lovastatin has been researched along with Elevated Cholesterol in 685 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 73 (10.66) | 18.7374 |
1990's | 472 (68.91) | 18.2507 |
2000's | 98 (14.31) | 29.6817 |
2010's | 31 (4.53) | 24.3611 |
2020's | 11 (1.61) | 2.80 |
Authors | Studies |
---|---|
Asanuma, K; Kaneko, R; Kobayashi, D; Tanabe, H; Tsuji, N; Watanabe, N | 1 |
Rai, SK; Sharma, M; Tiwari, M | 1 |
Heřmánková, E; Hobzová, R; Hromádka, R; Poláková, L; Širc, J; Žák, A | 1 |
Antonic, T; Bogavac-Stanojevic, N; Gojkovic, T; Kotur-Stevuljevic, J; Spasojevic-Kalimanovska, V; Vekic, J; Vladimirov, S; Zeljkovic, A | 1 |
Endo, A; Hattori, A; Hayashi, A; Ide, K; Ide, S; Inagaki, M; Ishikawa, T; Kitamoto, T; Kobayashi, J; Kobayashi, K; Koshizaka, M; Maezawa, Y; Minamizuka, T; Sakamoto, K; Shoji, M; Takemoto, M; Yamaga, M; Yokote, K | 1 |
Benjian, C; Danping, XU; Huanlin, WU; Huiting, P; Xiaodan, H; Yishi, LI; Yongtao, C | 1 |
Arnás, C; Corbella, E; de Dios, S; Florido, M; Licerán, M; Martin, D; Martinez-Martin, F; Petitbò, D; Pintó, X; Sánchez, A; Sánchez-Hernández, RM; Sarasa, I; Trias, F | 1 |
Shi, Y; Yan, M; Zhang, G; Zhang, L | 1 |
Antonicelli, R; Bonfigli, AR; Di Pillo, R; Galeazzi, R; Giuliani, A; Gurău, F; Matacchione, G; Montesanto, A; Olivieri, F; Protic, O; Sabbatinelli, J; Silvestrini, A | 1 |
Ameneiros-Lago, E; Fernández-Fernández, FJ; Sardina-Ferreiro, R | 1 |
Cicero, AFG; Fogacci, F; Stoian, AP; Toth, PP | 1 |
Androulakis, I; Angelopoulos, N; Argyrakopoulou, G; Boniakos, A; Livadas, S; Paparodis, RD | 1 |
Banach, M; Bruckert, E; Catapano, AL; Descamps, OS; Ellegård, L; Ezhov, M; Föger, B; Fras, Z; Kovanen, PT; Latkovskis, G; März, W; Panagiotakos, DB; Paragh, G; Pella, D; Pirillo, A; Poli, A; Reiner, Ž; Silbernagel, G; Viigimaa, M; Vrablík, M | 1 |
Carbone, F; Cremonini, AL; Di Pierro, F; Favari, E; Formisano, E; Pasta, A; Pisciotta, L; Ronca, A; Semino, T; Sukkar, SG | 1 |
Chen, X; Ji, X; Shang, J; Wei, Y; Xie, L; Zhang, C; Zhang, Q; Zhu, G | 1 |
Hosseinpour, F; Rafieian-Kopaei, M; Shomali, T | 1 |
Bonechi, C; Consumi, M; Donati, A; Lamponi, S; Leone, G; Magnani, A; Pepi, S; Rossi, C; Tamasi, G | 1 |
Cicero, AFG | 1 |
Airoldi, G; Ceccarini, G; Fierabracci, P; Jaccheri, R; Magno, S; Minale, M; Pelosini, C; Salvetti, G; Santini, F; Saponati, G; Vitti, J | 1 |
Lenti, S; Mazza, A; Montanaro, F; Rigatelli, G; Schiavon, L; Torin, G | 1 |
Di Giacomo, E; Lenti, S; Manunta, R; Mazza, A; Rubello, D; Schiavon, L; Tomasi, M; Torin, G; Townsend, DM | 1 |
Bjune, K; Leren, TP; Naderi, S; Sundvold, H | 1 |
Maghsoomi, Z; Moghadasi, M | 1 |
Jan, MS; Lee, CY; Lin, CC; Shih, HC; Wei, JC; Yu, MC | 1 |
Borghi, C; Cicero, AF; Grandi, E; Morbini, M; Parini, A; Reggi, A; Rosticci, M | 1 |
Bukhari, SA; Javed, S; Meraj, M; Zovia, I | 1 |
Davison, KM; Kaplan, BJ | 1 |
Gerards, MC; Gerdes, VE; Koks, CH; Terlou, RJ; Yu, H | 1 |
Barbagallo, C; Cicero, AF; Derosa, G; Pisciotta, L | 1 |
Addabbo, F; Bonfrate, L; Carmosino, M; Castorani, L; Di Ciaula, A; Mastrofrancesco, L; Portincasa, P; Procino, G; Svelto, M | 1 |
Averna, M; Blom, D; Cefalù, AB; Ciccarese, M; Cossu, M; Croyal, M; Dallinga-Thie, G; Guédon, A; Hovingh, K; Lambert, G; Passard, M; Peter, J; Pintus, P; Pisciotta, L; Prampart-Fauvet, S; Raal, F; Santos, RD; Sjouke, B; Thedrez, A | 1 |
Bloks, VW; Brufau, G; de Boer, JF; Groen, AK; Kuivenhoven, JA; Mele, L; Schonewille, M; Tietge, UJ; Wolters, H; Wolters, JC | 1 |
Hsu, YW; Lee, CL; Pan, TM; Wen, JY | 1 |
Amento, EP; Bigos, M; Madasamy, S; Shivasubramani, U; Villanueva, J; Wu, AH | 1 |
Dufresne, SS; Frenette, J; Piette, AB | 1 |
Hadji, P; Hahn, A; Heinz, T; Möller, K; Schuchardt, JP | 1 |
Avello L, M; Bravo D, M; Calvo M, C; Mennickent C, S | 1 |
Glueck, CJ; Goldenberg, N; Khan, NA; Rawal, B; Wang, P; Yeramaneni, S | 1 |
Hanson, M; Hoffman, R; Strony, J; Veltri, E | 1 |
Abbasi, E; Nassiri-Asl, M; Zamansoltani, F; Ziaee, A | 1 |
Chen, CW; Hsueh, CH; Hwang, JJ; Lai, LP; Shen, MJ; Su, YN; Tsai, CT | 1 |
Jeon, TI; Osborne, TF; Seo, YK; Zhu, B | 1 |
Fereshtehnejad, SM; Homayounfar, R; Kalani, A; Shidfar, F | 1 |
Pokrovskiĭ, AV; Suntsov, DS | 1 |
Croze, R; Levy, BD; Pfeffer, MA; Planagumà, A; Rubin, G; Serhan, CN; Uddin, M | 1 |
Arranz Martínez, E; Gordillo López, FJ; Hermosa Hernán, JC; Ruiz García, A | 1 |
Cunningham, E | 1 |
Akhilender Naidu, K; Dhale, MA; Mohan-Kumari, HP; Vijayalakshmi, G | 1 |
Wang, X; Yu, P | 1 |
Arca, M; Budal, S; Degli Esposti, E; Degli Esposti, L; Sangiorgi, D; Vigna, GB | 1 |
Cai, J; Cayo, MA; Clark, BS; Collery, RF; DeLaForest, A; Duncan, SA; Nagaoka, M; Noto, FK; Si-Tayeb, K | 1 |
Chen, CH; Ding, YA; Tsao, HM; Yu, WC | 1 |
McCarty, MF | 1 |
Ahn, C; Aronow, WS | 1 |
Chmielewski, M; Rutkowski, B; Zdrojewski, Z | 1 |
Ferrières, J | 1 |
Corbelli, J; Kerzner, B; LeBeaut, A; Lipka, LJ; Melani, L; Mukhopadhyay, P; Sharp, S; Suresh, R; Veltri, EP | 1 |
Bouzamondo, A; Corvol, JC; Hulot, JS; Lechat, P; Sanchez, P; Sirol, M | 1 |
McBurney, CR; Smith, DG | 1 |
Curran, MP; Goa, KL | 1 |
Amin, AH; Bafna, PA; Balaraman, R; Gulati, OD; Mehta, K | 1 |
Osborne, TF; Shin, DJ | 1 |
Davidson, MH; Dicklin, MR; Liss, C; Palmisano, J; Wilson, H | 1 |
Plans-Rubió, P | 2 |
Cullen, EI; Friedhoff, LT; Lukacsko, P; Niecestro, R; Walters, EJ | 1 |
Edwards, JE; Moore, RA | 1 |
Dunbar-Jacob, J; Muldoon, MF; Ryan, CM; Sereika, S; Stilley, CS | 1 |
Tellier, P | 1 |
Caramelli, B; Praça, JM; Thomaz, A | 1 |
Corbelli, J; Crouse, JR; Insull, W; McGovern, ME; Schrott, H; Thompson, P; Zieve, F | 1 |
Anga, B; Harangi, F; Schneider, I; Sebök, B; Tóth, M | 1 |
Aguilar, P; Muñoz Díaz, AB | 1 |
Diament, J; Forti, N | 1 |
Endo, A; Sudo, H; Yammoto, A | 1 |
Bennett, S; Lipka, L; Melani, L; Sager, P; Suresh, R; Veltri, E | 1 |
Denke, MA | 1 |
Klose, G | 1 |
Battisti, WP; Brady, WE; Denke, MA; McBride, PE; Palmisano, J; Pearson, TA | 1 |
Brousseau, ME; Kajinami, K; Ordovas, JM; Schaefer, EJ | 1 |
Guharoy, R | 1 |
Alende Sixto, MR; Martínez Rey, C; Rodríguez Framil, M; Torre Carballada, JA | 1 |
Benson, V; Campen, D; Chan, J; Cheetham, TC; Levin, E; Richmond, C | 1 |
Gibson, K; Rindone, JP | 1 |
Antoniuk, MV; Gvozdenko, TA; Rudichenko, EV | 1 |
Hamirani, YS; Jones, PH; Vasudevan, AR | 1 |
Brown, BG; Brunzell, JD; Hokanson, JE; Motulsky, AG; Zambon, A | 1 |
Balogh, Z; Fóris, G; Fülöp, P; Koncsos, P; Kosztáczky, B; Paragh, G; Seres, I | 1 |
Griffin, KJ; Hsu, MH; Johnson, EF; Savas, U | 1 |
Ghavamian, R; Goel, S; Stein, CA | 1 |
Alsheikh-Ali, AA; Han, H; Karas, RH; Maddukuri, PV | 1 |
Connelly, PW; de Souza, R; Emam, A; Faulkner, DA; Gigleux, I; Jenkins, DJ; Kendall, CW; Lamarche, B; Lapsley, KG; Marchie, A; Parker, TL; Trautwein, EA; Wong, JM | 1 |
George, J; Keren, G; Luboshits, G; Mausner-Fainberg, K; Maysel-Auslender, S; Mor, A; Rubinstein, A | 1 |
Agrawal, AR; Sharma, PL; Tandon, M | 1 |
Blasetto, J; Gandhi, S; Harley, CR; Heien, H; Nelson, SP; Sasane, R | 1 |
Traynor, K | 1 |
Lee, T | 1 |
Basak, GW; Bil, J; Bojarski, L; Dabrowska-Iwanicka, A; Engelberts, PJ; Gaciong, Z; Glodkowska, E; Golab, J; Gorska, E; Issat, T; Jakobisiak, M; Kurzaj, Z; Lasek, W; Lekka, M; Mackus, WJ; Makowski, M; Mrowka, P; Nowis, D; Parren, PW; Sinski, M; Stoklosa, T; Warzocha, K; Wasik, M; Wilczek, E; Wilczynski, GM; Winiarska, M | 1 |
Brenner, H; Hahmann, H; Hoffmann, MM; Rothenbacher, D; Vossen, CY; Wüsten, B | 1 |
Johnson, A | 1 |
Brass, EP; Hwang, P; Levine, JG; Replogle, A; Rusche, S; Shiffman, S; Vassil, T | 1 |
Fox, KM; Gandhi, SK; McKenney, JM; Ohsfeldt, RL | 1 |
Alberts, AW; Chao, YS; Kroon, PA; Thompson, GM; Yamin, TT | 1 |
Nakamura, N; Uzawa, H; Yamaguchi, K | 1 |
Alberts, AW; Hand, KM; Huff, JW; Kroon, PA | 1 |
Bosisio, E; Cighetti, G; Di Padova, C; Galli Kienle, M; Galli, G; Paoletti, R; Rovagnati, P | 1 |
Fears, R; Ferres, H; Richards, DH | 1 |
Endo, A; Sudo, H; Yamamoto, A | 1 |
Oliver, MF | 1 |
Ahmad, S | 5 |
Iwasaki, T; Kato, S; Sasaki, H; Tada, N | 1 |
Thompson, GR | 1 |
Larsen, ML | 1 |
Jacob, BG; Richter, WO; Schwandt, P | 3 |
Smart, AJ; Walters, L | 1 |
Forti, N | 2 |
Altman, R; Bolzano, K; Davignon, J; DeWailly, P; Giannini, S; Jerums, G; Kastelein, JJ; Lansberg, PJ; Mitchel, YB; Shapiro, D | 1 |
Branchi, A; Fiorenza, AM; Rovellini, A; Sommariva, D | 1 |
Colquhoun, DM | 1 |
Burns, K; Ellis, A; Haberl, E; Hook, N; Kellick, KA; McAndrew, E | 1 |
Rubinstein, A; Weintraub, M | 1 |
Adachi, Y; Kamisako, T | 1 |
Block, G; Cutler, N; Lines, C; Sramek, J; Stauffer, L; Veroff, A | 1 |
Brack, T; Krähenbühl, S; Maggiorini, M; Meier, C; Risti, B; Stey, C | 1 |
Haffner, S; LaBelle, P; Orchard, T; Schmidt, D; Stein, E | 1 |
Levenstein, S | 1 |
Amano, M; Ino, T; Kasuga, M; Kazumi, T; Matsuba, K; Ohki, A; Yoshino, G | 1 |
Bonal, J; Cantarell, C; Capdevila, L; Lauzurica, R; Pastor, C; Sierra, C | 1 |
Agner, E; Agner, T; Malinowski, J; Meibom, J; Ramsing, D | 1 |
Hershman, R; Iqbal, A; Robbins, MJ | 1 |
Auerbach, BJ; Bisgaier, CL; Krause, BR; Newton, RS | 1 |
Banks, D; Feher, MD; Foxton, J; Lant, AF; Wray, R | 1 |
Beigel, Y; Fainaru, M; Gavish, D; Neuman, Y; Teplitzky, Y; Wurzel, M; Zafrir, N | 1 |
Lefer, AM; Ma, XL | 1 |
Jorge, PA; Metze, K; Ozaki, MR | 1 |
Eizyk, E; Kalén, J; Katzman, P; Nilsson, A; Sartor, G; Ugander, L; Ursing, D | 1 |
Hockwin, O; Paulus, U; Schmidt, J; Schmitt, C; von Bergmann, K | 1 |
Arndtz, N; Meiser, B; Reichart, B; Seidel, D; Thiery, J; Wenke, K | 1 |
Downey, P; Maiz, A; Martínez, L; Pinto, C; Retamal, F; Vaccarezza, A | 1 |
Bär, PR; Contermans, J; Erkelens, DW; Smit, JW | 1 |
Benson, VV; Borok, GM; Dudl, RJ; Epstein, A; Epstein, RS; Heys, JF; Menzin, J; Oster, G; Quinn, V | 1 |
Applegate, WB; Curtis, RC; Davis, CE; Gordon, DJ; McCormick, M | 1 |
Averna, M; Barbagallo, CM; Davì, G; Ganci, A; Giammarresi, C; La Placa, FP; Notarbartolo, A; Patrono, C | 1 |
Curtis, RC; Dameworth, KS; Dowdy, AA; Hegland, J; Levin, JA; Sousoulas, BG; Stoy, DB | 1 |
Ben Khalifa, F; Ftouhi, B; Kaabachi, A; Mebazaa, R; Mekaouer, A; Turki, S | 1 |
Alaupovic, P; Dudley, VS; Knight-Gibson, C; Lane, DM; Laughlin, LO | 1 |
Bertolami, MC; Diament, J; Faludi, AA; Forti, N; Giannini, SD; Schölz, J | 1 |
Chamone, D; da Luz, P; Mansur, AP; Maranhão, R; Pileggi, F; Ramires, JA; Solimene, MC | 1 |
Block, G; Cwudzinski, D; Gengo, F; Kinkel, P; Lines, C; Stauffer, L | 1 |
Brandl, U; Detter, C; Kreuzer, E; Kur, F; Mair, H; Meiser, BM; Seidel, D; Thiery, J; Uberfuhr, P; Wenke, K | 1 |
Arndtz, N; Meiser, B; Reichart, B; Seidel, D; Thiery, J; von Scheidt, W; Wenke, K | 1 |
Davidson, MH; Dujovne, CA; Goris, GB; Oliphant, TH; Phillips, JC; Schrott, HG; Shawaryn, GG; Stein, EA | 1 |
Himberg, JJ; Jokelainen, K; Laaksonen, R; Sahi, T; Tikkanen, MJ | 1 |
Anderson, TJ; Frei, B; Ganz, P; Meredith, IT; Selwyn, AP; Yeung, AC | 1 |
Kostis, JB; Rosen, RC; Wilson, AC | 1 |
Denke, MA; Grundy, SM | 1 |
Forfang, K; Geiran, O; Gullestad, L; Høstmark, AT; Ihlen, H; Nordal, KP; Simonsen, S | 1 |
Clifton, PM; Nestel, PJ; Noakes, M | 1 |
Chin, JP; Dart, AM | 1 |
Huchzermeyer, H; Münzenmaier, R | 1 |
Kulbertus, H; Legrand, V; Martinez, C | 1 |
Arndtz, N; Reichart, B; Seidel, D; Thiery, J; Wenke, K | 1 |
Beamish, RE; Dhalla, NS | 1 |
Coupal, L; Grover, SA; Hamilton, VH; Racicot, FE; Zowall, H | 1 |
Guimaraes, AC; Kettner, H; Lithell, H; Pitkänen, M; Sailer, D; Tuomilehto, J; Van Gaal, LF | 1 |
Elliott, HL; Marshall, S; Meredith, PA | 1 |
Panuccio, D; Romani, A; Trabatti, MR | 1 |
Argenio, GF; Bernini, GP; Franchi, F; Gasperi, M; Salvetti, A; Vivaldi, MS | 1 |
Campana, C; Gavazzi, A; Iacona, I; Perani, G; Regazzi, MB; Viganò, M | 1 |
Bradford, RH; Chremos, AN; Dujovne, CA; Franklin, FA; Grillo, RB; Higgins, J; Langendorfer, A; Nash, DT; Pool, JL; Shear, CL | 1 |
Black, HR; Christianson, DS; Davey, JA; Diotalevi, LJ; Isaacsohn, JL; Liskov, E; Nicholas, C; Setaro, JF; Stein, EA | 1 |
Alonso-Pulpón, L; Anguita, M; Arizón, JM; Cavero, MA; Concha, M; Crespo, M; Pérez-Jiménez, F; Segovia, J; Vallés, F | 1 |
Himberg, JJ; Laaksonen, R; Ojala, JP; Tikkanen, MJ | 1 |
Csanády, M; Gógl, A; Jánosi, A; Karádi, I; Ofner, P; Romics, L; Tarján, J; Varga, L; Wórum, F; Zeltner, G | 1 |
Adamska-Dyniewska, H; Chojnowska-Jezierska, J; Cybulska, B; Grzymisławski, M; Hryniewiecki, L; Kaliciński, A; Kawecka-Jaszcz, K; Kleinrok, A; Kokot, F; Kłos, ZJ | 1 |
Service, RF | 1 |
Kłosiewicz-Latoszek, L; Nowicka, G; Szostak, WB | 1 |
Cummings, MH; Watts, GF | 1 |
Alaupovic, P; Blankenhorn, DH; Cashin-Hemphill, L; Corder, CN; Hodis, HN; Knight-Gibson, C; Kramsch, DM; LaBree, L; Mack, WJ | 1 |
Steinhagen-Thiessen, E | 1 |
Arnadottir, M; Eriksson, LO; Germershausen, JI; Thysell, H | 1 |
Gross, W; Grützmacher, P; März, W; Paul, D; Schoeppe, W; Siekmeier, R | 1 |
Armitage, J; Collins, R; Fatemian, M; Kearney, E; Keech, A; Lawson, A; Lyon, V; MacMahon, S; Mindell, J; Wallendszus, K | 1 |
De Luca, N; Del Mirto, C; Fontana, D; Gisonni, P; Iovino, G; Marchegiano, R; Pompeo, F; Trimarco, B | 1 |
Hunninghake, DB; Probstfield, JL | 1 |
Dujovne, CA; Frost, PH; Greguski, RA; Illingworth, DR; Knopp, RH; Mitchel, YB; Stein, EA; Tun, P; Zupkis, RV | 1 |
Daenen, W; De Geest, H; Van Cleemput, J; Van Lierde, J; Vanhaecke, J | 1 |
Miettinen, TA; Partinen, M; Pihl, S; Räikkönen, K; Strandberg, TE; Vanhanen, H | 1 |
Keller, U; Miserez, AR; Rossi, FA | 1 |
Devuyst, O; Goffin, E; Pirson, Y; van Ypersele de Strihou, C | 1 |
Alberti, KG; Evans, K; Farrer, M; Kesteven, P; Laker, MF; Neil, HA; Winocour, PH | 1 |
Benhamou, JP; Degott, C; Grimbert, S; Pessayre, D | 1 |
Bos, FM; Duits, N | 2 |
D'Agostino, LC; D'Agostino, RB; Kannel, WB; Stepanians, MN | 2 |
Albers, JJ; Brown, BG; Dowdy, A; Fisher, LD; Hillger, LA; Sniderman, AD; Stewart, BF; Zhao, XQ | 1 |
Goldstein, MR | 1 |
Korman, LB | 1 |
Hathaway, SC; Paat, JJ; Paterson, RW; Steele, GH; Wong, JG | 1 |
Bonnefous, F; Debbas, N; Farnier, M; Irvine, A | 1 |
Lambrecht, LJ; Malini, PL | 1 |
Applegate, W; Crouse, JR; Davis, CE; Eckfeldt, JH; Gordon, DJ; Grimm, R; Hunninghake, DB; Knopp, R; LaRosa, JC | 1 |
Dudko, VA; Kanskaia, NV; Konstantinov, VO; Kryzhanovskiĭ, VA; Kukharchuk, VV; Liakishev, AA; Lipovetskiĭ, BM; Soliternova, IB; Titov, VN; Volkova, EI | 1 |
al-Jubouri, MA; Briston, PG; Chinn, RH; Sinclair, D; Young, RM | 1 |
Alessandri, C; Andreozzi, P; Basili, S; Bracaglia, D; Cordova, C; Maurelli, M | 1 |
Jacobs, MB | 1 |
Farbstein, S | 1 |
Block, G; Haigh, J; Miettinen, T; Murtomäki, E; Neafus, R; Partinen, M; Pihl, S; Reines, S; Strandberg, T; Vanhanen, H | 1 |
Carbonieri, E; Cemin, C; Franceschini, L; Ghebremariam-Tesfau, K; Rossi, L; Tomei, R; Zardini, P | 1 |
Akhmedzhanov, NM; Ivanova, TN; Metel'skaia, VA; Nikulina, SE; Olfer'ev, AM; Perova, NV; Poliakova, ED; Shcherbakova, IA | 1 |
de Koning Gans, HJ; Gørbitz, C; Harrison, EM; Ose, L; Tonstad, S | 1 |
Bratland, B; Dahlöf, B; Gisholt, K; Os, I; Syvertsen, JO; Tretli, S | 1 |
Camarda, G | 1 |
Bremer, J; Lintott, CJ; Scott, RS; Sutherland, WH | 1 |
Alberti, KG; Klausen, IC; Mogensen, CE; Møller, N; Nielsen, S; Pørksen, N; Schmitz, O | 1 |
Bedarida, GV; Blaschke, TF; Bushell, E; Haefeli, WE; Hoffman, BB | 1 |
Baum, H; Castelluccio, C; Quinn, PJ; Rice-Evans, C; Taub, NA; Watts, GF | 1 |
Heikkilä, JI; Kervinen, K; Kesäniemi, YA; Savolainen, MJ | 1 |
Harris, KP; Hattersley, JM; Moorhead, JF; Ramaswamy, C; Thomas, ME; Varghese, Z; Walls, J; Wheeler, DC; Williams, JD | 1 |
Peres, RB; Plavinik, F; Ribeiro, AB; Zampieri, M; Zanella, MT | 1 |
Baines, MG; McPherson, R; Melino, MR; Pross, HF; Tsoukas, C; Vost, A; Zupkis, RV | 1 |
Felgines, C; Lutton, C; Mathé, D; Mazur, A; Sérougne, C | 1 |
Aviram, M; Brook, JG; Cogan, U; Hochgraf, E; Levy, Y | 1 |
Arca, M; Grundy, SM; Vega, GL | 1 |
Chylack, LT; Friend, J; Mantell, G; Rosner, B; Wolfe, JK | 1 |
De Haan, AF; Kastelein, JJ; Kortmann, B; Kroon, AA; Lansberg, PJ; Stalenhoef, AF; Stuyt, PM | 1 |
Bondarenko, BB; Gurevich, VS; Kasennova, NI; Le Van Thach, TD; Mikhailova, IA | 1 |
Heudebert, GR; Hiatt, J; Schectman, G; Van Ruiswyk, J | 1 |
Cheung, AK; DeVault, GA; Gregory, MC | 1 |
McDonagh, J; Walker, DJ; Winocour, P | 1 |
Blank, D; Brun, LD; Campeau, L; Crockford, P; Curnew, G; Dafoe, W; Davignon, J; Dufour, R; Emery, G; Frohlich, J | 1 |
Chiu, K; Lai, KN; Lam, CW; Leung, CB; Li, PK; Lui, SF; Mak, GY; Mak, TW | 1 |
Holdcroft, C | 1 |
Bjornsson, TD; Conroy, JA; Fruncillo, RJ; Holland, SD; McCrea, JB; Shingo, S; Spector, R | 1 |
Brown, SE; Ornish, D | 1 |
Golay, A; James, R; Lehmann, T; Pometta, D | 1 |
Baigts, F; Devulder, B; Lecerf, JM; Luc, G | 1 |
Lai, KN; Lam, CW; Li, PK; Mak, TW | 1 |
Blankfield, RP | 1 |
Mattila, SP; Tikkanen, MJ; Tilly-Kiesi, M | 1 |
Alsina, J; Andrés, E; Castelao, AM; Castiñeiras, MJ; Galcerán, JM; Gilvernet, S; González, MT; Griñó, JM; Roca, M; Serón, D | 1 |
Hartz, A; Hiatt, J; Schectman, G | 1 |
Simons, LA | 1 |
Tobert, JA | 4 |
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Malminiemi, K; Malminiemi, O; Palomäki, A; Solakivi, T | 1 |
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Hunninghake, DB | 3 |
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Bakker-Arkema, RG; Black, DM; Davidson, MH; Henley, RW; Hunninghake, DB; Koren, MJ; McKenney, JM; McLain, RW; Schrott, HG; Smith, DG; Tresh, P; Weiss, SR | 1 |
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Bode-Böger, SM; Böger, RH; Brandes, RP; Brandes, S; Mügge, A | 1 |
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Aalto-Setälä, K; Ehnholm, C; Helve, E; Kontula, KK; Ojala, JP; Tikkanen, MJ | 1 |
Bednarek, M; Broda, G; Chotkowska, E; Kuzmińska, A; Polakowska, M; Rywik, S | 1 |
Ewing, SL; Gebhard, RL; Hunninghake, DB; Prigge, WF; Schlasner, LA | 1 |
Groskop, I; Lurie, Y; Rubinstein, A; Weintrob, M | 1 |
Bocanegra, TS; Boccuzzi, SJ; Keegan, ME; Shapiro, DR; Walker, JF | 1 |
Agheli, N; Jacotot, B | 1 |
Delanghe, J; Deslypere, JP; Vermeulen, A | 1 |
Bradford, RH; Chremos, AN; Downton, M; Dujovne, C; Franklin, FA; Gould, AL; Hesney, M; Higgins, J; Hurley, DP; Shear, CL | 1 |
Breslow, JL; Cobb, MM; Teitelbaum, HS | 1 |
Chremos, AN; Gould, AL; Hurley, DP; Keates, EU; Laties, AM; Lippa, EA; Shear, CL; Stephenson, WP; Taylor, HR; Tupy-Visich, MA | 1 |
Welborn, TA | 1 |
Bo, M; Bonino, F; Fabris, F; Gottero, M; Molaschi, M; Neirotti, M; Pernigotti, L | 1 |
Chousterman, M; Lons, T | 1 |
Basten, A; Seidel, D; Sommerburg, C; Thiery, J | 1 |
Tikkanen, MJ; Tilly-Kiesi, M | 1 |
Bo, M; Fabris, F; Fiandra, U; Pedrazzini, V; Pernigotti, L; Poli, L; Zanocchi, M | 1 |
Firth, JC; Fourie, J; Kotze, TJ; Marais, AD; Omar, MA; Stander, I; Steyn, K; Van Gelder, AL; Vermaak, WJ; Weich, HF | 1 |
Hörl, WH; Luley, CH; Wanner, C; Wieland, H | 1 |
Archibald, MP; McDowell, IF; Nicholls, DP; Shortt, JA; Smye, M; Trimble, ER; Trinick, T | 1 |
Barcina, C; Cuesta, L; Fernández, E; Lázaro-Carrasco, E; Navarro, A; Rivera, G; Rodríguez Padial, L; Sánchez Domínguez, J | 1 |
Alberts, AW; Beil, FU; Beisiegel, U; Eckardt, HG; Greten, H; Karkas, JD; Liou, R; Schrameyer-Wernecke, A; Till, AE | 1 |
Drouin, P; Ziegler, O | 1 |
Amadio, L; Antonicelli, R; Lipponi, G; Paciaroni, E | 1 |
Lundh, BL; Nilsson, SE | 1 |
Goa, KL; Todd, PA | 1 |
Hockwin, O; Schmidt, J; Schmitt, C | 1 |
Grundy, SM; Krauss, RM; Vega, GL | 1 |
Goryance, JM; Heim-Duthoy, KL; Kasiske, BL; Rao, KV; Tortorice, KL | 1 |
Cohn, PF | 1 |
Ishida, F; Kakubari, K; Kamei, T; Kitani, K; Sato, A; Taguchi, K; Watanabe, K | 1 |
Aronson, JK; Ng, LL | 1 |
Maher, VM; Thompson, GR | 1 |
Eisenberg, JM; Glick, H; Jacobson, TA; Kinosian, B; Koffer, H; Schulman, KA; Willian, MK | 1 |
Kreisberg, RA | 1 |
Caridis, R; Catalano, A; Gavelli, MS; Guarini, G; Rossi, FG; Santini, G; Serra, T; Tozzi, J; Vitaliano, E | 1 |
Caridis, R; Gavelli, MS; Rizzuti, A; Rossi, FG; Serra, T; Tozzi, J; Vitaliano, E | 1 |
Dachet, C; De Gennes, JL; Douste-Blazy, P; Drouin, P; Fricker, J; Keller, U | 1 |
Shapiro, DR; Walker, JF | 1 |
Thompson, WG | 1 |
Thiery, J | 1 |
Jankelow, D; Myburgh, DP; Neutel, JM; Smith, DH | 1 |
Clifton, P; Cooper, ME; Jennings, GL; Jerums, G; Nestel, PJ; O'Brien, RC; Simons, LA; Sullivan, D | 1 |
D'Agostino, LC; D'Agostino, RB; Kannel, WB; Stepanians, M | 1 |
Goldberg, R; La Belle, P; Ronca, P; Zupkis, R | 1 |
Bradford, RH; Chremos, AN; Dujovne, C; Franklin, FA; Hesney, M; Higgins, J; Langendörfer, A; Pool, JL; Schnaper, H; Shear, CL | 1 |
Creutzfeldt, C; Creutzfeldt, W; Seidel, D; Thiery, J; Walli, AK | 1 |
Barth, JD; Kruisbrink, OA; Van Dijk, AL | 1 |
Brownfield, E; Chuck, C; Kamjoo, P; Kawata, N; Kobashigawa, JA; Leonard, L; Moriguchi, JD; Murphy, FL; Stevenson, LW; Wilmarth, J | 1 |
Allan, J; Johnson, BF; LaBelle, P; Ronca, PD; Wilson, J; Zupkis, RV | 1 |
Grundy, SM; Vega, GL | 3 |
Dollerup, J; Leth, A; Munch, M; Nielsen, B | 1 |
Bentivoglio, M; Berioli, S; Conti, R; Corea, L; Osanna, RA; Savino, K; Zollino, L | 1 |
Degenaar, CP; Nieuwenhuijzen Kruseman, AC; van Deursen, RT; Wolffenbuttel, BH | 1 |
Folkers, K; Langsjoen, P; Richardson, P; Tamagawa, H; Willis, R; Xia, LJ; Ye, CQ | 1 |
Barlow, CW; Friedman, BM; Myburgh, DP; Smith, DH; Soicher, ER; Steenkamp, WF | 1 |
Abouganem, D; Núñez, P | 1 |
Kohn, IJ; Ribeiro, L | 1 |
de Góes, JM; Dereviack, BE; Diament, J; Forti, N; Giannini, SD; Machado, C | 1 |
Brusco, OJ | 1 |
Harris, KP; Klahr, S; Purkerson, ML; Yates, J | 1 |
Nye, ER | 1 |
French, JK; Greaves, SC; White, HD | 1 |
Anderson, A; Hopper, J; Macaskill, G; McDonald, P; Morgan, T | 1 |
Carlsson, M; Mölgaard, J; Nilsson, J; Olsson, AG | 1 |
Gross, TP; Pierce, LR; Wysowski, DK | 1 |
Helve, E; Karjalainen, K; Ojala, JP; Tarkkanen, A; Tikkanen, MJ | 1 |
Armstrong, V; Bosch, T; Eisenhauer, T; Schuff-Werner, P; Seidel, D; Thiery, J | 1 |
Adams, M; Dell, RB; Goldberg, IJ; Goodman, DS; Holleran, S; Palmer, RH; Ramakrishnan, R | 1 |
Bagdade, JD; Lane, JT; Ritter, MC; Stone, N; Subbaiah, PV | 1 |
Bach, LA; Cooper, ME; Jerums, G; O'Brien, RC | 1 |
Kreisberg, R; Mantell, G; Miller, V; Shapiro, DR; Stein, E; Washington, L | 1 |
Baker, SG; Berger, GM; Joffe, BI; Marais, AD; Mendelsohn, D; Seftel, HC; Welsh, NH | 1 |
Behrens-Baumann, W; Creutzfeldt, C; Morawietz, A; Seidel, D; Thiery, J | 1 |
Mölgaard, J; Olsson, AG; von Schenck, H | 2 |
Keller, U; Riesen, WF; Stohler, R | 1 |
Breslow, JL; Eisenberg, S; Weintraub, MS | 1 |
Bankhurst, AD; Cutts, JL | 1 |
Bolzano, K; Breslow, JL; Gavish, D; Kostner, GM; Leopold, B; Weintraub, MS | 1 |
Demacker, PN; Hermus, AR; Mol, MJ; Stalenhoef, AF; Stuyt, PM; Van 'T Laar, A | 1 |
Arnon, R; Eisenberg, S; Israeli, A; Raveh, D; Stein, Y | 1 |
Ashy, A; Jürgens, G; Zenker, G | 1 |
Frerman, FE; Greene, C; Walravens, PA | 1 |
Illingworth, DR; Maher, VM; Pappu, A; Thompson, GR | 1 |
Stoy, DB | 1 |
Frishman, WH; Rapier, RC | 1 |
Alexander, S; Cook, TJ; Mantell, G; Pietro, DA; Staggers, JE | 1 |
Bennett, WM; Golper, TA; Illingworth, DR; Morris, CD | 1 |
DiSesa, VJ; Gordon, J; Kirshenbaum, JM; Kuo, PC; Laffel, G; Mudge, GH; Vaughan, DE; Young, P | 1 |
Lintott, CJ; Nye, ER; Robertson, MC; Scott, RS; Sutherland, WH | 1 |
Nordøy, A; Ytre-Arne, K | 1 |
Deslypere, JP | 1 |
Carré, JM; Garcia, RC; Nakandakare, ER; Oliveira, HC; Quintão, EC; Zerbinatti, CV | 1 |
Bard, JM; Dachet, C; De Gennes, JL; Douste-Blazy, P; Drouin, P; Fruchart, JC; Jacotot, B; Luc, G; Ziegler, O | 1 |
Ammann, F; Baur, HR; Bertel, O; Del Bufalo, A; Golay, A; Keller, U; Kistler, H; Kummer, H; Reutter, FW; Riesen, WF | 1 |
Brusca, A; Caruzzo, C; Caruzzo, E; Marcolongo, M; Uslenghi, E; Varbella, F | 1 |
Ishida, F; Kamei, T; Kobayashi, M; Ohmura, I; Taguchi, K; Takahashi, T; Watanabe, K | 1 |
Dammann, HG; Dreyer, M; Grüneberger, S; Kangah, R; Müller, P; Reinicke, A; Simon, B; Staisch, C; Steinhagen-Thiessen, E | 1 |
Bojanovski, D; Bojanovski, M; Canzler, H; Jochim, A; Schulzeck, P | 1 |
Fusman, B; Lefer, AM; Lento, PH; Osborne, JA; Siegfried, MR; Stahl, GL | 1 |
Mol, MJ; Stalenhoef, AF; Stuyt, PM | 1 |
Costa, C; Guarini, G; Santese, D; Trimarco, C; Vitaliano, E | 1 |
Bard, JM; Devulder, B; Douste-Blazy, P; Fruchart, JC; Harvengt, C; Lecerf, JM; Leclerc, V | 1 |
Alberts, AW | 1 |
Helve, E; Jäättelä, A; Kaarsalo, E; Lehtonen, A; Malbecq, W; Oksa, H; Pääkkönen, P; Salmi, J; Tikkanen, MJ; Veharanta, T | 1 |
Garg, A; Grundy, SM | 1 |
Helve, E; Tikkanen, MJ | 1 |
Buchwald, H; Campos, CT; Dombrovskis, S; Esper, E; Matts, JP; Tijerina, O | 1 |
Schechter, RJ | 1 |
Corpier, CL; Jones, PH; Lederer, ED; Quinones, MA; Schmidt, SW; Suki, WN; Young, JB | 1 |
Ballantyne, CM; DeBakey, ME; Gotto, AM; Jones, PH; Noon, GP; Patsch, W; Payton-Ross, C; Short, HD; Young, JB | 1 |
Tobert, JA; Walker, JF | 1 |
Brewer, HB; Hoeg, JM | 1 |
Blake, GJ | 1 |
Fraunfelder, FT | 1 |
Bewley, DZ; Lamkin, GE; Stein, EA | 1 |
Olive, KE | 1 |
Duane, WC; Freeman, ML; Gebhard, RL; Hunninghake, DB; Prigge, WF | 1 |
Nikkilä, EA; Tikkanen, MJ | 1 |
Bailey, KR; Brewer, HB; Hoeg, JM; Maher, MB | 1 |
Escobar, A; Joven, J; Masana, L; Rubiés-Prat, J | 1 |
DiPalma, JR | 1 |
Santafé Oroz, J; Segarra Domènech, J | 1 |
71 review(s) available for lovastatin and Elevated Cholesterol
Article | Year |
---|---|
Polymeric bile acid sequestrants: Review of design, in vitro binding activities, and hypocholesterolemic effects.
