Compounds > lovastatin
Page last updated: 2024-08-23

lovastatin and Granulocytic Leukemia

lovastatin has been researched along with Granulocytic Leukemia in 13 studies

Research

Studies (13)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's6 (46.15)18.2507
2000's7 (53.85)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Higashi, Y; Pallis, M; Russell, N; Turzanski, J1
Appelbaum, FR; Banker, DE; Li, HY; Willman, CL; Zager, RA1
Appelbaum, FR; Banker, DE; Stirewalt, DL; Willman, CL; Zager, RA1
Burke, LP; Lewis, LD; Perez, RP1
Catovsky, D; Clutterbuck, RD; DeLord, C; Millar, JL; Newman, A; Powles, RL1
Clutterbuck, RD; Millar, JL; Newman, A; Powles, RL1
Catovsky, D; Clutterbuck, RD; Millar, JL; Newman, A; Powles, RL1
Chorváth, B; Chovancová, J; Duraj, J; Hunáková, L; Sedlák, J; Suliková, M1
Backway, KL; Dimitroulakos, J; Freedman, MH; Hedley, DW; Minden, MD; Nohynek, D; Penn, LZ; Yeger, H1
Dimitroulakos, J; Hedley, DW; Minden, MD; Penn, LZ; Thai, S; Wasfy, GH1
Dimitroulakos, J; Minden, MD; Penn, LZ; Tan, MM; Wong, WW; Xia, Z2
Hohl, RJ; Larson, RA; Mannickarottu, V; Yachnin, S1

Reviews

1 review(s) available for lovastatin and Granulocytic Leukemia

ArticleYear
P-glycoprotein in acute myeloid leukaemia: therapeutic implications of its association with both a multidrug-resistant and an apoptosis-resistant phenotype.
    Leukemia & lymphoma, 2002, Volume: 43, Issue:6

    Topics: Acute Disease; Adult; Antineoplastic Agents; Apoptosis; Arsenic Trioxide; Arsenicals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Cell Division; Ceramides; Child; Cyclosporine; Cyclosporins; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Enzyme Inhibitors; Humans; Hydrogen-Ion Concentration; Leukemia, Myeloid; Lovastatin; Multicenter Studies as Topic; Neoplasm Proteins; Oxides; Phenotype; Protein Kinase C; Randomized Controlled Trials as Topic; Signal Transduction; Tumor Cells, Cultured

2002

Other Studies

12 other study(ies) available for lovastatin and Granulocytic Leukemia

ArticleYear
Cholesterol-modulating agents kill acute myeloid leukemia cells and sensitize them to therapeutics by blocking adaptive cholesterol responses.
    Blood, 2003, May-01, Volume: 101, Issue:9

    Topics: Acute Disease; Antineoplastic Agents; Bone Marrow Cells; Bridged Bicyclo Compounds, Heterocyclic; Cholesterol; Cytarabine; Daunorubicin; Drug Synergism; HL-60 Cells; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Leukemia, Myeloid; Lipoproteins, LDL; Lovastatin; Membrane Lipids; Protein Prenylation; Protein Processing, Post-Translational; Radiation-Sensitizing Agents; Tricarboxylic Acids; Tumor Cells, Cultured

2003
Mevastatin can increase toxicity in primary AMLs exposed to standard therapeutic agents, but statin efficacy is not simply associated with ras hotspot mutations or overexpression.
    Leukemia research, 2003, Volume: 27, Issue:2

    Topics: Acute Disease; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Cells; Case-Control Studies; Cell Survival; Drug Synergism; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Leukemia, Myeloid; Lovastatin; Mutation; Myeloid Cells; ras Proteins; Tumor Cells, Cultured

2003
Ubiquinone does not rescue acute myeloid leukemia cells from growth inhibition by statins.
    Leukemia, 2003, Volume: 17, Issue:1

    Topics: Acute Disease; Cell Division; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Leukemia, Myeloid; Lovastatin; Myelodysplastic Syndromes; Tumor Cells, Cultured; Ubiquinone

2003
The sensitivity of leukemic bone marrow to simvastatin is lost at remission: a potential purging agent for autologous bone marrow transplantation.
    Journal of investigative medicine : the official publication of the American Federation for Clinical Research, 1995, Volume: 43, Issue:3

