Page last updated: 2024-08-23

lovastatin and Carcinoma, Hepatocellular

lovastatin has been researched along with Carcinoma, Hepatocellular in 41 studies

Research

Studies (41)

Timeframe	Studies, this research(%)	All Research%
pre-1990	4 (9.76)	18.7374
1990's	24 (58.54)	18.2507
2000's	8 (19.51)	29.6817
2010's	5 (12.20)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Baader, E; Bartmann, W; Beck, G; Bergmann, A; Granzer, E; Jendralla, H; Kesseler, K; Krause, R; Schacht, U; von Kerekjarto, B	1
Baader, E; Bartmann, W; Beck, G; Bergmann, A; Granzer, E; Jendralla, H; Kesseler, K; Krause, R; Schubert, W; von Kerekjarto, B	1
Draper, CD; Hutson, JL; Inglis, GG; Procopiou, PA; Ross, BC; Watson, NS	1
Connolly, PJ; Loughney, DA; Minor, LK; Westin, CD	1
Ashton, MJ; Brown, TJ; Fenton, G; Halley, F; Harper, MF; Lockey, PM; Porter, B; Roach, AG; Stuttle, KA; Vicker, N; Walsh, RJ	1
Beeson, CC; Beeson, GC; Christie, CF; Fang, D; Heslop, KA; Hunt, EG; Maldonado, EN; Morris, ME; Rovini, A	1
Andreux, PA; Auwerx, J; Bichet, S; Houtkooper, RH; Jovaisaite, V; Mottis, A; Mouchiroud, L; Moullan, N; Wang, X	1
Cheng, Z; Fu, SW; Hu, B; Ruan, LY; Wang, Y; Zheng, JN; Zheng, MH; Zhou, YY; Zhu, GQ	1
Bang, YJ; Jang, IJ; Kim, JR; Kim, W; Kim, YJ; Lee, HS; Yoon, JH	1
Popovich, DG; Tiaras, F; Yeo, CR; Zhang, W	1
Dandri, M; Kah, J; Keller, AD; Montalbano, R; Ocker, M; Sass, G; Sirma, H; Tiegs, G; Volz, T; Wüstenberg, A	1
Dai, P; Guan, G; Shechter, I	1
Dong, J; Fujii, S; Furumoto, T; Goto, D; Imagawa, S; Kaneko, T; Kitabatake, A; Mishima, T; Nakai, Y; Zaman, TA	1
Dong, J; Fujii, S; Furumoto, T; Goto, D; Imagawa, S; Kitabatake, A; Li, H; Nakabayashi, H; Nishi, S; Sakai, M; Zaman, TA	1
Goez, P; Hagelgans, A; Hempel, U; Heyne, B; Jaross, W; Menschikowski, M; Neumeister, V; Siegert, G	1
Marks, B; Raucy, J; Trubetskoy, O; Yueh, MF; Zielinski, T	1
Buchwald, H; Furcht, LL; Morris, TJ; Palm, SL	1
Conrad, DG; Jiang, G; McKenzie, TL; Shechter, I	1
Hrboticky, N; Lux, I; Tang, L; Weber, PC; Zimmer, B	1
Stephan, ZF; Yurachek, EC	1
Clark, RW; Gordon, DA; Parker, RA; Pearce, BC; Wright, JJ	1
Bentzen, C; Berkhout, TA; Jackson, B; Niesor, E; Patel, DD; Simon, HM; Suckling, KE	1
Ku, EC	1
Benoist, F; Grand-Perret, T	1
Galli, C; Marangoni, F; Petroni, A; Risé, P; Visioli, F	1
Joseph, SB; Kast, HR; Laffitte, BA; Mangelsdorf, DJ; Repa, JJ; Tontonoz, P; Wilpitz, DC	1
Brown, MS; DeBose-Boyd, RA; Goldstein, JL; Ou, J	1
Hidaka, Y; Horie, M; Hotta, H; Iwasawa, Y; Kamei, T; Nagata, Y	1
Adams, JL; Berkhout, TA; Bossard, MJ; Mayer, RJ	1
Cianflone, KM; Rodriguez, MA; Sniderman, AD; Vas, D; Yasruel, Z	1
Hidaka, Y; Kamei, T; Satoh, T	1
Elliott, JD; Fisher, M; Leber, J; Louis-Flamberg, P; Mayer, RJ	1
Antonov, AS; Fuki, IV; Kosykh, VA; Pavlov, MY; Podrez, EA; Repin, VS; Safonova, IG; Sviridov, DD	1
Ferguson, E; Krause, BR; Newton, RS; Roth, BD; Shaw, MK; Sliskovic, DR	1
Hidaka, Y; Ishida, F; Kamei, T; Nagata, Y	1
Brocia, RW; Fisher, EA; Williams, KJ	1
Barnhart, RL; Busch, SJ; Flanagan, MA; Jackson, RL; Martin, GA	1
Cohen, LH; Griffioen, M; van Miert, E	1
Cimis, GM; Molowa, DT	1
Cohen, LH; Griffioen, M	1
Boogaard, A; Cohen, LH; Griffioen, M	1

