lovastatin and Disease Models, Animal

Topics: Animals; Blood-Brain Barrier; Brain Ischemia; Disease Models, Animal; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Ischemic Stroke; Lovastatin; Mice; Neuroprotective Agents; Rats

Topics: Animals; Brain; Disease Models, Animal; Disease Progression; Drug Repositioning; Female; History, 20th Century; Humans; Lipid Metabolism; Lovastatin; Methyl-CpG-Binding Protein 2; Mice; Mutation; Quality of Life; Rett Syndrome

Topics: Animals; Benzofurans; Bone Morphogenetic Protein 2; Caco-2 Cells; Disease Models, Animal; Dose-Response Relationship, Drug; Humans; Mice; Mice, Inbred BALB C; Molecular Structure; Osteoporosis; Ovariectomy; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Thiophenes; Zebrafish

Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Drug Evaluation, Preclinical; High-Throughput Screening Assays; Immunocompetence; Inhibitory Concentration 50; Methacycline; Mice, Inbred C57BL; Protease Inhibitors; Quantitative Structure-Activity Relationship; Small Molecule Libraries; Vero Cells; Zika Virus; Zika Virus Infection

Topics: Animals; Apoptosis; Disease Models, Animal; Female; Interleukin-10; Lovastatin; Neuroprotective Agents; Rats; Rats, Wistar; Spinal Cord; Spinal Cord Injuries; Tumor Necrosis Factor-alpha

Topics: Animals; Apoptosis; Autophagy; Brain; Brain Injuries; Cerebral Hemorrhage; Disease Models, Animal; Lovastatin; Rats; Water

Topics: Animals; Caveolin 1; Cell Movement; Cell Proliferation; Diabetic Foot; Disease Models, Animal; ErbB Receptors; Female; Humans; Keratinocytes; Lovastatin; Phenotype; Signal Transduction; Skin; Swine; Wound Healing

Topics: Animals; Anticholesteremic Agents; Auditory Threshold; Cisplatin; Cochlea; Disease Models, Animal; Evoked Potentials, Auditory, Brain Stem; Female; Hair Cells, Auditory, Outer; Hearing; Hearing Loss; Heat-Shock Proteins; Heme Oxygenase-1; Lovastatin; Male; Membrane Proteins; Mice, Inbred CBA; Ototoxicity

Topics: Animals; Biological Products; Cholesterol; Citrinin; Colitis; Disease Models, Animal; Dysbiosis; Feces; Female; Fermentation; Fermented Foods; Gastrointestinal Microbiome; Gene Expression; Inflammation; Intestines; Lactobacillus; Lipids; Lovastatin; Mice; Mice, Inbred BALB C; Monascus; NF-kappa B; Protective Agents; Salmonella typhimurium; Serogroup

Topics: Adipogenesis; Animals; Apoptosis; Disease Models, Animal; Femur Head Necrosis; Glucocorticoids; Glycerophospholipids; Linoleic Acid; Lovastatin; Magnetic Resonance Imaging; Metabolomics; Osteocytes; Rabbits; Sphingolipids

Topics: Aminoquinolines; Animals; Antibiotics, Antineoplastic; Cardiotonic Agents; Cardiotoxicity; Diastole; Disease Models, Animal; DNA Damage; Dose-Response Relationship, Drug; Doxorubicin; Electrocardiography; Lovastatin; Male; Mice, Inbred C57BL; Neuropeptides; Pyrimidines; rac1 GTP-Binding Protein; Reactive Oxygen Species; Toxicity Tests, Subacute

Topics: Angelman Syndrome; Animals; Anticonvulsants; Disease Models, Animal; Epilepsy; Female; Hippocampus; Lovastatin; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Organ Culture Techniques; Seizures; Ubiquitin-Protein Ligases

Topics: Adenosine Triphosphate; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Biomarkers; Cell Line; Cytokines; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Female; Gene Expression; Humans; Lovastatin; Mice; Mitochondria; Peroxisomes; rho-Associated Kinases; rhoA GTP-Binding Protein; Ribonucleotides; Spinal Cord

Topics: Animals; Animals, Newborn; Anticholesteremic Agents; Antiviral Agents; Basic Helix-Loop-Helix Transcription Factors; Cell Differentiation; Cells, Cultured; Cerebral Cortex; Culture Media, Conditioned; Disease Models, Animal; Filipin; Gene Expression Regulation; Lovastatin; Mice; Mice, Inbred BALB C; Mice, Transgenic; Mutation; Myelin Proteins; Myelin Sheath; Niemann-Pick C1 Protein; Niemann-Pick Disease, Type C; Oligodendrocyte Transcription Factor 2; Oligodendroglia

Topics: Animals; Behavior, Animal; Brain; Disease Models, Animal; Hydroxycholesterols; Lovastatin; Methyl-CpG-Binding Protein 2; Mice; Mice, Inbred C57BL; Rett Syndrome

Topics: Animals; Disease Models, Animal; Down-Regulation; Epilepsy; Hepatocyte Growth Factor; Hippocampus; In Situ Nick-End Labeling; Lovastatin; Male; Neuroprotective Agents; NF-E2-Related Factor 2; Pilocarpine; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Wistar; RNA, Messenger

