lovastatin has been researched along with Colonic Neoplasms in 29 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 16 (55.17) | 18.2507 |
| 2000's | 9 (31.03) | 29.6817 |
| 2010's | 1 (3.45) | 24.3611 |
| 2020's | 3 (10.34) | 2.80 |
| Authors | Studies |
|---|---|
| Asanuma, K; Kaneko, R; Kobayashi, D; Tanabe, H; Tsuji, N; Watanabe, N | 1 |
| Ahmed, M; Chen, H; Gao, S; Go, MYY; He, HH; Liu, W; O'Brien, CA; Soares, F; Sung, JJY; Wang, S; Wong, CC; Yang, Z; Yu, J; Zeng, Y | 1 |
| Beton, K; Brozek-Pluska, B; Wysocki, P | 1 |
| Cai, X; Gu, Y; Guo, W; Hu, J; Li, X; Liu, W; Wang, M; Wang, Y; Wei, B; Wu, J; Xu, L; Xu, Q | 1 |
| Chen, Z; Duan, Q; Gong, L; Wang, R; Wen, Q; Wu, P; Xia, F; Xiao, Y; Xie, S; Xu, H; Yang, T; Zhao, T; Zheng, Z; Zhou, W; Zhu, L | 1 |
| Guruswamy, S; Rao, CV | 1 |
| Dutta, A; Ukomadu, C | 1 |
| Dimitroulakos, J; Goss, G; Hanson, JE; Lagarde, AE; Lorimer, IA; Mantha, AJ | 1 |
| Lin, WY; Pan, TM; Song, CY | 1 |
| Heber, D; Hong, MY; Seeram, NP; Zhang, Y | 1 |
| Ehehalt, R; Fullekrug, J; Krautter, M; Kulaksiz, H; Sparla, R; Stremmel, W; Zorn, M | 1 |
| Nagel, WW; Vallee, BL | 1 |
| Fukaura, Y; Ishikawa, C; Narisawa, T; Tanida, N; Terada, K; Umezawa, A; Yazawa, K | 1 |
| Biade, S; Mazière, C; Mazière, JC; Mora, L; Santus, R | 1 |
| Cowan, KH; Gudas, JM; He, R; Moscow, JA | 1 |
| Auclair, M; Biade, S; Dubertret, L; Mazière, C; Mazière, JC; Mora, L; Morlière, P; Santus, R | 1 |
| Broitman, SA; Cerda, SR; Wilkinson, J | 1 |
| Blegen, H; Carlberg, M; Dricu, A; Hjertman, M; Höög, A; Larsson, O; Wang, M; Zickert, P | 1 |
| Branch, SK; Broitman, SA; Cerda, S; Wilkinson, J | 1 |
| Blegen, H; Carlberg, M; Dricu, A; Hjertman, M; Larsson, O; Malec, M; Wang, M; Wejde, J | 1 |
| Guo, YS; Houston, CW; Jin, GF; Thompson, JC; Townsend, CM | 1 |
| Cohen, SA; Doerr, RJ; Hordines, J; Mehta, N; Sykes, D | 1 |
| Agarwal, B; Bhendwal, S; Halmos, B; Holt, PR; Moss, SF; Ramey, WG | 1 |
| Agarwal, B; Bhendwal, S; Holt, PR; Ramey, WR; Rao, CV; Reddy, BS; Shirin, H | 1 |
| Feleszko, W; Jakóbisiak, M | 1 |
| Cooma, I; Rao, CV; Reddy, BS; Swamy, MV | 1 |
| Nyce, JW; Schulz, S | 1 |
| Albright, E; Field, FJ; Kam, NT; Mathur, S | 1 |
| Broitman, SA; Fabricant, M | 1 |
1 trial(s) available for lovastatin and Colonic Neoplasms
| Article | Year |
|---|---|
Survivin down-regulation plays a crucial role in 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor-induced apoptosis in cancer.