Topics: Animals; Anticholesteremic Agents; Bile Acids and Salts; Binding Sites; Drug Design; Humans; Hypercholesterolemia; Molecular Structure; Polymers | 2018 |
Red Yeast Rice for the Improvement of Lipid Profiles in Mild-to-Moderate Hypercholesterolemia: A Narrative Review.
Topics: Anticholesteremic Agents; Atherosclerosis; Biological Products; Cholesterol; Cholesterol, LDL; Dietary Supplements; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Hyperlipidemias; Lovastatin | 2023 |
The role of red yeast rice (RYR) supplementation in plasma cholesterol control: A review and expert opinion.
Topics: Biological Products; Biotransformation; Cardiovascular Diseases; Cholesterol; Clinical Trials as Topic; Cytochrome P-450 CYP3A; Dietary Supplements; Double-Blind Method; Expert Testimony; Food-Drug Interactions; Gastrointestinal Diseases; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Lovastatin; Medicine, Chinese Traditional; Molecular Structure; Multicenter Studies as Topic; Musculoskeletal Diseases; Prodrugs; Randomized Controlled Trials as Topic; Self Medication | 2019 |
An overview on the biological activity and anti-cancer mechanism of lovastatin.
Topics: Apoptosis; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Lovastatin; Neoplasms | 2021 |
Traditional Chinese lipid-lowering agent red yeast rice results in significant LDL reduction but safety is uncertain - a systematic review and meta-analysis.
Topics: Anticholesteremic Agents; Biological Products; Biomarkers; Chi-Square Distribution; Cholesterol, LDL; Dietary Supplements; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Lovastatin; Medicine, Chinese Traditional; Odds Ratio; Risk Assessment; Risk Factors; Treatment Outcome | 2015 |
[Pleiotropic effects of statins].
Topics: Anticholesteremic Agents; Antioxidants; Atherosclerosis; Atorvastatin; Endothelium, Vascular; Fatty Acids, Monounsaturated; Fluorobenzenes; Fluvastatin; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Indoles; Lovastatin; Oxidative Stress; Pravastatin; Pyrimidines; Pyrroles; Rosuvastatin Calcium; Sulfonamides | 2008 |
[Statins in practice of the vascular surgeon and cardiologist].
Topics: Aged; Anticholesteremic Agents; Cardiovascular Diseases; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Hypolipidemic Agents; Lovastatin; Male; Meta-Analysis as Topic; Myocardial Infarction; Myocardial Ischemia; Randomized Controlled Trials as Topic; Risk Factors; Time Factors | 2009 |
Benefits and menaces related to the use of statins in patients after renal transplantation.
Topics: Atorvastatin; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Kidney Transplantation; Lovastatin; Postoperative Complications; Pravastatin; Pyrroles; Simvastatin | 2002 |
[Primary and secondary prevention of coronary disease by statins].
Topics: Anticholesteremic Agents; Cholesterol, LDL; Coronary Angiography; Coronary Disease; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Lovastatin; Pravastatin; Primary Prevention; Randomized Controlled Trials as Topic; Research Design; Risk Factors; Simvastatin; Survival Analysis; Survival Rate; Treatment Outcome | 1999 |
Differential effects of lipid-lowering therapies on stroke prevention: a meta-analysis of randomized trials.
Topics: Anticholesteremic Agents; Atorvastatin; Cholestyramine Resin; Clofibrate; Colestipol; Gemfibrozil; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Lovastatin; Myocardial Infarction; Pravastatin; Pyrroles; Randomized Controlled Trials as Topic; Regression Analysis; Risk Assessment; Risk Factors; Simvastatin; Stroke; Treatment Failure; Treatment Outcome | 2003 |
Lovastatin extended release: a review of its use in the management of hypercholesterolaemia.
Topics: Absorption; Administration, Oral; Anticholesteremic Agents; Coronary Disease; Delayed-Action Preparations; Dose-Response Relationship, Drug; Humans; Hypercholesterolemia; Lovastatin | 2003 |
Statins in hypercholesterolaemia: a dose-specific meta-analysis of lipid changes in randomised, double blind trials.
Topics: Atorvastatin; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Dose-Response Relationship, Drug; Fatty Acids, Monounsaturated; Female; Fluorobenzenes; Fluvastatin; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Indoles; Lovastatin; Male; Pravastatin; Pyridines; Pyrimidines; Pyrroles; Randomized Controlled Trials as Topic; Rosuvastatin Calcium; Simvastatin; Sulfonamides; Triglycerides | 2003 |
[Ezetimibe: from pharmacology to clinical trials].
Topics: Animals; Anticholesteremic Agents; Atorvastatin; Azetidines; Cholesterol, LDL; Clinical Trials as Topic; Coronary Disease; Depression, Chemical; Double-Blind Method; Drug Therapy, Combination; Ezetimibe; Heptanoic Acids; Hypercholesterolemia; Intestinal Absorption; Liver; Lovastatin; Pravastatin; Pyrroles; Safety; Simvastatin; Treatment Outcome | 2003 |
[Vastatins in atherosclerosis prevention. Current data].
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anticholesteremic Agents; Arteriosclerosis; Epidemiologic Methods; Female; Humans; Hypercholesterolemia; Lovastatin; Male; Middle Aged | 2004 |
Safety of statins: effects on muscle and the liver.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; C-Reactive Protein; Chemical and Drug Induced Liver Injury; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Liver; Liver Diseases; Lovastatin; Muscle, Skeletal; Rhabdomyolysis | 2005 |
Effect of the magnitude of lipid lowering on risk of elevated liver enzymes, rhabdomyolysis, and cancer: insights from large randomized statin trials.
Topics: Chemical and Drug Induced Liver Injury; Cholesterol, LDL; Dose-Response Relationship, Drug; Fatty Acids, Monounsaturated; Fluvastatin; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Indoles; Liver Diseases; Lovastatin; Neoplasms; Pravastatin; Rhabdomyolysis; Simvastatin | 2007 |
Recommendations for treatment of hyperlipidemia in adults. A joint statement of the Nutrition Committee and the Council on Arteriosclerosis.
Topics: Cholesterol; Clofibrate; Coronary Disease; Female; Gemfibrozil; Humans; Hypercholesterolemia; Hyperlipidemias; Hyperlipoproteinemia Type IV; Hyperlipoproteinemias; Lactation; Lipoproteins; Lovastatin; Naphthalenes; Niacin; Pentanoic Acids; Pregnancy; Pregnancy Complications; Probucol; Tangier Disease; Triglycerides | 1984 |
Angiographic trials of lipid-lowering therapy: end of an era?
Topics: Adult; Clinical Trials as Topic; Coronary Angiography; Coronary Disease; Female; Humans; Hypercholesterolemia; Hypolipidemic Agents; Lipids; Lovastatin; Male; Middle Aged; Simvastatin | 1995 |
Impact of intensive lipid modulation on angiographically defined coronary disease: clinical implications.
Topics: Angiography; Clinical Trials as Topic; Colestipol; Coronary Disease; Humans; Hypercholesterolemia; Lipids; Lovastatin; Niacin; Random Allocation | 1994 |
[Psychiatric disorders with use of simvastatin].
Topics: Adult; Anticholesteremic Agents; Anxiety Disorders; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Lovastatin; Middle Aged; Psychoses, Substance-Induced; Simvastatin | 1993 |
Statin therapy in clinical practice: new developments.
Topics: Angina Pectoris; Anticholesteremic Agents; Cholesterol; Enzyme Inhibitors; Female; Heart Diseases; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Lovastatin; Middle Aged; Myocardial Infarction; Simvastatin | 1995 |
The 4S study. Implications for prescribing.
Topics: Anticholesteremic Agents; Cholesterol; Controlled Clinical Trials as Topic; Coronary Disease; Cost-Benefit Analysis; Diet; Guidelines as Topic; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Life Style; Longitudinal Studies; Lovastatin; Simvastatin | 1996 |
Benefits and risks of HMG-CoA reductase inhibitors in the prevention of coronary heart disease: a reappraisal.
Topics: Clinical Trials as Topic; Coronary Disease; Dose-Response Relationship, Drug; Fatty Acids, Monounsaturated; Fluvastatin; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Indoles; Lovastatin; Pravastatin; Simvastatin | 1996 |
Hyperlipidaemia and cardiovascular disease.
Topics: Anticholesteremic Agents; Coronary Disease; Humans; Hypercholesterolemia; Lovastatin; Pravastatin | 1996 |
The new paradigm for coronary artery disease: altering risk factors, atherosclerotic plaques, and clinical prognosis.
Topics: Adrenergic beta-Antagonists; Angiotensin-Converting Enzyme Inhibitors; Anticholesteremic Agents; Antioxidants; Coronary Angiography; Coronary Artery Disease; Endothelium, Vascular; Exercise Test; Humans; Hypercholesterolemia; Inflammation; Lovastatin; Platelet Aggregation Inhibitors; Prognosis; Randomized Controlled Trials as Topic; Risk Factors; Simvastatin | 1996 |
Pharmacodynamics and pharmacokinetics of the HMG-CoA reductase inhibitors. Similarities and differences.
Topics: Anticholesteremic Agents; Arteriosclerosis; Brain; Enzyme Inhibitors; Fatty Acids, Monounsaturated; Fluvastatin; Food-Drug Interactions; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Indoles; Liver; Lovastatin; Pravastatin; Simvastatin | 1997 |
Cholesterol management in patients with heart disease. Emphasizing secondary prevention to increase longevity.
Topics: Anticholesteremic Agents; Coronary Disease; Humans; Hypercholesterolemia; Longevity; Lovastatin; Niacin; Simvastatin | 1997 |
[Prevention and therapy of vascular damage and endothelial dysfunction with hypocholesteremic agents].
Topics: Anticholesteremic Agents; Arteriosclerosis; Cholesterol; Cholesterol, LDL; Clinical Trials as Topic; Coronary Disease; Diet; Endothelium, Vascular; Follow-Up Studies; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Hypolipidemic Agents; Lovastatin; Male; Mevalonic Acid; Middle Aged; Physical Exertion; Primary Prevention; Simvastatin; Time Factors | 1998 |
Prevention. Who should take cholesterol-lowering drugs?
Topics: Aged; Anticholesteremic Agents; Cholesterol, HDL; Cholesterol, LDL; Estrogen Replacement Therapy; Female; Humans; Hypercholesterolemia; Lovastatin; Male; Middle Aged; Myocardial Ischemia; Pravastatin | 1998 |
[Are there differences in various statins?].
Topics: Anticholesteremic Agents; Cholesterol; Coronary Disease; Humans; Hypercholesterolemia; Lovastatin; Pravastatin; Simvastatin; Treatment Outcome; Triglycerides | 1998 |
Metabolism and drug interactions of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors in transplant patients: are the statins mechanistically similar?
Topics: Drug Interactions; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Hyperlipidemias; Immunosuppressive Agents; Lovastatin; Naphthalenes; Organ Transplantation | 1998 |
[Statins (HMG-CoA reductase inhibitors), cholesterol and stroke].
Topics: Adult; Arteriosclerosis; Cerebrovascular Disorders; Cholesterol; Clinical Trials as Topic; Drug Evaluation; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Ischemic Attack, Transient; Lipoproteins, HDL; Lipoproteins, LDL; Lovastatin; Male; Middle Aged; Pravastatin; Risk Factors; Simvastatin; Triglycerides | 1998 |
Is aggressive cholesterol control justified? Review of the post-coronary artery bypass graft trial.
Topics: Adult; Aged; Anticholesteremic Agents; Cholesterol, LDL; Coronary Artery Bypass; Coronary Disease; Dose-Response Relationship, Drug; Female; Humans; Hypercholesterolemia; Lovastatin; Male; Middle Aged; Postoperative Period; Randomized Controlled Trials as Topic; Treatment Outcome | 1998 |
Simvastatin: a pharmacoeconomic evaluation of its cost-effectiveness in hypercholesterolaemia and prevention of coronary heart disease.
Topics: Adult; Aged; Coronary Disease; Costs and Cost Analysis; Drug Prescriptions; Drug Tolerance; Economics, Pharmaceutical; Female; Formularies as Topic; Humans; Hypercholesterolemia; Lipids; Lovastatin; Male; Middle Aged; Primary Prevention; Risk Factors | 1992 |
Cost-effectiveness of drug therapy for hypercholesterolaemia: a review of the literature.
Topics: Age Factors; Cholestyramine Resin; Colestipol; Coronary Disease; Cost-Benefit Analysis; Humans; Hypercholesterolemia; Lovastatin; Risk Factors; Sex Factors; Treatment Outcome | 1992 |
[Clinical studies on hyperlipidemia].
Topics: Acyl Coenzyme A; Anticholesteremic Agents; Blood Component Removal; Clinical Trials as Topic; Humans; Hypercholesterolemia; Hyperlipoproteinemia Type II; Lovastatin | 1999 |
Statins and cerebrovascular disease: plaque attack to prevent brain attack.
Topics: Adult; Aged; Anticholesteremic Agents; Blood Vessels; Clinical Trials as Topic; Humans; Hypercholesterolemia; Lovastatin; Middle Aged; Pravastatin; Stroke | 1999 |
Safety profile of atorvastatin-treated patients with low LDL-cholesterol levels.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anticholesteremic Agents; Atorvastatin; Dose-Response Relationship, Drug; Female; Heptanoic Acids; Humans; Hypercholesterolemia; Lipoproteins, LDL; Lovastatin; Male; Middle Aged; Pravastatin; Pyrroles; Randomized Controlled Trials as Topic; Severity of Illness Index; Simvastatin; Treatment Outcome | 2000 |
[Additional effects of statins independent of the cholesterol-lowering as yet not shown to be clinically relevant].
Topics: Anticholesteremic Agents; Arteriosclerosis; Clinical Trials as Topic; Confounding Factors, Epidemiologic; Fatty Acids, Monounsaturated; Fluvastatin; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Indoles; Lovastatin; Pravastatin; Simvastatin | 2000 |
Bridging the treatment gap.
Topics: Adult; Anticholesteremic Agents; Cardiovascular Diseases; Coronary Disease; Female; Humans; Hypercholesterolemia; Lovastatin; Male; Middle Aged; Pravastatin; Risk Factors; Self Medication; Simvastatin; United States | 2000 |
"The lower the better" in hypercholesterolemia therapy: a reliable clinical guideline?.
Topics: Acyl Coenzyme A; Anticholesteremic Agents; Cholesterol, LDL; Clinical Trials as Topic; Coronary Disease; Humans; Hypercholesterolemia; Lovastatin; Practice Guidelines as Topic; Risk Factors; Simvastatin | 2000 |
More than cholesterol: the complexity of coronary artery disease.
Topics: Anticholesteremic Agents; Cholesterol, LDL; Coronary Disease; Disease Progression; Endothelium; Female; Humans; Hypercholesterolemia; Lovastatin; Male; Risk Factors | 2000 |
Statins in children: what do we know and what do we need to do?
Topics: Atorvastatin; Bezafibrate; Child; Child Welfare; Cost-Benefit Analysis; Drug Approval; Gemfibrozil; Heptanoic Acids; Humans; Hypercholesterolemia; Hypolipidemic Agents; Lovastatin; Pyridines; Pyrroles; Simvastatin | 2001 |
[Statins and stroke].
Topics: Anticholesteremic Agents; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Lipids; Lovastatin; Risk Factors; Stroke | 2001 |
[AFCAPS/TexCAPS [The Air Force/Texas Coronary Atherosclerosis Prevention Study]].
Topics: Aged; Anticholesteremic Agents; Arteriosclerosis; Coronary Disease; Female; Humans; Hypercholesterolemia; Lovastatin; Male; Middle Aged; Randomized Controlled Trials as Topic; Risk Factors; Texas; Treatment Outcome | 2001 |
Statins--similarities and differences.
Topics: Anticholesteremic Agents; Coronary Disease; Humans; Hypercholesterolemia; Lipoproteins, LDL; Lovastatin; Structure-Activity Relationship; United States | 2001 |
What do the statin trials tell us?
Topics: Anticholesteremic Agents; Clinical Trials as Topic; Coronary Disease; Female; Humans; Hypercholesterolemia; Lipoproteins, LDL; Lovastatin; Male; Outcome Assessment, Health Care; Pravastatin; Stroke; United States | 2001 |
[Substantiation of increasing doses of statins in clinical practice].
Topics: Adult; Aged; Angiography; Animals; Anticholesteremic Agents; Arteriosclerosis; Atorvastatin; Clinical Trials as Topic; Colestipol; Coronary Disease; Dogs; Drug Therapy, Combination; Female; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Hypolipidemic Agents; Lipids; Lovastatin; Male; Meta-Analysis as Topic; Middle Aged; Primates; Prospective Studies; Pyrroles; Retrospective Studies; Risk Factors; Simvastatin; Time Factors | 2001 |
Metabolism and drug interactions of 3-hydroxy-3-methylglutaryl coenzyme A-reductase inhibitors (statins).
Topics: Atorvastatin; Drug Interactions; Drug Therapy, Combination; Fatty Acids, Monounsaturated; Fluvastatin; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Indoles; Lovastatin; Pravastatin; Pyridines; Pyrroles; Simvastatin | 2001 |
Pharmacological interactions of statins.
Topics: Atorvastatin; Cytochrome P-450 Enzyme System; Drug Interactions; Drug Tolerance; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Lovastatin; Muscular Diseases; Pyrroles; Rhabdomyolysis | 2002 |
[Clinical evaluation of a selective inhibitor of cholesterol synthesis: pravastatin].
Topics: Adult; Animals; Anticholesteremic Agents; Cholesterol; Cholestyramine Resin; Clinical Trials as Topic; Drug Therapy, Combination; Female; Guinea Pigs; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Lovastatin; Male; Pravastatin; Rats; Risk Factors; Simvastatin; Time Factors | 1992 |
The discovery and development of HMG-CoA reductase inhibitors.
Topics: Animals; Anticholesteremic Agents; History, 20th Century; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Lovastatin | 1992 |
Lovastatin-induced rhabdomyolysis in the absence of concomitant drugs.
Topics: Humans; Hypercholesterolemia; Lovastatin; Male; Middle Aged; Rhabdomyolysis; Time Factors | 1992 |
Clinical implications of new drugs for lowering plasma cholesterol concentrations.
Topics: Anticholesteremic Agents; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Hyperlipidemias; Lovastatin; Naphthalenes; Pravastatin; Simvastatin | 1991 |
Lowering cholesterol with diet and lovastatin.
Topics: Cholesterol; Dietary Fats; Humans; Hypercholesterolemia; Lovastatin | 1991 |
[Hypercholesterolemia: therapeutic approach].
Topics: Adult; Aged; Anticholesteremic Agents; Enzyme Inhibitors; Female; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Lovastatin; Male; Middle Aged; Naphthalenes; Pravastatin; Simvastatin | 1991 |
[Advance in drug treatment of primary and familial hypercholesterolemia].
Topics: Animals; Cholestyramine Resin; Drugs, Chinese Herbal; Humans; Hypercholesterolemia; Hyperlipoproteinemia Type II; Lovastatin; Panax; Plants, Medicinal; Probucol | 1991 |
Long-term clinical tolerance of lovastatin and simvastatin.
Topics: Anticholesteremic Agents; Cholesterol; Drug Interactions; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Lovastatin; Simvastatin | 1990 |
Simvastatin. A review of its pharmacological properties and therapeutic potential in hypercholesterolaemia.
Topics: Animals; Anticholesteremic Agents; Humans; Hypercholesterolemia; Lovastatin; Simvastatin | 1990 |
HMG CoA reductase inhibitors in the treatment of hypercholesterolaemias.
Topics: Anticholesteremic Agents; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Lovastatin; Naphthalenes; Pravastatin; Simvastatin | 1990 |
Reducing high blood cholesterol level with drugs. Cost-effectiveness of pharmacologic management.
Topics: Anticholesteremic Agents; Cholestyramine Resin; Clinical Trials as Topic; Colestipol; Cost-Benefit Analysis; Drug Therapy, Combination; Gemfibrozil; Humans; Hypercholesterolemia; Lovastatin; Niacin; Probucol; Sensitivity and Specificity | 1990 |
Reductase inhibitor therapy of hypercholesterolemia.
Topics: Anticholesteremic Agents; Cholesterol, LDL; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Lovastatin; Rhabdomyolysis; Simvastatin | 1991 |
Simvastatin to lower cholesterol.
Topics: Anticholesteremic Agents; Humans; Hypercholesterolemia; Lovastatin; Simvastatin | 1990 |
Cholesterol: myth or reality?
Topics: Age Factors; Aged; Cholesterol; Cholesterol, HDL; Clinical Trials as Topic; Coronary Disease; Evaluation Studies as Topic; Female; Follow-Up Studies; Health Education; Humans; Hypercholesterolemia; Lovastatin; Male; Middle Aged; Reference Values; Risk Factors; Sex Factors | 1990 |
[Maximal treatment of hypercholesteremia: what is possible?].
Topics: Anticholesteremic Agents; Combined Modality Therapy; Extracorporeal Circulation; Humans; Hypercholesterolemia; Lovastatin; Simvastatin | 1990 |
Lovastatin: an HMG-CoA reductase inhibitor for lowering cholesterol.
Topics: Cholesterol; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Lipoproteins; Lovastatin | 1989 |
Discovery, biochemistry and biology of lovastatin.
Topics: Animals; Chemical Phenomena; Chemistry; Cholesterol; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Liver; Lovastatin; Receptors, LDL | 1988 |
Efficacy and long-term adverse effect pattern of lovastatin.
Topics: Alanine Transaminase; Clinical Trials as Topic; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Liver; Lovastatin; Muscular Diseases; Time Factors | 1988 |
The clinical efficacy and safety of lovastatin and MK-733--an overview.
Topics: Dose-Response Relationship, Drug; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Lipoproteins; Lovastatin; Simvastatin | 1987 |
3-Hydroxy-3-methylglutaryl--coenzyme A reductase inhibitors in the treatment of hypercholesterolemia.
Topics: Adult; Animals; Anticholesteremic Agents; Child; Cholesterol, LDL; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Lovastatin | 1987 |
[Pharmacologic therapy of arteriosclerosis. II. New directions].
Topics: Animals; Anticholesteremic Agents; Arachidonate Lipoxygenases; Arteriosclerosis; Blood Platelets; Cholesterol; Cholesterol Esters; Cholesterol, LDL; Enzyme Induction; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Hyperlipoproteinemia Type II; Lipoxygenase Inhibitors; Lovastatin; Male; Models, Biological; Muscle, Smooth, Vascular; Naphthalenes; Phosphatidylcholine-Sterol O-Acyltransferase; Platelet Aggregation; Rats; Receptors, LDL | 1985 |
279 trial(s) available for lovastatin and Elevated Cholesterol
Article | Year |
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Survivin down-regulation plays a crucial role in 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor-induced apoptosis in cancer.
Topics: Apoptosis; Apoptosis Regulatory Proteins; Cell Line, Tumor; Cholesterol; Colonic Neoplasms; Diterpenes; Down-Regulation; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hydroxymethylglutaryl-CoA-Reductases, NADP-dependent; Hypercholesterolemia; Inhibitor of Apoptosis Proteins; Lovastatin; Microtubule-Associated Proteins; Neoplasm Proteins; Phosphorylation; Polyisoprenyl Phosphates; Protein Prenylation; RNA Interference; Sesquiterpenes; Signal Transduction; Survivin | 2007 |
Low dose red yeast rice with monacolin K lowers LDL cholesterol and blood pressure in Japanese with mild dyslipidemia: A multicenter, randomized trial.
Topics: Biological Products; Blood Pressure; Cholesterol, LDL; Dietary Supplements; Dyslipidemias; Humans; Hypercholesterolemia; Japan; Lovastatin | 2021 |
Effectiveness and safety of red yeast rice predominated by monacolin K β-hydroxy acid form for hyperlipidemia treatment and management.
Topics: Biological Products; Cholesterol, LDL; Humans; Hydroxy Acids; Hypercholesterolemia; Hyperlipidemias; Lovastatin | 2022 |
Effects of treatment with monacolin K, berberine and coenzyme Q10 on lipid metabolism in patients with moderate cardiovascular risk.
Topics: Berberine; Cardiovascular Diseases; Cholesterol, LDL; Dietary Supplements; Heart Disease Risk Factors; Humans; Hypercholesterolemia; Lipid Metabolism; Lovastatin; Risk Factors; Treatment Outcome; Ubiquinone | 2022 |
Randomized, Double-Blind, Placebo-Controlled Trial to Test the Effects of a Nutraceutical Combination Monacolin K-Free on the Lipid and Inflammatory Profile of Subjects with Hypercholesterolemia.
Topics: Adult; Aged; Biomarkers; C-Reactive Protein; Cholesterol, LDL; Dietary Supplements; Double-Blind Method; Female; Humans; Hypercholesterolemia; Lipids; Lovastatin; Male; MicroRNAs; Middle Aged; Triglycerides | 2022 |
Low Dose Monacolin K Combined with Coenzyme Q10, Grape Seed, and Olive Leaf Extracts Lowers LDL Cholesterol in Patients with Mild Dyslipidemia: A Multicenter, Randomized Controlled Trial.
Topics: Anticholesteremic Agents; Cholesterol, LDL; Dietary Supplements; Dyslipidemias; Humans; Hypercholesterolemia; Lovastatin; Olea; Vitis | 2023 |
Efficacy of Nutraceutical Combination of Monacolin K, Berberine, and Silymarin on Lipid Profile and PCSK9 Plasma Level in a Cohort of Hypercholesterolemic Patients.
Topics: Berberine; Dietary Supplements; Humans; Hypercholesterolemia; Lipids; Lovastatin; Proprotein Convertase 9; Silymarin | 2020 |
LDL-cholesterol lowering effect of a new dietary supplement: an open label, controlled, randomized, cross-over clinical trial in patients with mild-to-moderate hypercholesterolemia.
Topics: Adolescent; Adult; Aged; Analysis of Variance; Anticholesteremic Agents; Arginine; Ascorbic Acid; Cholesterol, HDL; Cholesterol, LDL; Cross-Over Studies; Dietary Supplements; Female; Humans; Hypercholesterolemia; Lovastatin; Male; Middle Aged; Severity of Illness Index; Triglycerides; Ubiquinone | 2018 |
The short-term supplementation of monacolin K improves the lipid and metabolic patterns of hypertensive and hypercholesterolemic subjects at low cardiovascular risk.
Topics: Adult; Biological Products; Blood Glucose; Cardiovascular Diseases; Cholesterol, HDL; Cholesterol, LDL; Dietary Supplements; Female; Humans; Hypercholesterolemia; Hypertension; Lipids; Lovastatin; Male; Middle Aged; Risk Factors; Time Factors; Triglycerides | 2018 |
Effect of Monacolin K and COQ10 supplementation in hypertensive and hypercholesterolemic subjects with metabolic syndrome.
Topics: Aged; Anticholesteremic Agents; Blood Glucose; Cholesterol, HDL; Cholesterol, LDL; Diet, Mediterranean; Dietary Supplements; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Hypertension; Lovastatin; Male; Metabolic Syndrome; Middle Aged; Treatment Outcome; Triglycerides; Ubiquinone | 2018 |
Relationship between adiponectin and leptin, and blood lipids in hyperlipidemia patients treated with red yeast rice.
Topics: Adiponectin; Adult; Biological Products; Body Mass Index; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Dietary Supplements; Drug Combinations; Female; gamma-Aminobutyric Acid; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Hypertriglyceridemia; Intention to Treat Analysis; Leptin; Lipids; Lovastatin; Male; Medicine, Chinese Traditional; Middle Aged; Treatment Outcome | 2013 |
Berberine and monacolin effects on the cardiovascular risk profile of women with oestroprogestin-induced hypercholesterolemia.
Topics: Adult; Anticholesteremic Agents; Berberine; Cardiovascular Diseases; Contraception; Contraceptives, Oral; Dietary Supplements; Drug Combinations; Ethinyl Estradiol; Female; Humans; Hypercholesterolemia; Lipid Metabolism; Lovastatin; Norpregnenes; Pilot Projects; Polycystic Ovary Syndrome; Prospective Studies; Risk Factors; Treatment Outcome | 2014 |
Testing the Short-Term Efficacy of a Lipid-Lowering Nutraceutical in the Setting of Clinical Practice: A Multicenter Study.
Topics: Adult; Anticholesteremic Agents; Biological Products; Cholesterol; Cholesterol, LDL; Dietary Supplements; Fatty Acids, Unsaturated; Female; Humans; Hypercholesterolemia; Lipids; Lovastatin; Male; Metabolic Syndrome; Middle Aged; Phytosterols; Treatment Outcome; Triglycerides | 2015 |
Low daily dose of 3 mg monacolin K from RYR reduces the concentration of LDL-C in a randomized, placebo-controlled intervention.
Topics: Biological Products; Cholesterol; Cholesterol, LDL; Dietary Supplements; Female; Folic Acid; Fungi; Homocysteine; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Lovastatin; Male; Middle Aged | 2016 |
Should high creatine kinase discourage the initiation or continuance of statins for the treatment of hypercholesterolemia?
Topics: Atorvastatin; Cholesterol, LDL; Creatine Kinase; Fatty Acids, Monounsaturated; Fluorobenzenes; Fluvastatin; Follow-Up Studies; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Indoles; Lovastatin; Pravastatin; Prospective Studies; Pyrimidines; Pyrroles; Rhabdomyolysis; Rosuvastatin Calcium; Simvastatin; Sulfonamides | 2009 |
Tolerability and effects on lipids of ezetimibe coadministered with pravastatin or simvastatin for twelve months: results from two open-label extension studies in hypercholesterolemic patients.
Topics: Adult; Aged; Anticholesteremic Agents; Arthralgia; Azetidines; Body Mass Index; Cholesterol, HDL; Cholesterol, LDL; Drug Therapy, Combination; Ezetimibe; Female; Follow-Up Studies; Headache; Humans; Hypercholesterolemia; Lovastatin; Male; Middle Aged; Patient Dropouts; Pravastatin; Respiratory Tract Infections; Simvastatin; Sinusitis; Treatment Outcome; Triglycerides | 2008 |
Effect of folate supplementation on serum homocysteine and plasma total antioxidant capacity in hypercholesterolemic adults under lovastatin treatment: a double-blind randomized controlled clinical trial.
Topics: Adult; Anticholesteremic Agents; Antioxidants; Dietary Supplements; Double-Blind Method; Female; Folic Acid; Homocysteine; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Lipoproteins; Lovastatin; Male; Middle Aged; Vitamin B Complex | 2009 |
A randomized, double-blind comparison of cerivastatin and lovastatin for treatment of primary hypercholesterolemia.
Topics: Adult; Aged; Cholesterol, HDL; Cholesterol, LDL; Double-Blind Method; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Lovastatin; Male; Middle Aged; Prospective Studies; Pyridines; Triglycerides | 2002 |
Efficacy and safety of ezetimibe coadministered with lovastatin in primary hypercholesterolemia.
Topics: Aged; Anticholesteremic Agents; Apolipoprotein A-I; Apolipoproteins B; Azetidines; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Double-Blind Method; Drug Therapy, Combination; Ezetimibe; Female; Humans; Hypercholesterolemia; Lipoprotein(a); Lovastatin; Male; Middle Aged; Practice Guidelines as Topic; Safety; Treatment Outcome; Triglycerides | 2003 |
An economic analysis of the Atorvastatin Comparative Cholesterol Efficacy and Safety Study (ACCESS).
Topics: Adult; Aged; Atorvastatin; Cholesterol, LDL; Dose-Response Relationship, Drug; Fatty Acids, Monounsaturated; Female; Fluvastatin; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Indoles; Lovastatin; Male; Middle Aged; Pravastatin; Pyrroles; Risk Factors; Simvastatin; Treatment Outcome | 2003 |
A multicenter, randomized, double-blind clinical trial comparing the low-density lipoprotein cholesterol-lowering ability of lovastatin 10, 20, and 40 mg/d with fluvastatin 20 and 40 mg/d.
Topics: Cholesterol, LDL; Double-Blind Method; Fatty Acids, Monounsaturated; Female; Fluvastatin; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Indoles; Lovastatin; Male; Middle Aged; Prospective Studies | 2003 |
Efficacy of once-daily extended-release lovastatin as compared to immediate-release lovastatin in patients with hypercholesterolemia.