Reviews

1 review(s) available for lovastatin and Carcinoma, Hepatocellular

Article	Year
Systematic review with network meta-analysis: statins and risk of hepatocellular carcinoma. Oncotarget, 2016, Apr-19, Volume: 7, Issue:16 Topics: Atorvastatin; Bayes Theorem; Carcinoma, Hepatocellular; Drug Therapy, Combination; Fatty Acids, Monounsaturated; Fluvastatin; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Liver; Liver Neoplasms; Lovastatin; Observational Studies as Topic; Pravastatin; Pyridines; Rosuvastatin Calcium; Simvastatin; Treatment Outcome	2016

Article

Year

Systematic review with network meta-analysis: statins and risk of hepatocellular carcinoma.

Oncotarget, 2016, Apr-19, Volume: 7, Issue:16

Topics: Atorvastatin; Bayes Theorem; Carcinoma, Hepatocellular; Drug Therapy, Combination; Fatty Acids, Monounsaturated; Fluvastatin; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Liver; Liver Neoplasms; Lovastatin; Observational Studies as Topic; Pravastatin; Pyridines; Rosuvastatin Calcium; Simvastatin; Treatment Outcome

2016

Other Studies

40 other study(ies) available for lovastatin and Carcinoma, Hepatocellular

Article	Year
Synthesis and biological activity of new HMG-CoA reductase inhibitors. 3. Lactones of 6-phenoxy-3,5-dihydroxyhexanoic acids. Journal of medicinal chemistry, 1991, Volume: 34, Issue:10 Topics: Animals; Anticholesteremic Agents; Caproates; Carcinoma, Hepatocellular; Cholesterol; Dogs; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lactones; Liver; Liver Neoplasms; Lovastatin; Male; Molecular Structure; Rabbits; Rats; Structure-Activity Relationship; Tumor Cells, Cultured	1991
Synthesis and biological activity of new HMG-CoA reductase inhibitors. 2. Derivatives of 7-(1H-pyrrol-3-yl)-substituted-3,5-dihydroxyhept-6(E)-enoic (-heptanoic) acids. Journal of medicinal chemistry, 1990, Volume: 33, Issue:1 Topics: Animals; Anticholesteremic Agents; Carcinoma, Hepatocellular; Chemical Phenomena; Chemistry; Cholesterol; Dogs; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Liver; Liver Neoplasms; Lovastatin; Male; Molecular Structure; Pyrroles; Rabbits; Rats; Structure-Activity Relationship; Tumor Cells, Cultured	1990
Inhibitors of cholesterol biosynthesis. 2. 3,5-Dihydroxy-7-(N-pyrrolyl)-6-heptenoates, a novel series of HMG-CoA reductase inhibitors. Journal of medicinal chemistry, 1993, Nov-12, Volume: 36, Issue:23 Topics: Carcinoma, Hepatocellular; Cholesterol; Humans; Hydroxy Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Liver Neoplasms; Lovastatin; Molecular Structure; Pyrroles; Structure-Activity Relationship; Tumor Cells, Cultured	1993
HMG-CoA reductase inhibitors: design, synthesis, and biological activity of tetrahydroindazole-substituted 3,5-dihydroxy-6-heptenoic acid sodium salts. Journal of medicinal chemistry, 1993, Nov-12, Volume: 36, Issue:23 Topics: Acetates; Animals; Carcinoma, Hepatocellular; Cholesterol; Hydroxy Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indazoles; Liver; Liver Neoplasms; Lovastatin; Models, Molecular; Molecular Structure; Rats; Structure-Activity Relationship; Tumor Cells, Cultured	1993
New low-density lipoprotein receptor upregulators acting via a novel mechanism. Journal of medicinal chemistry, 1996, Aug-16, Volume: 39, Issue:17 Topics: Benzamides; Carcinoma, Hepatocellular; Cell Line; Cholesterol; Humans; Indicators and Reagents; Liver; Liver Neoplasms; Lovastatin; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Structure; Parabens; Phenylenediamines; Receptors, LDL; Structure-Activity Relationship; Transcription, Genetic; Tumor Cells, Cultured; Up-Regulation	1996
Statin-dependent modulation of mitochondrial metabolism in cancer cells is independent of cholesterol content. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2019, Volume: 33, Issue:7 Topics: Adenocarcinoma of Lung; Carcinoma, Hepatocellular; Hep G2 Cells; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Liver Neoplasms; Lovastatin; Lung Neoplasms; Membrane Potential, Mitochondrial; Mitochondria, Liver; Simvastatin	2019
A method to identify and validate mitochondrial modulators using mammalian cells and the worm C. elegans. Scientific reports, 2014, Jun-13, Volume: 4 Topics: Animals; Caenorhabditis elegans; Carcinoma, Hepatocellular; Cell Line; Cell Line, Tumor; Cluster Analysis; Drug Approval; Drug Evaluation, Preclinical; Fatty Acids, Monounsaturated; Fluvastatin; Gene Expression; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Imidazoles; Indoles; Lovastatin; MCF-7 Cells; Mice; Mitochondria; Oxidative Phosphorylation; Oxygen Consumption; Pharmaceutical Preparations; Reproducibility of Results; Simvastatin; United States; United States Food and Drug Administration	2014
Synergistic anti-tumor efficacy of lovastatin and protein kinase C-beta inhibitor in hepatocellular carcinoma. Cancer chemotherapy and pharmacology, 2009, Volume: 64, Issue:3 Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Carcinoma, Hepatocellular; Cell Line, Tumor; Disease Progression; Drug Synergism; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Situ Nick-End Labeling; Indoles; Liver Neoplasms, Experimental; Lovastatin; Male; Mice; Mice, Inbred C3H; Microvessels; Neoplasm Transplantation; Protein Kinase C; Protein Kinase C beta	2009
Lovastatin interacts with natural products to influence cultured hepatocarcinoma cell (hep-g2) growth. Journal of the American College of Nutrition, 2010, Volume: 29, Issue:3 Topics: Antineoplastic Agents; Capsaicin; Carcinoma, Hepatocellular; Catechin; Cell Line, Tumor; Cells, Cultured; Curcumin; Drug Synergism; Hep G2 Cells; Herb-Drug Interactions; Humans; Liver Neoplasms; Lovastatin; Plant Extracts	2010
Selective induction of apoptosis by HMG-CoA reductase inhibitors in hepatoma cells and dependence on p53 expression. Oncology reports, 2012, Volume: 28, Issue:3 Topics: Animals; Antineoplastic Agents; Apoptosis; Atorvastatin; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Survival; Cholesterol; Drug Screening Assays, Antitumor; Fatty Acids, Monounsaturated; Fluorobenzenes; Fluvastatin; Gene Expression; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Lipid Metabolism; Liver Neoplasms; Lovastatin; Mice; Mice, Inbred C57BL; Pyrimidines; Pyrroles; Rosuvastatin Calcium; Simvastatin; Sulfonamides; Tumor Suppressor Protein p53	2012
cDNA cloning and gene expression analysis of human myo-inositol 1-phosphate synthase. Archives of biochemistry and biophysics, 2003, Sep-15, Volume: 417, Issue:2 Topics: Amino Acid Sequence; Carcinoma, Hepatocellular; Cloning, Molecular; Gene Expression Profiling; Gene Expression Regulation, Enzymologic; GTP-Binding Proteins; Humans; Lovastatin; Molecular Sequence Data; Myo-Inositol-1-Phosphate Synthase; Organ Specificity; RNA, Messenger; Sequence Alignment; Tissue Distribution; Tumor Cells, Cultured	2003
Increased expression of plasminogen activator inhibitor-1 by mediators of the acute phase response: a potential progenitor of vasculopathy in hypertensives. Hypertension research : official journal of the Japanese Society of Hypertension, 2003, Volume: 26, Issue:9 Topics: Acute-Phase Reaction; Blotting, Northern; Blotting, Western; Carcinoma, Hepatocellular; Cell Line, Tumor; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension; Interleukin-1; Interleukin-6; Liver Neoplasms; Lovastatin; Mevalonic Acid; Plasminogen Activator Inhibitor 1; RNA, Messenger; Up-Regulation	2003
Interleukin-6 and mevastatin regulate plasminogen activator inhibitor-1 through CCAAT/enhancer-binding protein-delta. Arteriosclerosis, thrombosis, and vascular biology, 2005, Volume: 25, Issue:5 Topics: Animals; Atherosclerosis; Carcinoma, Hepatocellular; CCAAT-Enhancer-Binding Protein-delta; Cell Line, Tumor; Cell Nucleus; Chromosome Mapping; Gene Expression; Hepatocytes; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Interleukin-6; Liver Neoplasms; Lovastatin; Mice; Mice, Inbred ICR; Mutagenesis, Site-Directed; Plasminogen Activator Inhibitor 1; Promoter Regions, Genetic; Response Elements; RNA, Messenger; Thrombosis; Transfection	2005
Statins potentiate the IFN-gamma-induced upregulation of group IIA phospholipase A2 in human aortic smooth muscle cells and HepG2 hepatoma cells. Biochimica et biophysica acta, 2005, Apr-15, Volume: 1733, Issue:2-3 Topics: Amides; Aorta; Atorvastatin; Bacterial Proteins; Bacterial Toxins; Butadienes; Carcinoma, Hepatocellular; CCAAT-Enhancer-Binding Proteins; Cell Line, Tumor; Drug Synergism; Flavonoids; Group II Phospholipases A2; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Interferon-gamma; Janus Kinase 2; Lovastatin; Myocytes, Smooth Muscle; NF-kappa B; Nitriles; Phospholipases A; Phospholipases A2; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Pyridines; Pyrroles; RNA Stability; Up-Regulation	2005
A simultaneous assessment of CYP3A4 metabolism and induction in the DPX-2 cell line. The AAPS journal, 2005, Mar-04, Volume: 7, Issue:1 Topics: Carcinoma, Hepatocellular; Cell Line, Tumor; Chromans; Clotrimazole; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dexamethasone; Dimethyl Sulfoxide; Enhancer Elements, Genetic; Enzyme Induction; Genes, Reporter; Genes, Synthetic; Humans; Ketoconazole; Liver Neoplasms; Lovastatin; Luciferases; Mifepristone; Neoplasm Proteins; Nifedipine; Omeprazole; Paclitaxel; Phenytoin; Pregnane X Receptor; Receptors, Cytoplasmic and Nuclear; Receptors, Steroid; Recombinant Fusion Proteins; Rifampin; Thiazolidinediones; Transcription, Genetic; Troglitazone; Troleandomycin	2005
Effect of lovastatin alone and as an adjuvant chemotherapeutic agent on hepatoma tissue culture-4 cell growth. Annals of surgical oncology, 1995, Volume: 2, Issue:3 Topics: Animals; Carcinoma, Hepatocellular; Cell Adhesion; Cell Division; Chemotherapy, Adjuvant; Cholesterol; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Drug Therapy, Combination; Humans; Liver Neoplasms; Lovastatin; Mitomycin; Rats; Tumor Cells, Cultured	1995
Transcriptional regulation by lovastatin and 25-hydroxycholesterol in HepG2 cells and molecular cloning and expression of the cDNA for the human hepatic squalene synthase. The Journal of biological chemistry, 1993, Jun-15, Volume: 268, Issue:17 Topics: Amino Acid Sequence; Animals; Base Sequence; Carcinoma, Hepatocellular; Cell Division; Cloning, Molecular; DNA, Neoplasm; Farnesyl-Diphosphate Farnesyltransferase; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Hydroxycholesterols; Hydroxymethylglutaryl CoA Reductases; Kinetics; Liver; Liver Neoplasms; Lovastatin; Molecular Sequence Data; Oligodeoxyribonucleotides; Polymerase Chain Reaction; Rats; RNA; RNA, Messenger; Sequence Homology, Amino Acid; Transcription, Genetic; Tumor Cells, Cultured	1993
Lovastatin increases arachidonic acid levels and stimulates thromboxane synthesis in human liver and monocytic cell lines. The Journal of clinical investigation, 1994, Volume: 93, Issue:1 Topics: Analysis of Variance; Arachidonic Acid; Carcinoma, Hepatocellular; Cell Line; Cholesterol; Cholesterol Esters; Fatty Acids; Humans; Kinetics; Linoleic Acid; Linoleic Acids; Liver; Liver Neoplasms; Lovastatin; Monocytes; Phospholipids; Thromboxanes; Triglycerides; Tumor Cells, Cultured	1994
Rapid fluorometric assay of LDL receptor activity by DiI-labeled LDL. Journal of lipid research, 1993, Volume: 34, Issue:2 Topics: Binding, Competitive; Carbocyanines; Carcinoma, Hepatocellular; Fluorescent Dyes; Humans; Hydroxycholesterols; Iodine Radioisotopes; Lipoproteins, LDL; Liver Neoplasms; Lovastatin; Receptors, LDL; Tumor Cells, Cultured	1993
Tocotrienols regulate cholesterol production in mammalian cells by post-transcriptional suppression of 3-hydroxy-3-methylglutaryl-coenzyme A reductase. The Journal of biological chemistry, 1993, May-25, Volume: 268, Issue:15 Topics: Acetates; Acetic Acid; Androstenes; Animals; Carbon Radioisotopes; Carcinoma, Hepatocellular; Cell Line; Chickens; CHO Cells; Cholesterol; Chromans; Cricetinae; Gene Expression Regulation, Enzymologic; Humans; Hydroxycholesterols; Hydroxymethylglutaryl CoA Reductases; Ketoconazole; Kinetics; Liver Neoplasms; Liver Neoplasms, Experimental; Lovastatin; Mevalonic Acid; Rats; RNA Processing, Post-Transcriptional; RNA, Messenger; Suppression, Genetic; Tritium; Tumor Cells, Cultured; Vitamin E	1993
The novel cholesterol-lowering drug SR-12813 inhibits cholesterol synthesis via an increased degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase. The Journal of biological chemistry, 1996, Jun-14, Volume: 271, Issue:24 Topics: Acetates; Anticholesteremic Agents; Blotting, Western; Carcinoma, Hepatocellular; Cell Line; Cholesterol; Diphosphonates; Humans; Hydroxycholesterols; Hydroxymethylglutaryl CoA Reductases; Kinetics; Lanosterol; Lipoproteins, LDL; Liver Neoplasms; Lovastatin; Receptors, LDL; RNA, Messenger; Transcription, Genetic; Tritium; Tumor Cells, Cultured	1996
Regulation of fatty acid biosynthesis by intermediates of the cholesterol biosynthetic pathway. Biochemical and biophysical research communications, 1996, Aug-05, Volume: 225, Issue:1 Topics: Anticholesteremic Agents; Carboxy-Lyases; Carcinoma, Hepatocellular; Cholesterol; Fatty Acids; Homeostasis; Humans; Kinetics; Liver Neoplasms; Lovastatin; Mevalonic Acid; Structure-Activity Relationship; Tumor Cells, Cultured	1996
ApoB-100 secretion by HepG2 cells is regulated by the rate of triglyceride biosynthesis but not by intracellular lipid pools. Arteriosclerosis, thrombosis, and vascular biology, 1996, Volume: 16, Issue:10 Topics: Apolipoproteins B; Carcinoma, Hepatocellular; Enzyme Inhibitors; Furans; Humans; Hypolipidemic Agents; Lipid Metabolism; Lovastatin; Simvastatin; Triglycerides; Tumor Cells, Cultured	1996
Manipulation of the fate of long chain polyunsaturated fatty acids in cultured cells. Prostaglandins, leukotrienes, and essential fatty acids, 1997, Volume: 57, Issue:1 Topics: Arachidonic Acid; Carcinoma, Hepatocellular; Cell Differentiation; Cell Line; Cholesterol; Enzyme Inhibitors; Ethanol; Fatty Acids, Unsaturated; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Linoleic Acid; Linoleic Acids; Liver Neoplasms; Lovastatin; Mevalonic Acid; Monocytes; Neuroblastoma; Simvastatin; Tumor Cells, Cultured	1997
LXRs control lipid-inducible expression of the apolipoprotein E gene in macrophages and adipocytes. Proceedings of the National Academy of Sciences of the United States of America, 2001, Jan-16, Volume: 98, Issue:2 Topics: 3T3 Cells; Adipocytes; Animals; Anticholesteremic Agents; Apolipoproteins E; Arteriosclerosis; ATP Binding Cassette Transporter 1; ATP Binding Cassette Transporter, Subfamily G, Member 1; ATP-Binding Cassette Transporters; Carcinoma, Hepatocellular; Cell Differentiation; Cells, Cultured; Cholesterol; Diet, Atherogenic; Dimerization; DNA-Binding Proteins; Enhancer Elements, Genetic; Gene Expression Regulation; Humans; Hydrocarbons, Fluorinated; Hydroxycholesterols; Ligands; Lipids; Liver Neoplasms; Liver X Receptors; Lovastatin; Macrophages, Peritoneal; Male; Mevalonic Acid; Mice; Mice, Knockout; Organic Chemicals; Orphan Nuclear Receptors; Receptors, Cytoplasmic and Nuclear; Receptors, Retinoic Acid; Recombinant Fusion Proteins; Retinoid X Receptors; RNA, Messenger; Sulfonamides; Tetradecanoylphorbol Acetate; Transcription Factors; Tumor Cells, Cultured	2001
Expression of sterol regulatory element-binding protein 1c (SREBP-1c) mRNA in rat hepatoma cells requires endogenous LXR ligands. Proceedings of the National Academy of Sciences of the United States of America, 2001, Feb-13, Volume: 98, Issue:4 Topics: Animals; Carcinoma, Hepatocellular; CCAAT-Enhancer-Binding Proteins; Cholesterol; DNA-Binding Proteins; Gene Expression; Humans; Hydroxycholesterols; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Ligands; Liver X Receptors; Lovastatin; Orphan Nuclear Receptors; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Sterol Regulatory Element Binding Protein 1; Sterol Regulatory Element Binding Protein 2; Transcription Factors; Tumor Cells, Cultured	2001
Effect of a novel squalene epoxidase inhibitor, NB-598, on the regulation of cholesterol metabolism in Hep G2 cells. The Journal of biological chemistry, 1991, Jul-15, Volume: 266, Issue:20 Topics: Acetates; Anticholesteremic Agents; Benzylamines; Carcinoma, Hepatocellular; Cell Line; Cholesterol; Cycloheximide; Humans; Hydroxycholesterols; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Kinetics; Lipoproteins, LDL; Liver Neoplasms; Lovastatin; Mevalonic Acid; Nucleic Acid Hybridization; Oxygenases; RNA, Neoplasm; Simvastatin; Squalene Monooxygenase; Thiophenes	1991
Effects of a novel lanosterol 14 alpha-demethylase inhibitor on the regulation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase in Hep G2 cells. The Journal of biological chemistry, 1991, Oct-25, Volume: 266, Issue:30 Topics: Carcinoma, Hepatocellular; Cell-Free System; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme Inhibitors; Humans; Hydroxymethylglutaryl CoA Reductases; Lanosterol; Liver Neoplasms; Lovastatin; Mevalonic Acid; Oxidoreductases; Receptors, LDL; Sterol 14-Demethylase; Sterols; Tumor Cells, Cultured	1991
Regulation of apoB secretion from HepG2 cells: evidence for a critical role for cholesteryl ester synthesis in the response to a fatty acid challenge. Journal of lipid research, 1990, Volume: 31, Issue:11 Topics: Apolipoproteins B; Blood Proteins; Carcinoma, Hepatocellular; Cholesterol Esters; Complement C3a; Fatty Acids; Humans; Kinetics; Liver; Liver Neoplasms; Lovastatin; Oleic Acids; Progesterone; Sterol O-Acyltransferase; Triglycerides; Tumor Cells, Cultured	1990
Regulation of squalene epoxidase in HepG2 cells. Journal of lipid research, 1990, Volume: 31, Issue:11 Topics: Binding, Competitive; Carcinoma, Hepatocellular; Cholesterol; Detergents; Enzyme Induction; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Kinetics; Lipoproteins, LDL; Liver; Liver Neoplasms; Lovastatin; Mevalonic Acid; Microsomes, Liver; Octoxynol; Oxygenases; Polyethylene Glycols; Simvastatin; Squalene Monooxygenase; Tumor Cells, Cultured	1990
Inhibition of 3-hydroxy-3-methylglutaryl coenzyme A synthase by antibiotic 1233A and other beta-lactones. Biochemical and biophysical research communications, 1990, Jun-15, Volume: 169, Issue:2 Topics: Acetates; Animals; Anti-Bacterial Agents; Carcinoma, Hepatocellular; Cell Line; Cholestyramine Resin; Fatty Acids, Unsaturated; Humans; Hydroxymethylglutaryl-CoA Synthase; Kinetics; Lactones; Liver; Liver Neoplasms; Lovastatin; Molecular Structure; Oxo-Acid-Lyases; Rats; Structure-Activity Relationship; Tumor Cells, Cultured	1990
Inhibition of cholesterol synthesis by lovastatin tested on six human cell types in vitro. Lipids, 1990, Volume: 25, Issue:3 Topics: Anticholesteremic Agents; Carcinoma, Hepatocellular; Cells, Cultured; Cholesterol; Dose-Response Relationship, Drug; Fibroblasts; Humans; Intestinal Mucosa; Intestines; Liver; Liver Neoplasms; Lovastatin; Muscle, Smooth, Vascular; Receptors, LDL; Tumor Cells, Cultured	1990
Hep-G2 cells and primary rat hepatocytes differ in their response to inhibitors of HMG-CoA reductase. Biochemical and biophysical research communications, 1990, Jul-31, Volume: 170, Issue:2 Topics: Animals; Atorvastatin; Carcinoma, Hepatocellular; Fatty Acids, Monounsaturated; Fatty Acids, Unsaturated; Fibroblasts; Fluvastatin; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Liver Neoplasms; Lovastatin; Male; Naphthalenes; Pravastatin; Pyrroles; Rats; Rats, Inbred Strains; Sterols; Tetrazoles; Tumor Cells, Cultured	1990
Effect of simvastatin (MK-733) on the regulation of cholesterol synthesis in Hep G2 cells. Biochemical pharmacology, 1990, Aug-15, Volume: 40, Issue:4 Topics: Anticholesteremic Agents; Carcinoma, Hepatocellular; Cholesterol; Cholesterol Esters; Humans; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Liver Neoplasms; Lovastatin; Progesterone; Receptors, LDL; Simvastatin; Tumor Cells, Cultured	1990
The unstirred water layer as a site of control of apolipoprotein B secretion. The Journal of biological chemistry, 1990, Oct-05, Volume: 265, Issue:28 Topics: Antibodies; Apolipoproteins B; Carcinoma, Hepatocellular; Cell Line; Culture Media; Dideoxyadenosine; Humans; Liver Neoplasms; Lovastatin; Receptors, LDL; Water	1990
Differential regulation of hepatic triglyceride lipase and 3-hydroxy-3-methylglutaryl-CoA reductase gene expression in a human hepatoma cell line, HepG2. The Journal of biological chemistry, 1990, Dec-25, Volume: 265, Issue:36 Topics: Carcinoma, Hepatocellular; Cell Line; Cholesterol; Gene Expression Regulation; Hydroxymethylglutaryl CoA Reductases; Kinetics; Lipase; Liver Neoplasms; Lovastatin; Mevalonic Acid; RNA Probes; RNA, Messenger; Transcription, Genetic	1990
Regulation of squalene synthetase in human hepatoma cell line Hep G2 by sterols, and not by mevalonate-derived non-sterols. Biochimica et biophysica acta, 1989, Mar-14, Volume: 1002, Issue:1 Topics: Androstenes; Carcinoma, Hepatocellular; Cholesterol; Farnesyl-Diphosphate Farnesyltransferase; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Intramolecular Transferases; Isomerases; Lipoproteins, HDL; Lipoproteins, LDL; Liver Neoplasms; Lovastatin; Mevalonic Acid; Oxidoreductases; Sterols; Tumor Cells, Cultured	1989
Co-ordinate regulation of low-density-lipoprotein receptor and 3-hydroxy-3-methylglutaryl-CoA reductase and synthase gene expression in HepG2 cells. The Biochemical journal, 1989, Jun-15, Volume: 260, Issue:3 Topics: Carcinoma, Hepatocellular; DNA, Neoplasm; Gene Expression Regulation; Humans; Hydroxycholesterols; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Synthase; Liver Neoplasms; Lovastatin; Mevalonic Acid; Oxo-Acid-Lyases; Receptors, LDL; RNA, Messenger; Tumor Cells, Cultured	1989
Regulation of 3-hydroxy-3-methylglutaryl-CoA reductase mRNA contents in human hepatoma cell line Hep G2 by distinct classes of mevalonate-derived metabolites. The Biochemical journal, 1988, Oct-01, