lovastatin has been researched along with Cell Transformation, Neoplastic in 17 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (11.76) | 18.7374 |
| 1990's | 9 (52.94) | 18.2507 |
| 2000's | 5 (29.41) | 29.6817 |
| 2010's | 1 (5.88) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Barr, RJ; Carpenter, PM; Chen, WP; Cochran, AJ; Elmets, CA; Jakowatz, JG; Leachman, SA; Lim, SJ; Linden, KG; McLaren, CE; Meyskens, FL; Tangrea, JA; Viner, JL; Zager, JS | 1 |
| Bifulco, M; Caraglia, M; Fiorentino, L; Gazzerro, P; Laezza, C; Pisanti, S; Portella, G; Vitale, M | 1 |
| Kang, S; Kim, ES; Moon, A | 1 |
| Abe, H; Green, JE; Kavanaugh, C; Nguyen, P; Otsuki, Y; Shibata, E; Shibata, MA; Trepel, JB | 1 |
| Larsson, O | 1 |
| Ruch, RJ; Sigler, K | 1 |
| Klaunig, JE; Madhukar, BV; Ruch, RJ; Trosko, JE | 1 |
| Hamilton, AD; McGuire, TF; Qian, Y; Sebti, SM; Vogt, A | 1 |
| Annella, T; Bifulco, M; Gioielli, A; Iossa, S; Mondola, P; Santillo, M; Serù, R; Vitale, M | 1 |
| Bałkowiec, EZ; Czajka, A; Dabrowska, A; Feleszko, W; Giermasz, A; Jakóbisiak, M; Marczak, M; Sieberth, E | 1 |
| Lin, JK; Lin-Shiau, SY; Wang, IK | 1 |
| Clark, SS; Elegbede, JA; Jenkins, GJ; Perman, SM; Sahin, MB | 1 |
| DeClue, JE; Lowy, DR; Papageorge, AG; Vass, WC; Willumsen, BM | 1 |
| Jani, JP; Sebti, SM; Tkalcevic, GT | 1 |
| Bourne, JR; Buss, JE; Cochrane, CG; Der, CJ; Jackson, JH; Solski, PA | 1 |
| Dafgård, E; Engström, W; Larsson, O; Zetterberg, A | 1 |
| Maltese, WA; Sheridan, KM | 1 |
1 trial(s) available for lovastatin and Cell Transformation, Neoplastic
| Article | Year |
|---|---|
A randomized, double-blind, placebo-controlled phase II clinical trial of lovastatin for various endpoints of melanoma pathobiology.
Topics: Adult; Anticholesteremic Agents; Biomarkers, Tumor; Cell Transformation, Neoplastic; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Lovastatin; Male; Melanoma; Middle Aged; Nevus; Placebos; Skin Neoplasms | 2014 |
16 other study(ies) available for lovastatin and Cell Transformation, Neoplastic
| Article | Year |
|---|---|
Lovastatin induces apoptosis of k-ras-transformed thyroid cells via inhibition of ras farnesylation and by modulating redox state.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Cycle; Cell Line; Cell Transformation, Neoplastic; Female; Genes, ras; Lovastatin; Male; Mice; Mice, Nude; Prenylation; Rats; Reactive Oxygen Species; Signal Transduction; Thyroid Gland | 2008 |
Simvastatin and lovastatin inhibit breast cell invasion induced by H-Ras.
Topics: Antineoplastic Agents; Breast; Breast Neoplasms; Cell Line, Tumor; Cell Transformation, Neoplastic; Cells, Cultured; Dose-Response Relationship, Drug; Down-Regulation; Epithelial Cells; Female; Gene Expression Regulation, Neoplastic; Genes, ras; Humans; Lovastatin; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; ras Proteins; Signal Transduction; Simvastatin | 2009 |
Comparative effects of lovastatin on mammary and prostate oncogenesis in transgenic mouse models.
Topics: Animals; Apoptosis; Body Weight; Cell Cycle; Cell Division; Cell Transformation, Neoplastic; Female; Flow Cytometry; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Male; Mammary Neoplasms, Experimental; Mice; Mice, Transgenic; Prostatic Neoplasms | 2003 |
Effect of virus-transformation and growth factor stimulation on isoprene biosynthesis in human fibroblasts: a correlation to cell growth.
Topics: Butadienes; Cell Division; Cell Line; Cell Transformation, Neoplastic; Cell Transformation, Viral; Culture Media; Dolichols; Fibroblasts; Hemiterpenes; Humans; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Mevalonic Acid; Pentanes; Platelet-Derived Growth Factor; Simian virus 40 | 1995 |
Growth inhibition of rat liver epithelial tumor cells by monoterpenes does not involve Ras plasma membrane association.
Topics: Animals; Cell Division; Cell Membrane; Cell Transformation, Neoplastic; Cyclohexenes; Growth Inhibitors; In Vitro Techniques; Limonene; Liver; Lovastatin; Menthol; Mevalonic Acid; Proto-Oncogene Proteins p21(ras); Rats; Terpenes; Tumor Cells, Cultured | 1994 |
Reversal of ras-induced inhibition of gap-junctional intercellular communication, transformation, and tumorigenesis by lovastatin.
Topics: Animals; Cell Communication; Cell Division; Cell Membrane; Cell Transformation, Neoplastic; Cells, Cultured; Drug Interactions; Epithelial Cells; Genes, ras; Intercellular Junctions; Kinetics; Liver; Liver Neoplasms, Experimental; Lovastatin; Male; Mevalonic Acid; Phenotype; Proto-Oncogene Proteins p21(ras); Rats; Rats, Inbred F344 | 1993 |
Protein geranylgeranylation, not farnesylation, is required for the G1 to S phase transition in mouse fibroblasts.