Topics: Adult; Aged; Anesthetics, Local; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Cross-Over Studies; Delayed-Action Preparations; Double-Blind Method; Female; Humans; Hypercholesterolemia; Lovastatin; Male; Middle Aged; Triglycerides | 2004 |
Psychological and cognitive function: predictors of adherence with cholesterol lowering treatment.
Topics: Adult; Anticholesteremic Agents; Cognition; Emotions; Female; Humans; Hypercholesterolemia; Intelligence; Lovastatin; Male; Middle Aged; Patient Compliance; Personality; Personality Assessment; Predictive Value of Tests; Regression Analysis | 2004 |
Efficacy of extended-release niacin with lovastatin for hypercholesterolemia: assessing all reasonable doses with innovative surface graph analysis.
Topics: Delayed-Action Preparations; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Hypercholesterolemia; Lovastatin; Male; Middle Aged; Niacin; Probability; Reference Values; Risk Assessment; Severity of Illness Index; Treatment Outcome | 2004 |
A community-based, randomized trial of ezetimibe added to statin therapy to attain NCEP ATP III goals for LDL cholesterol in hypercholesterolemic patients: the ezetimibe add-on to statin for effectiveness (EASE) trial.
Topics: Aged; Anticholesteremic Agents; Atorvastatin; Azetidines; Cholesterol, LDL; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therapy, Combination; Ezetimibe; Fatty Acids, Monounsaturated; Female; Fluvastatin; Follow-Up Studies; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Indoles; Lovastatin; Male; Middle Aged; Nephelometry and Turbidimetry; Practice Guidelines as Topic; Pravastatin; Pyrroles; Retrospective Studies; Risk Factors; Simvastatin | 2005 |
A promoter polymorphism in cholesterol 7alpha-hydroxylase interacts with apolipoprotein E genotype in the LDL-lowering response to atorvastatin.
Topics: Aged; Anticholesteremic Agents; Apolipoproteins E; Atorvastatin; Bile Acids and Salts; Cholesterol 7-alpha-Hydroxylase; Cholesterol, LDL; Double-Blind Method; Female; Genotype; Heptanoic Acids; Humans; Hypercholesterolemia; Lovastatin; Male; Middle Aged; Placebos; Polymorphism, Genetic; Promoter Regions, Genetic; Pyrroles; Sex Factors; Treatment Outcome | 2005 |
Genetically determined apo B levels and peak LDL density predict angiographic response to intensive lipid-lowering therapy.
Topics: Adult; Analysis of Variance; Apolipoproteins B; Colestipol; Coronary Angiography; Coronary Stenosis; Drug Therapy, Combination; Dyslipidemias; Genetic Predisposition to Disease; Humans; Hypercholesterolemia; Hypolipidemic Agents; Lipoproteins, LDL; Lovastatin; Male; Middle Aged; Niacin; Pharmacogenetics; Treatment Outcome | 2006 |
Comparison of a dietary portfolio diet of cholesterol-lowering foods and a statin on LDL particle size phenotype in hypercholesterolaemic participants.
Topics: Aged; Analysis of Variance; C-Reactive Protein; Cardiovascular Diseases; Cholesterol, LDL; Cross-Over Studies; Diet, Fat-Restricted; Dietary Fats; Dietary Fiber; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Lipids; Lovastatin; Male; Middle Aged; Particle Size; Phytosterols; Risk | 2007 |
Effect of combining viscous fibre with lovastatin on serum lipids in normal human subjects.
Topics: Adolescent; Adult; Anticholesteremic Agents; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Drug Therapy, Combination; Humans; Hypercholesterolemia; Lovastatin; Male; Middle Aged; Psyllium; Treatment Outcome; Triglycerides | 2007 |
[The Scandinavian Simvastatin Survival Study: the clinical consequences].
Topics: Adult; Aged; Anticholesteremic Agents; Coronary Disease; Female; Humans; Hypercholesterolemia; Lovastatin; Male; Middle Aged; Scandinavian and Nordic Countries; Simvastatin; Survivors | 1995 |
Long-term efficacy and tolerability of simvastatin in a large cohort of elderly hypercholesterolemic patients.
Topics: Aged; Aged, 80 and over; Anticholesteremic Agents; Cholesterol; Double-Blind Method; Female; Follow-Up Studies; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Lipids; Lovastatin; Male; Middle Aged; Simvastatin | 1995 |
Effects of bezafibrate and of 2 HMG-CoA reductase inhibitors on lipoprotein (a) level in hypercholesterolemic patients.
Topics: Adult; Aged; Analysis of Variance; Anticholesteremic Agents; Bezafibrate; Cholesterol; Delayed-Action Preparations; Diet; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Hypolipidemic Agents; Lipoprotein(a); Lovastatin; Male; Middle Aged; Pravastatin; Receptors, LDL; Simvastatin | 1995 |
Escape phenomenon of low-density lipoprotein cholesterol during lovastatin treatment.
Topics: Adult; Aged; Cholesterol, LDL; Female; Humans; Hypercholesterolemia; Lovastatin; Male; Middle Aged; Time Factors | 1995 |
Effects of treatment with simvastatin and pravastatin on cognitive function in patients with hypercholesterolaemia.
Topics: Adult; Anticholesteremic Agents; Cognition; Cross-Over Studies; Double-Blind Method; Female; Humans; Hypercholesterolemia; Lipids; Lovastatin; Male; Middle Aged; Pravastatin; Simvastatin | 1995 |
Effect of simvastatin on Lp(a) concentrations.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anticholesteremic Agents; Cholesterol, LDL; Dose-Response Relationship, Drug; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Hypolipidemic Agents; Linear Models; Lipoprotein(a); Lipoproteins, LDL; Lovastatin; Male; Middle Aged; Prospective Studies; Simvastatin | 1995 |
Vitamin E in kidney transplantation: effect of treatment with simvastatin in hypercholesterolemia.
Topics: Anticholesteremic Agents; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Creatinine; Cyclosporine; Female; Follow-Up Studies; Humans; Hypercholesterolemia; Kidney Transplantation; Lovastatin; Male; Middle Aged; Simvastatin; Time Factors; Triglycerides; Vitamin E | 1995 |
The effect of lovastatin on early restenosis.
Topics: Adult; Aged; Angioplasty, Balloon, Coronary; Cholesterol, LDL; Coronary Angiography; Coronary Disease; Double-Blind Method; Exercise Test; Humans; Hypercholesterolemia; Incidence; Lovastatin; Male; Middle Aged; Prospective Studies; Recurrence | 1995 |
Simvastatin treatment of hypercholesterolemia in patients with insulin dependent diabetes mellitus.
Topics: Adult; Aged; Anticholesteremic Agents; Cholesterol, HDL; Cholesterol, LDL; Diabetes Mellitus, Type 1; Double-Blind Method; Humans; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Lipids; Lovastatin; Male; Middle Aged; Simvastatin | 1995 |
[Therapy of hypercholesterolemia after heart transplantation with the HMG-CoA reductase inhibitor simvastatin in long-term follow-up].
Topics: Adult; Aged; Anticholesteremic Agents; Cholesterol, LDL; Female; Heart Transplantation; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Lovastatin; Male; Middle Aged; Postoperative Complications; Prospective Studies; Simvastatin | 1995 |
A comparison of the effects of simvastatin and pravastatin monotherapy on muscle histology and permeability in hypercholesterolaemic patients.
Topics: Adult; Anticholesteremic Agents; Double-Blind Method; Ergometry; Female; Humans; Hypercholesterolemia; Lovastatin; Male; Middle Aged; Muscles; Permeability; Pravastatin; Prospective Studies; Simvastatin; Statistics as Topic | 1995 |
A randomized trial to assess effectiveness and cost in clinical practice: rationale and design of the Cholesterol Reduction Intervention Study (CRIS).
Topics: Adult; Aged; Cholesterol, LDL; Coronary Disease; Cost-Benefit Analysis; Costs and Cost Analysis; Follow-Up Studies; Gemfibrozil; Humans; Hypercholesterolemia; Lovastatin; Middle Aged; Niacin; Patient Selection; Prospective Studies; Risk Factors; Treatment Outcome | 1995 |
An empirical evaluation of the placebo run-in.
Topics: Aged; Cholesterol; Cholesterol, LDL; Educational Status; Feasibility Studies; Female; Follow-Up Studies; Humans; Hypercholesterolemia; Lovastatin; Male; Patient Compliance; Patient Selection; Pilot Projects; Placebos; Research Design; Treatment Outcome | 1995 |
Inhibition of thromboxane biosynthesis and platelet function by simvastatin in type IIa hypercholesterolemia.
Topics: Adult; Aged; Anticholesteremic Agents; Cholesterol; Double-Blind Method; Female; Humans; Hypercholesterolemia; Lipid Metabolism; Lovastatin; Male; Middle Aged; Platelet Aggregation; Platelet Aggregation Inhibitors; Simvastatin; Thromboxane A2 | 1995 |
[Therapeutic trial of simvastatin versus fenofibrate in primary hypercholesterolemia].
Topics: Adult; Aged; Anticholesteremic Agents; Cholesterol, HDL; Cholesterol, LDL; Female; Fenofibrate; Humans; Hypercholesterolemia; Lovastatin; Male; Middle Aged; Simvastatin; Triglycerides | 1994 |
Changes in plasma lipid and apolipoprotein levels between heparin-induced extracorporeal low-density lipoprotein precipitation (HELP) treatments.
Topics: Adult; Apolipoproteins; Apolipoproteins A; Apolipoproteins B; Blood Component Removal; Chemical Precipitation; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Combined Modality Therapy; Extracorporeal Circulation; Female; Gemfibrozil; Heparin; Humans; Hypercholesterolemia; Hyperlipidemias; Lipids; Lipoproteins, LDL; Lovastatin; Male | 1995 |
[Randomized, double-blind comparative study between pravastatin and lovastatin. Evaluation of efficacy and safety].
Topics: Adult; Aged; Cholesterol, LDL; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Hypercholesterolemia; Lovastatin; Male; Middle Aged; Pravastatin | 1994 |
Effect of gemfibrozil versus lovastatin on increased serum lipoprotein(a) levels of patients with hypercholesterolemia.
Topics: Adult; Aged; Cholesterol; Female; Gemfibrozil; Humans; Hypercholesterolemia; Lipoprotein(a); Lipoproteins, HDL; Lipoproteins, LDL; Lipoproteins, VLDL; Lovastatin; Male; Middle Aged; Treatment Outcome; Triglycerides | 1995 |
Effects of treatment with lovastatin and pravastatin on daytime cognitive performance.
Topics: Adult; Affect; Cognition; Cross-Over Studies; Double-Blind Method; Female; Humans; Hypercholesterolemia; Lovastatin; Male; Middle Aged; Pravastatin | 1995 |
Prevention and treatment of graft vessel disease after heart transplantation.
Topics: Adult; Arteriosclerosis; Blood Component Removal; Cholesterol; Double-Blind Method; Female; Graft Occlusion, Vascular; Graft vs Host Disease; Heart Transplantation; Humans; Hypercholesterolemia; Lovastatin; Male; Middle Aged; Oligopeptides; Peptides, Cyclic; Prospective Studies; Risk Factors; Simvastatin; Somatostatin; Tissue Donors | 1995 |
Is a reduction of graft vessel disease by maximal treatment of hypercholesterolemia after heart transplantation possible?
Topics: Adult; Coronary Disease; Cyclosporine; Female; Graft Occlusion, Vascular; Graft Rejection; Heart Transplantation; Humans; Hypercholesterolemia; Lovastatin; Male; Middle Aged; Simvastatin | 1995 |
Enhanced low-density lipoprotein cholesterol reduction and cost-effectiveness by low-dose colestipol plus lovastatin combination therapy.
Topics: Apolipoproteins; Cholesterol, LDL; Colestipol; Cost-Benefit Analysis; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Hypercholesterolemia; Lipids; Lipoproteins; Lovastatin; Male; Middle Aged | 1995 |
Decreases in serum ubiquinone concentrations do not result in reduced levels in muscle tissue during short-term simvastatin treatment in humans.
Topics: Acyl Coenzyme A; Adult; Anticholesteremic Agents; Cholesterol; Chromatography, High Pressure Liquid; Humans; Hypercholesterolemia; Lovastatin; Male; Middle Aged; Muscles; Simvastatin; Ubiquinone | 1995 |
The effect of cholesterol-lowering and antioxidant therapy on endothelium-dependent coronary vasomotion.
Topics: Acetylcholine; Anticholesteremic Agents; Antioxidants; Cholestyramine Resin; Coronary Artery Disease; Endothelium, Vascular; Female; Follow-Up Studies; Humans; Hypercholesterolemia; Lovastatin; Male; Middle Aged; Probucol; Regression Analysis; Vasoconstriction; Vasodilation | 1995 |
Central nervous system effects of HMG CoA reductase inhibitors: lovastatin and pravastatin on sleep and cognitive performance in patients with hypercholesterolemia.
Topics: Adult; Affect; Aged; Cholesterol, LDL; Cognition; Cross-Over Studies; Double-Blind Method; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Lipids; Lipoproteins; Lovastatin; Male; Middle Aged; Polysomnography; Pravastatin; Psychomotor Performance; Sleep | 1994 |
Efficacy of low-dose cholesterol-lowering drug therapy in men with moderate hypercholesterolemia.
Topics: Adult; Aged; Anticholesteremic Agents; Cholestyramine Resin; Drug Therapy, Combination; Humans; Hypercholesterolemia; Lipids; Lipoproteins; Lovastatin; Male; Middle Aged; Severity of Illness Index; Treatment Outcome | 1995 |
[Hypercholesterolemia--a clinical problem in heart transplantation. A therapeutic trial with low-dose lovastatin].
Topics: Adult; Aged; Female; Heart Transplantation; Humans; Hypercholesterolemia; Lovastatin; Male; Middle Aged; Retrospective Studies | 1995 |
Gender and diet interactions with simvastatin treatment.
Topics: Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Dietary Fats; Female; Humans; Hypercholesterolemia; Lovastatin; Male; Middle Aged; Sex Factors; Simvastatin; Triglycerides | 1994 |
HBPRCA Astra Award. Therapeutic restoration of endothelial function in hypercholesterolaemic subjects: effect of fish oils.
Topics: Acetylcholine; Adult; Australia; Awards and Prizes; Cholesterol; Cholesterol, LDL; Cholestyramine Resin; Drug Therapy, Combination; Endothelium, Vascular; Female; Fish Oils; Forearm; Humans; Hypercholesterolemia; Hypertension; Lovastatin; Male; Middle Aged; Regional Blood Flow; Simvastatin | 1994 |
[Moderate hypercholesterolemia and coronary disease: the MAAS study and the 4S study].
Topics: Anticholesteremic Agents; Cholesterol, LDL; Coronary Angiography; Coronary Artery Disease; Humans; Hydroxymethylglutaryl-CoA Synthase; Hypercholesterolemia; Lovastatin; Middle Aged; Primary Prevention; Risk Factors; Simvastatin | 1995 |
[Can hyperlipidemia after heart transplantation be optimally and safely treated?].
Topics: Adult; Aged; Cholesterol, HDL; Cholesterol, LDL; Female; Heart Transplantation; Humans; Hypercholesterolemia; Hypolipidemic Agents; Lovastatin; Male; Middle Aged; Prospective Studies; Simvastatin | 1994 |
Dose-response of simvastatin in primary hypercholesterolemia.
Topics: Anticholesteremic Agents; Diet; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Hypercholesterolemia; Lovastatin; Male; Middle Aged; Simvastatin; Triglycerides | 1994 |
Efficacy of low-density-lipoprotein lowering with statins.
Topics: Cholesterol, LDL; Dose-Response Relationship, Drug; Double-Blind Method; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Hypolipidemic Agents; Lovastatin; Simvastatin | 1994 |
Effects of long-term simvastatin treatment on testicular and adrenal steroidogenesis in hypercholesterolemic patients.
Topics: Adrenocorticotropic Hormone; Adult; Anticholesteremic Agents; Chorionic Gonadotropin; Hormones; Humans; Hypercholesterolemia; Hypothalamo-Hypophyseal System; Lipid Metabolism; Lovastatin; Male; Middle Aged; Pituitary-Adrenal System; Simvastatin; Steroids; Testis; Time Factors | 1994 |
Clinical efficacy and pharmacokinetics of HMG-CoA reductase inhibitors in heart transplant patients treated with cyclosporin A.
Topics: Alanine Transaminase; Alkaline Phosphatase; Aspartate Aminotransferases; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Cholesterol, VLDL; Creatinine; Cyclosporine; Follow-Up Studies; Heart Transplantation; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Lovastatin; Pravastatin; Simvastatin; Time Factors; Triglycerides | 1994 |
Expanded Clinical Evaluation of Lovastatin (EXCEL) study results: two-year efficacy and safety follow-up.
Topics: Alanine Transaminase; Cholesterol, HDL; Cholesterol, LDL; Cohort Studies; Creatine Kinase; Double-Blind Method; Female; Follow-Up Studies; Humans; Hypercholesterolemia; Life Tables; Liver; Lovastatin; Male; Middle Aged; Muscular Diseases; Triglycerides; United States | 1994 |
Effects of lovastatin therapy on plasminogen activator inhibitor-1 antigen levels.
Topics: Adult; Aged; Female; Fibrinolysis; Humans; Hypercholesterolemia; Lipids; Lovastatin; Male; Middle Aged; Plasminogen Activator Inhibitor 1 | 1994 |
Comparison of the effectiveness of lovastatin therapy for hypercholesterolemia after heart transplantation between patients with and without pretransplant atherosclerotic coronary artery disease.
Topics: Cholesterol; Coronary Artery Disease; Female; Heart Transplantation; Humans; Hypercholesterolemia; Lovastatin; Male; Middle Aged; Postoperative Complications; Retrospective Studies; Treatment Outcome; Triglycerides | 1994 |
Serum ubiquinone concentrations after short- and long-term treatment with HMG-CoA reductase inhibitors.
Topics: Adult; Cholesterol, HDL; Cholesterol, LDL; Double-Blind Method; Humans; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Lovastatin; Male; Middle Aged; Simvastatin; Time Factors; Ubiquinone | 1994 |
Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian Simvastatin Survival Study (4S)
Topics: Adult; Aged; Angina Pectoris; Anticholesteremic Agents; Cardiovascular Diseases; Cholesterol; Double-Blind Method; Female; Follow-Up Studies; Humans; Hypercholesterolemia; Lipids; Lovastatin; Male; Middle Aged; Myocardial Infarction; Risk Factors; Simvastatin; Survival Analysis | 1994 |
[Effect of lovastatin on serum lipids and lipoproteins. Hungarian multicenter, open-label study].
Topics: Adult; Cholesterol; Female; Humans; Hypercholesterolemia; Lipids; Lipoproteins; Lovastatin; Male; Middle Aged; Treatment Outcome; Triglycerides | 1994 |
[Lovastatin in the treatment of hypercholesterolemia].
Topics: Adult; Aged; Cholesterol; Cholesterol, HDL; Female; Humans; Hypercholesterolemia; Lovastatin; Male; Middle Aged; Triglycerides | 1994 |
Effects of lovastatin on ApoA- and ApoB-containing lipoproteins. Families in a subpopulation of patients participating in the Monitored Atherosclerosis Regression Study (MARS).
Topics: Adult; Aged; Apolipoproteins A; Apolipoproteins B; Cholesterol; Coronary Artery Disease; Disease Progression; Drug Monitoring; Female; Humans; Hypercholesterolemia; Lovastatin; Male; Middle Aged; Triglycerides | 1994 |
Comparative efficacy and tolerability of 5 and 10 mg simvastatin and 10 mg pravastatin in moderate primary hypercholesterolemia. Simvastatin Pravastatin European Study Group.
Topics: Adult; Aged; Anticholesteremic Agents; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Double-Blind Method; Female; Humans; Hypercholesterolemia; Lovastatin; Male; Middle Aged; Pravastatin; Simvastatin | 1994 |
Low-dose simvastatin is a well-tolerated and efficacious cholesterol-lowering agent in ciclosporin-treated kidney transplant recipients: double-blind, randomized, placebo-controlled study in 40 patients.
Topics: Adult; Anticholesteremic Agents; Cholesterol; Cyclosporine; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Kidney Transplantation; Lovastatin; Male; Middle Aged; Placebos; Risk Factors; Simvastatin | 1994 |
Three-year follow-up of the Oxford Cholesterol Study: assessment of the efficacy and safety of simvastatin in preparation for a large mortality study.
Topics: Adult; Aged; Anticholesteremic Agents; Cholesterol; Coronary Disease; Female; Follow-Up Studies; Humans; Hypercholesterolemia; Lipids; Liver Function Tests; Lovastatin; Male; Middle Aged; Myocardial Infarction; Prospective Studies; Simvastatin; Survival Analysis; Survival Rate; Treatment Outcome | 1994 |
Comparative effects of lovastatin and niacin in primary hypercholesterolemia. A prospective trial.
Topics: Adult; Aged; Female; Humans; Hypercholesterolemia; Lipids; Lipoproteins; Lovastatin; Male; Middle Aged; Niacin | 1994 |
Associations of cholesterol lowering by statins with anger and hostility in hypercholesterolemic men.
Topics: Adult; Aged; Anger; Cholesterol; Double-Blind Method; Hostility; Humans; Hypercholesterolemia; Lovastatin; Male; Middle Aged; Pravastatin | 1994 |
Simvastatin in non-insulin-dependent diabetes mellitus: effect on serum lipids, lipoproteins and haemostatic measures.
Topics: Adult; Aged; Apolipoproteins B; Blood Glucose; Cholesterol, LDL; Diabetes Mellitus, Type 2; Double-Blind Method; Female; Hemostasis; Humans; Hypercholesterolemia; Hypolipidemic Agents; Lipids; Lipoproteins; Lovastatin; Male; Middle Aged; Simvastatin; Triglycerides | 1994 |
Efficacy and tolerability of lovastatin in hypercholesterolemia in patients with systemic hypertension.
Topics: Adrenergic beta-Antagonists; Adult; Aged; Aged, 80 and over; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Blood Pressure; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Coronary Disease; Diuretics; Drug Tolerance; Female; Humans; Hypercholesterolemia; Hypertension; Lovastatin; Male; Middle Aged; Retrospective Studies; Time Factors; Triglycerides | 1993 |
Benefits of lipid-lowering therapy in men with elevated apolipoprotein B are not confined to those with very high low density lipoprotein cholesterol.
Topics: Adult; Analysis of Variance; Anticholesteremic Agents; Apolipoproteins B; Cholesterol, LDL; Colestipol; Coronary Angiography; Coronary Disease; Double-Blind Method; Humans; Hypercholesterolemia; Lovastatin; Male; Middle Aged; Niacin; Treatment Outcome | 1994 |
Comparative efficacy and safety of micronized fenofibrate and simvastatin in patients with primary type IIa or IIb hyperlipidemia.
Topics: Adolescent; Adult; Aged; Anticholesteremic Agents; Cholesterol, LDL; Double-Blind Method; Female; Fenofibrate; Humans; Hypercholesterolemia; Hypertriglyceridemia; Lovastatin; Male; Middle Aged; Prognosis; Simvastatin; Triglycerides | 1994 |
Efficacy and tolerability of simvastatin 20 mg vs pravastatin 20 mg in patients with primary hypercholesterolemia. European Study Group.
Topics: Adolescent; Adult; Aged; Anticholesteremic Agents; Apolipoprotein A-I; Apolipoproteins B; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Double-Blind Method; Drug Tolerance; Female; Humans; Hypercholesterolemia; Lovastatin; Male; Middle Aged; Pravastatin; Simvastatin; Triglycerides | 1993 |
Cholesterol lowering in the elderly. Results of the Cholesterol Reduction in Seniors Program (CRISP) pilot study.
Topics: Aged; Combined Modality Therapy; Double-Blind Method; Feasibility Studies; Female; Humans; Hypercholesterolemia; Lipids; Lovastatin; Male; Pilot Projects; Quality of Life; Treatment Outcome; Vision, Ocular | 1994 |
[An evaluation of the hypolipidemic effects of lovastatin in primary hypercholesterolemia. A multicenter study].
Topics: Adult; Aged; Drug Tolerance; Female; Humans; Hypercholesterolemia; Lipids; Lipoproteins; Lovastatin; Male; Middle Aged; Myocardial Ischemia; Time Factors; USSR | 1993 |
Comparison of effects on sleep of lovastatin and pravastatin in hypercholesterolemia.
Topics: Adult; Aged; Double-Blind Method; Humans; Hypercholesterolemia; Lipoproteins; Lovastatin; Male; Middle Aged; Polysomnography; Pravastatin; Sleep | 1994 |
[Efficacy and tolerability of simvastatin and omega-3 fatty acid combination in patients with coronary disease, hypercholesterolemia and hypertriglyceridemia].
Topics: Aged; Anticholesteremic Agents; Coronary Disease; Drug Tolerance; Fatty Acids, Omega-3; Female; Humans; Hypercholesterolemia; Hypertriglyceridemia; Hypolipidemic Agents; Lovastatin; Male; Middle Aged; Simvastatin | 1993 |
Effectiveness of low-dose lovastatin combined with low-dose colestipol in moderate to severe primary hypercholesterolaemia.
Topics: Adult; Aged; Cholesterol; Colestipol; Drug Therapy, Combination; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Lovastatin; Male; Middle Aged | 1993 |
Effect and tolerability of combining lovastatin with nifedipine or lisinopril.
Topics: Double-Blind Method; Drug Interactions; Drug Therapy, Combination; Female; Humans; Hypercholesterolemia; Hypertension; Lisinopril; Lovastatin; Male; Middle Aged; Nifedipine; Quality of Life; Risk Factors | 1993 |
Treating hypercholesterolaemia with HMG CoA reductase inhibitors: a direct comparison of simvastatin and pravastatin.
Topics: Adult; Aged; Anticholesteremic Agents; Double-Blind Method; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Lipids; Lovastatin; Male; Middle Aged; Pravastatin; Simvastatin | 1993 |
Renal function and insulin sensitivity during simvastatin treatment in type 2 (non-insulin-dependent) diabetic patients with microalbuminuria.
Topics: Aged; Albuminuria; Anticholesteremic Agents; Apolipoproteins B; Biomarkers; Blood Glucose; Blood Pressure; Cholesterol; Cholesterol, LDL; Diabetes Mellitus, Type 2; Double-Blind Method; Energy Intake; Female; Fructosamine; Glomerular Filtration Rate; Glycated Hemoglobin; Hexosamines; Humans; Hypercholesterolemia; Insulin; Kidney; Lovastatin; Male; Placebos; Simvastatin; Time Factors | 1993 |
Simvastatin therapy for hypercholesterolemic patients with nephrotic syndrome or significant proteinuria.
Topics: Adolescent; Adult; Aged; Anticholesteremic Agents; Apolipoprotein B-100; Apolipoproteins B; Cholesterol, HDL; Cholesterol, LDL; Creatinine; Double-Blind Method; Female; Humans; Hypercholesterolemia; Inulin; Lovastatin; Male; Middle Aged; Nephrotic Syndrome; Placebos; Proteinuria; Simvastatin; Triglycerides | 1993 |
[Reductions in lipid fraction plasma levels induced by simvastatin and bezafibrate. Brazilian multicenter study].
Topics: Bezafibrate; Double-Blind Method; Female; Humans; Hypercholesterolemia; Lipids; Lovastatin; Male; Middle Aged; Program Evaluation; Time Factors | 1993 |
[Lovastatin in the treatment of hypercholesterolemia in non-insulin-dependent diabetes mellitus patients].
Topics: Aged; Cholesterol, HDL; Cholesterol, LDL; Coronary Disease; Diabetes Mellitus, Type 2; Drug Administration Schedule; Female; Humans; Hypercholesterolemia; Lovastatin; Male; Middle Aged | 1993 |
Effects of lovastatin on natural killer cell function and other immunological parameters in man.
Topics: Adult; Aged; B-Lymphocytes; Cytotoxicity, Immunologic; Double-Blind Method; Female; Humans; Hypercholesterolemia; Killer Cells, Natural; Leukocyte Count; Lipids; Lovastatin; Lymphocyte Activation; Male; Middle Aged; Phytohemagglutinins; T-Lymphocytes | 1993 |
Hypercholesterolemia in postmenopausal women. Metabolic defects and response to low-dose lovastatin.
Topics: Aged; Apolipoproteins B; Cholesterol, LDL; Double-Blind Method; Drug Administration Schedule; Female; Humans; Hypercholesterolemia; Lipoproteins; Lipoproteins, LDL; Lipoproteins, VLDL; Lovastatin; Middle Aged; Postmenopause | 1994 |
Lovastatin and the human lens; results of a two year study. The MSDRL Study Group.
Topics: Cataract; Contrast Sensitivity; Double-Blind Method; Female; Follow-Up Studies; Humans; Hypercholesterolemia; Image Processing, Computer-Assisted; Lens, Crystalline; Longitudinal Studies; Lovastatin; Male; Middle Aged; Photography; Visual Acuity | 1993 |
Treatment of primary hypercholesterolaemia. Short-term efficacy and safety of increasing doses of simvastatin and pravastatin: a double-blind comparative study.
Topics: Adult; Aged; Anticholesteremic Agents; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Lipids; Lovastatin; Male; Middle Aged; Pravastatin; Simvastatin; Treatment Outcome | 1993 |
Comparison of the short term efficacy and tolerability of lovastatin and simvastatin in the management of primary hypercholesterolemia.
Topics: Anticholesteremic Agents; Double-Blind Method; Female; Humans; Hypercholesterolemia; Lovastatin; Male; Middle Aged; Simvastatin; Time Factors | 1993 |
Effect of lovastatin on serum lipid profile in the treatment of dyslipoproteinaemia in uraemic patients on continuous ambulatory peritoneal dialysis.
Topics: Female; Humans; Hypercholesterolemia; Hypertriglyceridemia; Lipids; Lovastatin; Male; Middle Aged; Peritoneal Dialysis, Continuous Ambulatory; Single-Blind Method; Uremia | 1993 |
Lovastatin does not affect oral glucose tolerance in hypercholesterolemic patients.
Topics: Adult; Aged; Blood Glucose; Cholesterol, LDL; Double-Blind Method; Fasting; Female; Glucose Tolerance Test; Humans; Hypercholesterolemia; Lovastatin; Male; Middle Aged; Time Factors; Triglycerides | 1993 |
[Comparison of 2 cholesterol synthesis inhibitors (simvastatin and pravastatin)].
Topics: Anticholesteremic Agents; Cholesterol; Humans; Hypercholesterolemia; Lovastatin; Pravastatin; Simvastatin | 1993 |
[Comparison of the efficacy between simvastatin and gemfibrozil in primary hypercholesterolemia].
Topics: Adult; Aged; Double-Blind Method; Female; Gemfibrozil; Humans; Hypercholesterolemia; Hypolipidemic Agents; Lovastatin; Male; Middle Aged; Simvastatin | 1993 |
Lovastatin treatment of dyslipoproteinemia in patients on continuous ambulatory peritoneal dialysis.
Topics: Adult; Aged; Female; Humans; Hypercholesterolemia; Lovastatin; Male; Middle Aged; Peritoneal Dialysis, Continuous Ambulatory; Single-Blind Method | 1993 |
Design and baseline results of the Scandinavian Simvastatin Survival Study of patients with stable angina and/or previous myocardial infarction.
Topics: Adult; Aged; Angina Pectoris; Anticholesteremic Agents; Double-Blind Method; Ethics, Medical; Female; Humans; Hypercholesterolemia; Lovastatin; Male; Middle Aged; Myocardial Infarction; Scandinavian and Nordic Countries; Simvastatin; Time Factors | 1993 |
HMGCoA reductase inhibitors lovastatin and simvastatin in the treatment of hypercholesterolemia after renal transplantation.
Topics: Adult; Anticholesteremic Agents; Apolipoproteins; Body Mass Index; Body Weight; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Immunosuppression Therapy; Kidney Transplantation; Lipids; Lipoproteins; Lovastatin; Male; Postoperative Complications; Proteinuria; Simvastatin; Triglycerides | 1993 |
A multicenter comparative trial of lovastatin and pravastatin in the treatment of hypercholesterolemia. The Lovastatin Pravastatin Study Group.
Topics: Cholesterol, LDL; Double-Blind Method; Female; Humans; Hypercholesterolemia; Lipoproteins; Liver Function Tests; Lovastatin; Male; Middle Aged; Pravastatin; Sleep | 1993 |
Simvastatin in severe primary hypercholesterolemia: efficacy, safety, and tolerability in 595 patients over 18 weeks. The Principal Investigators.
Topics: Adult; Aged; Alanine Transaminase; Anticholesteremic Agents; Aspartate Aminotransferases; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Creatine Kinase; Digestive System Diseases; Drug Tolerance; Female; Humans; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Lovastatin; Male; Middle Aged; Placebos; Safety; Simvastatin; Triglycerides | 1993 |
Relative safety and efficacy of pravastatin.
Topics: Humans; Hypercholesterolemia; Lovastatin; Pravastatin | 1993 |
Evidence of plasma CoQ10-lowering effect by HMG-CoA reductase inhibitors: a double-blind, placebo-controlled study.
Topics: Adult; Cholesterol; Double-Blind Method; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Lipids; Lovastatin; Male; Middle Aged; Pravastatin; Simvastatin; Ubiquinone | 1993 |
The efficacy of intensive dietary therapy alone or combined with lovastatin in outpatients with hypercholesterolemia.
Topics: Apolipoproteins; Cholesterol; Cholesterol, Dietary; Cholesterol, HDL; Combined Modality Therapy; Dietary Fats; Double-Blind Method; Female; Humans; Hypercholesterolemia; Lovastatin; Male; Middle Aged; Triglycerides | 1993 |
The effects of simvastatin and pravastatin on objective and subjective measures of nocturnal sleep: a comparison of two structurally different HMG CoA reductase inhibitors in patients with primary moderate hypercholesterolaemia.
Topics: Adult; Aged; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Lipids; Lovastatin; Male; Middle Aged; Polysomnography; Pravastatin; Simvastatin; Sleep; Sleep Wake Disorders | 1993 |
Efficacy and tolerability of lovastatin in 3390 women with moderate hypercholesterolemia.
Topics: Aged; Cholesterol, HDL; Cholesterol, LDL; Creatine Kinase; Double-Blind Method; Estrogen Replacement Therapy; Female; Humans; Hypercholesterolemia; Lovastatin; Middle Aged; Muscular Diseases; Sex Factors; Transaminases | 1993 |
Lovastatin 5-year safety and efficacy study. Lovastatin Study Groups I through IV.
Topics: Cardiovascular Diseases; Cause of Death; Female; Follow-Up Studies; Humans; Hypercholesterolemia; Lovastatin; Male; Middle Aged; Treatment Outcome; Visual Acuity | 1993 |
[Effectiveness and tolerability of simvastatin in subjects with primary hypercholesterolemia. Multicenter study].
Topics: Aged; Anticholesteremic Agents; Dose-Response Relationship, Drug; Drug Evaluation; Female; Humans; Hypercholesterolemia; Lipoproteins, HDL; Lipoproteins, LDL; Lovastatin; Male; Middle Aged; Simvastatin; Triglycerides | 1993 |
Comparison of the efficacy, safety and tolerability of simvastatin and pravastatin for hypercholesterolemia. The Simvastatin Pravastatin Study Group.
Topics: Adult; Aged; Anticholesteremic Agents; Double-Blind Method; Female; Humans; Hypercholesterolemia; Lipids; Lovastatin; Male; Middle Aged; Pravastatin; Simvastatin; Sleep; Treatment Outcome | 1993 |
Statin therapy and CHD.
Topics: Anticholesteremic Agents; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Lovastatin; Male; Simvastatin | 1996 |
Effects of simvastatin and cholestyramine on bile lipid composition and gall bladder motility in patients with hypercholesterolaemia.