Topics: Animals; Caspase 3; Caspase 7; Disease Models, Animal; Drug Interactions; Female; Fibric Acids; Gemfibrozil; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Mice; Mice, Inbred C57BL; Muscle, Skeletal; Real-Time Polymerase Chain Reaction; Rhabdomyolysis

Topics: Animals; Cell Survival; Cholesterol; Chondrocytes; Chondroma; Chondrosarcoma; Disease Models, Animal; Genetic Predisposition to Disease; Isocitrate Dehydrogenase; Lovastatin; Mice; Mice, Knockout; Xenograft Model Antitumor Assays

Topics: Animals; Disease Models, Animal; Exploratory Behavior; Fragile X Mental Retardation Protein; Fragile X Syndrome; Hippocampus; Learning; Lovastatin; Male; Memory; Mice; Neuronal Plasticity; Prefrontal Cortex; Rats; Recognition, Psychology; Task Performance and Analysis

Topics: Animals; Apoptosis; Brain-Derived Neurotrophic Factor; Ciliary Neurotrophic Factor; Disease Models, Animal; Epilepsy, Temporal Lobe; Glial Cell Line-Derived Neurotrophic Factor; Hippocampus; Lovastatin; Male; Nerve Growth Factors; Neurons; Neuroprotective Agents; Neurotrophin 3; Pilocarpine; Rats; Rats, Wistar

Topics: Animals; Aorta, Thoracic; Apolipoproteins E; Atherosclerosis; Diet, High-Fat; Disease Models, Animal; Dose-Response Relationship, Drug; Endothelium, Vascular; Genistein; Hyperlipidemias; Lipids; Lovastatin; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Nitrites; Vasodilation; von Willebrand Factor

Topics: Animals; Disease Models, Animal; Lovastatin; Male; Polycystic Kidney Diseases; Rats; Treatment Outcome

Topics: Analysis of Variance; Animals; Disease Models, Animal; Female; Hyaluronic Acid; Lovastatin; Peritoneal Diseases; Random Allocation; Rats; Rats, Wistar; Tissue Adhesions

Topics: Animals; Anticholesteremic Agents; Cholesterol, LDL; Disease Models, Animal; Hyperlipidemias; Liver; Lovastatin; Male; Nephrotic Syndrome; Rats; Rats, Sprague-Dawley; Receptors, LDL; Triglycerides

Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Chronic Disease; Disease Models, Animal; Excitatory Amino Acid Antagonists; Gene Expression Regulation; GTPase-Activating Proteins; Hippocampus; Hypercapnia; Hypoxia; Learning Disabilities; Lovastatin; Male; MAP Kinase Signaling System; Maze Learning; Membrane Microdomains; Memory Disorders; Neuropeptides; Nootropic Agents; Piperidines; Pulmonary Disease, Chronic Obstructive; Random Allocation; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Signal Transduction; Spatial Learning; Synaptosomes

Topics: Animals; Anticholesteremic Agents; Cytokines; Disease Models, Animal; Epilepsy; Gene Expression Regulation; Hippocampus; Lovastatin; Male; Muscarinic Agonists; Pilocarpine; Rats; Rats, Wistar; RNA, Messenger

Topics: Animals; Aorta, Thoracic; Atherosclerosis; Disease Models, Animal; Drug Carriers; Fluorescent Antibody Technique; Hyaluronic Acid; Lipoproteins, HDL; Lovastatin; Macrophages; Male; Matrix Metalloproteinase 9; Nanostructures; Particle Size; Rabbits; Static Electricity; Tissue Distribution

Topics: Achondroplasia; Animals; Bone Development; Cartilage; Cell Differentiation; Chondrocytes; Disease Models, Animal; Female; Fluorobenzenes; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Induced Pluripotent Stem Cells; Lovastatin; Male; Mice; Mice, Inbred C57BL; Phenotype; Pyrimidines; Receptor, Fibroblast Growth Factor, Type 3; Rosuvastatin Calcium; Sulfonamides; Thanatophoric Dysplasia

Topics: Animals; Disease Models, Animal; Female; Humans; Learning; Long-Term Potentiation; Lovastatin; Male; Maze Learning; Memory Disorders; Mice; Mice, 129 Strain; Mice, Inbred C57BL; Noonan Syndrome; Random Allocation; Rats; Treatment Outcome

Topics: Animals; Disease Models, Animal; Female; Humans; Learning; Long-Term Potentiation; Lovastatin; Male; Memory Disorders; Noonan Syndrome

Topics: Animals; Biomechanical Phenomena; Disease Models, Animal; Drug Delivery Systems; Drug Therapy, Combination; Female; Fracture Healing; Humans; Lovastatin; Osteoporosis, Postmenopausal; Rats; Rats, Sprague-Dawley; Tensile Strength; Tibial Fractures; Tocotrienols; Treatment Outcome; X-Ray Microtomography

Topics: 1-Methyl-4-phenylpyridinium; Animals; Aryldialkylphosphatase; Behavior, Animal; Corpus Striatum; Disease Models, Animal; Dopamine; Lipid Peroxidation; Lipid Peroxides; Lovastatin; Male; Motor Activity; Neuroprotective Agents; Parkinsonian Disorders; Rats, Wistar; Signal Transduction