    Topics: Acute Disease; Bone Marrow; Bone Marrow Purging; Bone Marrow Transplantation; Cell Death; Cells, Cultured; Humans; Leukemia, Myeloid; Lovastatin; Remission Induction; Simvastatin; Transplantation, Autologous

1995
Selective inhibition of primary acute myeloid leukaemia cell growth by simvastatin.
    Leukemia, 1994, Volume: 8, Issue:11

    Topics: Acute Disease; Bone Marrow Cells; Cell Division; Cell Survival; Cholesterol; Clone Cells; Hematopoiesis; Hematopoietic Stem Cells; Humans; Leukemia, Myeloid; Lovastatin; Neoplastic Stem Cells; Simvastatin; Time Factors; Tumor Cells, Cultured

1994
A comparison of the effect of the 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors simvastatin, lovastatin and pravastatin on leukaemic and normal bone marrow progenitors.
    Leukemia & lymphoma, 1997, Volume: 24, Issue:5-6

    Topics: Acute Disease; Antineoplastic Agents; Bone Marrow; Bone Marrow Cells; Enzyme Inhibitors; Hematopoietic Stem Cells; HL-60 Cells; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Leukemia, Myeloid; Lovastatin; Pravastatin; Simvastatin

1997
Human multidrug-resistant (MRP,p190) myeloid leukemia HL-60/ADR cells in vitro: resistance to the mevalonate pathway inhibitor lovastatin.
    Neoplasma, 1997, Volume: 44, Issue:6

    Topics: Antineoplastic Agents; Apoptosis; Cell Cycle; Drug Resistance, Multiple; HL-60 Cells; Humans; Leukemia, Myeloid; Lovastatin; Mevalonic Acid

1997
Increased sensitivity of acute myeloid leukemias to lovastatin-induced apoptosis: A potential therapeutic approach.
    Blood, 1999, Feb-15, Volume: 93, Issue:4

    Topics: Acute Disease; Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Apoptosis; Female; Flow Cytometry; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Leukemia, Myeloid; Lovastatin; Male; Microscopy, Electron; Middle Aged; Tumor Cells, Cultured

1999
Lovastatin induces a pronounced differentiation response in acute myeloid leukemias.
    Leukemia & lymphoma, 2000, Volume: 40, Issue:1-2

    Topics: Acute Disease; Adult; Antineoplastic Agents; Biomarkers, Tumor; CD18 Antigens; Cell Death; Cell Differentiation; Child; Down-Regulation; Genes, bcl-2; Humans; Leukemia, Myeloid; Lovastatin; Macrophage-1 Antigen; RNA, Messenger; Tumor Cells, Cultured

2000
Cerivastatin triggers tumor-specific apoptosis with higher efficacy than lovastatin.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2001, Volume: 7, Issue:7

    Topics: Acute Disease; Apoptosis; Atorvastatin; Cell Division; Dose-Response Relationship, Drug; Fatty Acids, Monounsaturated; Fluvastatin; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Leukemia, Myeloid; Lovastatin; Neoplasms; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Pyridines; Pyrroles; Sensitivity and Specificity; Tumor Cells, Cultured

2001
Blocking protein geranylgeranylation is essential for lovastatin-induced apoptosis of human acute myeloid leukemia cells.
    Leukemia, 2001, Volume: 15, Issue:9

    Topics: Acute Disease; Apoptosis; Benzamides; Deoxyuracil Nucleotides; Fluorescein-5-isothiocyanate; Humans; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Leukemia, Myeloid; Lovastatin; Methionine; Mevalonic Acid; Polyisoprenyl Phosphates; Protein Prenylation; Sesquiterpenes; Tumor Cells, Cultured

2001
Inhibition of hydroxymethylglutaryl coenzyme A reductase activity induces a paradoxical increase in DNA synthesis in myeloid leukemia cells.
    Blood, 1991, Mar-01, Volume: 77, Issue:5

    Topics: Cell Cycle; Cells, Cultured; Cholesterol; DNA, Neoplasm; Dose-Response Relationship, Drug; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Leukemia, Myeloid; Lovastatin

1991