Topics: Actins; Alkyl and Aryl Transferases; Animals; Benzamides; Cell Cycle; Cell Division; Cell Transformation, Neoplastic; Cells, Cultured; Cytoskeleton; Diterpenes; DNA; Enzyme Inhibitors; Farnesol; Fibroblasts; G1 Phase; Genes, ras; GTP-Binding Proteins; Lovastatin; Methionine; Mevalonic Acid; Mice; Protein Prenylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-raf; rap GTP-Binding Proteins; ras Proteins; Resting Phase, Cell Cycle; S Phase; Transferases | 1996 |
Inhibitors of Ras farnesylation revert the increased resistance to oxidative stress in K-Ras transformed NIH 3T3 cells.
Topics: 3T3 Cells; Animals; Antineoplastic Agents; Cell Transformation, Neoplastic; Genes, ras; Lovastatin; Mice; Organophosphonates; Oxidative Stress; Protein Prenylation | 1996 |
Lovastatin and tumor necrosis factor-alpha exhibit potentiated antitumor effects against Ha-ras-transformed murine tumor via inhibition of tumor-induced angiogenesis.
Topics: 3T3 Cells; Animals; Antineoplastic Agents; Cell Division; Cell Survival; Cell Transformation, Neoplastic; Endothelial Growth Factors; Female; Gene Expression Regulation, Neoplastic; Genes, ras; Lovastatin; Lymphokines; Macrophages; Mice; Mice, Inbred BALB C; Neoplasms, Experimental; Neovascularization, Pathologic; Transfection; Tumor Necrosis Factor-alpha; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 1999 |
Suppression of invasion and MMP-9 expression in NIH 3T3 and v-H-Ras 3T3 fibroblasts by lovastatin through inhibition of ras isoprenylation.
Topics: 3T3 Cells; Animals; Antineoplastic Agents; Cell Membrane; Cell Transformation, Neoplastic; Dose-Response Relationship, Drug; Electrophoresis; Gene Expression; Genes, ras; Lovastatin; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Mevalonic Acid; Mice; Neoplasm Invasiveness; NF-kappa B; Promoter Regions, Genetic; Protein Prenylation; ras Proteins; Reverse Transcriptase Polymerase Chain Reaction; Transcription Factor AP-1; Transcription, Genetic | 2000 |
Antileukemia activity of perillyl alcohol (POH): uncoupling apoptosis from G0/G1 arrest suggests that the primary effect of POH on Bcr/Abl-transformed cells is to induce growth arrest.
Topics: Amiloride; Animals; Apoptosis; Cell Line, Transformed; Cell Transformation, Neoplastic; Cytoplasm; DNA Fragmentation; Enzyme Inhibitors; Fusion Proteins, bcr-abl; G1 Phase; Hematopoietic Stem Cells; Hydrogen-Ion Concentration; Interleukin-3; Lovastatin; Membrane Lipids; Mice; Monoterpenes; Naphthalenes; Neoplastic Stem Cells; Phosphatidylserines; Phosphorylation; Protein Processing, Post-Translational; Recombinant Fusion Proteins; Resting Phase, Cell Cycle; Signal Transduction; Sodium-Hydrogen Exchangers; Staurosporine; Terpenes; Tetradecanoylphorbol Acetate | 2002 |
Inhibition of cell growth by lovastatin is independent of ras function.
Topics: Animals; Base Sequence; Cell Division; Cell Line; Cell Transformation, Neoplastic; Gene Expression; Genes, ras; Kinetics; Lovastatin; Mice; Mice, Inbred Strains; Molecular Sequence Data; Myristic Acid; Myristic Acids; Oligonucleotide Probes; Restriction Mapping | 1991 |
Lovastatin, a cholesterol biosynthesis inhibitor, inhibits the growth of human H-ras oncogene transformed cells in nude mice.
Topics: Animals; Blotting, Western; Cell Division; Cell Membrane; Cell Transformation, Neoplastic; Dose-Response Relationship, Drug; Genes, ras; Lovastatin; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasms, Experimental; Oncogene Protein p21(ras); Protein Processing, Post-Translational; Transfection; Tumor Cells, Cultured; Urinary Bladder Neoplasms | 1991 |
Farnesol modification of Kirsten-ras exon 4B protein is essential for transformation.
Topics: Animals; Anticholesteremic Agents; Cell Line; Cell Transformation, Neoplastic; Cells, Cultured; Exons; Farnesol; Genetic Vectors; Humans; Lovastatin; Mevalonic Acid; Mice; Mutation; Oligonucleotide Probes; Proto-Oncogene Proteins; Proto-Oncogene Proteins p21(ras); Transfection | 1990 |
The effect of factors released from the tumor-transformed cells on DNA synthesis, mitosis, and cellular enlargement in 3T3 fibroblasts.
Topics: Animals; Blood; Cell Division; Cell Line; Cell Transformation, Neoplastic; Cell Transformation, Viral; Culture Media; DNA; Embryo, Mammalian; Fibroblasts; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Mice; Mitosis; Naphthalenes; Protein Biosynthesis; Simian virus 40 | 1987 |
Differentiation of neuroblastoma cells induced by an inhibitor of mevalonate synthesis: relation of neurite outgrowth and acetylcholinesterase activity to changes in cell proliferation and blocked isoprenoid synthesis.
Topics: Acetates; Acetylcholinesterase; Animals; Axons; Cell Cycle; Cell Division; Cell Line; Cell Transformation, Neoplastic; Cholesterol; Cycloheximide; Glycoproteins; Growth Inhibitors; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Mevalonic Acid; Mice; Naphthalenes; Neuroblastoma; Terpenes | 1985 |