Topics: Animals; Apoptosis; Cell Line; Coculture Techniques; Cytokines; Disease Models, Animal; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inflammation; Lipopolysaccharides; Lovastatin; Membrane Potential, Mitochondrial; Mevalonate Kinase Deficiency; Mevalonic Acid; Mice; Microglia; Neurons

Topics: alpha-Tocopherol; Animals; Antioxidants; Body Weight; Brain; Cell Count; Disease Models, Animal; Drinking; Eating; Exploratory Behavior; L-Lactate Dehydrogenase; Lovastatin; Male; Malondialdehyde; Maze Learning; Memory Disorders; Rats; Rats, Inbred SHR; Stroke

Topics: Animals; Antineoplastic Agents; Carcinoma in Situ; Cell Line, Tumor; Cell Proliferation; Disease Models, Animal; DNA Replication; Female; Humans; Lovastatin; Mevalonic Acid; Mice; Ovarian Neoplasms; Signal Transduction; Tumor Suppressor Protein p53

Topics: Animals; Antimalarials; Cytokines; Disease Models, Animal; Drug Synergism; Female; Heme Oxygenase-1; Inflammation; Lovastatin; Malaria, Cerebral; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Oxidative Stress; Plasmodium berghei; Vascular Endothelial Growth Factor A

Topics: Administration, Oral; Animals; Biological Availability; Biomarkers; Chemistry, Pharmaceutical; Cholesterol; Cholesterol, HDL; Disease Models, Animal; Drug Carriers; Drug Stability; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperlipidemias; Lovastatin; Male; Models, Chemical; Nanoparticles; Rats, Wistar; Solubility; Technology, Pharmaceutical

Topics: Animals; Bone Development; Disease Models, Animal; Drug Administration Routes; Drug Therapy, Combination; Estrogens; Estrogens, Conjugated (USP); Female; Fracture Healing; Gene Expression; Lovastatin; Osteoporosis; Ovariectomy; Rats; Rats, Sprague-Dawley; Tocotrienols

Topics: Animals; Disease Models, Animal; Female; Filtering Surgery; Glaucoma; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Intraocular Pressure; Lovastatin; Postoperative Care; Rabbits; Treatment Outcome; Wound Healing

Topics: Animals; Cell Cycle Proteins; Cell Proliferation; Disease Models, Animal; Estrogen Receptor alpha; Estrogen Receptor beta; Fatty Acid Synthases; Fatty Acids, Omega-3; Gene Expression; Hedgehog Proteins; Intestinal Polyps; Lactones; Lovastatin; Mice; Olive Oil; Orlistat; Proteins; RNA-Binding Proteins; Zinc Finger Protein GLI1

Topics: Animals; Blood Glucose; Cell Survival; Diabetes Complications; Diabetes Mellitus, Type 1; Disease Models, Animal; Drug Carriers; Drug Liberation; Gene Expression; Glucose; Human Umbilical Vein Endothelial Cells; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Male; Neovascularization, Physiologic; Nitrates; Nitric Oxide; Nitric Oxide Synthase Type III; Nitrites; Rats; Skin Ulcer; Tissue Scaffolds; Wound Healing

Topics: Animals; Disease Models, Animal; Endothelial Cells; GTP Cyclohydrolase; HEK293 Cells; Human Umbilical Vein Endothelial Cells; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Mice; MicroRNAs; Nitric Oxide; Nitric Oxide Synthase Type III; Rats; Risk Factors; RNA, Messenger; Up-Regulation

Topics: Animals; Anticholesteremic Agents; Autophagosomes; Autophagy; Cells, Cultured; Diet, High-Fat; Disease Models, Animal; Drug Therapy, Combination; Ezetimibe; Group VI Phospholipases A2; Hepatocytes; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Male; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Signal Transduction; Sterol Regulatory Element Binding Protein 2; Triglycerides

Topics: Animals; Capsules; Disease Models, Animal; Glycols; Guillain-Barre Syndrome; Lactic Acid; Lovastatin; Nanoparticles; Neuritis, Autoimmune, Experimental; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Rats; Sciatic Nerve; T-Lymphocytes

Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Line, Tumor; Cell Proliferation; Disease Models, Animal; Glioblastoma; HEK293 Cells; Humans; Lovastatin; MAP Kinase Signaling System; Mice, Inbred BALB C; Mice, Nude; Models, Biological; NF-kappa B; Receptors, TNF-Related Apoptosis-Inducing Ligand; Subcutaneous Tissue; TNF-Related Apoptosis-Inducing Ligand; Up-Regulation

Topics: Adipocytes; Adipogenesis; Animals; Anticholesteremic Agents; Bone Marrow Cells; Cell Size; Disease Models, Animal; Femur Head; Femur Head Necrosis; Humerus; Lipids; Lovastatin; Male; Methylprednisolone; Methylprednisolone Acetate; Osteocytes; Rabbits

Topics: Animals; Central Nervous System; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Encephalomyelitis, Autoimmune, Experimental; Female; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immunologic Factors; Lovastatin; Nerve Fibers, Myelinated; Nerve Regeneration; Neuroprotective Agents; Phosphodiesterase Inhibitors; Rats; Rats, Inbred Lew; Rolipram; Treatment Outcome; Wallerian Degeneration

