphocytes; Encephalomyelitis, Autoimmune, Experimental; Female; Guinea Pigs; Immunosuppression Therapy; Inflammation; Lovastatin; Lymphoid Tissue; Mevalonic Acid; Protein Kinase Inhibitors; Rats; Rats, Inbred Lew; rho-Associated Kinases; rhoA GTP-Binding Protein; Signal Transduction; Spinal Cord; Steroid Hydroxylases; Vitamin D; Vitamin D3 24-Hydroxylase

2012
Overexpression of steroidogenic acute regulatory protein in rat aortic endothelial cells attenuates palmitic acid-induced inflammation and reduction in nitric oxide bioavailability.
    Cardiovascular diabetology, 2012, Nov-21, Volume: 11

    Topics: Animals; Anti-Inflammatory Agents; Aorta, Thoracic; Biological Availability; Blotting, Western; Cells, Cultured; Cerulenin; Cholesterol; Endothelial Cells; Enzyme-Linked Immunosorbent Assay; Fatty Acid Synthesis Inhibitors; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inflammation; Inflammation Mediators; Interleukin-1beta; Interleukin-6; Lovastatin; Male; NF-kappa B; Nitric Oxide; Palmitic Acid; Phosphoproteins; Rats; Real-Time Polymerase Chain Reaction; RNA Interference; RNA, Messenger; Time Factors; Transfection; Tumor Necrosis Factor-alpha; Up-Regulation; Vascular Cell Adhesion Molecule-1

2012
Statins decrease neuroinflammation and prevent cognitive impairment after cerebral malaria.
    PLoS pathogens, 2012, Volume: 8, Issue:12

    Topics: Animals; Brain; CD11b Antigen; Chemokines; Chloroquine; Cognition Disorders; Cytokines; Edema; Endothelium; Heme Oxygenase-1; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inflammation; Inflammation Mediators; Intercellular Adhesion Molecule-1; Leukocytes; Lovastatin; Malaria, Cerebral; Membrane Proteins; Mice; Mice, Inbred C57BL; Oxidative Stress; Plasmodium berghei; RNA, Messenger

2012
HMG-CoA reductase inhibitors regulate inflammatory transcription factors in human endothelial and vascular smooth muscle cells.
    Arteriosclerosis, thrombosis, and vascular biology, 2003, Jan-01, Volume: 23, Issue:1

    Topics: Atorvastatin; Cell Line; Cell Survival; Down-Regulation; Endothelial Growth Factors; Endothelium, Vascular; Gene Expression Regulation; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypoxia-Inducible Factor 1, alpha Subunit; I-kappa B Proteins; Inflammation; Lovastatin; Muscle, Smooth, Vascular; NF-kappa B; NF-KappaB Inhibitor alpha; Plasminogen Activator Inhibitor 1; Protein Binding; Proto-Oncogene Proteins c-jun; Pyrroles; RNA, Messenger; Simvastatin; Transcription Factor AP-1; Transcription Factors; Vascular Endothelial Growth Factor A

2003
HMG-CoA reductase inhibition reduces the proinflammatory activation of human vascular smooth muscle cells by the terminal complement factor C5b-9.
    Basic research in cardiology, 2003, Volume: 98, Issue:6

    Topics: Cell Division; Cell Survival; Complement Membrane Attack Complex; Enzyme Activation; Humans; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inflammation; Interleukin-6; Lovastatin; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Muscle, Smooth, Vascular; NF-kappa B; Pyridines; Transcription Factor AP-1

2003
C-reactive protein is not only an inflammatory marker but also a direct cause of cardiovascular diseases.
    Medical hypotheses, 2004, Volume: 62, Issue:4

    Topics: Acute-Phase Reaction; Aspirin; Atorvastatin; Biomarkers; C-Reactive Protein; Cardiovascular Diseases; Clinical Trials as Topic; Coronary Artery Disease; Heptanoic Acids; Humans; Incidence; Inflammation; Interleukin-6; Lovastatin; Pravastatin; Predictive Value of Tests; Pyrroles; Risk Factors; Simvastatin