Topics: Anticholesteremic Agents; Bile; Cholesterol; Cholestyramine Resin; Drug Therapy, Combination; Female; Gallbladder; Humans; Hypercholesterolemia; Lovastatin; Male; Middle Aged; Prospective Studies; Simvastatin; Ultrasonography | 1995 |
[Effectiveness, tolerance and safety of simvastatin in comparison with bezafibrate in treatment of hypercholesterolemia].
Topics: Adult; Aged; Anticholesteremic Agents; Apolipoproteins; Bezafibrate; Cholesterol, HDL; Cholesterol, LDL; Combined Modality Therapy; Diet, Fat-Restricted; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Humans; Hypercholesterolemia; Lovastatin; Male; Middle Aged; Simvastatin; Triglycerides | 1995 |
Cholesterol-reduction intervention study (CRIS): a randomized trial to assess effectiveness and costs in clinical practice.
Topics: Adult; Aged; Anticholesteremic Agents; Cost-Benefit Analysis; Drug Therapy, Combination; Female; Humans; Hypercholesterolemia; Lovastatin; Male; Middle Aged; Niacin; Treatment Outcome | 1996 |
Effects of colestipol alone and in combination with simvastatin on apolipoprotein B metabolism.
Topics: Adult; Apolipoproteins B; Colestipol; Drug Combinations; Humans; Hypercholesterolemia; Hypolipidemic Agents; Lipids; Lipoproteins; Lovastatin; Male; Middle Aged; Simvastatin | 1996 |
Comparison of the effects on quality of life and of the efficacy and tolerability of lovastatin versus pravastatin. The Quality of Life Multicenter Group.
Topics: Adult; Anticholesteremic Agents; Double-Blind Method; Female; Humans; Hypercholesterolemia; Lipids; Lovastatin; Male; Middle Aged; Pravastatin; Quality of Life; Treatment Outcome | 1996 |
Physician extenders for cost-effective management of hypercholesterolemia.
Topics: Anticholesteremic Agents; Cholesterol; Cost-Benefit Analysis; Diet Therapy; Follow-Up Studies; Humans; Hypercholesterolemia; Lipoproteins; Lovastatin; Middle Aged; Physician Assistants; Prospective Studies; Treatment Outcome | 1996 |
Testicular function in hypercholesterolemic male patients during prolonged simvastatin treatment.
Topics: Androgens; Anticholesteremic Agents; Apolipoproteins; Chorionic Gonadotropin; Estradiol; Humans; Hypercholesterolemia; Lipids; Lovastatin; Male; Middle Aged; Simvastatin; Testis; Testosterone | 1996 |
Efficacy and tolerability of lovastatin in 459 African-Americans with hypercholesterolemia.
Topics: Anticholesteremic Agents; Black or African American; Black People; Cholesterol; Cholesterol, LDL; Creatine Kinase; Dose-Response Relationship, Drug; Double-Blind Method; Drug Tolerance; Female; Humans; Hypercholesterolemia; Incidence; Lovastatin; Male; Middle Aged; Placebos; Safety; Triglycerides | 1996 |
[Multicenter comparative study on safety, tolerance, and effectiveness of lovastatin combined or not with cholestyramine, and gemfibrozil combined or not with cholestyramine in the treatment of primary hypercholesterolemia].
Topics: Adolescent; Adult; Aged; Anticholesteremic Agents; Cholesterol; Cholestyramine Resin; Double-Blind Method; Drug Therapy, Combination; Female; Gemfibrozil; Humans; Hypercholesterolemia; Hypolipidemic Agents; Lovastatin; Male; Middle Aged; Triglycerides | 1996 |
Effects of short-term reduction in serum cholesterol with simvastatin in patients with stable angina pectoris and mild to moderate hypercholesterolemia.
Topics: Analysis of Variance; Angina Pectoris; Anticholesteremic Agents; Cholesterol; Cholesterol, LDL; Electrocardiography; Exercise Test; Forearm; Humans; Hypercholesterolemia; Lovastatin; Middle Aged; Regional Blood Flow; Simvastatin; Single-Blind Method | 1996 |
Safety and tolerability of cholesterol lowering with simvastatin during 5 years in the Scandinavian Simvastatin Survival Study.
Topics: Adult; Aged; Anticholesteremic Agents; Cholesterol; Coronary Disease; Double-Blind Method; Humans; Hypercholesterolemia; Lovastatin; Middle Aged; Simvastatin | 1996 |
Lipid-lowering effects of simvastatin and gemfibrozil in CAPD patients: a prospective cross-over study.
Topics: Adult; Aged; Cholesterol; Combined Modality Therapy; Cross-Over Studies; Diet, Fat-Restricted; Female; Gemfibrozil; Humans; Hypercholesterolemia; Hypertriglyceridemia; Hypolipidemic Agents; Kidney Failure, Chronic; Lovastatin; Male; Middle Aged; Peritoneal Dialysis, Continuous Ambulatory; Prospective Studies; Simvastatin; Triglycerides | 1996 |
Meeting national cholesterol education goals in clinical practice--a comparison of lovastatin and fluvastatin in primary prevention.
Topics: Fatty Acids, Monounsaturated; Female; Fluvastatin; Health Education; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Indoles; Lovastatin; Male; Middle Aged | 1996 |
Low density lipoprotein apheresis improves regional myocardial perfusion in patients with hypercholesterolemia and extensive coronary artery disease. LDL-Apheresis Atherosclerosis Regression Study (LAARS).
Topics: Adult; Aged; Angiography, Digital Subtraction; Anticholesteremic Agents; Blood Component Removal; Combined Modality Therapy; Coronary Angiography; Coronary Artery Disease; Coronary Circulation; Female; Humans; Hypercholesterolemia; Lipoproteins, LDL; Lovastatin; Male; Middle Aged; Simvastatin | 1996 |
Effect of apheresis of low-density lipoprotein on peripheral vascular disease in hypercholesterolemic patients with coronary artery disease.
Topics: Adult; Aged; Anticholesteremic Agents; Blood Component Removal; Cholesterol, LDL; Combined Modality Therapy; Coronary Artery Disease; Disease Progression; Enzyme Inhibitors; Hemodynamics; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Lovastatin; Male; Middle Aged; Peripheral Vascular Diseases; Simvastatin | 1996 |
The effect of aggressive lowering of low-density lipoprotein cholesterol levels and low-dose anticoagulation on obstructive changes in saphenous-vein coronary-artery bypass grafts.
Topics: Adult; Aged; Anticholesteremic Agents; Anticoagulants; Cholesterol, LDL; Cholestyramine Resin; Coronary Angiography; Coronary Artery Bypass; Coronary Artery Disease; Coronary Thrombosis; Drug Therapy, Combination; Female; Graft Occlusion, Vascular; Humans; Hypercholesterolemia; Life Tables; Lovastatin; Male; Middle Aged; Saphenous Vein; Treatment Outcome; Warfarin | 1997 |
Effect of pharmacologic lipid lowering on health-related quality of life in older persons: results from the Cholesterol Reduction in Seniors Program (CRISP) Pilot Study.
Topics: Activities of Daily Living; Aged; Aged, 80 and over; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Hypercholesterolemia; Lovastatin; Male; Prospective Studies; Quality of Life; Surveys and Questionnaires | 1997 |
The effect of simvastatin on progression of coronary artery disease. The Multicenter coronary Intervention Study (CIS).
Topics: Adult; Anticholesteremic Agents; Cholesterol, LDL; Coronary Disease; Disease Progression; Dose-Response Relationship, Drug; Double-Blind Method; Follow-Up Studies; Humans; Hypercholesterolemia; Lovastatin; Male; Middle Aged; Prospective Studies; Simvastatin; Treatment Outcome | 1997 |
Randomized placebo-controlled study of the effects of simvastatin on haemostatic variables, lipoproteins and free fatty acids. The Oxford Cholesterol Study Group.
Topics: Adult; Aged; Chromatography, Thin Layer; Coronary Disease; Enzyme-Linked Immunosorbent Assay; Factor VII; Factor XII; Fatty Acids, Nonesterified; Female; Fibrinogen; Follow-Up Studies; Hemostasis; Humans; Hydroxymethylglutaryl CoA Reductases; Hypercholesterolemia; Hypolipidemic Agents; Lipoproteins; Lovastatin; Male; Middle Aged; Prospective Studies; Prothrombin; Risk Factors; Simvastatin; Single-Blind Method | 1997 |
No influence of simvastatin treatment on platelet function in vivo in patients with hypercholesterolemia.
Topics: Blood Platelets; Cross-Over Studies; Double-Blind Method; Enzyme Inhibitors; Humans; Hypercholesterolemia; Lipids; Lovastatin; Male; Platelet Aggregation; Rest; Simvastatin; Stress, Psychological; Thromboxane B2; Thyroglobulin | 1997 |
The role of triglyceride-rich lipoprotein families in the progression of atherosclerotic lesions as determined by sequential coronary angiography from a controlled clinical trial.
Topics: Adult; Aged; Apolipoproteins; Arteriosclerosis; Coronary Angiography; Female; Humans; Hypercholesterolemia; Lipoproteins; Lovastatin; Male; Middle Aged; Odds Ratio; Time Factors; Triglycerides | 1997 |
[Long term treatment of moderate to severe hypercholesterolemia with low dose statin. Comparison of simvastatin and pravastatin].
Topics: Aged; Anticholesteremic Agents; Female; Humans; Hypercholesterolemia; Hypolipidemic Agents; Lovastatin; Male; Middle Aged; Pravastatin; Severity of Illness Index; Simvastatin; Time Factors | 1996 |
Intermediate-density lipoproteins and progression of carotid arterial wall intima-media thickness.
Topics: Adult; Aged; Arteriosclerosis; Carotid Artery, Common; Carotid Stenosis; Cholesterol, Dietary; Cholesterol, HDL; Cholesterol, LDL; Disease Progression; Double-Blind Method; Endothelium, Vascular; Female; Follow-Up Studies; Humans; Hypercholesterolemia; Lipoproteins; Lipoproteins, IDL; Lipoproteins, VLDL; Lovastatin; Male; Middle Aged; Risk Factors; Triglycerides; Ultrasonography | 1997 |
Effect of simvastatin therapy on cell membrane cholesterol content and membrane function as assessed by polymorphonuclear cell NADPH oxidase activity.
Topics: Adult; Anticholesteremic Agents; Cell Membrane; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Lovastatin; Male; Membrane Fluidity; Membrane Lipids; Middle Aged; NADPH Oxidases; Neutrophils; Simvastatin | 1997 |
Comparison of one-year efficacy and safety of atorvastatin versus lovastatin in primary hypercholesterolemia. Atorvastatin Study Group I.
Topics: Analysis of Variance; Anticholesteremic Agents; Atorvastatin; Cholesterol; Double-Blind Method; Female; Heptanoic Acids; Humans; Hypercholesterolemia; Lovastatin; Male; Middle Aged; Pyrroles; Treatment Outcome | 1997 |
A multicenter, double-blind, one-year study comparing safety and efficacy of atorvastatin versus simvastatin in patients with hypercholesterolemia.
Topics: Adult; Aged; Aged, 80 and over; Anticholesteremic Agents; Apolipoproteins B; Arthralgia; Atorvastatin; Cholesterol; Cholesterol, Dietary; Cholesterol, LDL; Double-Blind Method; Female; Heptanoic Acids; Humans; Hypercholesterolemia; Hyperhidrosis; Hyperlipidemias; Lovastatin; Male; Middle Aged; Patient Education as Topic; Pyrroles; Simvastatin; Triglycerides | 1997 |
Short-term safety and efficacy of low-dose simvastatin in elderly patients with hypertensive hypercholesterolemia and fasting hyperinsulinemia.
Topics: Aged; Anticholesteremic Agents; Double-Blind Method; Enzyme Inhibitors; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Hyperinsulinism; Hypertension; Lovastatin; Male; Patient Compliance; Simvastatin | 1997 |
The efficacy of lovastatin in lowering cholesterol in African Americans with primary hypercholesterolemia.
Topics: Anticholesteremic Agents; Black People; Cholesterol; Double-Blind Method; Female; Humans; Hypercholesterolemia; Lovastatin; Male; Middle Aged | 1997 |
Enhanced oxidizability of ubiquinol and alpha-tocopherol during lovastatin treatment.
Topics: Adult; Aged; Anticholesteremic Agents; Antioxidants; Apolipoproteins A; Apolipoproteins B; Cholesterol; Cholesterol, LDL; Copper; Coronary Disease; Cross-Over Studies; Double-Blind Method; Humans; Hypercholesterolemia; Lovastatin; Male; Middle Aged; Oxidation-Reduction; Triglycerides; Ubiquinone; Vitamin E | 1997 |
Dose-related decrease of serum coenzyme Q10 during treatment with HMG-CoA reductase inhibitors.
Topics: Adult; Aged; Antioxidants; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Cholesterol, VLDL; Coenzymes; Coronary Disease; Double-Blind Method; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Lovastatin; Male; Middle Aged; Oxidation-Reduction; Pravastatin; Risk Factors; Ubiquinone | 1997 |
Crossover trial of simvastatin versus pravastatin in patients with primary hypercholesterolemia.
Topics: Adult; Aged; Anticholesteremic Agents; Apolipoproteins; Cholesterol; Cross-Over Studies; Enzyme Inhibitors; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Lipids; Lovastatin; Male; Middle Aged; Pravastatin; Simvastatin | 1997 |
Estrogen and progestin compared with simvastatin for hypercholesterolemia in postmenopausal women.
Topics: Aged; Anticholesteremic Agents; Cholesterol; Cross-Over Studies; Drug Therapy, Combination; Estrogen Replacement Therapy; Estrogens, Conjugated (USP); Female; Humans; Hypercholesterolemia; Linear Models; Lovastatin; Medroxyprogesterone; Middle Aged; Postmenopause; Simvastatin; Triglycerides | 1997 |
[The effect of hypolipidemia treatment on the function of kidney transplanted from cadavers].
Topics: Adult; Anticholesteremic Agents; Azathioprine; Cadaver; Cholesterol; Cholesterol, LDL; Creatinine; Cyclosporine; Drug Therapy, Combination; Female; Humans; Hypercholesterolemia; Kidney; Kidney Transplantation; Lovastatin; Male; Middle Aged; Prednisone; Prospective Studies; Triglycerides | 1997 |
Effects of lovastatin on the immune system.
Topics: Adult; Anticholesteremic Agents; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Immune System; Lovastatin; Middle Aged | 1997 |
[The effect of hypolipemic treatment on the pharmacokinetics of propranolol].
Topics: Administration, Oral; Anticholesteremic Agents; Bezafibrate; Chromatography, High Pressure Liquid; Drug Interactions; Female; Humans; Hydroxylation; Hypercholesterolemia; Hyperlipidemias; Hypertriglyceridemia; Hypolipidemic Agents; Lovastatin; Male; Phenotype; Propranolol; Triglycerides | 1997 |
[Gemfibrozil reduces elevated lipoprotein (a) levels in hypercholesterolemic patients].
Topics: Analysis of Variance; Anticholesteremic Agents; Chi-Square Distribution; Female; Gemfibrozil; Humans; Hypercholesterolemia; Hypolipidemic Agents; Lipoprotein(a); Lovastatin; Male; Middle Aged | 1997 |
Comparative dose efficacy study of atorvastatin versus simvastatin, pravastatin, lovastatin, and fluvastatin in patients with hypercholesterolemia (the CURVES study)
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anticholesteremic Agents; Atorvastatin; Cholesterol, LDL; Fatty Acids, Monounsaturated; Female; Fluvastatin; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Indoles; Lovastatin; Male; Middle Aged; Pravastatin; Pyrroles; Simvastatin; Treatment Outcome | 1998 |
Ubiquinone supplementation during lovastatin treatment: effect on LDL oxidation ex vivo.
Topics: Analysis of Variance; Anticholesteremic Agents; Antioxidants; Apolipoprotein A-I; Apolipoproteins B; Cholesterol; Copper Sulfate; Coronary Disease; Cross-Over Studies; Diet; Double-Blind Method; Humans; Hypercholesterolemia; Lipoproteins, HDL; Lipoproteins, LDL; Lovastatin; Male; Middle Aged; Oxidation-Reduction; Oxidative Stress; Triglycerides; Ubiquinone | 1998 |
Clinical efficacy of cerivastatin: phase IIa dose-ranging and dose-scheduling studies.
Topics: Apolipoproteins B; Cholesterol, HDL; Cholesterol, LDL; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Female; Follow-Up Studies; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Lovastatin; Male; Middle Aged; Pyridines; Safety; Simvastatin; Treatment Outcome; Triglycerides | 1998 |
Clinical efficacy and safety of cerivastatin: summary of pivotal phase IIb/III studies.
Topics: Adolescent; Adult; Aged; Apolipoprotein A-I; Cholesterol, HDL; Cholesterol, LDL; Dose-Response Relationship, Drug; Double-Blind Method; Drug Evaluation; Female; Follow-Up Studies; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Lovastatin; Male; Middle Aged; Pravastatin; Pyridines; Safety; Simvastatin; Treatment Outcome | 1998 |
Comparison of the effects of pravastatin and lovastatin on sleep disturbance in hypercholesterolemic subjects.
Topics: Adult; Cross-Over Studies; Double-Blind Method; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Lovastatin; Male; Middle Aged; Pravastatin; Sleep Wake Disorders; Sleep, REM | 1999 |
Comparative efficacy and tolerability of low-dose pravastatin versus lovastatin in patients with hypercholesterolemia.
Topics: Aged; Alkaline Phosphatase; Anticholesteremic Agents; Aspartate Aminotransferases; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Creatine Kinase; Cross-Over Studies; Drug Costs; Female; Follow-Up Studies; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Incidence; L-Lactate Dehydrogenase; Liver; Lovastatin; Male; Middle Aged; Pravastatin; Triglycerides | 1999 |
When the vessel is bad, lowering cholesterol may save the ship.
Topics: Adult; Aged; Anticholesteremic Agents; Coronary Disease; Denmark; Evidence-Based Medicine; Female; Humans; Hypercholesterolemia; Iceland; Lovastatin; Male; Middle Aged; Mortality; Norway; Sweden; Treatment Outcome | 1997 |
The cost of reaching National Cholesterol Education Program (NCEP) goals in hypercholesterolaemic patients. A comparison of atorvastatin, simvastatin, lovastatin and fluvastatin.
Topics: Aged; Anticholesteremic Agents; Atorvastatin; Cost-Benefit Analysis; Fatty Acids, Monounsaturated; Female; Fluvastatin; Health Policy; Heptanoic Acids; Humans; Hypercholesterolemia; Indoles; Lovastatin; Male; Middle Aged; Pyrroles; Simvastatin; United States | 1998 |
The effect of the apolipoprotein E phenotype on cholesteryl ester transfer protein activity, plasma lipids and apolipoprotein A I levels in hypercholesterolaemic patients on colestipol and lovastatin treatment.
Topics: Adult; Apolipoproteins E; Carrier Proteins; Cholesterol; Cholesterol Ester Transfer Proteins; Colestipol; Female; Glycoproteins; Humans; Hypercholesterolemia; Hypolipidemic Agents; Lovastatin; Male; Middle Aged; Phenotype; Triglycerides | 1999 |
Additional reduction in blood pressure after cholesterol-lowering treatment by statins (lovastatin or pravastatin) in hypercholesterolemic patients using angiotensin-converting enzyme inhibitors (enalapril or lisinopril).
Topics: Angiotensin-Converting Enzyme Inhibitors; Anticholesteremic Agents; Blood Pressure; Drug Interactions; Enalapril; Female; Heart Rate; Humans; Hypercholesterolemia; Hypertension; Lisinopril; Lovastatin; Male; Middle Aged; Pravastatin | 1999 |
Effect of cholesterol lowering treatment on positive exercise tests in patients with hypercholesterolaemia and normal coronary angiograms.
Topics: Adult; Analysis of Variance; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Combined Modality Therapy; Coronary Angiography; Diet, Fat-Restricted; Exercise Test; Exercise Tolerance; Female; Follow-Up Studies; Humans; Hypercholesterolemia; Hypolipidemic Agents; Lovastatin; Male; Middle Aged; Simvastatin | 1999 |
Effects of lovastatin on cognitive function and psychological well-being.
Topics: Adult; Affect; Anger; Anticholesteremic Agents; Attention; Cognition; Double-Blind Method; Female; Hostility; Humans; Hypercholesterolemia; Lipids; Lovastatin; Male; Memory; Middle Aged; Psychomotor Performance; Quality of Life; Thinking; Treatment Outcome | 2000 |
Comparative study of the efficacy and tolerability of policosanol and lovastatin in patients with hypercholesterolemia and noninsulin dependent diabetes mellitus.
Topics: Anticholesteremic Agents; Blood Pressure; Diabetes Mellitus, Type 2; Double-Blind Method; Fatty Alcohols; Female; Headache; Humans; Hypercholesterolemia; Lovastatin; Male; Middle Aged; Risk Factors; Treatment Outcome | 1999 |
Application of the National Cholesterol Education Program and joint European treatment criteria and clinical benefit in the Air Force/Texas Coronary Atherosclerosis Prevention Study (AFCAPS/TexCAPS).
Topics: Aged; Anticholesteremic Agents; Cholesterol, LDL; Coronary Artery Disease; Female; Humans; Hypercholesterolemia; Incidence; Lovastatin; Male; Middle Aged; Military Personnel; Patient Education as Topic; Practice Guidelines as Topic; Program Evaluation; Texas | 2000 |
Reduction of LDL cholesterol in patients with primary hypercholesterolemia by SCH 48461: results of a multicenter dose-ranging study.
Topics: Anticholesteremic Agents; Apolipoprotein A-I; Azetidines; Cholesterol, HDL; Cholesterol, LDL; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Hypercholesterolemia; Lovastatin; Male; Middle Aged; Placebos; Triglycerides | 2001 |
Comparative efficacy study of atorvastatin vs simvastatin, pravastatin, lovastatin and placebo in type 2 diabetic patients with hypercholesterolaemia.
Topics: Aged; Anticholesteremic Agents; Atorvastatin; Blood Glucose; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Diabetes Mellitus, Type 2; Female; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Insulin; Lovastatin; Male; Middle Aged; Placebos; Pravastatin; Pyrroles; Simvastatin; Triglycerides | 2000 |
Statin therapy and plasma C-reactive protein levels in primary prevention.
Topics: Aged; Anticholesteremic Agents; Arteriosclerosis; Biomarkers; C-Reactive Protein; Cholesterol; Female; Humans; Hypercholesterolemia; Lovastatin; Male; Middle Aged; Pravastatin | 2000 |
Low-dose combination therapy with colesevelam hydrochloride and lovastatin effectively decreases low-density lipoprotein cholesterol in patients with primary hypercholesterolemia.
Topics: Allylamine; Analysis of Variance; Anticholesteremic Agents; Cholesterol, LDL; Colesevelam Hydrochloride; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Hypercholesterolemia; Lovastatin; Male; Middle Aged; Treatment Outcome | 2001 |
Apolipoprotein E genotype affects plasma lipid response to atorvastatin in a gender specific manner.
Topics: Anticholesteremic Agents; Apolipoproteins E; Atorvastatin; Double-Blind Method; Female; Genotype; Heptanoic Acids; Heterozygote; Homozygote; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Lipids; Lipoproteins; Lovastatin; Male; Middle Aged; Pyrroles; Sex Factors | 2001 |
Effects of lovastatin and pravastatin on cognitive function in military aircrew.
Topics: Adult; Anticholesteremic Agents; Cognition; Double-Blind Method; Humans; Hypercholesterolemia; Lovastatin; Male; Middle Aged; Military Personnel; Neuropsychological Tests; Pravastatin; Psychomotor Performance | 2001 |
Dose response, safety, and efficacy of an extended-release formulation of lovastatin in adults with hypercholesterolemia.
Topics: Adult; Aged; Anticholesteremic Agents; Delayed-Action Preparations; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Hypercholesterolemia; Lovastatin; Male; Middle Aged; Treatment Outcome | 2002 |
A multiple-dose pharmacodynamic, safety, and pharmacokinetic comparison of extended- and immediate-release formulations of lovastatin.
Topics: Adult; Aged; Anticholesteremic Agents; Area Under Curve; Cholesterol; Delayed-Action Preparations; Female; Humans; Hydroxymethylglutaryl CoA Reductases; Hypercholesterolemia; Liver Function Tests; Lovastatin; Male; Middle Aged; Patient Compliance; Single-Blind Method | 2002 |
Pharmacological concentrations of the HMG-CoA reductase inhibitor lovastatin decrease the formation of the Alzheimer beta-amyloid peptide in vitro and in patients.
Topics: Adult; Aged; Alzheimer Disease; Amyloid beta-Peptides; Animals; Cell Line; CHO Cells; Cholesterol; Cricetinae; Dogs; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Lovastatin; Male; Middle Aged; Peptide Fragments | 2002 |
Lipid-lowering long-term effects of six different statins in hypercholesterolemic renal transplant patients under cyclosporine immunosuppression.
Topics: Adult; Anticholesteremic Agents; Cholesterol; Cyclosporine; Female; Follow-Up Studies; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Immunosuppressive Agents; Kidney Failure, Chronic; Kidney Transplantation; Lipoproteins; Lovastatin; Male; Middle Aged; Time Factors; Triglycerides | 2002 |
Lathosterol and other noncholesterol sterols during treatment of hypercholesterolemia with lovastatin alone and with cholestyramine or guar gum.
Topics: Adult; Cholesterol; Cholestyramine Resin; Dietary Fiber; Female; Galactans; Humans; Hypercholesterolemia; Hyperlipoproteinemia Type II; Lovastatin; Male; Mannans; Middle Aged; Plant Gums; Sterols | 1992 |
A randomized placebo controlled trial on the effects of simvastatin, a HMG-CoA reductase inhibitor, on blood lipids and fibrinolytic parameters.
Topics: Adult; Aged; Anticholesteremic Agents; Apolipoproteins B; Blood Coagulation Tests; Cholesterol; Double-Blind Method; Humans; Hydroxymethylglutaryl-CoA Synthase; Hypercholesterolemia; Lovastatin; Male; Middle Aged; Plasminogen Inactivators; Simvastatin | 1992 |
[Effects of lovastatin therapy on the level of low density lipoproteins and atherogenic potential of serum in patients with ischemic heart disease and hypercholesterolemia].
Topics: Animals; Antigen-Antibody Complex; Cells, Cultured; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Coronary Disease; Humans; Hypercholesterolemia; Lipoproteins, LDL; Lovastatin; Macrophages; Mice | 1992 |
Successful management of primary hypercholesterolaemia with simvastatin and low-dose colestipol.
Topics: Anticholesteremic Agents; Apolipoproteins B; Cholesterol; Cholesterol, LDL; Colestipol; Double-Blind Method; Drug Therapy, Combination; Humans; Hypercholesterolemia; Lipoproteins, HDL; Lovastatin; Simvastatin; Treatment Outcome; Triglycerides | 1992 |
Efficacy and tolerability of simvastatin and pravastatin in patients with primary hypercholesterolemia (multicountry comparative study). The European Study Group.
Topics: Adolescent; Adult; Aged; Anticholesteremic Agents; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Female; Humans; Hypercholesterolemia; Lovastatin; Male; Middle Aged; Pravastatin; Simvastatin; Triglycerides | 1992 |
Changes in Lp(a) lipoprotein levels during the treatment of hypercholesterolaemia with simvastatin.
Topics: Adult; Aged; Anticholesteremic Agents; Cholesterol; Double-Blind Method; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Lipoprotein(a); Lovastatin; Male; Middle Aged; Risk Factors; Simvastatin | 1992 |
Simvastatin in non-insulin-dependent diabetic patients with hypercholesterolaemia.
Topics: Adult; Aged; Anticholesteremic Agents; Cholesterol; Cholesterol, HDL; Diabetes Mellitus, Type 2; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Lovastatin; Male; Middle Aged; Simvastatin; Triglycerides | 1992 |
Treatment of hypercholesterolemia and prevention of coronary artery disease after heart transplantation by combination of low-dose simvastatin and HELP-LDL-apheresis.
Topics: Adult; Anticholesteremic Agents; Blood Component Removal; Chemical Precipitation; Cholesterol, LDL; Combined Modality Therapy; Coronary Disease; Dose-Response Relationship, Drug; Female; Follow-Up Studies; Heart Transplantation; Humans; Hypercholesterolemia; Lovastatin; Male; Middle Aged; Postoperative Complications; Simvastatin | 1992 |
[Lovastatin in primary hypercholesterolemia. A Norwegian multicenter study].
Topics: Adult; Aged; Cholesterol; Cholestyramine Resin; Drug Evaluation; Drug Therapy, Combination; Female; Humans; Hypercholesterolemia; Lovastatin; Male; Middle Aged; Triglycerides | 1992 |
Lens opacity in patients with hypercholesterolemia and ischaemic heart disease. Electronic lens opacity measurements.
Topics: Adult; Aged; Cataract; Double-Blind Method; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Lovastatin; Male; Middle Aged; Myocardial Ischemia; Ophthalmology; Reproducibility of Results; Simvastatin | 1992 |
Comparison of gemfibrozil and lovastatin in patients with high low-density lipoprotein and low high-density lipoprotein cholesterol levels.
Topics: Cholesterol, Dietary; Cholesterol, HDL; Cholesterol, LDL; Double-Blind Method; Female; Gemfibrozil; Humans; Hypercholesterolemia; Lovastatin; Male; Middle Aged | 1992 |
Expanded Clinical Evaluation of Lovastatin (EXCEL) study results. Effect of patient characteristics on lovastatin-induced changes in plasma concentrations of lipids and lipoproteins.
Topics: Cholesterol, HDL; Cholesterol, LDL; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Hypercholesterolemia; Linear Models; Lovastatin; Male; Middle Aged; Triglycerides | 1992 |
The cost of simvastatin therapy in treatment of hypercholesterolaemia in a hospital lipid clinic.
Topics: Anticholesteremic Agents; Drug Costs; Humans; Hypercholesterolemia; Hyperlipoproteinemia Type II; Lovastatin; Middle Aged; Simvastatin | 1992 |
Effect of simvastatin in patients with type I (insulin-dependent) diabetes mellitus and hypercholesterolemia.
Topics: Adult; Anticholesteremic Agents; Blood Glucose; Diabetes Mellitus, Type 1; Female; Hormones; Humans; Hypercholesterolemia; Lovastatin; Male; Middle Aged; Simvastatin | 1992 |
A multicenter comparison of the effects of simvastatin and fenofibrate therapy in severe primary hypercholesterolemia, with particular emphasis on lipoproteins defined by their apolipoprotein composition.
Topics: Adolescent; Adult; Aged; Anticholesteremic Agents; Apolipoproteins; Cholesterol; Female; Fenofibrate; Humans; Hypercholesterolemia; In Vitro Techniques; Lipoproteins; Lovastatin; Male; Middle Aged; Simvastatin | 1992 |
Effect of simvastatin, ursodeoxycholic acid and simvastatin plus ursodeoxycholic acid on biliary lipid secretion and cholic acid kinetics in nonfamilial hypercholesterolemia.
Topics: Adult; Aged; Anticholesteremic Agents; Bile; Cholesterol; Cholic Acid; Cholic Acids; Drug Therapy, Combination; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Kinetics; Lipid Metabolism; Liver; Lovastatin; Male; Middle Aged; Simvastatin; Ursodeoxycholic Acid | 1992 |
Is fat restriction needed with HMGCoA reductase inhibitor treatment?
Topics: Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Combined Modality Therapy; Dietary Fats; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Lovastatin; Male; Middle Aged; Simvastatin; Triglycerides | 1992 |
Comparison between lovastatin and cholestyramine in the treatment of moderate to severe primary hypercholesterolaemia.
Topics: Adult; Aged; Apolipoprotein A-I; Apolipoproteins B; Cholesterol, HDL; Cholesterol, LDL; Cholestyramine Resin; Female; Humans; Hypercholesterolemia; Hyperlipoproteinemia Type II; Lovastatin; Male; Middle Aged; Triglycerides | 1992 |
Lovastatin alters blood rheology in primary hyperlipoproteinemia: dependence on lipoprotein(a)?
Topics: Bezafibrate; Blood Viscosity; Delayed-Action Preparations; Erythrocyte Aggregation; Erythrocyte Deformability; Female; Humans; Hypercholesterolemia; Hyperlipoproteinemias; Lipids; Lipoproteins; Lovastatin; Male; Middle Aged; Rheology; Single-Blind Method | 1992 |
Lipid control with low-dosage simvastatin in patients with moderate hypercholesterolaemia. An Italian multicentre double-blind placebo-controlled study.
Topics: Adult; Aged; Anticholesteremic Agents; Cholesterol, HDL; Cholesterol, LDL; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Italy; Lipids; Lovastatin; Male; Middle Aged; Simvastatin; Triglycerides | 1992 |
Worldwide experience with simvastatin/lovastatin.
Topics: Anticholesteremic Agents; Chemical and Drug Induced Liver Injury; Cholesterol, LDL; Coronary Artery Disease; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Long-Term Care; Lovastatin; Rhabdomyolysis; Simvastatin | 1992 |
[Effect of HMG-CoA reductase inhibitors on the erythrocyte membrane].
Topics: Cholesterol; Erythrocyte Membrane; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Lipids; Lovastatin; Male; Membrane Fluidity; Membrane Lipids; Middle Aged; Simvastatin; Sodium-Potassium-Exchanging ATPase | 1991 |
Lack of hypotension with lovastatin and pravastatin.
Topics: Adult; Aged; Double-Blind Method; Humans; Hypercholesterolemia; Hypotension, Orthostatic; Lovastatin; Male; Middle Aged; Pravastatin | 1991 |
Combination therapy with lovastatin and guar gum versus lovastatin and cholestyramine in treatment of hypercholesterolemia.
Topics: Adult; Aged; Apolipoprotein A-I; Apolipoproteins B; Blood Pressure; Body Weight; Cholestyramine Resin; Double-Blind Method; Drug Therapy, Combination; Female; Galactans; Humans; Hypercholesterolemia; Hyperlipoproteinemia Type II; Lipids; Lovastatin; Male; Mannans; Middle Aged; Plant Gums | 1991 |
A comparison between lovastatin and gemfibrozil in the treatment of primary hypercholesterolemia.
Topics: Adult; Aged; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Double-Blind Method; Female; Gemfibrozil; Humans; Hypercholesterolemia; Lovastatin; Male; Middle Aged; Multivariate Analysis; Research Design; Triglycerides | 1992 |
Low-dose simvastatin for the treatment of hypercholesterolaemia in recipients of cardiac transplantation.
Topics: Adult; Anticholesteremic Agents; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Female; Heart Transplantation; Humans; Hypercholesterolemia; Lovastatin; Male; Middle Aged; Postoperative Care; Simvastatin; Triglycerides | 1991 |
[Comparison about the efficacy and tolerability between simvastatin and bezafibrate in the treatment of hypercholesterolemia].
Topics: Adult; Anticholesteremic Agents; Bezafibrate; Double-Blind Method; Female; Humans; Hypercholesterolemia; Lovastatin; Male; Middle Aged; Simvastatin | 1991 |
Significant increase of high-density lipoprotein2-cholesterol under prolonged simvastatin treatment.
Topics: Aged; Anticholesteremic Agents; Apolipoproteins; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Double-Blind Method; Female; Gemfibrozil; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Lovastatin; Male; Middle Aged; Simvastatin; Triglycerides | 1991 |
Long-term efficacy and safety of simvastatin alone and in combination therapy in treatment of hypercholesterolaemia.
Topics: Adult; Aged; Anticholesteremic Agents; Cholestyramine Resin; Clinical Trials as Topic; Drug Therapy, Combination; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Lens, Crystalline; Lipids; Liver; Lovastatin; Male; Middle Aged; Simvastatin | 1991 |
Lipoprotein particle analysis comparing simvastatin and fenofibrate.
Topics: Adolescent; Adult; Aged; Anticholesteremic Agents; Apolipoprotein A-I; Apolipoprotein A-II; Apolipoproteins; Apolipoproteins B; Double-Blind Method; Fenofibrate; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Lipoproteins; Lovastatin; Middle Aged; Simvastatin | 1991 |
A multicenter double-blind study comparing lovastatin and gemfibrozil in the treatment of primary hypercholesterolemia.