Topics: Animals; Anti-Bacterial Agents; Antioxidants; Cell Death; Cell Line; Cysteine Proteinase Inhibitors; Disease Models, Animal; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Imipenem; Lipopolysaccharides; Lovastatin; Macrophages; Mice; Nitric Oxide; Proteasome Inhibitors; Quercetin; Shock, Septic; Tumor Necrosis Factor-alpha

Topics: Acetylcholine; Animals; Antigens; Asthma; Atropine; Bronchial Hyperreactivity; Bronchodilator Agents; Cholinergic Agents; Disease Models, Animal; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indomethacin; Lovastatin; Male; Mice; Mice, Inbred BALB C; Muscle Contraction; Muscle, Smooth; Ovalbumin

Topics: Alkylating Agents; Animals; Anticarcinogenic Agents; Anticholesteremic Agents; Antineoplastic Agents, Hormonal; Apoptosis; Atorvastatin; Bexarotene; Cell Proliferation; Diet; Disease Models, Animal; Female; Genes, erbB-2; Heptanoic Acids; Lovastatin; Mammary Neoplasms, Experimental; Methylnitrosourea; Mice; Mice, Knockout; Mice, Transgenic; Pyrroles; Rats; Rats, Sprague-Dawley; Receptors, Estrogen; Retinoid X Receptors; Tamoxifen; Tetrahydronaphthalenes; Treatment Outcome; Tumor Suppressor Protein p53

Topics: Analysis of Variance; Animals; Avoidance Learning; Basal Nucleus of Meynert; Behavioral Symptoms; Choline O-Acetyltransferase; Chromones; Disease Models, Animal; Drug Administration Schedule; Drug Interactions; Enzyme Inhibitors; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Male; Maze Learning; Mice; Mice, Inbred C57BL; Morpholines; N-Methylaspartate; Neurodegenerative Diseases; Reaction Time

Topics: Animals; Anti-Inflammatory Agents; Antigens; Asthma; Bronchoalveolar Lavage Fluid; Cell Count; Cytokines; Disease Models, Animal; Eosinophilia; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immunoglobulin E; Inflammation Mediators; Leukotriene B4; Lovastatin; Male; Mice; Mice, Inbred BALB C; Ovalbumin; Pneumonia

Topics: Animals; Cell Survival; Disease Models, Animal; DNA Damage; Dose-Response Relationship, Radiation; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inflammation Mediators; Intestines; Liver; Lovastatin; Lung; Mice; Mice, Inbred BALB C; NF-kappa B; Probability; Radiation Dosage; Radiation Injuries; Radiation Injuries, Experimental; Radiation, Ionizing; Random Allocation; Reference Values; RNA, Messenger; Tumor Necrosis Factor-alpha

Topics: Animals; Blood Platelets; Carotid Artery Injuries; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Infusions, Intravenous; Lovastatin; Organelles; Platelet Activation; Swine; Thrombosis; Time Factors

Topics: alpha-Synuclein; Analysis of Variance; Animals; Brain; Cholesterol; Dendrites; Disease Models, Animal; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lewy Body Disease; Lovastatin; Mice; Mice, Transgenic; Microtubule-Associated Proteins; Neurons; Oxidation-Reduction; Parkinson Disease; Platelet-Derived Growth Factor; Thy-1 Antigens

Topics: Administration, Topical; Animals; Anticholesteremic Agents; Bone Density; Bone Morphogenetic Protein 2; Bone Transplantation; Cell Count; Disease Models, Animal; Lovastatin; Male; Mice; Mice, Inbred MRL lpr; Osteoclasts; Osteogenesis; RANK Ligand; RNA, Messenger; Tibia; Up-Regulation

Topics: 8,11,14-Eicosatrienoic Acid; Acute Disease; Animals; Anticholesteremic Agents; Cell Line; Disease Models, Animal; Female; Humans; Hypercholesterolemia; Inflammation; Inflammation Mediators; Lipoxins; Lovastatin; Male; Mice; Neutrophils; Pneumonia; Respiratory Mucosa

Topics: Acetylcholine; Alzheimer Disease; Animals; Basal Nucleus of Meynert; Binding, Competitive; Cerebral Cortex; Choline O-Acetyltransferase; Denervation; Disease Models, Animal; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Ibotenic Acid; Lovastatin; Male; Neurotoxins; p38 Mitogen-Activated Protein Kinases; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Receptors, Muscarinic; Receptors, N-Methyl-D-Aspartate; Recovery of Function; Treatment Outcome

Topics: Alkyl and Aryl Transferases; Animals; Asthma; Bronchi; Disease Models, Animal; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Male; Mice; Mice, Inbred BALB C; Muscle, Smooth; Up-Regulation

Topics: Animals; Anticarcinogenic Agents; Apoptosis; Body Weight; Cell Growth Processes; Cholesterol; Disease Models, Animal; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Liver; Liver Neoplasms, Experimental; Lovastatin; Male; Mevalonic Acid; Organ Size; Precancerous Conditions; Rats; Rats, Inbred F344; Ubiquinone

Topics: Alendronate; Animals; Bone Density; Disease Models, Animal; Femur; Lovastatin; Male; Omeprazole; Organ Size; Osteogenesis; Rats; Rats, Sprague-Dawley; Wound Healing; X-Ray Microtomography

Topics: Animals; Anti-Inflammatory Agents; Atherosclerosis; Cell Adhesion; Cells, Cultured; Chemokine CXCL16; Chemokines, CXC; Coculture Techniques; Cytokines; Disease Models, Animal; Human Umbilical Vein Endothelial Cells; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperlipidemias; Immunohistochemistry; Inflammation Mediators; Lovastatin; Macrophages; Monocytes; Rabbits; Receptors, Scavenger; Thiazolidinediones

Topics: Animals; Aorta; Biological Products; Blood Coagulation Tests; Cell Survival; Cholecalciferol; Cholesterol; Diet, High-Fat; Disease Models, Animal; Drugs, Chinese Herbal; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lipoproteins, LDL; Lovastatin; Macrophages; Male; Mice; NADPH Oxidases; Oryza; Random Allocation; Rats; Rats, Wistar; Reactive Oxygen Species; Thrombophilia; Thromboplastin; Vitamins

Topics: Acyl Coenzyme A; Administration, Oral; Angiotensin II Type 1 Receptor Blockers; Animals; Anticholesteremic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line, Tumor; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Imidazoles; Injections, Intravenous; Losartan; Lovastatin; Male; Rats; Rats, Sprague-Dawley; Rhodamine 123; Simvastatin; Tetrazoles; Time Factors

Topics: Animals; Bone Density; Dioscorea; Diosgenin; Disease Models, Animal; Female; Fermentation; Flavins; Glycine max; Heterocyclic Compounds, 3-Ring; Isoflavones; Lovastatin; Monascus; Osteoporosis; Ovariectomy; Phytoestrogens; Plant Roots; Rats; Rats, Sprague-Dawley

Topics: Animals; Apoptosis; Autophagy; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Survival; Cytostatic Agents; Disease Models, Animal; Humans; Inositol 1,4,5-Trisphosphate Receptors; Lovastatin; Male; Mesothelioma; Mice; Mice, Inbred NOD; Mice, SCID; Neuropeptides; Pleural Neoplasms; Prenylation; rac GTP-Binding Proteins; rac1 GTP-Binding Protein

Topics: 1-Butanol; Animals; Antioxidants; Blood Coagulation; Diet, High-Fat; Dioscorea; Disease Models, Animal; Drugs, Chinese Herbal; Hyperlipidemias; Hypolipidemic Agents; Lipid Peroxidation; Lipids; Lovastatin; Male; Malondialdehyde; Oxidative Stress; Phytotherapy; Rats; Rats, Sprague-Dawley; Rhizome; Saponins; Solvents; Superoxide Dismutase

Topics: Animals; Cicatrix, Hypertrophic; Disease Models, Animal; Ear; Female; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Pravastatin; Rabbits; Simvastatin; Wound Healing

Topics: Animals; Cholesterol; Cholesterol, HDL; Disease Models, Animal; Hypercholesterolemia; Lactobacillus plantarum; Liver; Lovastatin; Male; Rats; Rats, Sprague-Dawley

Topics: Animals; Biocompatible Materials; Bone Regeneration; Cell Line; Disease Models, Animal; Femur; Injections; Kinetics; Lovastatin; Mice; Microspheres; Polyurethanes; Rats; Tissue Scaffolds; X-Ray Microtomography

Topics: Animals; Anticholesteremic Agents; Blotting, Western; Dentate Gyrus; Disease Models, Animal; Electrophysiology; Epilepsy, Temporal Lobe; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Intercellular Signaling Peptides and Proteins; Lovastatin; Male; Mossy Fibers, Hippocampal; Muscarinic Agonists; Nerve Tissue Proteins; Pilocarpine; Rats; Rats, Wistar; Seizures; Status Epilepticus

Topics: Animals; Bronchoalveolar Lavage Fluid; Cell Movement; Disease Models, Animal; Female; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Interleukin-6; Interleukin-8; Lovastatin; Lung; Macrophages, Alveolar; Neutrophils; Particulate Matter; Phagocytosis; Pneumonia; Rabbits

Topics: Animals; Atorvastatin; Cell Communication; Disease Models, Animal; Endothelial Cells; Gene Expression; Hepatic Stellate Cells; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension, Portal; Kruppel-Like Transcription Factors; Liver; Liver Circulation; Liver Cirrhosis, Experimental; Lovastatin; Male; Paracrine Communication; Pyrroles; Rats; Rats, Wistar; Simvastatin; Stress, Mechanical

Topics: Animals; Disease Models, Animal; Epilepsy; Fragile X Syndrome; Lovastatin; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Protein Biosynthesis

Topics: Animals; Cell Culture Techniques; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Enzyme-Linked Immunosorbent Assay; Female; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Interferon-gamma; Interleukin-10; Interleukin-6; Lovastatin; Myelin Basic Protein; Nitrites; Phytohemagglutinins; Rats; Rats, Inbred Lew; Spleen

Topics: Alkyl and Aryl Transferases; Alzheimer Disease; Amyloid beta-Peptides; Animals; Animals, Newborn; Apolipoproteins E; Astrocytes; Brain; Cells, Cultured; Disease Models, Animal; Dose-Response Relationship, Drug; Farnesyltranstransferase; Hippocampus; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Mevalonic Acid; Mice; Mice, Transgenic; Microglia; Neuroglia; Polyisoprenyl Phosphates; Protein Prenylation

Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals; Anticholesteremic Agents; Aspartic Acid Endopeptidases; Blotting, Western; Body Weight; Cerebral Cortex; Cholesterol; Disease Models, Animal; Eating; Endopeptidases; Female; Hippocampus; Humans; Immunohistochemistry; Lovastatin; Male; Membrane Proteins; Mice; Mice, Transgenic; Plaque, Amyloid; Presenilin-1; Sex Factors; Time Factors

Topics: Anemia, Sickle Cell; Animals; Disease Models, Animal; Endothelium, Vascular; Humans; Lovastatin; Mice; Mice, Inbred C57BL; Mice, Transgenic; Thromboplastin

Topics: Animals; Antineoplastic Agents; Apoptosis; bcl-2-Associated X Protein; Caspase Inhibitors; Caspases; Cell Cycle; Cytochromes c; Disease Models, Animal; Enzyme Inhibitors; Female; Flow Cytometry; In Situ Nick-End Labeling; Lovastatin; Lung Neoplasms; Mammary Neoplasms, Experimental; Membrane Potentials; Mice; Mice, Inbred BALB C; Microscopy, Electron; Mitochondria; Mutation; Protein Transport; Proto-Oncogene Proteins c-bcl-2; Tumor Suppressor Protein p53

Topics: Animals; Cytokines; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Female; Gene Expression Regulation; Genes, MHC Class II; Growth Substances; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Multiple Sclerosis; Oligonucleotide Array Sequence Analysis; Rats; Rats, Inbred Lew; RNA, Messenger; Severity of Illness Index; Spinal Cord; Transcription Factors; Up-Regulation

Topics: Acyl-CoA Oxidase; Acyltransferases; Adenosine Triphosphatases; Animals; Anticholesteremic Agents; ATP-Binding Cassette Transporters; ATPases Associated with Diverse Cellular Activities; Catalase; Central Nervous System; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Fatty Acids; Female; Freund's Adjuvant; Immunohistochemistry; Inflammation; Lovastatin; Membrane Proteins; Microarray Analysis; Peroxisomal Disorders; Peroxisomes; Rats; Rats, Inbred Lew; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger

Topics: Animals; Cyclic AMP Response Element-Binding Protein; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Disease Models, Animal; Kidney; Kidney Function Tests; Kidney Glomerulus; Lovastatin; Male; p38 Mitogen-Activated Protein Kinases; Random Allocation; Rats; Rats, Wistar; Signal Transduction

Topics: Animals; Cell Differentiation; Cell Movement; Cell Proliferation; Cell Survival; Cells, Cultured; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Female; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Multiple Sclerosis; Myelin Sheath; Oligodendroglia; Rats; Rats, Inbred Lew; Stem Cells

Topics: Amides; Animals; Antineoplastic Agents; Apoptosis; Blotting, Southern; Blotting, Western; Caspases; Cell Survival; Disease Models, Animal; DNA Fragmentation; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Flow Cytometry; Humans; Immunohistochemistry; In Situ Nick-End Labeling; Intracellular Signaling Peptides and Proteins; Lovastatin; Male; Mevalonic Acid; Mice; Neoplasms; Neoplasms, Experimental; Polyisoprenyl Phosphates; Protein Serine-Threonine Kinases; Pyridines; Rats; Rats, Wistar; rho-Associated Kinases; rhoA GTP-Binding Protein; Signal Transduction; Tetrazolium Salts; Thiazoles; Time Factors; Tumor Cells, Cultured

Topics: Acid Phosphatase; Alkaline Phosphatase; Allyl Compounds; Animals; Bone Density; Calcium; Cholesterol; Creatinine; Disease Models, Animal; Estradiol; Female; Humans; Hydroxyproline; Isoenzymes; Lovastatin; Osteoporosis, Postmenopausal; Ovariectomy; Phosphates; Rats; Recovery of Function; Sulfides; Tartrate-Resistant Acid Phosphatase

Topics: Animals; Cell Count; Cell Death; Disease Models, Animal; Hippocampus; Lovastatin; Male; Muscarinic Agonists; Neurons; Neuroprotective Agents; Pilocarpine; Rats; Rats, Wistar; Status Epilepticus

Topics: Animals; Disease Models, Animal; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Gene Transfer Techniques; Goiter; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperplasia; Hypertrophy; Lovastatin; Male; MAP Kinase Signaling System; Phosphorylation; Proliferating Cell Nuclear Antigen; Propylthiouracil; Protein Kinase Inhibitors; Protein Prenylation; ras Proteins; Rats; Rats, Wistar; Terpenes; Thyroid Gland; Thyrotropin

Topics: Animals; beta-Cyclodextrins; Cells, Cultured; Cholesterol; Disease Models, Animal; Evoked Potentials; Hippocampus; Intracellular Signaling Peptides and Proteins; Lovastatin; Mice; Mice, Knockout; Neuroglia; Niemann-Pick C1 Protein; Niemann-Pick Disease, Type C; Proteins; Rats; Rats, Sprague-Dawley; Synaptic Transmission; Synaptic Vesicles; Vesicle-Associated Membrane Protein 2