Topics: Apoptosis; Apoptosis Regulatory Proteins; Cell Line, Tumor; Cholesterol; Colonic Neoplasms; Diterpenes; Down-Regulation; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hydroxymethylglutaryl-CoA-Reductases, NADP-dependent; Hypercholesterolemia; Inhibitor of Apoptosis Proteins; Lovastatin; Microtubule-Associated Proteins; Neoplasm Proteins; Phosphorylation; Polyisoprenyl Phosphates; Protein Prenylation; RNA Interference; Sesquiterpenes; Signal Transduction; Survivin | 2007 |
28 other study(ies) available for lovastatin and Colonic Neoplasms
| Article | Year |
|---|---|
CRISPR screens identify cholesterol biosynthesis as a therapeutic target on stemness and drug resistance of colon cancer.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Proliferation; Cholesterol; Colonic Neoplasms; CRISPR-Cas Systems; Dimethylallyltranstransferase; Drug Resistance, Neoplasm; Farnesyltranstransferase; Fluorouracil; Geranyltranstransferase; Humans; Lovastatin; Male; Mice; Mice, Nude; Neoplastic Stem Cells; Tumor Cells, Cultured; Xenograft Model Antitumor Assays; Zoledronic Acid | 2021 |
Mevastatin in colon cancer by spectroscopic and microscopic methods - Raman imaging and AFM studies.
Topics: Caco-2 Cells; Colonic Neoplasms; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin | 2022 |
SHP2-Mediated Inhibition of DNA Repair Contributes to cGAS-STING Activation and Chemotherapeutic Sensitivity in Colon Cancer.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Cycle; Cell Proliferation; Colonic Neoplasms; DNA Damage; DNA Repair; Female; Gene Expression Regulation, Neoplastic; Humans; Irinotecan; Lovastatin; Membrane Proteins; Mice; Mice, Inbred BALB C; Mice, Nude; Nucleotidyltransferases; Poly (ADP-Ribose) Polymerase-1; Protein Tyrosine Phosphatase, Non-Receptor Type 11; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2021 |
The mevalonate coordinates energy input and cell proliferation.
Topics: Adaptor Proteins, Signal Transducing; Amino Acids; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; Glucose; Humans; Lovastatin; Mevalonic Acid; Proteomics; Signal Transduction; Transcription Factors; Wnt Signaling Pathway; YAP-Signaling Proteins | 2019 |
Synergistic effects of lovastatin and celecoxib on caveolin-1 and its down-stream signaling molecules: Implications for colon cancer prevention.
Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Blotting, Western; Caveolin 1; Celecoxib; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; Drug Synergism; Fluorescent Antibody Technique; Humans; Lovastatin; Pyrazoles; Signal Transduction; Sulfonamides | 2009 |
p21-dependent inhibition of colon cancer cell growth by mevastatin is independent of inhibition of G1 cyclin-dependent kinases.
Topics: CDC2-CDC28 Kinases; Cell Cycle; Cell Division; Cell Line; Cell Line, Tumor; Colonic Neoplasms; Cyclin A; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinases; Cyclins; Flow Cytometry; G1 Phase; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immunoblotting; Lovastatin; Male; Microscopy, Fluorescence; Models, Biological; Phosphorylation; Precipitin Tests; Prostatic Neoplasms; Retinoblastoma Protein; RNA, Messenger; RNA, Small Interfering | 2003 |
Targeting the mevalonate pathway inhibits the function of the epidermal growth factor receptor.
Topics: Adenosine Triphosphate; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Binding Sites; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Colonic Neoplasms; Drug Synergism; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Gefitinib; Humans; Lovastatin; Lung Neoplasms; Mevalonic Acid; Mitogen-Activated Protein Kinases; Mutation; Phosphorylation; Quinazolines; Signal Transduction; Tumor Cells, Cultured | 2005 |
Proteomic analysis of Caco-2 cells treated with monacolin K.
Topics: Antineoplastic Agents; Blotting, Western; Caco-2 Cells; Cell Division; Cell Survival; Colonic Neoplasms; Dose-Response Relationship, Drug; Electrophoresis, Gel, Two-Dimensional; Gene Expression; Humans; Lovastatin; Neoplasm Proteins; Protein Prenylation; Proteomics; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 2006 |
Anticancer effects of Chinese red yeast rice versus monacolin K alone on colon cancer cells.
Topics: Antineoplastic Agents; Apoptosis; Ascomycota; Biological Products; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; Dietary Supplements; Humans; Hydroxymethylglutaryl CoA Reductases; Lovastatin; Sterol Regulatory Element Binding Protein 2 | 2008 |
Increased basolateral sorting of carcinoembryonic antigen in a polarized colon carcinoma cell line after cholesterol depletion-Implications for treatment of inflammatory bowel disease.
Topics: Adenocarcinoma; Anticholesteremic Agents; beta-Cyclodextrins; Biological Transport; Caco-2 Cells; Carcinoembryonic Antigen; Cell Line, Tumor; Cell Membrane; Cholesterol; Colonic Neoplasms; Humans; Inflammatory Bowel Diseases; Lovastatin | 2008 |
Cell cycle regulation of metallothionein in human colonic cancer cells.
Topics: Antibodies, Monoclonal; Binding, Competitive; Cell Cycle; Colonic Neoplasms; Cross Reactions; Enzyme-Linked Immunosorbent Assay; Gene Expression Regulation, Neoplastic; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immunohistochemistry; Lovastatin; Metallothionein; Time Factors | 1995 |
Prevention of 1,2-dimethylhydrazine-induced colon tumorigenesis by HMG-CoA reductase inhibitors, pravastatin and simvastatin, in ICR mice.
Topics: 1,2-Dimethylhydrazine; Adenocarcinoma; Animals; Anticarcinogenic Agents; Carcinogens; Cholesterol; Colonic Neoplasms; Dimethylhydrazines; Female; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Mice; Mice, Inbred ICR; Pravastatin; Simvastatin | 1994 |
[Potentiation of the photocytotoxic effect of photofrin II: synergistic action of verapamil and lovastatin].
Topics: Colonic Neoplasms; Dihematoporphyrin Ether; Drug Synergism; Humans; Lovastatin; Photochemotherapy; Tumor Cells, Cultured; Verapamil | 1994 |
Utilization of multiple polyadenylation signals in the human RHOA protooncogene.
Topics: Base Sequence; Breast Neoplasms; Colonic Neoplasms; DNA, Complementary; Gene Expression Regulation; GTP-Binding Proteins; Humans; Liver; Lovastatin; Lung Neoplasms; Molecular Sequence Data; Poly A; Proto-Oncogenes; rhoA GTP-Binding Protein; Tissue Distribution; Tumor Cells, Cultured | 1994 |
Lovastatin potentiates the photocytotoxic effect of photofrin II delivered to HT29 human colonic adenocarcinoma cells by low density lipoprotein.
Topics: Adenocarcinoma; Biological Transport; Cell Survival; Colonic Neoplasms; Dihematoporphyrin Ether; Drug Synergism; Humans; Light; Lipoproteins, LDL; Lovastatin; Receptors, LDL; Sterols; Tumor Cells, Cultured | 1993 |
Regulation of cholesterol synthesis in four colonic adenocarcinoma cell lines.
Topics: Adenocarcinoma; Binding, Competitive; Blood; Cholesterol; Cholesterol, LDL; Colonic Neoplasms; Culture Media; Enzyme Inhibitors; Humans; Hydroxycholesterols; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lipoproteins, LDL; Lovastatin; Receptors, LDL; Tumor Cells, Cultured | 1995 |
Mevalonic acid is limiting for N-linked glycosylation and translocation of the insulin-like growth factor-1 receptor to the cell surface. Evidence for a new link between 3-hydroxy-3-methylglutaryl-coenzyme a reductase and cell growth.
Topics: Base Sequence; Cell Division; Cell Line; Cell Membrane; Colonic Neoplasms; DNA Primers; DNA, Neoplasm; Dolichol Phosphates; Enzyme Inhibitors; Gene Expression; Glycosylation; Growth Substances; Hepatoblastoma; Humans; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Insulin; Insulin-Like Growth Factor I; Kinetics; Liver Neoplasms; Lovastatin; Melanoma; Mevalonic Acid; Models, Biological; Molecular Sequence Data; Oligonucleotides, Antisense; Protein Processing, Post-Translational; Receptor, IGF Type 1; RNA, Messenger; Transcription, Genetic; Tumor Cells, Cultured | 1996 |
Effects of monoterpenes and mevinolin on murine colon tumor CT-26 in vitro and its hepatic "metastases" in vivo.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Colonic Neoplasms; Cyclohexenes; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Limonene; Liver Neoplasms; Lovastatin; Mice; Mice, Inbred BALB C; Monoterpenes; Protein Prenylation; Terpenes; Tumor Cells, Cultured | 1996 |
Mevalonate-regulated mechanisms in cell growth control: role of dolichyl phosphate in expression of the insulin-like growth factor-1 receptor (IGF-1R) in comparison to Ras prenylation and expression of c-myc.