Topics: Adult; Aged; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Double-Blind Method; Female; Gemfibrozil; Humans; Hypercholesterolemia; Lovastatin; Male; Middle Aged; Triglycerides | 1991 |
[Comparison between lovastatin and gemfibrozil in treatment of primary hyperlipidemias].
Topics: Adult; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Female; Gemfibrozil; Humans; Hypercholesterolemia; Hyperlipidemias; Hypertriglyceridemia; Lovastatin; Male; Middle Aged; Triglycerides | 1991 |
[Effects of lovastatin and probucol on lipoprotein fractions in patients with hypercholesterolemia. A Brazilian multicenter study].
Topics: Analysis of Variance; Brazil; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Cholesterol, VLDL; Female; Humans; Hypercholesterolemia; Lovastatin; Male; Probucol; Triglycerides | 1991 |
[Therapy of hypercholesterolemia and hypertriglyceridemia. Comparison of hypolipemic effects of lovastatin and gemfibrozil].
Topics: Aged; Apolipoproteins B; Cholesterol; Female; Gemfibrozil; Humans; Hypercholesterolemia; Lovastatin; Male; Middle Aged; Phospholipids; Triglycerides | 1991 |
Expanded clinical evaluation of lovastatin (EXCEL) study results: IV. Additional perspectives on the tolerability of lovastatin.
Topics: Alanine Transaminase; Aspartate Aminotransferases; Combined Modality Therapy; Creatine Kinase; Dietary Fats; Double-Blind Method; Drug Eruptions; Female; Gastrointestinal Diseases; Humans; Hypercholesterolemia; Incidence; Lovastatin; Male; Middle Aged; Muscular Diseases; Nervous System Diseases | 1991 |
[Effects and side effects of a 1-year treatment of primary hypercholesterolemia with simvastatin].
Topics: Anticholesteremic Agents; Cholesterol; Creatine Kinase; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Hyperlipoproteinemia Type II; Liver; Lovastatin; Male; Simvastatin; Single-Blind Method; Transaminases; Triglycerides | 1991 |
The effect of lovastatin treatment on low-density lipoprotein hydrated density distribution and composition in patients with intermittent claudication and primary hypercholesterolemia.
Topics: Apolipoproteins; Apolipoproteins B; Arteriosclerosis; Cholesterol; Cholesterol Esters; Female; Humans; Hypercholesterolemia; Intermittent Claudication; Lipoproteins; Lipoproteins, LDL; Lovastatin; Male; Phospholipids; Triglycerides | 1991 |
Expanded clinical evaluation of lovastatin (EXCEL) study results: III. Efficacy in modifying lipoproteins and implications for managing patients with moderate hypercholesterolemia.
Topics: Cholesterol, HDL; Cholesterol, LDL; Combined Modality Therapy; Dietary Fats; Double-Blind Method; Female; Humans; Hypercholesterolemia; Lipoproteins; Lovastatin; Male; Middle Aged; Triglycerides | 1991 |
Lovastatin therapy in hypercholesterolemia: effect on fibrinogen, hemorrheologic parameters, platelet activity, and red blood cell morphology.
Topics: Adolescent; Adult; Aged; Blood Viscosity; Cholesterol, HDL; Cholesterol, LDL; Erythrocyte Deformability; Fibrinogen; Humans; Hypercholesterolemia; Lovastatin; Middle Aged; Platelet Aggregation; Platelet Count; Rheology | 1991 |
Treatment of primary hypercholesterolaemia with simvastatin. New Zealand multicentre evaluation.
Topics: Adult; Aged; Anticholesteremic Agents; Bezafibrate; Cholesterol; Cholesterol, LDL; Cohort Studies; Drug Therapy, Combination; Female; Humans; Hypercholesterolemia; Lovastatin; Male; Middle Aged; New Zealand; Simvastatin | 1991 |
Effect of apolipoprotein E polymorphism and XbaI polymorphism of apolipoprotein B on response to lovastatin treatment in familial and non-familial hypercholesterolaemia.
Topics: Adult; Aged; Apolipoproteins B; Apolipoproteins E; Deoxyribonucleases, Type II Site-Specific; Female; Genotype; Humans; Hypercholesterolemia; Hyperlipoproteinemia Type II; Lovastatin; Male; Middle Aged; Phenotype; Polymorphism, Genetic | 1991 |
Long-term safety and efficacy profile of simvastatin.
Topics: Aged; Anticholesteremic Agents; Cataract; Coronary Disease; Female; Follow-Up Studies; Humans; Hypercholesterolemia; Liver; Lovastatin; Male; Middle Aged; Muscles; Simvastatin | 1991 |
Comparative effects of two HMG-CoA reductase inhibitors (lovastatin and pravastatin) on serum lipids and lipoproteins.
Topics: Cholesterol; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Lipids; Lipoproteins; Lovastatin; Middle Aged; Pravastatin | 1991 |
Effect of simvastatin and fenofibrate on the fatty acid composition of hypercholesterolaemic patients.
Topics: Adult; Aged; Anticholesteremic Agents; Cholesterol Esters; Double-Blind Method; Fatty Acids; Female; Fenofibrate; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Lipoproteins; Lovastatin; Male; Middle Aged; Phospholipids; Simvastatin; Triglycerides | 1991 |
Expanded Clinical Evaluation of Lovastatin (EXCEL) study results. I. Efficacy in modifying plasma lipoproteins and adverse event profile in 8245 patients with moderate hypercholesterolemia.
Topics: Adult; Aged; Cholesterol, HDL; Cholesterol, LDL; Creatine Kinase; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Hypercholesterolemia; Lipoproteins; Liver Function Tests; Lovastatin; Male; Middle Aged; Muscular Diseases; Patient Compliance; Triglycerides | 1991 |
Lovastatin efficacy in reducing low-density lipoprotein cholesterol levels on high- vs low-fat diets.
Topics: Apolipoproteins; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Cholesterol, VLDL; Combined Modality Therapy; Dietary Fats; Double-Blind Method; Female; Humans; Hypercholesterolemia; Lovastatin; Male; Middle Aged; Multivariate Analysis; Retrospective Studies | 1991 |
Expanded clinical evaluation of lovastatin (EXCEL) study results. II. Assessment of the human lens after 48 weeks of treatment with lovastatin.
Topics: Adolescent; Adult; Aged; Cataract; Double-Blind Method; Female; Humans; Hypercholesterolemia; Lens, Crystalline; Lovastatin; Male; Middle Aged; Visual Acuity | 1991 |
Hemorheologic and coagulative pattern in hypercholesterolemic subjects treated with lipid-lowering drugs.
Topics: Adult; Aged; Anticholesteremic Agents; Bezafibrate; Blood Coagulation; Blood Coagulation Factors; Cholesterol; Female; Hemostasis; Humans; Hypercholesterolemia; Lovastatin; Male; Middle Aged; Simvastatin; Triglycerides | 1991 |
[Lovastatin efficacy and tolerance in primary hypercholesterolemia. The German Lovastatin Study Group].
Topics: Adult; Clinical Trials as Topic; Drug Tolerance; Female; Humans; Hypercholesterolemia; Lipids; Lipoproteins; Lovastatin; Male; Middle Aged; Tablets | 1991 |
[Treatment of hypercholesterolemic patients of different age with simvastatin: 1-year study].
Topics: Adult; Age Factors; Aged; Anticholesteremic Agents; Cholesterol; Cholesterol, LDL; Cholestyramine Resin; Drug Therapy, Combination; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Lovastatin; Middle Aged; Simvastatin; Time Factors | 1991 |
A 6-month trial of simvastatin (HMG-CoA reductase inhibitor) in the treatment of hypercholesterolaemia.
Topics: Adolescent; Adult; Aged; Anticholesteremic Agents; Cholesterol; Cholesterol, LDL; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Lovastatin; Male; Middle Aged; Simvastatin | 1991 |
Effects of HMG-CoA reductase inhibitors in hypercholesterolemic patients on hemodialysis.
Topics: Adult; Aged; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Hypertriglyceridemia; Kidney Failure, Chronic; Lipids; Lipoproteins; Lovastatin; Male; Middle Aged; Renal Dialysis; Simvastatin | 1991 |
Simvastatin in severe hypercholesterolaemia: a placebo controlled trial.
Topics: Adult; Aged; Anticholesteremic Agents; Apolipoproteins B; Blood Pressure; Blood Viscosity; Cholesterol; Double-Blind Method; Female; Humans; Hydroxymethylglutaryl CoA Reductases; Hypercholesterolemia; Leukocytes; Lipids; Liver; Lovastatin; Male; Middle Aged; Simvastatin; Transaminases; Triglycerides | 1991 |
[The comparative treatment with lovastatin and bezafibrate of primary hypercholesterolemia. A randomized and double-blind trial].
Topics: Apolipoproteins A; Apolipoproteins B; Bezafibrate; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Double-Blind Method; Humans; Hypercholesterolemia; Lovastatin; Spain; Triglycerides | 1991 |
Lovastatin versus bezafibrate: efficacy, tolerability, and effect on urinary mevalonate.
Topics: Adult; Aged; Bezafibrate; Female; Humans; Hypercholesterolemia; Lipids; Lovastatin; Male; Mevalonic Acid; Middle Aged; Single-Blind Method | 1990 |
Safety, tolerability, and efficacy of simvastatin and fenofibrate--a multicenter study. Simvastatin-Fenofibrate Study Group.
Topics: Adolescent; Adult; Aged; Anticholesteremic Agents; Apolipoproteins; Cholesterol; Double-Blind Method; Female; Fenofibrate; Humans; Hypercholesterolemia; Lovastatin; Male; Middle Aged; Simvastatin; Triglycerides | 1990 |
Lens changes in matched normals and hyperlipidemic patients treated with simvastatin for 2 years.
Topics: Adult; Aged; Cataract; Female; Follow-Up Studies; Humans; Hypercholesterolemia; Lens, Crystalline; Lovastatin; Male; Middle Aged; Simvastatin; Vacuoles | 1990 |
Pravastatin therapy in primary moderate hypercholesterolaemia: changes in metabolism of apolipoprotein B-containing lipoproteins.
Topics: Adult; Aged; Anticholesteremic Agents; Apolipoproteins B; Biological Transport; Cholesterol; Double-Blind Method; Heptanoic Acids; Humans; Hypercholesterolemia; Kinetics; Lipoproteins, LDL; Lovastatin; Middle Aged; Naphthalenes; Pravastatin | 1990 |
Lovastatin treatment of hypercholesterolemia in renal transplant recipients.
Topics: Adolescent; Apolipoprotein A-I; Apolipoproteins A; Azathioprine; Child; Child, Preschool; Cholesterol, HDL; Cholesterol, LDL; Diet, Reducing; Humans; Hypercholesterolemia; Kidney Transplantation; Leukocyte Count; Lovastatin; Postoperative Complications | 1990 |
HMG CoA reductase inhibitors as lipid-lowering agents: five years experience with lovastatin and an appraisal of simvastatin and pravastatin.
Topics: Adult; Aged; Anticholesteremic Agents; Cholestyramine Resin; Clinical Trials as Topic; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Lovastatin; Male; Middle Aged; Naphthalenes; Phenotype; Pravastatin; Simvastatin; Time Factors | 1990 |
[Therapy of hypercholesterolemia and hypertriglyceridemia. Comparison of the lipid-lowering effect of simvastatin and tiadenol].
Topics: Aged; Anticholesteremic Agents; Clinical Trials as Topic; Double-Blind Method; Fatty Alcohols; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Hypertriglyceridemia; Hypolipidemic Agents; Lovastatin; Male; Middle Aged; Simvastatin | 1990 |
[Comparison of the lowering effect on blood cholesterol of clofibrate and simvastatin].
Topics: Aged; Anticholesteremic Agents; Clofibrate; Drug Evaluation; Female; Humans; Hypercholesterolemia; Lovastatin; Male; Middle Aged; Simvastatin; Time Factors | 1990 |
[The efficacy and tolerance of simvastatin and fenofibrate in primary hypercholesterolemia].
Topics: Adolescent; Adult; Aged; Anticholesteremic Agents; Apolipoproteins; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Drug Tolerance; Female; Fenofibrate; Humans; Hypercholesterolemia; Lovastatin; Male; Middle Aged; Placebos; Simvastatin | 1990 |
Hydroxymethylglutaryl coenzyme A reductase inhibitors as monotherapy in the treatment of hypercholesterolemia.
Topics: Bezafibrate; Cholestyramine Resin; Double-Blind Method; Gemfibrozil; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Lipids; Lovastatin; Probucol; Randomized Controlled Trials as Topic; Simvastatin | 1990 |
Cholesterol: myth or reality?
Topics: Age Factors; Aged; Cholesterol; Cholesterol, HDL; Clinical Trials as Topic; Coronary Disease; Evaluation Studies as Topic; Female; Follow-Up Studies; Health Education; Humans; Hypercholesterolemia; Lovastatin; Male; Middle Aged; Reference Values; Risk Factors; Sex Factors | 1990 |
Bezafibrate and simvastatin (MK-733) in the treatment of primary hypercholesterolaemia.
Topics: Adult; Aged; Anticholesteremic Agents; Bezafibrate; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Clinical Trials as Topic; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Lovastatin; Male; Middle Aged; Simvastatin; Triglycerides | 1990 |
Comparison of simvastatin and cholestyramine in the treatment of primary hypercholesterolaemia.
Topics: Adult; Aged; Analysis of Variance; Anticholesteremic Agents; Australia; Cholesterol; Cholestyramine Resin; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Lovastatin; Male; Middle Aged; Multicenter Studies as Topic; Randomized Controlled Trials as Topic; Simvastatin; Triglycerides | 1990 |
Efficacy and tolerability of lovastatin in a six-month study: analysis by gender, age and hypertensive status.
Topics: Adult; Age Factors; Aged; Aged, 80 and over; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Drug Evaluation; Female; Humans; Hypercholesterolemia; Hypertension; Lovastatin; Male; Middle Aged; Multicenter Studies as Topic; Sex Factors; Triglycerides | 1990 |
Comparison of the effects of lovastatin and gemfibrozil on lipids and glucose control in non-insulin-dependent diabetes mellitus.
Topics: Adult; Aged; Aged, 80 and over; Blood Glucose; Cholesterol; Diabetes Mellitus, Type 2; Double-Blind Method; Female; Gemfibrozil; Humans; Hypercholesterolemia; Lovastatin; Male; Middle Aged; Randomized Controlled Trials as Topic; Triglycerides | 1990 |
A multicenter comparison of lovastatin and probucol for treatment of severe primary hypercholesterolemia. The Lovastatin Study Group IV.
Topics: Adult; Aged; Apolipoproteins; Cholesterol; Cholesterol, LDL; Double-Blind Method; Drug Evaluation; Female; Humans; Hypercholesterolemia; Hyperlipidemias; Lovastatin; Male; Middle Aged; Multicenter Studies as Topic; Phenols; Probucol; Randomized Controlled Trials as Topic; Triglycerides | 1990 |
Expanded clinical evaluation of lovastatin (EXCEL) study: design and patient characteristics of a double-blind, placebo-controlled study in patients with moderate hypercholesterolemia.
Topics: Adult; Aged; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Double-Blind Method; Female; Humans; Hypercholesterolemia; Lovastatin; Male; Middle Aged; Placebos; Randomized Controlled Trials as Topic; Triglycerides | 1990 |
Inhibitors of hydroxymethylglutaryl coenzyme A reductase for treating hypercholesterolaemia.
Topics: Adult; Anticholesteremic Agents; Colestipol; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Lovastatin; Male; Middle Aged; Simvastatin; Sleep Wake Disorders | 1990 |
Low-dose lovastatin safely lowers cholesterol after cardiac transplantation.
Topics: Cholesterol; Female; Heart Transplantation; Humans; Hypercholesterolemia; Immunosuppressive Agents; Lovastatin; Male; Middle Aged | 1990 |
Primary hypertriglyceridemia with borderline high cholesterol and elevated apolipoprotein B concentrations. Comparison of gemfibrozil vs lovastatin therapy.
Topics: Adult; Aged; Apolipoproteins B; Cholesterol; Gemfibrozil; Humans; Hypercholesterolemia; Hypertriglyceridemia; Lipids; Lipoproteins; Lovastatin; Male; Middle Aged | 1990 |
[Treatment of severe primary hypercholesterolemia with lovastatin (Mevacor). A new therapeutic principle].
Topics: Adult; Aged; Denmark; Drug Evaluation; Female; Humans; Hypercholesterolemia; Hyperlipoproteinemia Type II; Lovastatin; Male; Middle Aged | 1990 |
[Simvastatin versus gemfibrozil in the treatment of primary hypercholesterolemia in hypertensive patients treated with hydrochlorothiazide].
Topics: Adult; Aged; Anticholesteremic Agents; Cholesterol; Female; Gemfibrozil; Humans; Hydrochlorothiazide; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Hypertension; Lipoproteins, HDL; Lipoproteins, LDL; Lovastatin; Male; Middle Aged; Simvastatin; Triglycerides | 1990 |
[Lovastatin: short-term treatment of hypercholesterolemia; multicenter clinical trial].
Topics: Adult; Aged; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Drug Administration Schedule; Drug Evaluation; Female; Humans; Hypercholesterolemia; Lovastatin; Male; Middle Aged; Triglycerides | 1990 |
Simvastatin in the treatment of hypercholesterolaemia in patients with essential hypertension.
Topics: Adult; Aged; Anticholesteremic Agents; Cholesterol; Dietary Fats, Unsaturated; Female; Humans; Hypercholesterolemia; Hypertension; Lovastatin; Male; Middle Aged; Random Allocation; Simvastatin | 1990 |
The use of simvastatin, an HMG CoA reductase inhibitor, in older patients with hypercholesterolemia and atherosclerosis.
Topics: Aged; Anticholesteremic Agents; Arteriosclerosis; Cataract; Cholesterol, HDL; Cholesterol, LDL; Drug Administration Schedule; Female; Follow-Up Studies; Humans; Hypercholesterolemia; Lovastatin; Male; Randomized Controlled Trials as Topic; Simvastatin | 1990 |
Effects of simvastatin and cholestyramine in familial and nonfamilial hypercholesterolemia. Multicenter Group I.
Topics: Adult; Alanine Transaminase; Anticholesteremic Agents; Cataract; Cholesterol; Cholestyramine Resin; Creatine Kinase; Female; Humans; Hypercholesterolemia; Hyperlipoproteinemia Type II; Lipoproteins; Lovastatin; Male; Middle Aged; Multicenter Studies as Topic; Randomized Controlled Trials as Topic; Simvastatin; Triglycerides | 1990 |
Treatment of hypercholesterolemia with the HMG CoA reductase inhibitor, simvastatin.
Topics: Adult; Anticholesteremic Agents; Cholesterol, HDL; Cholesterol, LDL; Double-Blind Method; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Lipids; Lipoproteins; Lovastatin; Male; Middle Aged; Simvastatin | 1989 |
Comparative effects of simvastatin and cholestyramine in treatment of patients with hypercholesterolaemia.
Topics: Adult; Aged; Anticholesteremic Agents; Apolipoprotein A-I; Apolipoproteins A; Apolipoproteins B; Apoproteins; Cholestyramine Resin; Female; Humans; Hypercholesterolemia; Lipids; Lipoproteins; Lovastatin; Male; Middle Aged; Patient Compliance; Simvastatin; Time Factors | 1989 |
Effects of simvastatin and fenofibrate on serum lipoproteins and apolipoproteins in primary hypercholesterolaemia.
Topics: Adult; Aged; Anticholesteremic Agents; Apolipoprotein A-I; Apolipoprotein A-II; Apolipoproteins; Apolipoproteins A; Apolipoproteins B; Cholesterol, HDL; Female; Fenofibrate; Humans; Hypercholesterolemia; Lipoproteins; Lipoproteins, LDL; Lovastatin; Male; Middle Aged; Propionates; Simvastatin; Triglycerides | 1989 |
Effects of simvastatin and probucol in hypercholesterolemia (Simvastatin Multicenter Study Group II).
Topics: Adult; Aged; Anticholesteremic Agents; Double-Blind Method; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Lovastatin; Male; Middle Aged; Multicenter Studies as Topic; Phenols; Probucol; Random Allocation; Simvastatin | 1989 |
Lovastatin in the treatment of multifactorial hyperlipidemia associated with proteinuria.
Topics: Adrenal Cortex Hormones; Adult; Cholesterol, Dietary; Cholesterol, HDL; Cholesterol, LDL; Clinical Trials as Topic; Female; Humans; Hypercholesterolemia; Lovastatin; Male; Middle Aged; Nephrotic Syndrome; Proteinuria; Random Allocation | 1989 |
Simvastatin (MK 733): an effective treatment for hypercholesterolemia.
Topics: Adult; Aged; Anticholesteremic Agents; Cholesterol; Cholesterol, LDL; Cholestyramine Resin; Clinical Trials as Topic; Drug Therapy, Combination; Female; Humans; Hypercholesterolemia; Lovastatin; Male; Middle Aged; Random Allocation; Simvastatin | 1989 |
Simvastatin and cholestyramine in the long-term treatment of hypercholesterolaemia.
Topics: Adult; Aged; Alanine Transaminase; Anticholesteremic Agents; Cholestyramine Resin; Clinical Trials as Topic; Drug Therapy, Combination; Female; Humans; Hypercholesterolemia; Lipids; Lovastatin; Male; Middle Aged; Random Allocation; Simvastatin; Time Factors | 1989 |
Comparison between low-dose simvastatin and cholestyramine in moderately severe hypercholesterolemia.
Topics: Adolescent; Adult; Aged; Anticholesteremic Agents; Cholesterol, HDL; Cholesterol, LDL; Cholestyramine Resin; Drug Administration Schedule; Female; Humans; Hypercholesterolemia; Lovastatin; Male; Middle Aged; Multicenter Studies as Topic; Randomized Controlled Trials as Topic; Simvastatin | 1989 |
[Effects of lovastatin in primary hypercholesterolemia].
Topics: Adolescent; Adult; Aged; Cholesterol; Cholesterol, LDL; Clinical Trials as Topic; Female; Humans; Hypercholesterolemia; Lovastatin; Male; Middle Aged | 1989 |
[Swiss simvastatin multicenter study: 1. Efficacy of 10 mg simvastatin daily in patients with primary hypercholesterolemia].
Topics: Adult; Aged; Anticholesteremic Agents; Apolipoproteins; Cholesterol; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Lipids; Lipoproteins; Lovastatin; Middle Aged; Multicenter Studies as Topic; Simvastatin; Single-Blind Method; Switzerland | 1989 |
[Effects of simvastatin on plasma levels of lipids, lipoproteins and apolipoproteins in primary hypercholesterolemia].
Topics: Anticholesteremic Agents; Apolipoproteins; Clinical Trials as Topic; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Lipids; Lipoproteins; Lovastatin; Male; Middle Aged; Simvastatin; Time Factors | 1989 |
Comparison between simvastatin and bezafibrate in effect on plasma lipoproteins and apolipoproteins in primary hypercholesterolaemia.
Topics: Adult; Aged; Apolipoproteins; Apolipoproteins B; Bezafibrate; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Clinical Trials as Topic; Double-Blind Method; Drug Administration Schedule; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Hyperlipoproteinemia Type II; Lipoproteins; Lipoproteins, VLDL; Lovastatin; Male; Middle Aged; Simvastatin; Triglycerides | 1988 |
A multicenter comparison of lovastatin and cholestyramine therapy for severe primary hypercholesterolemia. The Lovastatin Study Group III.
Topics: Adult; Aged; Alkaline Phosphatase; Apolipoproteins; Cholesterol; Cholestyramine Resin; Creatine Kinase; Female; Humans; Hypercholesterolemia; Lipoproteins; Lovastatin; Male; Middle Aged; Random Allocation; Transaminases; Triglycerides | 1988 |
[Effects on lipid metabolism of inhibitors of cholesterol synthesis].
Topics: Aged; Anticholesteremic Agents; Cholesterol; Clinical Trials as Topic; Clofibrate; Double-Blind Method; Female; Humans; Hypercholesterolemia; Lipid Metabolism; Lipids; Lovastatin; Male; Middle Aged; Niacin; Triglycerides | 1988 |
Efficacy and long-term adverse effect pattern of lovastatin.
Topics: Alanine Transaminase; Clinical Trials as Topic; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Liver; Lovastatin; Muscular Diseases; Time Factors | 1988 |
Comparison between lovastatin and gemfibrozil in the treatment of primary hypercholesterolemia: the Finnish Multicenter Study.
Topics: Adult; Double-Blind Method; Female; Finland; Gemfibrozil; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Lovastatin; Male; Multicenter Studies as Topic; Random Allocation | 1988 |
Treatment of dyslipidemia in non-insulin-dependent diabetes mellitus with lovastatin.
Topics: Clinical Trials as Topic; Coronary Disease; Diabetes Mellitus, Type 2; Double-Blind Method; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Lovastatin; Male; Random Allocation | 1988 |
Comparison of lovastatin and probucol in treatment of familial and non-familial hypercholesterolemia: different effects on lipoprotein profiles.
Topics: Apolipoproteins; Clinical Trials as Topic; Genetic Carrier Screening; Humans; Hypercholesterolemia; Hyperlipoproteinemia Type II; Lipase; Lipoprotein Lipase; Lipoproteins; Lovastatin; Phenols; Probucol; Random Allocation | 1988 |
New developments in lipid-lowering therapy: the role of inhibitors of hydroxymethylglutaryl-coenzyme A reductase.
Topics: Animals; Anticholesteremic Agents; Apolipoproteins B; Cholesterol; Cholesterol, LDL; Cholesterol, VLDL; Clinical Trials as Topic; Dogs; Double-Blind Method; Drug Evaluation; Drug Tolerance; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Indoles; Lipoproteins, HDL; Lipoproteins, VLDL; Lovastatin; Middle Aged; Naphthalenes; Pravastatin; Simvastatin; Triglycerides | 1987 |
Lovastatin for hypercholesterolemia.
Topics: Cataract; Chemical and Drug Induced Liver Injury; Clinical Trials as Topic; Humans; Hypercholesterolemia; Lovastatin; Myositis; Random Allocation | 1987 |
Therapeutic response to lovastatin (mevinolin) in nonfamilial hypercholesterolemia. A multicenter study. The Lovastatin Study Group II.
Topics: Anticholesteremic Agents; Apolipoproteins; Clinical Trials as Topic; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Female; Humans; Hypercholesterolemia; Lipids; Lovastatin; Male; Middle Aged; Naphthalenes | 1986 |
Treatment of primary moderate hypercholesterolemia with lovastatin (mevinolin) and colestipol.
Topics: Aged; Anticholesteremic Agents; Apolipoproteins; Cholesterol, HDL; Cholesterol, LDL; Clinical Trials as Topic; Colestipol; Drug Therapy, Combination; Female; Humans; Hypercholesterolemia; Kinetics; Lipids; Lovastatin; Male; Middle Aged; Naphthalenes; Polyamines | 1987 |
Influence of mevinolin on metabolism of low density lipoproteins in primary moderate hypercholesterolemia.
Topics: Aged; Anticholesteremic Agents; Apolipoproteins B; Cholesterol; Humans; Hypercholesterolemia; Kinetics; Lipoproteins, LDL; Lovastatin; Male; Middle Aged; Naphthalenes; Triglycerides | 1985 |
337 other study(ies) available for lovastatin and Elevated Cholesterol
Article | Year |
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Synthesis, DNA binding, and cytotoxic evaluation of new analogs of diallyldisulfide, an active principle of garlic.
Topics: Allyl Compounds; Animals; Antineoplastic Agents, Phytogenic; Cells, Cultured; Circular Dichroism; DNA; Garlic; Hepatocytes; Hypercholesterolemia; Hypolipidemic Agents; Male; Nucleic Acid Denaturation; Rats; Rats, Wistar; Sulfides | 2008 |
Effects of monacolin K-containing nutraceutical on cholesterol homeostasis re-establishment and CVD risk reduction in hypercholesterolemic subjects.
Topics: Aged; Anticholesteremic Agents; Cardiovascular Diseases; Cholesterol; Cholesterol, LDL; Chromatography, High Pressure Liquid; Dietary Supplements; Female; Heart Disease Risk Factors; Humans; Hypercholesterolemia; Longitudinal Studies; Lovastatin; Male; Middle Aged; Risk Reduction Behavior; Tandem Mass Spectrometry; Triglycerides | 2021 |
Modulatory action of withaferin-A on oxidative damage through regulation of inflammatory mediators and apoptosis via PI3K/AKT signaling pathway in high cholesterol-induced atherosclerosis in experimental rats.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Apoptosis; Atherosclerosis; Caspase 3; Cholesterol; Cytokines; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Inflammation Mediators; Lovastatin; Male; Oxidative Stress; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Sprague-Dawley; Receptors, Tumor Necrosis Factor; Signal Transduction | 2022 |
[Nutraceuticals (monacolin K, berberine and coenzyme Q10) in patients with moderate hypercholesterolemia and low-moderate cardiovascular risk. Potential benefits of combined therapies].
Topics: Berberine; Cardiovascular Diseases; Dietary Supplements; Heart Disease Risk Factors; Humans; Hypercholesterolemia; Lovastatin; Risk Factors | 2023 |
Hypocholesterolemic activity of cornelian cherry (Cornus mas L.) fruits.
Topics: Animals; Anticholesteremic Agents; Antioxidants; Blood Glucose; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Cornaceae; Diabetes Mellitus, Experimental; Fruit; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Liver; Lovastatin; Male; Phytotherapy; Plant Extracts; Powders; Rats, Wistar | 2017 |
Alginate-gelatin formulation to modify lovastatin release profile from red yeast rice for hypercholesterolemia therapy.
Topics: Alginates; Biological Products; Delayed-Action Preparations; Drug Carriers; Drug Liberation; Gelatin; Glucuronic Acid; Hexuronic Acids; Hypercholesterolemia; Lovastatin | 2017 |
[Red yeast rice, monacolin K, and pleiotropic effects.]
Topics: Anticholesteremic Agents; Biological Products; Biomarkers; Cholesterol; Dietary Supplements; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Lovastatin; Pulse Wave Analysis | 2018 |
MK-2206, an allosteric inhibitor of AKT, stimulates LDLR expression and LDL uptake: A potential hypocholesterolemic agent.
Topics: Anticholesteremic Agents; Biological Transport; Cholesterol, LDL; HeLa Cells; Hep G2 Cells; Hepatocytes; Heterocyclic Compounds, 3-Ring; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Lovastatin; Protein Kinase Inhibitors; Proteolysis; Proto-Oncogene Proteins c-akt; Receptors, LDL; Signal Transduction; Sterol Regulatory Element Binding Protein 2 | 2018 |
Statins Can Lead to Acute Hemolysis.
Topics: Adult; Anemia, Hemolytic; Atorvastatin; Female; Hemolysis; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Lovastatin; Rosuvastatin Calcium | 2018 |
Screening of indigenously isolated fungi for lovastatin production and its in vivo evaluation.
Topics: Alanine Transaminase; Animals; Anticholesteremic Agents; Aspartate Aminotransferases; Cholesterol; Fermentation; Fungi; Hydrogen-Ion Concentration; Hypercholesterolemia; Lovastatin; Male; Rats; Temperature; Triglycerides | 2014 |
Lipophilic statin use and suicidal ideation in a sample of adults with mood disorders.
Topics: Adult; Bipolar Disorder; Cross-Sectional Studies; Depressive Disorder; Depressive Disorder, Major; Dietary Fats; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Lovastatin; Male; Middle Aged; Risk Factors; Simvastatin; Suicidal Ideation | 2014 |
[Dyslipidemia. Red rice supplements change in nutrition].
Topics: Anticholesteremic Agents; Combined Modality Therapy; Dietary Supplements; Humans; Hypercholesterolemia; Life Style; Lovastatin; Oryza; Randomized Controlled Trials as Topic; Weight Loss | 2014 |
Simvastatin increases AQP2 urinary excretion in hypercholesterolemic patients: A pleiotropic effect of interest for patients with impaired AQP2 trafficking.
Topics: Adult; Aged; Anticholesteremic Agents; Aquaporin 2; Diuresis; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Lovastatin; Male; Middle Aged; Osmolar Concentration; Simvastatin; Time Factors | 2016 |
Proprotein Convertase Subtilisin Kexin Type 9 Inhibition for Autosomal Recessive Hypercholesterolemia-Brief Report.
Topics: Adaptor Proteins, Signal Transducing; Adolescent; Adult; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Anticholesteremic Agents; Case-Control Studies; Cells, Cultured; Cholesterol, LDL; Drug Therapy, Combination; Female; Genetic Predisposition to Disease; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Hyperlipoproteinemia Type III; Lovastatin; Lymphocytes; Male; Middle Aged; Mutation; PCSK9 Inhibitors; Phenotype; Proprotein Convertase 9; Receptors, LDL; Serine Proteinase Inhibitors; Young Adult | 2016 |
Statins increase hepatic cholesterol synthesis and stimulate fecal cholesterol elimination in mice.
Topics: Animals; Cholesterol; Drug Evaluation, Preclinical; Gene Expression; Glutarates; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Intestinal Elimination; Intestine, Small; Liver; Lovastatin; Male; Mice, Inbred C57BL | 2016 |
The blood lipid regulation of Monascus-produced monascin and ankaflavin via the suppression of low-density lipoprotein cholesterol assembly and stimulation of apolipoprotein A1 expression in the liver.
Topics: Acetyl-CoA C-Acetyltransferase; Animals; Apolipoprotein A-I; Apolipoprotein B-100; Bile Acids and Salts; Body Weight; Carrier Proteins; Cholesterol, HDL; Cholesterol, LDL; Diet, High-Fat; Eating; Feces; Fermentation; Flavins; Heterocyclic Compounds, 3-Ring; Hypercholesterolemia; Lipids; Liver; Lovastatin; Male; Monascus; Rats | 2018 |
Nonenzymatic Mechanism of Statins in Modulating Cholesterol Particles Formation.
Topics: Atorvastatin; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Flow Cytometry; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; In Vitro Techniques; Lovastatin; Pilot Projects; Prodrugs; Simvastatin | 2016 |
A short-term statin treatment changes the contractile properties of fast-twitch skeletal muscles.
Topics: Animals; Creatine Kinase; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Isometric Contraction; Lovastatin; Male; Mice; Mice, Inbred C57BL; Muscle Contraction; Muscle Fibers, Fast-Twitch; Muscle Fibers, Slow-Twitch | 2016 |
Effects of rutin on lipid profile in hypercholesterolaemic rats.
Topics: Animals; Anticholesteremic Agents; Cholesterol; Cholesterol, Dietary; Cholesterol, LDL; Dose-Response Relationship, Drug; Drug Therapy, Combination; Hypercholesterolemia; Liver; Lovastatin; Male; Organ Size; Rats; Rats, Wistar; Rutin | 2009 |
The g.-762T>C polymorphism of the NPC1L1 gene is common in Chinese and contributes to a higher promoter activity and higher serum cholesterol levels.
Topics: Asian People; Azetidines; China; Cholesterol; Demography; Ezetimibe; Female; Gene Frequency; Genotype; Hep G2 Cells; Humans; Hypercholesterolemia; Lovastatin; Male; Membrane Proteins; Membrane Transport Proteins; Middle Aged; Polymorphism, Single Nucleotide; Promoter Regions, Genetic | 2009 |
Regulation of steroid 5-alpha reductase type 2 (Srd5a2) by sterol regulatory element binding proteins and statin.
Topics: 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; Animals; Atorvastatin; Azetidines; Cell Line, Tumor; Ezetimibe; Gene Expression Regulation, Enzymologic; Heptanoic Acids; Hydroxymethylglutaryl CoA Reductases; Hypercholesterolemia; Liver; Lovastatin; Male; Mice; Promoter Regions, Genetic; Prostate; Prostatic Neoplasms; Pyrroles; Sterol Regulatory Element Binding Protein 2; Transfection | 2009 |
Lovastatin decreases acute mucosal inflammation via 15-epi-lipoxin A4.