2004
Impaired peroxisomal function in the central nervous system with inflammatory disease of experimental autoimmune encephalomyelitis animals and protection by lovastatin treatment.
    Brain research, 2004, Oct-01, Volume: 1022, Issue:1-2

    Topics: Acyl-CoA Oxidase; Acyltransferases; Adenosine Triphosphatases; Animals; Anticholesteremic Agents; ATP-Binding Cassette Transporters; ATPases Associated with Diverse Cellular Activities; Catalase; Central Nervous System; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Fatty Acids; Female; Freund's Adjuvant; Immunohistochemistry; Inflammation; Lovastatin; Membrane Proteins; Microarray Analysis; Peroxisomal Disorders; Peroxisomes; Rats; Rats, Inbred Lew; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger

2004
Lovastatin improves histological and functional outcomes and reduces inflammation after experimental traumatic brain injury.
    Life sciences, 2007, Jul-04, Volume: 81, Issue:4

    Topics: Animals; Brain Injuries; Cytokines; Disease Models, Animal; Encephalitis; Gene Expression Regulation; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immunohistochemistry; Inflammation; Interleukin-1beta; Lovastatin; Male; Neurons; Rats; Rats, Sprague-Dawley; Reaction Time; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Rotarod Performance Test; Treatment Outcome; Tumor Necrosis Factor-alpha

2007
Inhibition of rho family functions by lovastatin promotes myelin repair in ameliorating experimental autoimmune encephalomyelitis.
    Molecular pharmacology, 2008, Volume: 73, Issue:5

    Topics: Animals; Benzamides; Cell Differentiation; Cell Proliferation; Cells, Cultured; Cholesterol; Encephalomyelitis, Autoimmune, Experimental; Female; Hydroxymethylglutaryl CoA Reductases; Inflammation; Lovastatin; Methionine; Mevalonic Acid; Myelin Sheath; Nerve Growth Factors; Neuroglia; Oligodendroglia; Polyisoprenyl Phosphates; ras Proteins; Rats; Rats, Inbred Lew; Rats, Sprague-Dawley; rho GTP-Binding Proteins; Spinal Cord; Wound Healing

2008
Lovastatin inhibits bronchial hyperresponsiveness by reducing RhoA signaling in rat allergic asthma.
    American journal of physiology. Lung cellular and molecular physiology, 2008, Volume: 294, Issue:4

    Topics: Animals; Antigens, Helminth; Ascaris suum; Asthma; Bordetella pertussis; Bronchial Hyperreactivity; Disease Models, Animal; Inflammation; Lovastatin; Male; Muscle Contraction; Muscle, Smooth; Rats; Rats, Wistar; Respiratory System; rhoA GTP-Binding Protein

2008
Impact of the FcgammaII-receptor on quartz uptake and inflammatory response by alveolar macrophages.
    American journal of physiology. Lung cellular and molecular physiology, 2008, Volume: 294, Issue:6

    Topics: Aminoquinolines; Animals; Cell Line; Flow Cytometry; Inflammation; Lovastatin; Macrophages, Alveolar; Monomeric GTP-Binding Proteins; Phagocytosis; Poly I; Polysaccharides; Protein-Tyrosine Kinases; Pyrimidines; Quartz; Rats; Receptors, IgG; Signal Transduction

2008
Red mold rice extract represses amyloid beta peptide-induced neurotoxicity via potent synergism of anti-inflammatory and antioxidative effect.
    Applied microbiology and biotechnology, 2008, Volume: 79, Issue:5

    Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Anti-Inflammatory Agents; Anticholesteremic Agents; Antioxidants; Cell Survival; Drug Synergism; Drugs, Chinese Herbal; Humans; Inflammation; Lovastatin; Monascus; Oryza; Oxidative Stress; PC12 Cells; Rats; Signal Transduction

2008