Topics: Cell Division; Cell Membrane; Colonic Neoplasms; DNA, Neoplasm; Dolichol Phosphates; Glycosylation; Humans; Kinetics; Lovastatin; Melanoma; Mevalonic Acid; Neoplasm Proteins; Polymerase Chain Reaction; Protein Prenylation; ras Proteins; Receptor, IGF Type 1; Skin Neoplasms; Tumor Cells, Cultured | 1997 |
Insulin-like growth factor-I promotes multidrug resistance in MCLM colon cancer cells.
Topics: Animals; Apoptosis; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Survival; Colonic Neoplasms; Dactinomycin; Doxorubicin; Drug Resistance, Multiple; Gene Expression Regulation; Genes, MDR; Genes, ras; Insulin-Like Growth Factor I; Lovastatin; Mice; Mitochondria; RNA, Messenger; Superoxide Dismutase; Tetrazolium Salts; Thiazoles; Tumor Cells, Cultured | 1998 |
Low density lipoproteins and Lovastatin modulate the organ-specific transendothelial migration of primary and metastatic human colon adenocarcinoma cell lines in vitro.
Topics: Adenocarcinoma; Animals; Cell Adhesion; Cell Movement; Colonic Neoplasms; Endothelium, Vascular; Humans; Lipoproteins, LDL; Liver Neoplasms; Lovastatin; Mice; Mice, Inbred BALB C; Organ Specificity; Time Factors; Tumor Cells, Cultured | 1998 |
Lovastatin augments apoptosis induced by chemotherapeutic agents in colon cancer cells.
Topics: Antineoplastic Agents; Apoptosis; bcl-2-Associated X Protein; Cell Division; Cisplatin; Colonic Neoplasms; Dose-Response Relationship, Drug; Drug Therapy, Combination; Flow Cytometry; Fluorouracil; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Situ Nick-End Labeling; Lovastatin; Mevalonic Acid; Microscopy, Electron; Polyisoprenyl Phosphates; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Sesquiterpenes; Tumor Cells, Cultured | 1999 |
Lovastatin augments sulindac-induced apoptosis in colon cancer cells and potentiates chemopreventive effects of sulindac.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Apoptosis; Azoxymethane; Carcinogens; Colon; Colonic Neoplasms; Cyclooxygenase Inhibitors; Drug Synergism; Isoenzymes; Lovastatin; Male; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Inbred F344; Sulindac; Tumor Cells, Cultured | 1999 |
Lovastatin augments apoptosis induced by chemotherapeutic agents in colon cancer cells.
Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cisplatin; Colonic Neoplasms; Drug Synergism; Fluorouracil; Humans; Lovastatin | 2000 |
Lamin B, caspase-3 activity, and apoptosis induction by a combination of HMG-CoA reductase inhibitor and COX-2 inhibitors: a novel approach in developing effective chemopreventive regimens.
Topics: Apoptosis; Caspase 3; Caspases; Celecoxib; Cell Survival; Colonic Neoplasms; Cyclooxygenase Inhibitors; Cytochrome c Group; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lamin Type B; Lamins; Lovastatin; Mitochondria; Nuclear Proteins; Proteins; Pyrazoles; Sulfonamides; Tumor Cells, Cultured | 2002 |
Inhibition of protein isoprenylation and p21ras membrane association by dehydroepiandrosterone in human colonic adenocarcinoma cells in vitro.
Topics: Adenocarcinoma; Blotting, Western; Cell Compartmentation; Cell Division; Cell Membrane; Colonic Neoplasms; Dehydroepiandrosterone; Humans; In Vitro Techniques; Lovastatin; Mevalonic Acid; Protein Processing, Post-Translational; Proto-Oncogene Proteins p21(ras); Terpenes; Tumor Cells, Cultured | 1991 |
Effect of lovastatin on acyl-CoA: cholesterol O-acyltransferase (ACAT) activity and the basolateral-membrane secretion of newly synthesized lipids by CaCo-2 cells.
Topics: Adenocarcinoma; Biological Transport; Cell Line; Cell Membrane; Cholesterol; Cholesterol Esters; Colonic Neoplasms; Humans; Hydroxymethylglutaryl CoA Reductases; Kinetics; Lovastatin; Mevalonic Acid; Sterol O-Acyltransferase; Triglycerides | 1990 |
Evidence for deficiency of low density lipoprotein receptor on human colonic carcinoma cell lines.
Topics: Antibodies, Monoclonal; Carcinoma; Cholesterol; Colonic Neoplasms; Humans; In Vitro Techniques; Lipoproteins, LDL; Lovastatin; Receptors, LDL; Tumor Cells, Cultured | 1990 |