Topics: 8,11,14-Eicosatrienoic Acid; Acute Disease; Animals; Anticholesteremic Agents; Cell Line; Disease Models, Animal; Female; Humans; Hypercholesterolemia; Inflammation; Inflammation Mediators; Lipoxins; Lovastatin; Male; Mice; Neutrophils; Pneumonia; Respiratory Mucosa | 2010 |
[Pharmaco-economic optimization of cholesterol-lowering treatment with statins].
Topics: Atorvastatin; Cholesterol, LDL; Cost-Benefit Analysis; Fatty Acids, Monounsaturated; Fluorobenzenes; Fluvastatin; Goals; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Indoles; Lovastatin; Practice Guidelines as Topic; Pravastatin; Pyrimidines; Pyrroles; Rosuvastatin Calcium; Simvastatin; Spain; Sulfonamides | 2011 |
Is red yeast rice safe and effective for lowering serum cholesterol?
Topics: Biological Products; Cholesterol; Dietary Supplements; Fermentation; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Lovastatin; Treatment Outcome | 2011 |
Antioxidant effect of red mould rice in hypercholesterolemic Wistar male rats.
Topics: Animals; Antioxidants; Ascorbic Acid; Catalase; Cholesterol; Fermentation; Glutathione Reductase; Hypercholesterolemia; Lipid Peroxidation; Liver; Lovastatin; Male; Monascus; Oryza; Oxidative Stress; Rats; Rats, Wistar; Superoxide Dismutase | 2011 |
[Cholesterol-degrading in mice by Lactobacillus plantarum LpT1 and LpT2 in vivo].
Topics: Animals; Cholesterol; Cholesterol, HDL; Disease Models, Animal; Hypercholesterolemia; Lactobacillus plantarum; Liver; Lovastatin; Male; Rats; Rats, Sprague-Dawley | 2012 |
[Achievement of therapeutic target in subjects on statin treatment in clinical practice. Results of the STAR (Statins Target Assessment in Real practice) study].
Topics: Aged; Algorithms; Azetidines; Biomarkers; Cardiovascular Diseases; Cerebrovascular Disorders; Cholesterol, LDL; Cohort Studies; Diabetes Complications; Diabetes Mellitus; Ezetimibe; Female; Fluorobenzenes; Follow-Up Studies; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Italy; Lovastatin; Male; Medication Adherence; Middle Aged; Pravastatin; Pyrimidines; Retrospective Studies; Risk Assessment; Risk Factors; Rosuvastatin Calcium; Simvastatin; Sulfonamides; Treatment Outcome | 2011 |
JD induced pluripotent stem cell-derived hepatocytes faithfully recapitulate the pathophysiology of familial hypercholesterolemia.
Topics: Adolescent; Alleles; Anticholesteremic Agents; Apolipoprotein B-100; Cell Differentiation; Cells, Cultured; Cholesterol, LDL; Fibroblasts; Gene Expression Regulation; Genome-Wide Association Study; Hepatocytes; Humans; Hypercholesterolemia; Lipoproteins, LDL; Lovastatin; Male; Mutation; Pluripotent Stem Cells; Receptors, LDL; RNA, Messenger; Sterol Regulatory Element Binding Protein 2 | 2012 |
Policosanol safely down-regulates HMG-CoA reductase - potential as a component of the Esselstyn regimen.
Topics: Animals; Cholesterol, LDL; Clinical Trials as Topic; Cohort Studies; Diet, Vegetarian; Dietary Fats; Dietary Supplements; Double-Blind Method; Drug Costs; Enzyme Activation; Fatty Alcohols; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Insulin Resistance; Lovastatin; Myocardial Infarction; Platelet Activation; Protein Prenylation; Protein Processing, Post-Translational; Rabbits; Rats; rho GTP-Binding Proteins; Safety | 2002 |
Frequency of new coronary events in older persons with peripheral arterial disease and serum low-density lipoprotein cholesterol > or = 125 mg/dl treated with statins versus no lipid-lowering drug.
Topics: Aged; Aged, 80 and over; Anticholesteremic Agents; Cholesterol, HDL; Cholesterol, LDL; Female; Follow-Up Studies; Health Services for the Aged; Humans; Hypercholesterolemia; Incidence; Lovastatin; Male; Middle Aged; Myocardial Infarction; New York; Peripheral Vascular Diseases; Pravastatin; Prospective Studies; Simvastatin; Treatment Outcome; Triglycerides | 2002 |
Effect of fruits of Moringa oleifera on the lipid profile of normal and hypercholesterolaemic rabbits.
Topics: Animals; Cholesterol, HDL; Fruit; Hypercholesterolemia; Hypolipidemic Agents; Lipids; Lovastatin; Male; Moringa oleifera; Phytotherapy; Plant Preparations; Rabbits | 2003 |
Thyroid hormone regulation and cholesterol metabolism are connected through Sterol Regulatory Element-Binding Protein-2 (SREBP-2).
Topics: Animals; Anticholesteremic Agents; Blotting, Northern; Cell Line; Cell Nucleus; Cholesterol; DNA-Binding Proteins; Gene Expression Regulation; Humans; Hypercholesterolemia; Hypothyroidism; Lipoproteins, LDL; Liver; Lovastatin; Male; Mice; Plasmids; Promoter Regions, Genetic; Protein Binding; Ribonucleases; RNA, Messenger; Sterol Regulatory Element Binding Protein 2; Thyroid Hormones; Transcription Factors; Transfection | 2003 |
Allocation of resources between smoking cessation methods and lovastatin treatment of hypercholesterolaemia: based on cost effectiveness and the social welfare function.
Topics: Administration, Cutaneous; Administration, Oral; Algorithms; Anticholesteremic Agents; Cost-Benefit Analysis; Female; Health Care Rationing; Humans; Hypercholesterolemia; Lovastatin; Male; Nicotine; Smoking Cessation; Social Welfare; Socioeconomic Factors; Spain | 2004 |
Eggplant (Solanum melongena) extract does not alter serum lipid levels.
Topics: Anticholesteremic Agents; Beverages; Case-Control Studies; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Citrus sinensis; Female; Fruit; Humans; Hypercholesterolemia; Lipids; Lovastatin; Male; Phytotherapy; Plant Extracts; Plant Preparations; Solanum melongena; Triglycerides | 2004 |
Lichenoid drug eruption with HMG-CoA reductase inhibitors (fluvastatin and lovastatin).
Topics: Drug Eruptions; Fatty Acids, Monounsaturated; Female; Fluvastatin; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Indoles; Lichen Planus; Lovastatin; Middle Aged | 2004 |
[Idiopathic membranous nephropathy associated with anti-calcineurin toxicity. Prognosis and other immunosuppressive treatments].
Topics: Adult; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Calcineurin Inhibitors; Calcium Channel Blockers; Creatinine; Cyclosporine; Drug Therapy, Combination; Glomerulonephritis, Membranous; Humans; Hypercholesterolemia; Hypertension; Hypolipidemic Agents; Immunosuppressive Agents; Kidney Diseases; Lisinopril; Lovastatin; Male; Nephrotic Syndrome; Prednisone; Recurrence; Verapamil | 2004 |
Therapeutic effects of ml-236B in primary hypercholesterolemia. 1980.
Topics: History, 20th Century; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Lovastatin | 2004 |
Consistency in efficacy and safety of ezetimibe coadministered with statins for treatment of hypercholesterolemia in women and men.
Topics: Adult; Aged; Aged, 80 and over; Analysis of Variance; Anticholesteremic Agents; Azetidines; Cholesterol, LDL; Double-Blind Method; Drug Therapy, Combination; Ezetimibe; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Lovastatin; Male; Middle Aged; Multicenter Studies as Topic; Randomized Controlled Trials as Topic; Sex Factors; Simvastatin; Time Factors; Treatment Outcome; Women's Health | 2004 |
Reviewing your investment strategy: where does diet fit in your personal portfolio.
Topics: Anticholesteremic Agents; Cholesterol, Dietary; Cholesterol, LDL; Diet; Humans; Hypercholesterolemia; Lovastatin; Treatment Outcome | 2005 |
[The "healthy" patient with hypercholesterolemia].
Topics: Aged; Aged, 80 and over; Anticholesteremic Agents; Antihypertensive Agents; Cholesterol, LDL; Clinical Trials as Topic; Coronary Disease; Female; Follow-Up Studies; Geriatric Assessment; Health Status; Humans; Hypercholesterolemia; Hypertension; Lipoprotein(a); Lovastatin; Practice Guidelines as Topic; Risk Factors | 2005 |
Risks of a nonprescription lovastatin.
Topics: Anticholesteremic Agents; Drug Approval; Humans; Hypercholesterolemia; Lovastatin; Nonprescription Drugs; Risk; United States; United States Food and Drug Administration | 2005 |
[Hypothyroidism and lovastatin-induced myositis].
Topics: Aged; Diabetes Mellitus, Type 2; Disease Susceptibility; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Hypothyroidism; Lovastatin; Myositis | 2005 |
Successful conversion of patients with hypercholesterolemia from a brand name to a generic cholesterol-lowering drug.
Topics: Aged; Anticholesteremic Agents; California; Drug Prescriptions; Drugs, Generic; Female; Health Maintenance Organizations; Humans; Hypercholesterolemia; Lovastatin; Male; Middle Aged; Practice Patterns, Physicians'; Simvastatin; Treatment Outcome | 2005 |
Experience with statin use in patients with chronic hepatitis C infection.
Topics: Aged; Alanine Transaminase; Anticholesteremic Agents; Aspartate Aminotransferases; Biomarkers; Cholesterol; Hepatitis C, Chronic; Humans; Hypercholesterolemia; Lovastatin; Male; Middle Aged; Prevalence; Simvastatin; Treatment Outcome; United States | 2005 |
[Impact of dietotherapy with enterosorbent of marine origin on the indices of mineral and lipid metabolism for patients suffering from kidney diseases].
Topics: Alginates; Anticholesteremic Agents; Data Interpretation, Statistical; Electrolytes; Enterosorption; Humans; Hypercholesterolemia; Kidney Diseases; Laminaria; Lipid Metabolism; Lovastatin; Middle Aged; Minerals; Pyelonephritis; Time Factors; Urinary Calculi | 2005 |
Cost-effectiveness analysis of cholesterol-lowering therapies in Spain.
Topics: Anticholesteremic Agents; Atorvastatin; Cholesterol, LDL; Cholestyramine Resin; Clinical Trials as Topic; Coronary Disease; Cost-Benefit Analysis; Fatty Acids, Monounsaturated; Fluvastatin; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Indoles; Lovastatin; Meta-Analysis as Topic; Pravastatin; Pyrroles; Risk Factors; Simvastatin; Spain | 2006 |
Neuropeptides induced a pronounced and statin-sensitive dysregulation of mevalonate cycle in human monocytes of patients with hypercholesterolemia.
Topics: Aged; Cell Separation; Cholesterol; Female; Humans; Hydroxycholesterols; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; In Vitro Techniques; Ligands; Lovastatin; Male; Mevalonic Acid; Middle Aged; Monocytes; Neuropeptides; Signal Transduction; Stimulation, Chemical; Superoxides | 2006 |
Regulation of human cytochrome P450 4F2 expression by sterol regulatory element-binding protein and lovastatin.
Topics: Anticholesteremic Agents; Cell Line, Tumor; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 4; Gene Expression Regulation, Enzymologic; Hepatocytes; Humans; Hydroxycholesterols; Hypercholesterolemia; Intracellular Signaling Peptides and Proteins; Lovastatin; Membrane Proteins; Mutation; Response Elements; Sterol Regulatory Element Binding Protein 1; Sterol Regulatory Element Binding Protein 2; Transcriptional Activation | 2007 |
Hepatitis and rhabdomyolysis in a patient with hormone refractory prostate cancer on ketoconazole and concurrent lovastatin therapy.
Topics: Aged, 80 and over; Antineoplastic Agents; Chemical and Drug Induced Liver Injury; Drug Interactions; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Ketoconazole; Lovastatin; Male; Prostatic Neoplasms; Rhabdomyolysis; Treatment Outcome | 2007 |
The effect of HMG-CoA reductase inhibitors on naturally occurring CD4+CD25+ T cells.
Topics: Adult; Animals; Atorvastatin; Forkhead Transcription Factors; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Lovastatin; Mice; Mice, Inbred C57BL; Pravastatin; Pyrroles; T-Lymphocytes, Regulatory; Up-Regulation | 2008 |
Low-density lipoprotein cholesterol (LDL-C) levels and LDL-C goal attainment among elderly patients treated with rosuvastatin compared with other statins in routine clinical practice.
Topics: Aged; Aged, 80 and over; Anticholesteremic Agents; Atorvastatin; Cholesterol, LDL; Cohort Studies; Coronary Disease; Databases, Factual; Fatty Acids, Monounsaturated; Female; Fluorobenzenes; Fluvastatin; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Indoles; Lovastatin; Male; Managed Care Programs; Odds Ratio; Pravastatin; Pyrimidines; Pyrroles; Retrospective Studies; Rosuvastatin Calcium; Simvastatin; Sulfonamides; Treatment Outcome | 2007 |
FDA advisers again reject nonprescription lovastatin.
Topics: Drug Approval; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Lovastatin; Nonprescription Drugs; United States; United States Food and Drug Administration | 2008 |
Ask the doctor. I saw a newspaper column that said red yeast rice is a safer, more effective way to treat high cholesterol than statin drugs. Is that true?
Topics: Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Lovastatin; Monascus; Oryza; Phytotherapy | 2007 |
Statins impair antitumor effects of rituximab by inducing conformational changes of CD20.
Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Murine-Derived; Antibody-Dependent Cell Cytotoxicity; Antigens, CD20; Antineoplastic Agents; B-Lymphocytes; Cell Line, Tumor; Cholesterol; Cytotoxicity, Immunologic; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Lovastatin; Lymphoma, B-Cell; Membrane Microdomains; Protein Conformation; Rituximab | 2008 |
Effect of APOE genotype on lipid levels in patients with coronary heart disease during a 3-week inpatient rehabilitation program.
Topics: Adult; Aged; Alleles; Apolipoprotein E2; Apolipoprotein E3; Apolipoprotein E4; Apolipoproteins E; Atorvastatin; Cholesterol, HDL; Cholesterol, LDL; Coronary Disease; Decision Making; Fatty Acids, Monounsaturated; Female; Fluvastatin; Genotype; Germany; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Indoles; Inpatients; Linear Models; Lovastatin; Male; Middle Aged; Multivariate Analysis; Pravastatin; Predictive Value of Tests; Pyridines; Pyrroles; Simvastatin; Triglycerides | 2008 |
Red yeast rice and omega-3 fatty acids for cholesterol management.
Topics: Biological Products; Cholesterol; Fatty Acids, Omega-3; Humans; Hypercholesterolemia; Lovastatin | 2008 |
Can consumers self-select for appropriate use of an over-the-counter statin? The Self Evaluation of Lovastatin to Enhance Cholesterol Treatment Study.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Algorithms; Cholesterol, LDL; Community Participation; Drug Labeling; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Lovastatin; Male; Middle Aged; Nonprescription Drugs; Prevalence; Prospective Studies; Public Health; Risk Factors; Self-Evaluation Programs; Surveys and Questionnaires; United States | 2008 |
Statin cost-effectiveness comparisons using real-world effectiveness data: formulary implications.
Topics: Aged; Atorvastatin; Cholesterol, LDL; Cost-Benefit Analysis; Drugs, Generic; Female; Fluorobenzenes; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Lovastatin; Male; Middle Aged; Pyrimidines; Pyrroles; Retrospective Studies; Rosuvastatin Calcium; Simvastatin; Sulfonamides | 2008 |
Regulation of hepatic receptor-dependent degradation of LDL by mevinolin in rabbits with hypercholesterolemia induced by a wheat starch-casein diet.
Topics: Animals; Anticholesteremic Agents; Caseins; Diet; Hypercholesterolemia; Lipoproteins, LDL; Lipoproteins, VLDL; Liver; Lovastatin; Male; Naphthalenes; Rabbits; Receptors, Cell Surface; Receptors, LDL; Starch | 1983 |
Blocking 3-hydroxy-3-methylglutaryl coenzyme A reductase with ML-236B enhances the plasma cortisol response to adrenocorticotropin in patients with hypercholesterolemia.
Topics: Adrenocorticotropic Hormone; Anticholesteremic Agents; Female; Humans; Hydrocortisone; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Lipids; Lovastatin; Male; Middle Aged; Naphthalenes | 1984 |
The effects of mevinolin on serum cholesterol levels of rabbits with endogenous hypercholesterolemia.
Topics: Animals; Anticholesteremic Agents; Caseins; Cholesterol; Diet; Dose-Response Relationship, Drug; Hypercholesterolemia; Lovastatin; Male; Naphthalenes; Rabbits; Time Factors; Triticum | 1982 |
Effects of compactin (ML-236 B) on biliary lipid composition and cholesterol catabolism in the hamster.
Topics: Animals; Anticholesteremic Agents; Bile; Body Weight; Cholesterol; Cricetinae; Diet; Hypercholesterolemia; Lipid Metabolism; Liver; Lovastatin; Mesocricetus; Naphthalenes; Organ Size | 1982 |
The effect of compactin, a potent inhibitor of 3-hydroxy-3-methylglutaryl coenzyme-A reductase activity, on cholesterogenesis and serum cholesterol levels in rats and chicks.
Topics: Animals; Anticholesteremic Agents; Chickens; Cholesterol; Cholestyramine Resin; Circadian Rhythm; Dose-Response Relationship, Drug; Drug Therapy, Combination; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Lipoproteins, HDL; Lipoproteins, VLDL; Lovastatin; Male; Naphthalenes; Rats | 1980 |
Therapeutic effects of ML-236B in primary hypercholesterolemia.
Topics: Adult; Aged; Anticholesteremic Agents; Child, Preschool; Cholesterol; Dose-Response Relationship, Drug; Drug Evaluation; Female; Humans; Hypercholesterolemia; Lovastatin; Male; Middle Aged; Naphthalenes | 1980 |
Statins prevent coronary heart disease.
Topics: Anticholesteremic Agents; Cholesterol, LDL; Coronary Disease; Humans; Hydroxymethylglutaryl CoA Reductases; Hypercholesterolemia; Lovastatin; Male; Middle Aged; Pravastatin; Randomized Controlled Trials as Topic; Risk Factors; Simvastatin | 1995 |
Lovastatin and peripheral neuropathy.
Topics: Anticholesteremic Agents; Female; Humans; Hypercholesterolemia; Lovastatin; Male; Middle Aged; Peripheral Nervous System Diseases | 1995 |
High retinol/retinol-binding protein ratio in noninsulin-dependent diabetes mellitus.
Topics: Anticholesteremic Agents; Antioxidants; Apolipoprotein C-II; Apolipoprotein C-III; Apolipoproteins C; beta Carotene; Blood Glucose; Carotenoids; Cholesterol; Diabetes Mellitus, Type 2; Diterpenes; Female; Humans; Hypercholesterolemia; Lovastatin; Male; Middle Aged; Retinol-Binding Proteins; Retinyl Esters; Sex Characteristics; Simvastatin; Triglycerides; Vitamin A | 1995 |
Long-term treatment (2 years) with the HMG CoA reductase inhibitors lovastatin or pravastatin in combination with cholestyramine in patients with severe primary hypercholesterolemia.
Topics: Adult; Aged; Cholesterol, HDL; Cholesterol, LDL; Cholestyramine Resin; Drug Therapy, Combination; Female; Humans; Hypercholesterolemia; Lovastatin; Male; Middle Aged; Pravastatin; Triglycerides | 1993 |
Pharmaco-economic assessment of the HMG-CoA reductase inhibitors.
Topics: Anticholesteremic Agents; Cost Control; Cost-Benefit Analysis; Health Care Costs; Humans; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Lovastatin; Pravastatin; Simvastatin | 1994 |
[Is treatment of hypercholesterolemia able to reduce total mortality?].
Topics: Adult; Aged; Anticholesteremic Agents; Coronary Disease; Female; Humans; Hypercholesterolemia; Lovastatin; Male; Middle Aged; Risk Factors; Simvastatin | 1995 |
Doctors, research funds and marketing.
Topics: Advertising; Anticholesteremic Agents; Coronary Disease; Humans; Hypercholesterolemia; Lovastatin; Simvastatin | 1995 |
Outcome monitoring of fluvastatin in a Department of Veterans Affairs lipid clinic.
Topics: Adult; Anticholesteremic Agents; Cholesterol, LDL; Coronary Disease; Cost Savings; Drug Costs; Drug Monitoring; Fatty Acids, Monounsaturated; Fluvastatin; Hospitals, Veterans; Humans; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Indoles; Lovastatin; New York; Primary Prevention; Treatment Outcome; United States; United States Department of Veterans Affairs | 1995 |
Marked improvement in cholestasis and hypercholesterolemia with simvastatin in a patient with primary biliary cirrhosis.
Topics: Adult; Anticholesteremic Agents; Cholestasis; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Liver Cirrhosis, Biliary; Lovastatin; Simvastatin | 1995 |
[Rhabdomyolysis in patients treated with simvastatin and cyclosporin: role of the hepatic cytochrome P450 enzyme system activity].
Topics: Anticholesteremic Agents; Cyclosporine; Cytochrome P-450 Enzyme Inhibitors; Heart Transplantation; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Liver; Lovastatin; Male; Middle Aged; Rhabdomyolysis; Simvastatin | 1995 |
Pravastatin versus simvastatin--what happens in the real world?
Topics: Anticholesteremic Agents; Humans; Hypercholesterolemia; Lovastatin; Pravastatin; Product Surveillance, Postmarketing; Simvastatin | 1995 |
Long-term effects of simvastatin in hypercholesterolemic patients with NIDDM and additional atherosclerotic risk factors. Hyogo Simvastatin Study Group.
Topics: Anticholesteremic Agents; Arteriosclerosis; Diabetes Mellitus, Type 2; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Lovastatin; Male; Middle Aged; Prospective Studies; Risk Factors; Simvastatin | 1995 |
Lovastatin-induced myopathy in a hypothyroid patient.
Topics: Female; Humans; Hypercholesterolemia; Hypothyroidism; Lovastatin; Middle Aged; Muscular Diseases | 1995 |
Effect of systemic treatment with cholesterol-lowering drugs on the skin barrier function in humans.
Topics: Adult; Aged; Anticholesteremic Agents; Biological Availability; Cholesterol; Erythema; Female; Galvanic Skin Response; Humans; Hypercholesterolemia; Irritants; Lovastatin; Male; Middle Aged; Patch Tests; Permeability; Pravastatin; Simvastatin; Skin; Sodium Dodecyl Sulfate; Water Loss, Insensible | 1995 |
Lovastatin-induced hemolytic anemia: not a class-specific reaction.
Topics: Anemia, Hemolytic; Female; Humans; Hypercholesterolemia; Lovastatin; Middle Aged | 1995 |
Comparative effects of HMG-CoA reductase inhibitors on apo B production in the casein-fed rabbit: atorvastatin versus lovastatin.
Topics: Analysis of Variance; Animals; Anticholesteremic Agents; Apolipoproteins B; Atorvastatin; Caseins; Cholesterol; Diet; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Iodine Radioisotopes; Lipoproteins, LDL; Lovastatin; Male; Pyrroles; Rabbits; Random Allocation | 1995 |
Long-term safety of statin-fibrate combination treatment in the management of hypercholesterolaemia in patients with coronary artery disease.
Topics: Adult; Aged; Aspartate Aminotransferases; Bezafibrate; Cohort Studies; Coronary Disease; Creatine Kinase; Drug Therapy, Combination; Female; Fenofibrate; Follow-Up Studies; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Hypolipidemic Agents; Lovastatin; Male; Middle Aged; Pravastatin; Retrospective Studies; Simvastatin | 1995 |
Decreased basal nitric oxide release in hypercholesterolemia increases neutrophil adherence to rabbit coronary artery endothelium.
Topics: Amino Acid Oxidoreductases; Animals; Arginine; Cell Adhesion; Cholesterol, Dietary; Coronary Vessels; Endothelium, Vascular; Hypercholesterolemia; Lovastatin; Male; Neutrophils; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Rabbits | 1993 |
Effects of simvastatin and pravastatin on endothelium-dependent relaxation in hypercholesterolemic rabbits.
Topics: Acetylcholine; Animals; Anticholesteremic Agents; Aorta, Thoracic; Cholesterol; Endothelium, Vascular; Hypercholesterolemia; In Vitro Techniques; Lovastatin; Male; Pravastatin; Rabbits; Simvastatin; Vasodilation | 1994 |
Ocular drug safety and HMG-CoA-reductase inhibitors.
Topics: Color Perception; Contrast Sensitivity; Eye; Female; Fenofibrate; Humans; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Intraocular Pressure; Lens, Crystalline; Lovastatin; Male; Middle Aged; Photography; Refraction, Ocular; Safety; Simvastatin; Visual Acuity | 1994 |
Renal transplantation and dyslipidemia: characterization of a population and treatment with diet and low dose lovastatin.
Topics: Adult; Cholesterol; Diet, Fat-Restricted; Female; Humans; Hypercholesterolemia; Kidney Transplantation; Lipoproteins, HDL; Lipoproteins, LDL; Lovastatin; Male; Postoperative Complications; Triglycerides | 1995 |
The successful recruitment of elderly black subjects in a clinical trial: the CRISP experience. Cholesterol Reduction in Seniors Program.
Topics: Aged; Black People; Clinical Trials as Topic; Cohort Studies; Double-Blind Method; Female; Follow-Up Studies; Humans; Hypercholesterolemia; Lovastatin; Male; Patient Selection; Randomized Controlled Trials as Topic | 1995 |
[Lovastatin-induced acute cholestatic hepatitis].
Topics: Alkaline Phosphatase; Cholestasis, Intrahepatic; Cholinesterases; Female; Glutamate Dehydrogenase; Humans; Hypercholesterolemia; Liver; Lovastatin; Male; Middle Aged; Transaminases | 1995 |
Cholesterol hypothesis vindicated by simvastatin study. Why did it take so long?
Topics: Animals; Anticholesteremic Agents; Coronary Disease; Humans; Hypercholesterolemia; Lovastatin; Simvastatin | 1995 |
The cost-effectiveness of HMG-CoA reductase inhibitors to prevent coronary heart disease. Estimating the benefits of increasing HDL-C.
Topics: Adult; Age Factors; Aged; Canada; Cholesterol, HDL; Coronary Disease; Cost-Benefit Analysis; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Life Expectancy; Lovastatin; Male; Middle Aged; Models, Theoretical; Sex Factors; United States; Value of Life | 1995 |
[Treatment of dyslipidemia of the elderly with simvastatin and pravastatin. Effectiveness and tolerance].
Topics: Aged; Cholesterol; Humans; Hypercholesterolemia; Hypolipidemic Agents; Lovastatin; Middle Aged; Pravastatin; Simvastatin; Triglycerides | 1994 |
Dropping cholesterol--safely.
Topics: Cholesterol; Controlled Clinical Trials as Topic; Coronary Artery Bypass; Coronary Disease; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Lovastatin; Scandinavian and Nordic Countries; Simvastatin | 1994 |
[Effect of combined treatment with lovastatin and colestipol on serum lipids and lipoproteins].
Topics: Adult; Aged; Colestipol; Drug Therapy, Combination; Humans; Hypercholesterolemia; Hyperlipidemias; Lipids; Lipoproteins; Lovastatin; Male; Middle Aged | 1993 |
Drug treatment of hypercholesterolaemia in a patient with Gilbert's syndrome.
Topics: Administration, Oral; Bezafibrate; Bilirubin; Colestipol; Gilbert Disease; Humans; Hypercholesterolemia; Hypolipidemic Agents; Lipids; Liver; Liver Function Tests; Lovastatin; Male; Middle Aged; Pravastatin; Pyrazines; Simvastatin | 1994 |
Effects of lovastatin (20-80 mg daily) on lipoprotein fractions in patients with severe primary hypercholesterolemia.
Topics: Adult; Aged; Apolipoproteins; Cholesterol; Dose-Response Relationship, Drug; Female; Humans; Hypercholesterolemia; Lipoproteins; Lovastatin; Male; Middle Aged; Triglycerides | 1994 |
[The effects of plasma cholesterol reduction on vasoconstriction due to sympathetic activation in patients with moderate primary hypercholesterolemia].
Topics: Adult; Aged; Analysis of Variance; Anticholesteremic Agents; Cholesterol; Cold Temperature; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Linear Models; Lovastatin; Male; Middle Aged; Plethysmography; Simvastatin; Sympathetic Nervous System; Vasoconstriction | 1994 |
Nicotinic acid as a lipoprotein-altering agent. Therapy directed by the primary physician.
Topics: Coronary Disease; Humans; Hypercholesterolemia; Lipoproteins; Lovastatin; Niacin | 1994 |
Safety and efficacy of low dose simvastatin in cardiac transplant recipients treated with cyclosporine.
Topics: Anticholesteremic Agents; Cholesterol; Cyclosporine; Female; Follow-Up Studies; Graft Survival; Heart Transplantation; Humans; Hypercholesterolemia; Lovastatin; Male; Middle Aged; Simvastatin; Triglycerides | 1994 |
Prediction of the therapeutic response to simvastatin by pretreatment lipid concentrations in 2082 subjects.
Topics: Adult; Aged; Anticholesteremic Agents; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Lipids; Lipoproteins; Lovastatin; Male; Middle Aged; Multivariate Analysis; Predictive Value of Tests; Simvastatin; Treatment Outcome | 1994 |
Hypercholesterolemia treatment in a renal transplant patient.
Topics: Anticholesteremic Agents; Bezafibrate; Clofibric Acid; Female; Fenofibrate; Fibric Acids; Humans; Hypercholesterolemia; Kidney Transplantation; Lovastatin; Male; Middle Aged; Postoperative Complications; Simvastatin | 1994 |
Acute hepatitis induced by HMG-CoA reductase inhibitor, lovastatin.
Topics: Acute Disease; Biopsy; Chemical and Drug Induced Liver Injury; Humans; Hypercholesterolemia; Lovastatin; Male; Middle Aged | 1994 |
Depressive symptoms and cholesterol-lowering drugs.
Topics: Adult; Anticholesteremic Agents; Depressive Disorder; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Lovastatin; Middle Aged; Simvastatin | 1993 |
Lovastatin versus pravastatin for hypercholesterolemia.
Topics: Cholesterol, LDL; Humans; Hypercholesterolemia; Lovastatin; Pravastatin | 1994 |
"A real world" dose comparison of lovastatin and pravastatin.
Topics: Cholesterol; Cholesterol, LDL; Humans; Hypercholesterolemia; Lovastatin; Pravastatin | 1994 |
Myxoedema revealed by simvastatin induced myopathy.
Topics: Adult; Anticholesteremic Agents; Humans; Hypercholesterolemia; Lovastatin; Male; Muscular Diseases; Myxedema; Simvastatin | 1994 |
[Effects of simvastatin on plasma lipoproteins].
Topics: Adult; Aged; Cholesterol; Female; Humans; Hypercholesterolemia; Hypolipidemic Agents; Lipoproteins; Lovastatin; Male; Middle Aged; Retrospective Studies; Simvastatin | 1994 |
HMG-CoA reductase inhibitor therapy and peripheral neuropathy.
Topics: Female; Humans; Hypercholesterolemia; Lovastatin; Middle Aged; Peripheral Nervous System Diseases; Pravastatin | 1994 |
Lovastatin in pravastatin comparative trial: cost-effectiveness.
Topics: Cholesterol, LDL; Cost-Benefit Analysis; Humans; Hypercholesterolemia; Lovastatin; Pravastatin | 1994 |
[Changes in the rate of cholesterol synthesis in lymphocytes, and blood lipid and lipoprotein levels in patients with ischemic heart disease and hypercholesterolemia during treatment with lovastatin and obsidan].
Topics: Adult; Cholesterol; Drug Interactions; Drug Therapy, Combination; Humans; Hypercholesterolemia; Lipids; Lipoproteins; Lovastatin; Lymphocytes; Male; Middle Aged; Myocardial Ischemia; Propranolol | 1994 |
[Use and effect of simvastin in patients with type II diabetes].
Topics: Anticholesteremic Agents; Cholesterol; Diabetes Mellitus, Type 2; Female; Humans; Hypercholesterolemia; Lipoproteins, HDL; Lipoproteins, LDL; Lovastatin; Male; Middle Aged; Simvastatin; Triglycerides | 1993 |
Responsiveness to bradykinin in veins of hypercholesterolemic humans.
Topics: Adult; Aged; Aged, 80 and over; Bradykinin; Dose-Response Relationship, Drug; Drug Resistance; Endothelium, Vascular; Female; Humans; Hypercholesterolemia; Indomethacin; Lovastatin; Male; Middle Aged; Models, Cardiovascular; Nitric Oxide; Nitroglycerin; Vasodilation | 1993 |
Plasma coenzyme Q (ubiquinone) concentrations in patients treated with simvastatin.
Topics: Adult; Aged; Cholesterol; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Hypolipidemic Agents; Lipids; Lipoproteins; Lovastatin; Male; Middle Aged; Simvastatin; Ubiquinone | 1993 |
Lovastatin enhances hepatic uptake of low density lipoprotein in humans.
Topics: Adult; Apolipoproteins B; Cholesterol, LDL; Female; Humans; Hypercholesterolemia; Hyperlipoproteinemia Type II; Iodine Radioisotopes; Lipoproteins, LDL; Liver; Lovastatin; Lung; Male; Middle Aged; Myocardium; Technetium | 1993 |
Effect of simvastatin treatment on plasma apolipoproteins and hepatic apolipoprotein mRNA levels in the genetically hypercholesterolemic rat (RICO).
Topics: Animals; Apolipoproteins E; Apoproteins; Gene Expression; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Hypolipidemic Agents; Lipoproteins; Liver; Lovastatin; Male; Phospholipids; Rats; Rats, Inbred Strains; RNA, Messenger; Simvastatin; Time Factors; Triglycerides | 1994 |
Lovastatin decreases plasma and platelet cholesterol levels and normalizes elevated platelet fluidity and aggregation in hypercholesterolemic patients.
Topics: Administration, Oral; Adult; Blood Platelets; Cholesterol; Female; Fluorescence Polarization; Humans; Hypercholesterolemia; Lovastatin; Male; Membrane Fluidity; Middle Aged; Phosphatidylcholines; Phospholipids; Platelet Aggregation; Sphingomyelins | 1994 |
Evidence of combined therapy of dyslipoproteinemia by HMG-CoA reductase inhibitors and "essential" phospholipids.
Topics: Adult; Cholesterol; Coronary Disease; Drug Therapy, Combination; Humans; Hypercholesterolemia; Lipoproteins, LDL; Lovastatin; Male; Phosphatidylcholines; Platelet Aggregation | 1993 |
Combination drug therapy for hypercholesterolemia. The trade-off between cost and simplicity.
Topics: Aged; Algorithms; Anticholesteremic Agents; Decision Trees; Drug Costs; Drug Therapy, Combination; Female; Hospitals, Veterans; Humans; Hypercholesterolemia; Lovastatin; Male; Middle Aged; Midwestern United States; Niacin; Probability; Prospective Studies; Treatment Outcome | 1993 |
A prospective study on treatment of hypercholesterolemia with lovastatin in renal transplant patients receiving cyclosporine.
Topics: Adult; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Cyclosporine; Female; Humans; Hypercholesterolemia; Kidney Transplantation; Lovastatin; Male; Middle Aged; Postoperative Care; Prospective Studies | 1993 |
Musculoskeletal manifestations during simvastatin therapy.
Topics: Anticholesteremic Agents; Cholesterol; Female; Humans; Hypercholesterolemia; Lovastatin; Middle Aged; Musculoskeletal Diseases; Simvastatin | 1993 |
Simvastatin, pravastatin and lovastatin: three options for lowering cholesterol.
Topics: Anticholesteremic Agents; Drug Costs; Drug Interactions; Humans; Hypercholesterolemia; Lovastatin; Pravastatin; Simvastatin | 1993 |
Treatment of and screening for hyperlipidemia.
Topics: Cholesterol, LDL; Dietary Fats, Unsaturated; Humans; Hypercholesterolemia; Lovastatin | 1993 |
Lovastatin vs PIB.
Topics: Health Care Costs; Humans; Hypercholesterolemia; Jejunoileal Bypass; Lovastatin | 1993 |
Effects of lovastatin on high-density lipoprotein subfractions in hypercholesterolemic patients with peripheral vascular disease.
Topics: Adult; Apolipoprotein A-I; Apolipoprotein A-II; Arteriosclerosis; Case-Control Studies; Cholesterol, HDL; Female; Humans; Hypercholesterolemia; Intermittent Claudication; Lipids; Lipoproteins, HDL; Lipoproteins, HDL2; Lipoproteins, HDL3; Lovastatin; Male; Middle Aged; Peripheral Vascular Diseases | 1993 |
Evaluation of the effectiveness of lipid-lowering therapy (bile acid sequestrants, niacin, psyllium and lovastatin) for treating hypercholesterolemia in veterans.
Topics: Age Factors; Anticholesteremic Agents; Cholesterol; Humans; Hypercholesterolemia; Lovastatin; Middle Aged; Niacin; Patient Compliance; Prospective Studies; Psyllium; Regression Analysis; Treatment Refusal; United States; Veterans | 1993 |
Hypercholesterolemia in non-insulin-dependent diabetes mellitus: different effect of simvastatin on VLDL and LDL cholesterol levels.
Topics: Anticholesteremic Agents; Apolipoproteins; Cholesterol, LDL; Cholesterol, VLDL; Diabetes Mellitus, Type 2; Female; Humans; Hypercholesterolemia; Lipids; Lovastatin; Male; Middle Aged; Simvastatin | 1993 |
[Effectiveness and tolerability of simvastatin in patients with moderate-to-severe hypercholesterolemia. Results of a 12-month study].
Topics: Anticholesteremic Agents; Cholesterol; Coronary Disease; Enzyme Inhibitors; Female; Follow-Up Studies; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Lipoproteins, LDL; Lovastatin; Male; Risk Factors; Severity of Illness Index; Simvastatin | 1993 |
HMGCoA reductase inhibitors.
Topics: Anticholesteremic Agents; Coronary Disease; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Lovastatin; Male | 1993 |
Effect of lovastatin on cholesterol absorption in cholesterol-fed rabbits.
Topics: Animals; Cholesterol; Cholesterol, Dietary; Hypercholesterolemia; Intestinal Absorption; Lovastatin; Male; Rabbits; Sitosterols | 1993 |
Profiling a landmark clinical trial: Scandinavian Simvastatin Survival Study.
Topics: Adult; Aged; Anticholesteremic Agents; Clinical Trials as Topic; Coronary Disease; Diet Therapy; Female; Follow-Up Studies; Humans; Hypercholesterolemia; Lipids; Lovastatin; Male; Middle Aged; Multicenter Studies as Topic; Randomized Controlled Trials as Topic; Risk; Scandinavian and Nordic Countries; Simvastatin; Survival Analysis | 1995 |
Thromboxane biosynthesis, neutrophil and coagulative activation in type IIa hypercholesterolemia.
Topics: Adult; Aged; Cross-Sectional Studies; Female; Humans; Hypercholesterolemia; Hypolipidemic Agents; Lovastatin; Male; Middle Aged; Neutrophil Activation; Pancreatic Elastase; Simvastatin; Thrombin; Thromboxanes | 1995 |
[The 4-S study--a turning point in the cholesterol debate. Work Group Lipids and Atherosclerosis of the Swiss Society for Cardiology].
Topics: Adult; Aged; Anticholesteremic Agents; Coronary Disease; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Lovastatin; Male; Middle Aged; Randomized Controlled Trials as Topic; Scandinavian and Nordic Countries; Simvastatin | 1995 |
Vestibular vertigo and lovastatin therapy.
Topics: Aged; Anticholesteremic Agents; Female; Humans; Hypercholesterolemia; Lovastatin; Male; Middle Aged; Vertigo | 1996 |
Treating hypercholesterolemia aggressively.
Topics: Anticholesteremic Agents; Cholesterol, LDL; Clinical Trials as Topic; Combined Modality Therapy; Coronary Disease; Diet, Fat-Restricted; Humans; Hypercholesterolemia; Lovastatin; Practice Guidelines as Topic; Simvastatin | 1996 |
Statins, cholesterol, and mevalonate pathways?
Topics: Anticholesteremic Agents; Cholesterol; Coronary Disease; Female; Humans; Hypercholesterolemia; Lovastatin; Male; Mevalonic Acid; Simvastatin | 1996 |
Implementation of the 4S study in first myocardial infarction.
Topics: Anticholesteremic Agents; Female; Humans; Hypercholesterolemia; Lovastatin; Male; Myocardial Infarction; Simvastatin | 1996 |
Simvastatin-oral anticoagulant interaction.
Topics: Acenocoumarol; Aged; Anticholesteremic Agents; Anticoagulants; Drug Synergism; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Lovastatin; Male; Simvastatin; Thrombosis | 1996 |
Primary prevention of stroke.
Topics: Acyl Coenzyme A; Anticholesteremic Agents; Arteriosclerosis; Cerebrovascular Disorders; Controlled Clinical Trials as Topic; Enzyme Inhibitors; Humans; Hypercholesterolemia; Lovastatin; Meta-Analysis as Topic; Oxidoreductases; Pravastatin; Simvastatin | 1996 |
The effect of simvastatin treatment on natural antioxidants in low-density lipoproteins and high-energy phosphates and ubiquinone in skeletal muscle.
Topics: Adenosine Triphosphate; Adult; Anticholesteremic Agents; Antioxidants; Cholesterol, LDL; Humans; Hypercholesterolemia; Lovastatin; Male; Middle Aged; Muscle, Skeletal; Phosphocreatine; Simvastatin; Ubiquinone | 1996 |
Levels of soluble cell adhesion molecules in patients with dyslipidemia.
Topics: Anticholesteremic Agents; Arteriosclerosis; Atorvastatin; Cell Adhesion Molecules; Colestipol; Drug Therapy, Combination; E-Selectin; Endothelium, Vascular; Enzyme Inhibitors; Female; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Hypertriglyceridemia; Hypolipidemic Agents; Intercellular Adhesion Molecule-1; Lovastatin; Male; Middle Aged; Pyrroles; Risk Factors; Simvastatin; Solubility; Vascular Cell Adhesion Molecule-1 | 1996 |
[Current developments in prevention of coronary heart disease].
Topics: Anticholesteremic Agents; Cholesterol; Cholesterol, Dietary; Coronary Disease; Female; Humans; Hypercholesterolemia; Lovastatin; Male; Randomized Controlled Trials as Topic; Risk Factors; Simvastatin; Survival Rate | 1996 |
Photosensitivity to simvastatin with an unusual response to photopatch and photo tests.
Topics: Dermatitis, Photoallergic; Humans; Hypercholesterolemia; Hypolipidemic Agents; Lovastatin; Male; Middle Aged; Patch Tests; Simvastatin | 1995 |
[The cholesterol hypothesis has been proved true at last].
Topics: Adult; Aged; Angina Pectoris; Anticholesteremic Agents; Cholesterol; Female; Humans; Hypercholesterolemia; Lovastatin; Male; Middle Aged; Myocardial Infarction; Simvastatin | 1995 |
Addressing the spectrum of hypercholesterolemia.
Topics: Adult; Aged; Algorithms; Anticholesteremic Agents; Coronary Disease; Diet, Fat-Restricted; Exercise; Female; Humans; Hypercholesterolemia; Lovastatin; Male; Middle Aged; Risk Factors; Simvastatin; Smoking Cessation | 1996 |
[Limitations of interventions against hypercholesterolemia].
Topics: Adult; Age Factors; Anticholesteremic Agents; Cardiovascular Diseases; Cholesterol; Cost-Benefit Analysis; Female; Humans; Hypercholesterolemia; Hypolipidemic Agents; Lovastatin; Male; Middle Aged; Risk Factors; Sex Factors; Simvastatin | 1996 |
Effects of systemic treatment with statins on skin barrier function and stratum corneum water-holding capacity.
Topics: Administration, Oral; Adult; Analysis of Variance; Anticholesteremic Agents; Cell Membrane Permeability; Epidermis; Female; Humans; Hypercholesterolemia; Lovastatin; Male; Middle Aged; Pravastatin; Simvastatin; Water Loss, Insensible | 1996 |
The effect of manganese-induced hypercholesterolemia on learning in rats.
Topics: Administration, Oral; Animals; Anticholesteremic Agents; Cholesterol; Disease Models, Animal; Female; Hippocampus; Hypercholesterolemia; Lovastatin; Manganese; Manganese Poisoning; Maze Learning; Rats | 1996 |
[Terminal myoglobinuric renal failure in lovastatin therapy with pre-existing chronic renal insufficiency].
Topics: Aged; Anticholesteremic Agents; Humans; Hypercholesterolemia; Kidney Failure, Chronic; Kidney Function Tests; Lovastatin; Male; Myoglobinuria; Nephrotic Syndrome; Renal Dialysis | 1996 |
Dermatomyositis with lung involvement in a patient treated with simvastatin.
Topics: Aged; Anticholesteremic Agents; Biopsy; Dermatomyositis; Fatal Outcome; Female; Humans; Hypercholesterolemia; Lovastatin; Lung Diseases; Muscle, Skeletal; Simvastatin | 1995 |
Lipid-lowering activity of atorvastatin and lovastatin in rodent species: triglyceride-lowering in rats correlates with efficacy in LDL animal models.
Topics: Animals; Anticholesteremic Agents; Apolipoproteins B; Atorvastatin; Cholesterol, LDL; Guinea Pigs; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Hypertriglyceridemia; Liver; Lovastatin; Male; Pyrroles; Rabbits; Rats; Rats, Sprague-Dawley; Triglycerides | 1995 |
Cost-effectiveness of cholesterol lowering. Results from the Scandinavian Simvastatin Survival Study (4S)
Topics: Anticholesteremic Agents; Case-Control Studies; Clinical Trials as Topic; Coronary Disease; Cost of Illness; Cost-Benefit Analysis; Evaluation Studies as Topic; Humans; Hypercholesterolemia; Lovastatin; Prospective Studies; Reproducibility of Results; Scandinavian and Nordic Countries; Simvastatin; Survival Rate | 1996 |
Behavior of Lp(a) and apoproteins (A1, B, C2, C3, E) during and after therapy with simvastatin.
Topics: Adult; Aged; Anticholesteremic Agents; Apoproteins; Enzyme Inhibitors; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Lipoprotein(a); Lovastatin; Male; Middle Aged; Simvastatin | 1995 |
The statin trials: closing arguments in the case against cholesterol?
Topics: Anticholesteremic Agents; Coronary Disease; Female; Humans; Hypercholesterolemia; Lovastatin; Male; Middle Aged; Risk Factors; Simvastatin | 1996 |
Urinary excretion of mevalonic acid as an indicator of cholesterol synthesis.
Topics: Adult; Aged; Anticholesteremic Agents; Cholesterol; Cholestyramine Resin; Circadian Rhythm; Female; Humans; Hypercholesterolemia; Lovastatin; Male; Mevalonic Acid; Middle Aged; Pravastatin; Reproducibility of Results; Simvastatin; Xanthomatosis, Cerebrotendinous | 1996 |
Cost effectiveness of lowering cholesterol. Study greatly underestimates the cost effectiveness of statin treatment.
Topics: Cardiovascular Diseases; Cost-Benefit Analysis; Drug Costs; Humans; Hypercholesterolemia; Lovastatin; Risk Factors; Simvastatin | 1996 |
Cost effectiveness of lowering cholesterol. Statin treatment should be started early.
Topics: Cardiovascular Diseases; Cost-Benefit Analysis; Fatty Acids, Monounsaturated; Fluvastatin; Humans; Hypercholesterolemia; Indoles; Lovastatin; Pravastatin; Simvastatin | 1996 |
Myoglobinuric renal failure due to long-standing lovastatin therapy in a patient with pre-existing chronic renal insufficiency.
Topics: Acute Kidney Injury; Aged; Anticholesteremic Agents; Enzyme Inhibitors; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Kidney Failure, Chronic; Lovastatin; Male; Myoglobinuria; Rhabdomyolysis | 1996 |
Beneficial effects of statins.
Topics: Anticholesteremic Agents; Fibrinogen; Humans; Hypercholesterolemia; Lovastatin; Platelet Aggregation; Pravastatin; Simvastatin | 1996 |
[Effect of hypercholesteremia on vascular endothelial function and albumin excretion rate in patients with diabetes mellitus].
Topics: Albuminuria; Anticholesteremic Agents; Diabetes Mellitus, Type 2; Endothelium, Vascular; Female; Humans; Hypercholesterolemia; Lovastatin; Male; Middle Aged; Simvastatin; Tissue Plasminogen Activator; von Willebrand Factor | 1996 |
Effects of simvastatin on the number and composition of apoproteinB-containing lipoproteins in hypercholesterolemia: analysis of apoproteinB in each lipoprotein fraction by highly sensitive latex method.
Topics: Adult; Aged; Apolipoproteins B; Cholesterol; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Hypolipidemic Agents; Latex Fixation Tests; Lipoproteins; Lovastatin; Male; Middle Aged; Sensitivity and Specificity; Simvastatin; Triglycerides; Ultracentrifugation | 1996 |
Simvastatin increases plasma NO2- and NO3- levels in patients with hypercholesterolemia.
Topics: Administration, Oral; Anticholesteremic Agents; Cholesterol, LDL; Cholesterol, VLDL; Female; Follow-Up Studies; Humans; Hypercholesterolemia; Lovastatin; Male; Middle Aged; Nitrates; Nitrites; Simvastatin; Ultracentrifugation | 1996 |
Cost effectiveness of simvastatin treatment to lower cholesterol levels in patients with coronary heart disease. Scandinavian Simvastatin Survival Study Group.
Topics: Adult; Age Factors; Aged; Anticholesteremic Agents; Cholesterol; Clinical Trials as Topic; Coronary Disease; Cost of Illness; Cost-Benefit Analysis; Female; Humans; Hypercholesterolemia; Lovastatin; Male; Markov Chains; Middle Aged; Proportional Hazards Models; Sex Factors; Simvastatin; Value of Life | 1997 |
[Increase of myocardial perfusion during antilipemic treatment in patients with ischemic cardiopathy].
Topics: Adult; Aged; Anticholesteremic Agents; Coronary Circulation; Female; Humans; Hypercholesterolemia; Lovastatin; Male; Middle Aged; Myocardial Ischemia; Pilot Projects; Simvastatin; Tomography, Emission-Computed, Single-Photon | 1996 |
Effects of initial BMI and on-treatment weight change on the lipid-lowering efficacy of fibrates.
Topics: Body Mass Index; Clofibric Acid; Female; Fenofibrate; Fibric Acids; Gemfibrozil; Humans; Hypercholesterolemia; Hypolipidemic Agents; Lipids; Lovastatin; Male; Middle Aged; Prospective Studies; Sex Factors; Simvastatin; Weight Loss | 1997 |
[The characteristics of the hypolipidemic effect of Mevacor with its permanent multiyear use].
Topics: Adult; Aged; Child; Diseases in Twins; Dose-Response Relationship, Drug; Drug Evaluation; Female; Humans; Hypercholesterolemia; Hyperlipoproteinemia Type II; Hypolipidemic Agents; Lipids; Lovastatin; Male; Middle Aged; Time Factors | 1996 |
Reversal of cyclosporine-inhibited low-density lipoprotein receptor activity in HepG2 cells by 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors.
Topics: Anticholesteremic Agents; Biological Transport, Active; Cyclosporine; Down-Regulation; Enzyme Inhibitors; Fatty Acids, Monounsaturated; Fluvastatin; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Indoles; Lipoproteins, LDL; Lovastatin; Receptors, LDL; Tumor Cells, Cultured; Up-Regulation | 1997 |
Recent developments in coronary heart disease prevention: the Scandinavian and west of Scotland studies.
Topics: Adult; Aged; Anticholesteremic Agents; Cholesterol, LDL; Coronary Disease; Enzyme Inhibitors; Female; Finland; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Lovastatin; Male; Middle Aged; Morbidity; Pravastatin; Randomized Controlled Trials as Topic; Risk Factors; Scotland; Simvastatin | 1997 |
[Lowering LDL cholesterol with Simvastatin. Also, economically reasonable!].
Topics: Anticholesteremic Agents; Cholesterol, LDL; Drug Costs; Humans; Hypercholesterolemia; Lovastatin; Simvastatin | 1995 |
Beneficial effect of lovastatin on sphincter of Oddi dyskinesia in hypercholesterolemia and hypertriglyceridemia.
Topics: Aged; Anticholesteremic Agents; Bile Duct Diseases; Female; Humans; Hypercholesterolemia; Hypertriglyceridemia; Lovastatin; Movement Disorders; Sphincter of Oddi | 1997 |
The clinical therapeutic implications of the Scandinavian Simvastatin Survival Study.
Topics: Anticholesteremic Agents; Coronary Disease; Female; Humans; Hypercholesterolemia; Lovastatin; Male; Simvastatin | 1997 |
Polymyositis associated with simvastatin.
Topics: Adult; Anticholesteremic Agents; Humans; Hypercholesterolemia; Lovastatin; Male; Methylprednisolone; Polymyositis; Simvastatin | 1997 |
The use of alternate-day lovastatin in hypercholesterolemic men.
Topics: Aged; Anticholesteremic Agents; Cholesterol, HDL; Cholesterol, LDL; Drug Administration Schedule; Humans; Hypercholesterolemia; Lovastatin; Male; Middle Aged; Retrospective Studies; Treatment Outcome; Triglycerides | 1997 |
Prevention of atherosclerosis in coronary-artery bypass grafts.
Topics: Cholesterol, LDL; Coronary Artery Bypass; Coronary Artery Disease; Cost-Benefit Analysis; Humans; Hypercholesterolemia; Lovastatin; Recurrence; Saphenous Vein | 1997 |
Simvastatin reduces forearm vascular responsiveness to norepinephrine.
Topics: Anticholesteremic Agents; Brachial Artery; Cholesterol; Endothelium, Vascular; Follow-Up Studies; Forearm; Humans; Hypercholesterolemia; Lovastatin; Male; Middle Aged; Norepinephrine; Simvastatin; Vasoconstriction; Vasoconstrictor Agents | 1997 |
Simvastatin-induced myopathy in a patient treated for hypercholesterolemia. Morphological aspects.
Topics: Humans; Hypercholesterolemia; Lovastatin; Male; Middle Aged; Muscle, Skeletal; Muscular Diseases; Simvastatin | 1997 |
Results of recent large cholesterol-lowering trials and implications for clinical management.
Topics: Anticholesteremic Agents; Cholesterol, LDL; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Lovastatin; Randomized Controlled Trials as Topic; Simvastatin | 1997 |
Simvastatin in the secondary prevention of coronary heart disease.
Topics: Anticholesteremic Agents; Coronary Disease; Humans; Hypercholesterolemia; Lovastatin; Simvastatin | 1997 |
The 4S study: a critical review.
Topics: Anticholesteremic Agents; Cholesterol; Coronary Disease; Humans; Hypercholesterolemia; Lovastatin; Simvastatin | 1997 |
The 4S study: a critical review.
Topics: Adult; Aged; Anticholesteremic Agents; Cholesterol; Coronary Disease; Female; Humans; Hypercholesterolemia; Lovastatin; Male; Middle Aged; Randomized Controlled Trials as Topic; Simvastatin | 1997 |
The effect of Simvastatin on the plasma antioxidant concentrations in patients with hypercholesterolaemia.
Topics: Adult; Anticholesteremic Agents; Antioxidants; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Coenzymes; Enzyme Inhibitors; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Hyperlipoproteinemia Type II; Lipid Peroxidation; Lovastatin; Male; Middle Aged; Simvastatin; Ubiquinone; Vitamin E | 1997 |
Dietary L-arginine reduces the progression of atherosclerosis in cholesterol-fed rabbits: comparison with lovastatin.
Topics: Animals; Anticholesteremic Agents; Arginine; Arteriosclerosis; Cholesterol; Cholesterol, Dietary; Cyclic GMP; Diet, Atherogenic; Endothelium, Vascular; Hypercholesterolemia; Lovastatin; Male; Nitrates; Nitric Oxide; Rabbits; Superoxides | 1997 |
[Data on cholesterol level screening of patients with ischemic heart disease in the light of the Scandinavian Simvastatin Survival Study].
Topics: Adult; Aged; Anticholesteremic Agents; Cholesterol; Death, Sudden, Cardiac; Drug Costs; Female; Humans; Hungary; Hypercholesterolemia; Lovastatin; Male; Mass Screening; Middle Aged; Myocardial Ischemia; Prevalence; Risk Factors; Scandinavian and Nordic Countries; Simvastatin; Survival Rate | 1997 |
[The mechanism of action of hypolipidemic drugs].
Topics: Adipose Tissue; Anticholesteremic Agents; Cholesterol, LDL; Enzyme Inhibitors; Fatty Acids, Monounsaturated; Fluvastatin; Humans; Hydroxymethylglutaryl CoA Reductases; Hypercholesterolemia; Hypolipidemic Agents; Indoles; Lipase; Lipid Peroxidation; Lipoproteins, VLDL; Liver; Lovastatin; Microbodies; Nuclear Proteins; Pravastatin; Receptors, Cytoplasmic and Nuclear; Receptors, LDL; Simvastatin; Transcription Factors | 1997 |
Petechial eruptions due to simvastatin in a patient with diabetes mellitus and liver cirrhosis.
Topics: Anticholesteremic Agents; Biopsy, Needle; Diabetes Mellitus, Type 1; Humans; Hypercholesterolemia; Japan; Liver Cirrhosis; Lovastatin; Male; Middle Aged; Purpura; Simvastatin | 1997 |
HMG-CoA reductase inhibitors reduce stroke risk, total mortality.
Topics: Cerebrovascular Disorders; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Lovastatin; Meta-Analysis as Topic; Mortality; Pravastatin; Simvastatin | 1997 |
Rhabdomyolysis, acute renal failure and hepatopathy induced by lovastatin monotherapy.
Topics: Acute Kidney Injury; Anticholesteremic Agents; Chemical and Drug Induced Liver Injury; Female; Humans; Hypercholesterolemia; Lovastatin; Middle Aged; Rhabdomyolysis | 1997 |
HMG-CoA reductase inhibitors decrease CD11b expression and CD11b-dependent adhesion of monocytes to endothelium and reduce increased adhesiveness of monocytes isolated from patients with hypercholesterolemia.
Topics: Cell Adhesion; Cells, Cultured; Endothelium, Vascular; Fluorescent Antibody Technique; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Lovastatin; Macrophage-1 Antigen; Male; Monocytes; Simvastatin | 1997 |
Lack of left ventricular dysfunction associated with sustained exposure to hyperlipidemia following lung transplantation.
Topics: Anticholesteremic Agents; Arteriosclerosis; Cholesterol; Cholestyramine Resin; Echocardiography; Female; Follow-Up Studies; Gemfibrozil; Humans; Hypercholesterolemia; Hyperlipidemias; Hyperlipoproteinemias; Hypertriglyceridemia; Hypolipidemic Agents; Immunosuppressive Agents; Lipids; Lipoproteins, HDL; Lipoproteins, LDL; Lovastatin; Lung Transplantation; Male; Middle Aged; Myocardial Ischemia; Probucol; Radionuclide Angiography; Retrospective Studies; Triglycerides; Ventricular Dysfunction, Left; Ventricular Function, Left | 1997 |
Interactions of platelets, macrophages, and lipoproteins in hypercholesterolemia: antiatherogenic effects of HMG-CoA reductase inhibitor therapy.
Topics: Adult; Aged; Animals; Anticholesteremic Agents; Blood Platelets; Cell Communication; Fatty Acids, Monounsaturated; Fluvastatin; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Indoles; Lipid Peroxidation; Lipoproteins; Lipoproteins, LDL; Lovastatin; Macrophages; Mice; Middle Aged; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors | 1998 |
A retrospective drug utilization evaluation of antihyperlipidaemic agents in a medical centre in Taiwan.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anticholesteremic Agents; Child; Drug Monitoring; Drug Prescriptions; Drug Utilization; Female; Guidelines as Topic; Humans; Hypercholesterolemia; Insurance, Health; Lovastatin; Male; Middle Aged; Pravastatin; Random Allocation; Retrospective Studies; Taiwan | 1997 |
Lack of interaction of apolipoprotein E phenotype with the lipoprotein response to lovastatin or gemfibrozil in patients with primary hypercholesterolemia.
Topics: Adult; Aged; Anticholesteremic Agents; Apolipoproteins E; Data Interpretation, Statistical; Drug Interactions; Female; Gemfibrozil; Humans; Hypercholesterolemia; Hyperlipidemias; Hypolipidemic Agents; Lipoproteins; Lovastatin; Male; Middle Aged; Phenotype; Polymorphism, Genetic | 1998 |
Reducing expenditures for statin-type lipid-lowering agents.
Topics: Cost Control; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Hyperlipidemias; Hypolipidemic Agents; Lovastatin; Managed Care Programs; United States | 1998 |
Insulin-mediated venodilation is impaired in patients with high cholesterol.
Topics: Adult; Aged; Analysis of Variance; Anticholesteremic Agents; Cholesterol; Cholesterol, LDL; Endothelium, Vascular; Female; Hand; Humans; Hypercholesterolemia; Insulin; Lovastatin; Male; Middle Aged; Nitroprusside; Norepinephrine; Regression Analysis; Ultrasonography; Vasoconstrictor Agents; Vasodilation; Vasodilator Agents; Veins | 1998 |
Do you need cholesterol-lowering drugs?
Topics: Anticholesteremic Agents; Humans; Hypercholesterolemia; Lovastatin | 1998 |
Comparative dose efficacy study of atorvastatin versus simvastatin, pravastatin, lovastatin, and fluvastatin in patients with hypercholesterolemia (the CURVES study)
Topics: Anticholesteremic Agents; Atorvastatin; Cholesterol; Dose-Response Relationship, Drug; Fatty Acids, Monounsaturated; Fluvastatin; Heptanoic Acids; Humans; Hypercholesterolemia; Indoles; Lovastatin; Pravastatin; Pyrroles; Randomized Controlled Trials as Topic; Simvastatin; Treatment Outcome | 1998 |
[Lipid lowering: myth or therapeutic necessity?].
Topics: Coronary Disease; Humans; Hypercholesterolemia; Hyperlipidemias; Hypolipidemic Agents; Lipoproteins, HDL; Lipoproteins, LDL; Lovastatin; Pyridines; Risk Factors | 1998 |
Lovastatin maintains nitric oxide--but not EDHF-mediated endothelium-dependent relaxation in the hypercholesterolemic rabbit carotid artery.
Topics: Acetylcholine; Animals; Anticholesteremic Agents; Biological Factors; Carotid Arteries; Cholesterol; Enzyme Inhibitors; Hypercholesterolemia; In Vitro Techniques; Lovastatin; Male; Nitric Oxide; Nitroarginine; Rabbits; Vasodilation; Vasodilator Agents | 1999 |
"Care," cancer and coenzyme Q10.
Topics: Aging; Biomarkers, Tumor; Breast Neoplasms; Coenzymes; Cytoprotection; Female; Humans; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Incidence; Lovastatin; Postmenopause; Ubiquinone | 1999 |
Effects of LY295427, a low-density lipoprotein (LDL) receptor up-regulator, on LDL receptor gene transcription and cholesterol metabolism in normal and hypercholesterolemic hamsters.
Topics: Acetates; Animals; Anticholesteremic Agents; Cholestanols; Cholesterol; Cholesterol, Dietary; Cholesterol, LDL; Coconut Oil; Cocos; Cricetinae; Dietary Fats; Homeostasis; Hypercholesterolemia; Intestinal Absorption; Liver; Lovastatin; Male; Mesocricetus; Plant Oils; Receptors, LDL; RNA, Messenger; Up-Regulation | 1999 |
Immunoadsorption and dextran sulfate cellulose LDL-apheresis for severe hypercholesterolemia: the Rogosin Institute experience 1982-1992.
Topics: Adult; Aged; Blood Component Removal; Child; Cholesterol; Cholesterol, LDL; Cholestyramine Resin; Coronary Disease; Dextran Sulfate; Humans; Hypercholesterolemia; Immunosorbent Techniques; Lovastatin; Middle Aged; Niacin; Pilot Projects | 1993 |
Cost-effectiveness of simvastatin versus cholestyramine: results for Sweden.
Topics: Adult; Cholestyramine Resin; Coronary Disease; Cost Savings; Cost-Benefit Analysis; Health Care Costs; Humans; Hypercholesterolemia; Life Expectancy; Lovastatin; Male; Middle Aged; Multivariate Analysis; Sweden | 1992 |
By the way, doctor. I have high cholesterol, and have been taking Mevacor (lovastatin) for two years. Recently, I was switched to Pravachol (pravastatin) because my insurance company would no longer pay for Mevacor. Is it as good?
Topics: Anticholesteremic Agents; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Lovastatin; Pravastatin | 1999 |
L-arginine supplementation in hypercholesterolemic rabbits normalizes leukocyte adhesion to non-endothelial matrix.
Topics: Animals; Arginine; Cell Adhesion; Hypercholesterolemia; Leukocytes; Lovastatin; Male; Rabbits; Vitamin E | 2000 |
Which statin is most efficient for the treatment of hypercholesterolemia? A cost-effectiveness analysis.
Topics: Administration, Oral; Algorithms; Cholesterol, LDL; Cost-Benefit Analysis; Dose-Response Relationship, Drug; Fatty Acids, Monounsaturated; Female; Fluvastatin; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Indoles; Lovastatin; Male; Middle Aged; Models, Economic; Pravastatin; Simvastatin; Treatment Outcome | 1999 |
On call. I am 58 years old. I've always been healthy, but my doctor found that my cholesterol was 279. He prescribed Mevacor, and my cholesterol came down to 210. Do I still need to be on a low-fat diet?
Topics: Anticholesteremic Agents; Dietary Fats; Humans; Hypercholesterolemia; Lovastatin | 2000 |
A need to redefine the consensus on the use of statins in coronary heart disease prevention.
Topics: Anticholesteremic Agents; Cholesterol; Clinical Trials as Topic; Coronary Disease; Humans; Hypercholesterolemia; Lovastatin; Practice Guidelines as Topic; Pravastatin | 2000 |
Development of tachyphylaxis among patients taking HMG CoA reductase inhibitors.
Topics: Atorvastatin; Cholesterol, LDL; Fatty Acids, Monounsaturated; Fluvastatin; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Indoles; Least-Squares Analysis; Linear Models; Lovastatin; Nonlinear Dynamics; Pravastatin; Pyrroles; Retrospective Studies; Simvastatin; Tachyphylaxis; Time Factors | 2000 |
Effect of preoperative statin therapy and cardiac outcomes after coronary artery bypass grafting.
Topics: Aged; Anticholesteremic Agents; Arrhythmias, Cardiac; Atorvastatin; Cause of Death; Coronary Artery Bypass; Coronary Disease; Female; Heart Failure; Heptanoic Acids; Humans; Hypercholesterolemia; Incidence; Lovastatin; Male; Middle Aged; Multivariate Analysis; Myocardial Infarction; Preoperative Care; Pyrroles; Recurrence; Retrospective Studies; Risk Factors; Simvastatin; Stroke; Treatment Outcome | 2000 |
Are statins right for you?
Topics: Anticholesteremic Agents; Cholesterol; Coronary Disease; Humans; Hypercholesterolemia; Lovastatin; United States | 2000 |
Is a statin a statin?
Topics: Anticholesteremic Agents; Humans; Hypercholesterolemia; Lipoproteins, HDL; Lipoproteins, LDL; Lovastatin; Pravastatin; Simvastatin | 2001 |
Statins are magic when you gotta have heart.
Topics: Anticholesteremic Agents; Cholesterol, HDL; Cholesterol, LDL; Drug Costs; Humans; Hypercholesterolemia; Lovastatin; United States | 2001 |
Statins and dementia.
Topics: Anticholesteremic Agents; Cognition; Cognition Disorders; Dose-Response Relationship, Drug; Humans; Hypercholesterolemia; Lovastatin; Pravastatin; Randomized Controlled Trials as Topic; Selection Bias; Simvastatin | 2001 |
Cholesterol-lowering drugs. Some drugs with demonstrated efficacy but different benefits in primary and secondary prevention.
Topics: Anticholesteremic Agents; Bezafibrate; Cholestyramine Resin; Clinical Trials as Topic; Clofibrate; Female; Gemfibrozil; Humans; Hypercholesterolemia; Lovastatin; Male; Myocardial Infarction; Pravastatin; Treatment Outcome | 1999 |
The synergistic hypocholesterolemic activity of the potent cholesterol absorption inhibitor, ezetimibe, in combination with 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitors in dogs.
Topics: Animals; Anticholesteremic Agents; Azetidines; Cholesterol; Cholesterol, Dietary; Dogs; Drug Combinations; Drug Synergism; Ezetimibe; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Liver; Lovastatin; Male; Pravastatin; Simvastatin; Time Factors | 2001 |
Naringin has an antiatherogenic effect with the inhibition of intercellular adhesion molecule-1 in hypercholesterolemic rabbits.
Topics: Animals; Anticholesteremic Agents; Aorta, Thoracic; Arteriosclerosis; Cholesterol; Cholesterol, HDL; Diet, Atherogenic; Flavanones; Flavonoids; Foam Cells; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Immunohistochemistry; Intercellular Adhesion Molecule-1; Liver; Lovastatin; Male; Rabbits; Time Factors; Triglycerides | 2001 |
3-hydroxy-3-methylglutaryl-coenzyme a reductase inhibitors reduce human pancreatic cancer cell invasion and metastasis.
Topics: Adenocarcinoma; Animals; Cell Division; Cell Membrane; Cytosol; Epidermal Growth Factor; Fatty Acids, Monounsaturated; Fluvastatin; Humans; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Indoles; Liver Neoplasms, Experimental; Lovastatin; Mice; Mice, Nude; Neoplasm Invasiveness; Pancreatic Neoplasms; rhoA GTP-Binding Protein; Tumor Cells, Cultured | 2002 |
Goals of statin conversion program.
Topics: Anticholesteremic Agents; Drug Utilization; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Lovastatin; Simvastatin | 2002 |
Effects of ML-236B on cholesterol metabolism in mice and rats: lack of hypocholesterolemic activity in normal animals.
Topics: Animals; Anticholesteremic Agents; Bile Acids and Salts; Cholesterol; Cholesterol, Dietary; Feces; Hydroxymethylglutaryl CoA Reductases; Hypercholesterolemia; Hyperlipidemias; Liver; Lovastatin; Male; Mice; Naphthalenes; Polyethylene Glycols; Rats; Species Specificity; Sterols | 1979 |
[Effect of lovastatin on platelet function in hypercholesterolemic patients].
Topics: Adult; Aged; Blood Platelets; Cholesterol, HDL; Female; Humans; Hypercholesterolemia; Lovastatin; Male; Middle Aged; Platelet Aggregation | 1992 |
Long-term therapy with high-dose simvastatin does not affect adrenocortical and gonadal hormones in hypercholesterolemic patients.
Topics: Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Anticholesteremic Agents; Apolipoprotein A-I; Apolipoproteins B; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Estradiol; Female; Follicle Stimulating Hormone; Follow-Up Studies; Humans; Hypercholesterolemia; Lovastatin; Luteinizing Hormone; Male; Middle Aged; Progesterone; Simvastatin; Testosterone; Triglycerides | 1992 |
An overview: long-term tolerability of lovastatin and simvastatin.
Topics: Anticholesteremic Agents; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Lovastatin; Male; Middle Aged; Simvastatin | 1992 |
Cholesterol inhibition, cancer, and chemotherapy.
Topics: Adjuvants, Pharmaceutic; Animals; Antineoplastic Agents; Cholesterol; Dogs; Drug Evaluation, Preclinical; Humans; Hydroxymethylglutaryl CoA Reductases; Hypercholesterolemia; Lovastatin; Mevalonic Acid; Mice; Neoplasms; Neoplasms, Experimental; Rats | 1992 |
Simvastatin use in children.
Topics: Adolescent; Anticholesteremic Agents; Child; Child, Preschool; Humans; Hypercholesterolemia; Lovastatin; Simvastatin | 1992 |
Treatment of hypercholesterolaemia in children.
Topics: Child; Cholestyramine Resin; Female; Humans; Hypercholesterolemia; Lovastatin; Male | 1992 |
Effect of simvastatin in CAPD patients with hypercholesterolemia.
Topics: Anticholesteremic Agents; Female; Humans; Hypercholesterolemia; Lovastatin; Male; Middle Aged; Peritoneal Dialysis, Continuous Ambulatory; Simvastatin | 1992 |
Lovastatin in the treatment of hypercholesterolemia in CAPD.
Topics: Adult; Aged; Female; Humans; Hypercholesterolemia; Lovastatin; Middle Aged; Peritoneal Dialysis, Continuous Ambulatory | 1992 |
Effect of lovastatin on hypercholesterolemia in chronic renal failure.
Topics: Animals; Blood Urea Nitrogen; Cholesterol; Hydroxymethylglutaryl CoA Reductases; Hypercholesterolemia; Kidney Failure, Chronic; Lovastatin; Mice; Mice, Inbred C57BL | 1992 |
The cholesterol controversy.
Topics: Coronary Disease; Humans; Hypercholesterolemia; Lovastatin | 1992 |
Using changes in attributable risk to predict long-term efficacy of simvastatin treatment.
Topics: Adult; Anticholesteremic Agents; Cholesterol; Coronary Disease; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Lovastatin; Male; Middle Aged; Risk Factors; Simvastatin | 1992 |
[The effect of lovastatin in the treatment of primary hypercholesterolemia].
Topics: Adult; Aged; Apolipoproteins B; Child; Cholesterol; Cholesterol, LDL; Female; Humans; Hypercholesterolemia; Lovastatin; Male; Middle Aged | 1992 |
[Effects of lovastatin (mevacor) on platelet function in hypercholesterolemia in patients with ischemic heart disease].
Topics: Adult; Blood Platelets; Cholesterol; Coronary Disease; Humans; Hypercholesterolemia; Lovastatin; Male; Middle Aged; Platelet Aggregation; Time Factors | 1992 |
3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitor simvastatin and the human lens. Clinical results of a 3-year follow-up.
Topics: Adult; Aged; Cataract; Cholesterol; Cholesterol, HDL; Female; Follow-Up Studies; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Lens, Crystalline; Lovastatin; Male; Middle Aged; Simvastatin; Triglycerides | 1992 |
Efficacy and tolerability of medium-term treatment with simvastatin in primary hypercholesterolaemia.
Topics: Adult; Aged; Anticholesteremic Agents; Cholesterol; Cholesterol, LDL; Enzymes; Female; Humans; Hypercholesterolemia; Lovastatin; Male; Middle Aged; Simvastatin; Triglycerides | 1992 |
3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors. 9. The synthesis and biological evaluation of novel simvastatin analogs.
Topics: Administration, Oral; Animals; Anticholesteremic Agents; Disease Models, Animal; Dogs; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Lovastatin; Magnetic Resonance Spectroscopy; Rats; Simvastatin; Structure-Activity Relationship | 1992 |
Effect of simvastatin on qualitative and quantitative changes of lipoprotein metabolism in CAPD patients.
Topics: Adult; Aged; Cholesterol; Cholesterol, LDL; Cholesterol, VLDL; Dose-Response Relationship, Drug; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Lipoproteins; Lovastatin; Male; Middle Aged; Peritoneal Dialysis, Continuous Ambulatory; Radioimmunoassay; Simvastatin | 1992 |
Subcutaneous administration of HMG-CoA reductase inhibitors in hyperlipidaemic and normal rats.
Topics: Administration, Oral; Animals; Anticholesteremic Agents; Female; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Infusion Pumps, Implantable; Injections, Subcutaneous; Lovastatin; Pravastatin; Rats; Rats, Mutant Strains; Rats, Sprague-Dawley; Simvastatin | 1992 |
Effect of lovastatin on lipoprotein fluidity in patients with hypercholesterolaemia.
Topics: Adult; Aged; Chemical Phenomena; Chemistry, Physical; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Cholesterol, VLDL; Diphenylhexatriene; Female; Fluorescence Polarization; Humans; Hypercholesterolemia; Lipoproteins; Lovastatin; Male; Middle Aged; Temperature | 1992 |
Reduction of plasma cholesterol by lovastatin normalizes erythrocyte membrane fluidity in patients with severe hypercholesterolaemia.
Topics: Adult; Aged; Cholesterol; Cholesterol, LDL; Erythrocyte Deformability; Erythrocyte Membrane; Female; Humans; Hypercholesterolemia; Lipids; Lovastatin; Male; Middle Aged | 1992 |
Possible mechanism and treatment of o,p'DDD-induced hypercholesterolaemia.
Topics: Adult; Aged; Anticholesteremic Agents; Cholesterol; Cushing Syndrome; Cytochrome P-450 Enzyme System; Female; Humans; Hypercholesterolemia; Lipids; Lovastatin; Male; Mevalonic Acid; Middle Aged; Mitotane; Simvastatin | 1992 |
Influence of age and gender on the plasma profiles of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitory activity following multiple doses of lovastatin and simvastatin.
Topics: Adult; Aged; Aging; Female; Humans; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Lovastatin; Male; Sex Characteristics; Simvastatin | 1992 |
[Mid-term clinical study of the effectiveness of and tolerability to simvastatin ++ in dyslipidemic patients].
Topics: Adult; Aged; Cholesterol; Female; Humans; Hypercholesterolemia; Hypolipidemic Agents; Lovastatin; Male; Middle Aged; Simvastatin; Triglycerides | 1992 |
[Diabetes mellitus, hypercholesterolemia, and therapeutic prospects with simvastatin. General considerations and personal contribution].
Topics: Adult; Anticholesteremic Agents; Cholesterol; Diabetes Mellitus, Type 2; Female; Humans; Hypercholesterolemia; Lovastatin; Male; Middle Aged; Simvastatin; Triglycerides | 1992 |
Lupuslike syndrome associated with simvastatin.
Topics: Aged; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Lovastatin; Lupus Erythematosus, Systemic; Simvastatin | 1992 |
Short- and long-term effects of lovastatin and pravastatin alone and in combination with cholestyramine on serum lipids, lipoproteins and apolipoproteins in primary hypercholesterolaemia.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Apolipoproteins; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Cholesterol, VLDL; Cholestyramine Resin; Drug Therapy, Combination; Female; Humans; Hypercholesterolemia; Lipids; Lipoproteins; Lovastatin; Male; Middle Aged; Pravastatin; Time Factors; Triglycerides | 1992 |
[Simvastatin-induced hepatitis].
Topics: Anticholesteremic Agents; Chemical and Drug Induced Liver Injury; Humans; Hypercholesterolemia; Lovastatin; Male; Middle Aged; Simvastatin | 1992 |
Clinical investigation on the hypolipidemic effect of simvastatin in primary hypercholesterolemia.
Topics: Anticholesteremic Agents; Capsules; Drug Evaluation; Fasting; Humans; Hypercholesterolemia; Lipids; Lovastatin; Simvastatin; Time Factors | 1992 |
Lovastatin-induced hepatitis.
Topics: Chemical and Drug Induced Liver Injury; Female; Humans; Hypercholesterolemia; Lovastatin; Middle Aged | 1992 |
Cataracts by lipid lowering drugs? Three different HMG-CoA reductase inhibitors studied in hypercholesterolemic rabbits.
Topics: Animals; Anticholesteremic Agents; Cataract; Cholesterol; Female; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Lipids; Lovastatin; Pravastatin; Rabbits; Simvastatin | 1992 |
Increased thromboxane biosynthesis in type IIa hypercholesterolemia.
Topics: Adult; Aged; Anticholesteremic Agents; Aspirin; Blood Platelets; Dose-Response Relationship, Drug; Female; Humans; Hypercholesterolemia; Lovastatin; Male; Middle Aged; Simvastatin; Thromboxane A2 | 1992 |
Pravastatin, simvastatin, and lovastatin for lowering serum cholesterol concentrations.
Topics: Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Lovastatin; Pravastatin; Simvastatin | 1992 |
[Simvastatin in the treatment of hypercholesterolemia in the aged. An epidemiological and clinical study].
Topics: Adult; Age Factors; Aged; Anticholesteremic Agents; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Female; Follow-Up Studies; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Lovastatin; Male; Middle Aged; Risk Factors; Simvastatin; Time Factors; Triglycerides | 1992 |
Lovastatin in the treatment of hypercholesterolemia in nephrotic syndrome due to diabetic nephropathy stage IV-V.
Topics: Adult; Aged; Cholesterol; Creatinine; Diabetic Nephropathies; Female; Humans; Hypercholesterolemia; Lovastatin; Male; Middle Aged; Nephrotic Syndrome; Triglycerides | 1992 |
Interaction between fibre and lovastatin.
Topics: Cholesterol, LDL; Dietary Fiber; Drug Interactions; Female; Humans; Hypercholesterolemia; Lovastatin; Middle Aged; Pectins | 1991 |
Simvastatin and side effects.
Topics: Adult; Aged; Anticholesteremic Agents; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Lovastatin; Male; Middle Aged; Simvastatin; Surveys and Questionnaires | 1991 |
[Quality of treatment in hypercholesterolemia in ambulatory patients].
Topics: Adult; Anticholesteremic Agents; Cholesterol, Dietary; Cohort Studies; Decision Making; Female; Humans; Hypercholesterolemia; Long-Term Care; Lovastatin; Male; Middle Aged; Simvastatin | 1991 |
[Simvastatin-induced acute pancreatitis: two cases].
Topics: Acute Disease; Adult; Aged; Anticholesteremic Agents; Humans; Hypercholesterolemia; Lovastatin; Male; Pancreatitis; Simvastatin | 1991 |
[A new case of simvastatin-induced acute pancreatitis].
Topics: Acute Disease; Anticholesteremic Agents; Female; Humans; Hypercholesterolemia; Lovastatin; Middle Aged; Pancreatitis; Simvastatin | 1991 |
Response to cholesterol-lowering drugs in familial defective apolipoprotein B-100.
Topics: Adult; Aged; Anticholesteremic Agents; Apolipoprotein B-100; Apolipoproteins B; Apolipoproteins E; Cholesterol; Cholesterol, LDL; Cholestyramine Resin; Drug Therapy, Combination; Female; Heterozygote; Humans; Hypercholesterolemia; Lovastatin; Male; Middle Aged; Phenotype; Simvastatin; Triglycerides | 1991 |
Effect of lovastatin on intimal hyperplasia after balloon angioplasty: a study in an atherosclerotic hypercholesterolemic rabbit.
Topics: Angioplasty, Balloon; Animals; Arteriosclerosis; Femoral Artery; Hypercholesterolemia; Hyperplasia; Lovastatin; Male; Muscle, Smooth, Vascular; Rabbits; Recurrence | 1991 |
[Simvastatin in the treatment of hypercholesterolemia].
Topics: Aged; Anticholesteremic Agents; Blood Pressure; Cholesterol; Drug Evaluation; Eye; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Hyperlipoproteinemia Type II; Lovastatin; Male; Middle Aged; Simvastatin; Triglycerides | 1991 |
[Personal experience with lovastatin, a HMG-CoA reductase inhibitor (Mevacor, MSD) in the treatment of hypercholesterolemia].
Topics: Female; Humans; Hypercholesterolemia; Lipids; Lovastatin; Male; Middle Aged | 1991 |
Hypercholesterolemia: new findings and clinical applications. Introduction.
Topics: Cholesterol, LDL; Humans; Hypercholesterolemia; Lovastatin; Triparanol | 1991 |
Hypercholesterolemia: new findings and clinical applications. Proceedings of a symposium. April 25, 1990, Chicago, Illinois.
Topics: Humans; Hypercholesterolemia; Lovastatin | 1991 |
Effect of simvastatin treatment on the dyslipoproteinemia in CAPD patients.
Topics: Adult; Aged; Apolipoproteins; Cholesterol; Female; Humans; Hydroxymethylglutaryl CoA Reductases; Hypercholesterolemia; Lipoproteins; Lovastatin; Male; Middle Aged; Peritoneal Dialysis, Continuous Ambulatory; Simvastatin; Triglycerides | 1991 |
Cost-effectiveness of HMG-CoA reductase inhibition for primary and secondary prevention of coronary heart disease.
Topics: Adult; Aged; Aged, 80 and over; Cholesterol; Coronary Disease; Cost-Benefit Analysis; Female; Humans; Hypercholesterolemia; Lovastatin; Male; Middle Aged; Primary Prevention; Sensitivity and Specificity | 1991 |
Pravastatin and simvastatin for hypercholesterolemia.
Topics: Anticholesteremic Agents; Chemical and Drug Induced Liver Injury; Clinical Trials as Topic; Drug Therapy, Combination; Heptanoic Acids; Humans; Hypercholesterolemia; Lovastatin; Muscular Diseases; Naphthalenes; Pravastatin; Simvastatin | 1991 |
An economic evaluation of lovastatin for cholesterol lowering and coronary artery disease reduction.
Topics: Adult; Age Factors; Cholesterol; Coronary Disease; Cost-Benefit Analysis; Costs and Cost Analysis; Disability Evaluation; Evaluation Studies as Topic; Fees, Medical; Female; Humans; Hypercholesterolemia; Life Expectancy; Lovastatin; Male; Middle Aged; Risk Factors; Sensitivity and Specificity; Smoking; Value of Life | 1991 |
Hypercholesterolaemia: simvastatin and pravastatin alter cholesterol metabolism by different mechanisms.
Topics: Adult; Aged; Anticholesteremic Agents; Cholesterol; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hydroxymethylglutaryl-CoA-Reductases, NADP-dependent; Hypercholesterolemia; Leukocytes; Lovastatin; Middle Aged; Naphthalenes; Pravastatin; Simvastatin | 1991 |
[Cost-effectiveness of lowering of blood cholesterol using simvastatin and cholestyramine].
Topics: Adult; Age Factors; Anticholesteremic Agents; Cholestyramine Resin; Cost-Benefit Analysis; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Lovastatin; Male; Middle Aged; Netherlands; Sex Factors; Simvastatin | 1991 |
Comparison of different HMG-CoA reductase inhibitors.
Topics: Anticholesteremic Agents; Apolipoproteins; Cholesterol, HDL; Female; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Lipids; Lovastatin; Male; Middle Aged; Naphthalenes; Pravastatin; Simvastatin; Triglycerides | 1991 |
Simvastatin.
Topics: Anticholesteremic Agents; Contraindications; Drug Interactions; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Lovastatin; Pregnancy; Simvastatin | 1991 |
[Lovastatin in the treatment of primary hypercholesterolemia].
Topics: Adult; Aged; Apolipoproteins B; Humans; Hypercholesterolemia; Hyperlipoproteinemia Type II; Lipoproteins; Lovastatin; Male; Middle Aged; Triglycerides | 1991 |
Effect of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibition on human gut mucosa.
Topics: Anticholesteremic Agents; Cell Division; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Intestinal Mucosa; Jejunum; Lovastatin; Male; Middle Aged; Mitotic Index; Simvastatin | 1991 |
Cholesterol-lowering effects of a 10 mg daily dose of lovastatin in patients with initial total cholesterol levels 200 to 240 mg/dl (5.18 to 6.21 mmol/liter).
Topics: Cholesterol; Cholesterol, LDL; Coronary Disease; Drug Administration Schedule; Female; Humans; Hypercholesterolemia; Lovastatin; Male; Risk Factors | 1991 |
Proteinuria as complication of simvastatin treatment.
Topics: Albuminuria; Anticholesteremic Agents; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Lovastatin; Male; Proteinuria; Simvastatin; Transferrin | 1990 |
Cholesterol-lowering simvastatin achieves listing as a pharmaceutical benefit.
Topics: Adult; Anticholesteremic Agents; Humans; Hypercholesterolemia; Lovastatin; Middle Aged; Pharmacopoeias as Topic; Simvastatin | 1991 |
[Simvastatin: a new drug responsible for acute pancreatitis?].
Topics: Acute Disease; Anticholesteremic Agents; Humans; Hypercholesterolemia; Lovastatin; Male; Middle Aged; Pancreatitis; Simvastatin | 1991 |
Lovastatin and nephrotic syndrome.
Topics: Adult; Humans; Hypercholesterolemia; Lovastatin; Male; Nephrotic Syndrome; Recurrence; Remission Induction | 1991 |
Low density lipoprotein density and composition in hypercholesterolaemic men treated with HMG CoA reductase inhibitors and gemfibrozil.
Topics: Adult; Gemfibrozil; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Hyperlipoproteinemia Type II; Lipoproteins, LDL; Lovastatin; Male; Middle Aged; Simvastatin | 1991 |
[The problem of hypercholesterolemia in the aged].
Topics: Adult; Age Factors; Aged; Aged, 80 and over; Anticholesteremic Agents; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Lovastatin; Male; Middle Aged; Simvastatin | 1990 |
No lens changes caused by simvastatin results from a prospective drug safety study.
Topics: Adult; Aged; Cataract; Drug Evaluation; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Intraocular Pressure; Lens, Crystalline; Lovastatin; Male; Middle Aged; Photography; Prospective Studies; Simvastatin; Visual Acuity | 1990 |
Silent myocardial ischemia--classification and management.
Topics: Angina Pectoris; Atenolol; Drug Therapy, Combination; Heart Function Tests; Hemodynamics; Humans; Hypercholesterolemia; Lovastatin; Male; Middle Aged; Myocardial Infarction; Nifedipine; Risk Factors | 1990 |
Comparative effects of simvastatin (MK-733) and pravastatin (CS-514) on hypercholesterolemia induced by cholesterol feeding in rabbits.
Topics: Animals; Bile; Cholesterol; Cholesterol, Dietary; Heptanoic Acids; Hypercholesterolemia; Lipoproteins; Lipoproteins, LDL; Lovastatin; Male; Microsomes, Liver; Naphthalenes; Pravastatin; Rabbits; Receptors, LDL; Simvastatin; Statistics as Topic; Sterol O-Acyltransferase | 1990 |
Effects of long-term treatment with simvastatin on plasma lipids and lipoproteins in patients with primary hypercholesterolemia.
Topics: Adult; Aged; Anticholesteremic Agents; Cholesterol, HDL; Cholesterol, LDL; Cholesterol, VLDL; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Hyperlipoproteinemia Type II; Lipids; Lipoproteins; Lovastatin; Male; Middle Aged; Simvastatin; Triglycerides | 1990 |
Effects of lovastatin in diabetic patients treated with chlorpropamide.
Topics: Acyl Coenzyme A; Administration, Oral; Apolipoproteins B; Blood Glucose; Chlorpropamide; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Diabetes Mellitus, Type 2; Female; Humans; Hypercholesterolemia; Lipoproteins, VLDL; Lovastatin; Male; Middle Aged; Time Factors | 1990 |
Lovastatin. Warfarin interaction.
Topics: Atrial Fibrillation; Drug Interactions; Epistaxis; Gastrointestinal Hemorrhage; Hematuria; Humans; Hypercholesterolemia; Hypoprothrombinemias; Intracranial Embolism and Thrombosis; Lovastatin; Male; Middle Aged; Warfarin | 1990 |
[The effects of the cholesterol synthesis inhibitor simvastatin in patients with hypercholesterolemia with and without diabetes mellitus].
Topics: Anticholesteremic Agents; Cholesterol; Diabetes Complications; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Lovastatin; Male; Middle Aged; Simvastatin | 1990 |
Lovastatin decreases coenzyme Q levels in humans.
Topics: Adolescent; Cardiac Output; Coronary Disease; Female; Humans; Hypercholesterolemia; Lovastatin; Male; Middle Aged; Myocardial Contraction; Stroke Volume; Ubiquinone | 1990 |
Effects of therapy with diet and simvastatin on atherosclerosis in hypercholesterolemic patients.
Topics: Adult; Aged; Anticholesteremic Agents; Combined Modality Therapy; Coronary Angiography; Coronary Artery Disease; Female; Follow-Up Studies; Humans; Hypercholesterolemia; Lovastatin; Male; Middle Aged; Simvastatin | 1990 |
[Lovastatin. A new drug for the treatment of hypercholesterolemia].
Topics: Adult; Aged; Cholesterol; Female; Humans; Hypercholesterolemia; Lovastatin; Male; Middle Aged | 1990 |
[New perspectives in the control of hypercholesterolemia with the use of HMG CoA reductase inhibitors].
Topics: Cholesterol; Cholesterol, LDL; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Hyperlipoproteinemia Type II; Lovastatin | 1990 |
[Simvastatin (MK-733), a new HMG-CoA reductase inhibitor, in the treatment of hypercholesterolemia in elderly patients with atherosclerosis].
Topics: Aged; Alanine Transaminase; Arteriosclerosis; Cholesterol; Cholesterol, LDL; Creatine Kinase; Female; Humans; Hydroxymethylglutaryl CoA Reductases; Hypercholesterolemia; Lipids; Lovastatin; Male; Simvastatin | 1990 |
Lovastatin ameliorates the development of glomerulosclerosis and uremia in experimental nephrotic syndrome.
Topics: Animals; Blood Urea Nitrogen; Cholesterol; Female; Glomerulonephritis; Glomerulosclerosis, Focal Segmental; Hypercholesterolemia; Kidney Glomerulus; Lovastatin; Nephrotic Syndrome; Rats; Rats, Inbred Strains; Uremia | 1990 |
The politics of cholesterol lowering drugs.
Topics: Anticholesteremic Agents; Humans; Hypercholesterolemia; Lovastatin; Middle Aged; New Zealand; Politics; Simvastatin | 1990 |
Simvastatin therapy for hypercholesterolaemia in patients with coronary heart disease.
Topics: Anticholesteremic Agents; Cholesterol; Cholesterol, LDL; Coronary Disease; Drug Tolerance; Female; Humans; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Lovastatin; Male; Middle Aged; Placebos; Simvastatin; Single-Blind Method; Triglycerides | 1990 |
Decreased mitogenic activity in hypercholesterolaemic plasma.
Topics: Adult; Aged; Animals; Anticholesteremic Agents; Apolipoproteins B; Cells, Cultured; Cholesterol; DNA; Female; Humans; Hypercholesterolemia; Lipoproteins; Lovastatin; Male; Middle Aged; Mitogens; Muscle, Smooth, Vascular; Rats; Simvastatin | 1990 |
Myopathy and rhabdomyolysis associated with lovastatin-gemfibrozil combination therapy.
Topics: Acute Kidney Injury; Adult; Aged; Creatine Kinase; Drug Interactions; Drug Therapy, Combination; Female; Gemfibrozil; Humans; Hypercholesterolemia; Lovastatin; Male; Middle Aged; Muscular Diseases; Rhabdomyolysis | 1990 |
Effects of lovastatin therapy on LDL receptor activity in circulating monocytes and on structure and composition of plasma lipoproteins.
Topics: Apolipoproteins; Centrifugation, Zonal; Humans; Hypercholesterolemia; Hyperlipoproteinemia Type II; Lipids; Lipoproteins; Lovastatin; Monocytes; Receptors, LDL | 1990 |
Long-term maintenance of therapeutic response to lovastatin in patients with familial and non-familial hypercholesterolemia: a 3-year follow-up.
Topics: Adult; Aged; Cholesterol, LDL; Colestipol; Female; Follow-Up Studies; Humans; Hypercholesterolemia; Hyperlipoproteinemia Type II; Lipids; Lipoproteins; Lovastatin; Male; Middle Aged; Polyamines; Probucol; Triglycerides | 1990 |
[Maximal therapy of hypercholesterolemia in coronary heart disease].
Topics: Adult; Anticholesteremic Agents; Blood Component Removal; Cholesterol, LDL; Combined Modality Therapy; Coronary Disease; Enzyme Inhibitors; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Lovastatin; Male; Middle Aged; Plasma Exchange; Simvastatin | 1990 |
Lack of effect of lovastatin therapy on the parameters of whole-body cholesterol metabolism.
Topics: Adult; Aged; Cholesterol; Colestipol; Female; Humans; Hypercholesterolemia; Lovastatin; Male; Metabolic Clearance Rate; Middle Aged; Niacin | 1990 |
Persistent abnormalities in lipoprotein composition and cholesteryl ester transfer following lovastatin treatment.
Topics: Adult; Aged; Carrier Proteins; Cholesterol Ester Transfer Proteins; Cholesterol Esters; Female; Glycoproteins; Humans; Hypercholesterolemia; Lipoproteins; Lipoproteins, HDL; Lipoproteins, LDL; Lipoproteins, VLDL; Lovastatin; Male; Middle Aged | 1990 |
Ocular side effects of the lipid-lowering drug simvastatin? A one year follow-up.
Topics: Cataract; Cholesterol; Cholesterol, LDL; Female; Follow-Up Studies; Humans; Hypercholesterolemia; Hyperlipoproteinemia Type II; Lovastatin; Male; Middle Aged; Simvastatin | 1989 |
Lovastatin reduces postprandial lipoprotein levels in hypercholesterolaemic patients with mild hypertriglyceridaemia.
Topics: Adult; Aged; Cholesterol, LDL; Cholesterol, VLDL; Cholestyramine Resin; Drug Therapy, Combination; Female; Humans; Hypercholesterolemia; Hypertriglyceridemia; Lipoproteins; Lovastatin; Male; Middle Aged; Triglycerides | 1989 |
Suppression of lymphoid cell function in vitro by inhibition of 3-hydroxy-3-methylglutaryl coenzyme A reductase by lovastatin.
Topics: Cytotoxicity, Immunologic; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; In Vitro Techniques; Interferon-gamma; Interleukin-2; Lovastatin; Lymphocyte Activation; Lymphocytes; Mevalonic Acid; Mitogens | 1989 |
HMG CoA reductase inhibitors lower LDL cholesterol without reducing Lp(a) levels.
Topics: Adult; Aged; Anticholesteremic Agents; Cholesterol, LDL; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Lipoprotein(a); Lipoproteins; Lovastatin; Male; Middle Aged; Simvastatin | 1989 |
Effects of inhibition of cholesterol synthesis by simvastatin on the production of adrenocortical steroid hormones and ACTH.
Topics: Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Adult; Cholesterol; Female; Humans; Hydrocortisone; Hypercholesterolemia; Hypothalamo-Hypophyseal System; Insulin; Lipoproteins, HDL; Lipoproteins, LDL; Lovastatin; Male; Middle Aged; Pituitary-Adrenal System; Placebos; Simvastatin | 1989 |
Lovastatin and elevated creatine kinase: results of rechallenge.
Topics: Aged; Creatine Kinase; Female; Humans; Hypercholesterolemia; Lovastatin; Male; Middle Aged | 1989 |
Raised serum lipoprotein during treatment with lovastatin.
Topics: Humans; Hypercholesterolemia; Lipoprotein(a); Lipoproteins; Lovastatin | 1989 |
Lovastatin, isoprenes, and myopathy.
Topics: Creatine Kinase; Humans; Hypercholesterolemia; Lovastatin; Male; Middle Aged; Muscular Diseases; Ubiquinone | 1989 |
Plasma mevalonate response in lovastatin-related myopathy.
Topics: Aged; Creatine Kinase; Female; Humans; Hypercholesterolemia; Lovastatin; Male; Mevalonic Acid; Middle Aged; Muscular Diseases | 1989 |
Controlling cholesterol with drugs.
Topics: Anticholesteremic Agents; Cholestyramine Resin; Drug Therapy, Combination; Humans; Hypercholesterolemia; Lovastatin; Niacin | 1989 |
Lovastatin therapy for hypercholesterolemia in cardiac transplant recipients.
Topics: Adult; Cholesterol; Cholesterol, LDL; Female; Follow-Up Studies; Heart Transplantation; Humans; Hypercholesterolemia; Immunosuppressive Agents; Lovastatin; Male; Middle Aged; Postoperative Complications; Time Factors | 1989 |
Effect of simvastatin on plasma lipids, apolipoproteins and lipoprotein particles in patients with primary hypercholesterolaemia.
Topics: Adolescent; Adult; Aged; Anticholesteremic Agents; Apolipoproteins; Cholesterol; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Immunoenzyme Techniques; Lipoproteins; Lovastatin; Male; Middle Aged; Phospholipids; Simvastatin; Triglycerides | 1989 |
Preventive effect of MK-733 (simvastatin), an inhibitor of HMG-CoA reductase, on hypercholesterolemia and atherosclerosis induced by cholesterol feeding in rabbits.
Topics: Animals; Aorta; Arteriosclerosis; Cholesterol; Cholesterol, Dietary; Hypercholesterolemia; Lipids; Liver; Lovastatin; Male; Myocardium; Rabbits; Simvastatin | 1989 |
Simvastatin: a one-a-day treatment for hypercholesterolemia. Symposium. June 10 to 12, 1988, Pebble Beach, California.
Topics: Animals; Anticholesteremic Agents; Humans; Hypercholesterolemia; Lovastatin; Simvastatin | 1989 |
Simvastatin: the clinical profile.
Topics: Aged; Creatine Kinase; Drug Therapy, Combination; Eye; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Hyperlipoproteinemia Type II; Liver; Lovastatin; Male; Middle Aged; Simvastatin; Transaminases | 1989 |
[Lowering of the plasma lipid concentration with lovastatin. A clinical study in patients with primary hypercholesterolemia].
Topics: Adult; Aged; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Female; Humans; Hypercholesterolemia; Lipids; Lovastatin; Male; Middle Aged; Molecular Structure; Triglycerides | 1989 |
Cardiovascular effects of acute hypercholesterolemia in rabbits. Reversal with lovastatin treatment.
Topics: Animals; Cardiovascular System; Cholesterol, Dietary; Coronary Disease; Creatine Kinase; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Isoenzymes; Lovastatin; Male; Myocardium; Rabbits | 1989 |
[Efficacy and safety of simvastatin, a new cholesterol-lowering drug].
Topics: Anticholesteremic Agents; Cholesterol; Cholestyramine Resin; Drug Therapy, Combination; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Lovastatin; Male; Middle Aged; Simvastatin | 1989 |
[Type IIa dyslipoproteinemia. Effects of simvastatin and bezafibrate on atherogenic and non-atherogenic lipoprotein particles].
Topics: Bezafibrate; Humans; Hypercholesterolemia; Hyperlipoproteinemia Type II; Lipoproteins; Lovastatin; Simvastatin | 1988 |
HMG-CoA reductase inhibitors for hypercholesterolemia.
Topics: Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Lovastatin; Middle Aged | 1988 |
Low plasma lipid levels and increased cholesterol synthesis after partial ileal bypass plus lovastatin in hypercholesterolemic rabbits.
Topics: Animals; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Cholesterol, VLDL; Combined Modality Therapy; Diet; Hypercholesterolemia; Ileum; Intestinal Mucosa; Lipids; Lovastatin; Male; Rabbits | 1988 |
Unnecessary alarm about lovastatin and cataracts.
Topics: Cataract; Humans; Hypercholesterolemia; Lovastatin | 1988 |
Current and new therapy for hypercholesterolemia.
Topics: Anticholesteremic Agents; Colestipol; Gemfibrozil; Humans; Hypercholesterolemia; Lovastatin; Niacin; Probucol | 1988 |
Rhabdomyolysis and renal injury with lovastatin use. Report of two cases in cardiac transplant recipients.
Topics: Acute Kidney Injury; Adult; Creatine Kinase; Heart Transplantation; Humans; Hypercholesterolemia; Legionellosis; Lovastatin; Male; Middle Aged; Rhabdomyolysis | 1988 |
Hyperlipidemia following heart transplantation: natural history and intervention with mevinolin (lovastatin).
Topics: Adult; Anticholesteremic Agents; Cholesterol; Female; Heart Transplantation; Humans; Hypercholesterolemia; Hyperlipidemias; Lovastatin; Male; Middle Aged; Naphthalenes; Postoperative Complications; Triglycerides | 1987 |
Lovastatin to lower cholesterol levels.
Topics: Humans; Hypercholesterolemia; Lovastatin | 1988 |
Ocular examination before initiation of lovastatin (Mevacor) therapy.
Topics: Cataract; Humans; Hypercholesterolemia; Lovastatin | 1988 |
Lovastatin alone and in combination for treatment of primary hypercholesterolemia.
Topics: Adult; Aged; Anion Exchange Resins; Cholesterol, HDL; Cholesterol, LDL; Drug Therapy, Combination; Female; Humans; Hypercholesterolemia; Hyperlipoproteinemia Type II; Lovastatin; Male; Middle Aged; Niacin; Patient Compliance | 1988 |
Drug management of hypercholesterolemia.
Topics: Humans; Hypercholesterolemia; Lovastatin | 1988 |
Effects of simvastatin on plasma lipid, lipoprotein and apolipoprotein concentrations in hypercholesterolaemia.
Topics: Adult; Aged; Apolipoproteins; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Female; Humans; Hypercholesterolemia; Lipoproteins; Lovastatin; Male; Middle Aged; Simvastatin | 1988 |
Intestinal HMG-CoA reductase activity is low in hypercholesterolemic patients and is further decreased with lovastatin therapy.
Topics: Bile; Cholestyramine Resin; Female; Humans; Hydroxymethylglutaryl CoA Reductases; Hypercholesterolemia; Intestinal Mucosa; Jejunum; Lovastatin; Male; Middle Aged | 1988 |
Current pharmacologic treatment of elevated serum cholesterol.
Topics: Adult; Anticholesteremic Agents; Cholesterol; Cholesterol, LDL; Cholestyramine Resin; Clofibrate; Colestipol; Drug Tolerance; Female; Gemfibrozil; Humans; Hypercholesterolemia; Hyperlipidemias; Hyperlipoproteinemia Type II; Lovastatin; Male; Middle Aged; Naphthalenes; Neomycin; Niacin; Pentanoic Acids; Probucol; Simvastatin; Triglycerides | 1987 |
Lipoprotein fractions and receptors: a role for probucol?
Topics: Anticholesteremic Agents; Biological Transport; Cholesterol; Cholesterol, Dietary; Cholesterol, HDL; Cholesterol, LDL; Colestipol; Humans; Hydroxymethylglutaryl CoA Reductases; Hypercholesterolemia; Hyperlipoproteinemia Type II; Lipoproteins; Lipoproteins, HDL; Lipoproteins, IDL; Lipoproteins, VLDL; Lovastatin; Naphthalenes; Phenols; Probucol; Receptors, LDL | 1986 |
Comparison of six pharmacologic regimens for hypercholesterolemia.
Topics: Adult; Aged; Cholestyramine Resin; Drug Therapy, Combination; Female; Humans; Hypercholesterolemia; Hyperlipoproteinemia Type II; Lovastatin; Male; Middle Aged; Naphthalenes; Neomycin; Niacin; Retrospective Studies | 1987 |
[Treatment with mevinolin in a patient with pseudo-homozygous hypercholesterolemia].
Topics: Anticholesteremic Agents; Diagnosis, Differential; Female; Humans; Hypercholesterolemia; Hyperlipoproteinemia Type II; Lovastatin; Naphthalenes | 1987 |
Long term administration of lovastatin in the treatment of hypercholesterolaemia.
Topics: Adult; Cholesterol; Drug Administration Schedule; Female; Humans; Hypercholesterolemia; Hyperlipidemia, Familial Combined; Hyperlipoproteinemia Type II; Lipoproteins; Lovastatin; Male; Middle Aged | 1987 |
Lovastatin: cholesterol-lowering agent.
Topics: Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Cholestyramine Resin; Humans; Hypercholesterolemia; Lovastatin; Probucol | 1987 |