Topics: Animals; Ascitic Fluid; Cells, Cultured; Disease Models, Animal; Epithelium; Fibrinolysis; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Laparotomy; Lovastatin; Male; Peritoneum; Plasminogen Activator Inhibitor 1; Postoperative Complications; Prognosis; Rats; Rats, Wistar; RNA, Messenger; Tissue Adhesions; Tissue Plasminogen Activator

Topics: Animals; Cells, Cultured; Disease Models, Animal; Epithelium; Fibrinolysis; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Laparotomy; Lovastatin; Peritoneum; Postoperative Complications; Rats; Tissue Adhesions; Tissue Plasminogen Activator

Topics: Action Potentials; Alanine Transaminase; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspartate Aminotransferases; B7-1 Antigen; Cell Movement; Cell Proliferation; Creatine Kinase; Cytokines; Disease Models, Animal; Guillain-Barre Syndrome; Histocompatibility Antigens Class II; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Leukocytes, Mononuclear; Lovastatin; Male; Neural Conduction; Neuritis; Rats; Rats, Inbred Lew; Sciatic Nerve; Spleen

Topics: Action Potentials; Adrenergic beta-Agonists; Analysis of Variance; Animals; Anti-Arrhythmia Agents; Antioxidants; Blood Pressure; Body Surface Potential Mapping; Cardiac Pacing, Artificial; Cyclic N-Oxides; Disease Models, Animal; Dogs; Electrophysiologic Techniques, Cardiac; Female; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Isoproterenol; Lovastatin; Male; Mevalonic Acid; Microelectrodes; Myocardial Ischemia; Refractory Period, Electrophysiological; Research Design; Ventricular Fibrillation

Topics: Animals; Animals, Newborn; Anticholesteremic Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Delivery Systems; Female; Femoral Fractures; Fracture Healing; Lovastatin; Mice; Mice, Inbred ICR; Nanoparticles; Organ Culture Techniques; Osteogenesis; Radiography; Rats; Rats, Sprague-Dawley; Skull

Topics: Animals; Brain Injuries; Cytokines; Disease Models, Animal; Encephalitis; Gene Expression Regulation; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immunohistochemistry; Inflammation; Interleukin-1beta; Lovastatin; Male; Neurons; Rats; Rats, Sprague-Dawley; Reaction Time; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Rotarod Performance Test; Treatment Outcome; Tumor Necrosis Factor-alpha

Topics: Alzheimer Disease; Amyloid beta-Peptides; Analysis of Variance; Animals; Avoidance Learning; Behavior, Animal; Brain; Disease Models, Animal; Drug Interactions; Injections, Intraventricular; Learning; Lovastatin; Male; Maze Learning; Memory Disorders; Nerve Tissue Proteins; Oryza; PC12 Cells; Peptide Fragments; Phytotherapy; Plant Extracts; Rats; Rats, Wistar

Topics: Animals; Antigens, Helminth; Ascaris suum; Asthma; Bordetella pertussis; Bronchial Hyperreactivity; Disease Models, Animal; Inflammation; Lovastatin; Male; Muscle Contraction; Muscle, Smooth; Rats; Rats, Wistar; Respiratory System; rhoA GTP-Binding Protein

Topics: Animals; Blotting, Western; Disease Models, Animal; Down-Regulation; Drug Administration Schedule; Enzyme Activation; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Ischemic Preconditioning, Myocardial; Lovastatin; Male; Mitogen-Activated Protein Kinase 1; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; Phosphorylation; Proto-Oncogene Proteins c-akt; Rats; Rats, Wistar; Ubiquinone

Topics: Aged; Alzheimer Disease; Animals; Anticholesteremic Agents; Disease Models, Animal; Glutamic Acid; Humans; Lovastatin; Mice; Mice, Inbred C57BL; Neurons; Neuroprotective Agents; NF-kappa B; Phosphorylation; Proto-Oncogene Proteins c-akt; Receptors, Tumor Necrosis Factor, Type II; Signal Transduction; Stroke; Tumor Necrosis Factor-alpha

Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Line, Tumor; Disease Models, Animal; Doxorubicin; Drug Synergism; Female; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Mice; Neoplasm Invasiveness; Neoplasm Metastasis; Oligonucleotide Array Sequence Analysis; Rats

Topics: Acyl Coenzyme A; Animals; Cholesterol; Cholic Acid; Cholic Acids; Dehydrocholesterols; Disease Models, Animal; Liver; Lovastatin; Male; Microsomes, Liver; Oxidoreductases; Oxidoreductases Acting on CH-CH Group Donors; Piperazines; Rats; Rats, Sprague-Dawley; Smith-Lemli-Opitz Syndrome

Topics: Analysis of Variance; Animals; Arteriosclerosis; Body Weight; Cholesterol; Cholesterol, HDL; Cricetinae; Diet, Atherogenic; Disease Models, Animal; Foam Cells; Lipids; Liver; Lovastatin; Male; Mesocricetus; Triglycerides

Topics: Aldehydes; Animals; Anticholesteremic Agents; Antigen-Antibody Complex; Basement Membrane; Cholesterol; Collagen; Disease Models, Animal; Epithelial Cells; Glomerulonephritis; Kidney Glomerulus; Lipid Peroxidation; Lovastatin; Lysine; Male; Malondialdehyde; Probucol; Proteinuria; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Simvastatin

Topics: Animals; Disease Models, Animal; Disease Progression; Drug Therapy, Combination; Enalapril; Glomerular Filtration Rate; Lovastatin; Male; Nephrotic Syndrome; Rats; Rats, Sprague-Dawley

Topics: Angioplasty, Balloon, Coronary; Animals; Coronary Disease; Disease Models, Animal; Drug Evaluation, Preclinical; Enzyme Inhibitors; Hyperplasia; Linear Models; Lovastatin; Random Allocation; Recurrence; Single-Blind Method; Swine; Tunica Intima

Topics: Administration, Oral; Animals; Anticholesteremic Agents; Cholesterol; Disease Models, Animal; Female; Hippocampus; Hypercholesterolemia; Lovastatin; Manganese; Manganese Poisoning; Maze Learning; Rats

Topics: Albuminuria; Animals; Blood Glucose; Cells, Cultured; Cholesterol; Creatinine; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Disease Models, Animal; Fibronectins; Glomerular Mesangium; Kidney Glomerulus; Lovastatin; Male; Mevalonic Acid; Organ Size; Protein Biosynthesis; Rats; Rats, Sprague-Dawley; RNA, Messenger; Streptozocin; Transforming Growth Factor beta

Topics: Adipocytes; Animals; Anticholesteremic Agents; Bone Marrow Cells; Bone Marrow Transplantation; Chickens; Clone Cells; Dexamethasone; Disease Models, Animal; Drug Evaluation, Preclinical; Female; Gene Expression Regulation; Glucocorticoids; Lovastatin; Methylprednisolone; Mice; Mice, Inbred BALB C; Osteonecrosis; Time Factors; Transfection

Topics: Animals; Animals, Newborn; Anticholesteremic Agents; Antioxidants; Arteriosclerosis; Cells, Cultured; Cricetinae; Diabetes Mellitus, Experimental; Disease Models, Animal; Foam Cells; Hyperlipidemias; Lipid Peroxidation; Lovastatin; Male; Mesocricetus; Probucol; Reference Values; Streptozocin; Vitamin E

Topics: 3T3 Cells; Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Division; Cell Line, Transformed; Cell Survival; Disease Models, Animal; Dose-Response Relationship, Drug; Doxorubicin; Drug Resistance, Neoplasm; Drug Synergism; Female; Heart Diseases; Lovastatin; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred DBA; Neoplasm Transplantation; Neoplasms, Experimental; Time Factors; Troponin T; Tumor Cells, Cultured

Topics: Administration, Oral; Animals; Anticholesteremic Agents; Cardiomyopathies; Cricetinae; Disease Models, Animal; Female; Lovastatin; Male; Pravastatin; Sex Factors; Survival Analysis; Ubiquinone

Topics: Animals; Aorta; Blood Flow Velocity; Blood Gas Analysis; Blood Pressure; Cerebrovascular Circulation; Cholesterol; Disease Models, Animal; Dose-Response Relationship, Drug; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immunoblotting; Lovastatin; Male; Mice; Mice, Inbred Strains; Mice, Knockout; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; RNA, Messenger; Stroke; Treatment Outcome; Up-Regulation

Topics: Allosteric Site; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Adhesion; Disease Models, Animal; Drug Design; Humans; Integrin alpha4beta1; Integrins; Intercellular Adhesion Molecule-1; Lovastatin; Lymphocyte Activation; Lymphocyte Function-Associated Antigen-1; Macrophage-1 Antigen; Mice; Models, Molecular; Molecular Structure; Mutagenesis, Site-Directed; Naphthalenes; Peritonitis; Pravastatin; Protein Binding; Receptors, Lymphocyte Homing; T-Lymphocytes

Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Adhesion; Chemotaxis, Leukocyte; Cytokines; Demyelinating Diseases; Disease Models, Animal; Drug Evaluation, Preclinical; Encephalomyelitis, Autoimmune, Experimental; Endothelium, Vascular; Enzyme Induction; Female; Gene Expression Regulation; Intercellular Adhesion Molecule-1; Lovastatin; Lymphocyte Function-Associated Antigen-1; Monocytes; Multiple Sclerosis; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Rats; Rats, Inbred Lew; Spinal Cord

Topics: Administration, Oral; Animals; Anticholesteremic Agents; Disease Models, Animal; Dogs; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Lovastatin; Magnetic Resonance Spectroscopy; Rats; Simvastatin; Structure-Activity Relationship

Topics: Animals; Biological Transport; Cell Membrane Permeability; Cholestanes; Cholestanols; Cholesterol; Dehydrocholesterols; Disease Models, Animal; Dose-Response Relationship, Drug; Endothelium; Hydroxycholesterols; Hypolipidemic Agents; In Vitro Techniques; Ketocholesterols; Lovastatin; Serum Albumin; Swine; Time Factors

Topics: Animals; Cholesterol; Clofibrate; Clofibric Acid; Disease Models, Animal; Glomerulonephritis; Glomerulosclerosis, Focal Segmental; Hyperlipidemias; Kidney; Kidney Failure, Chronic; Kidney Glomerulus; Lovastatin; Male; Nephrectomy; Nephrons; Rats; Rats, Inbred Strains; Triglycerides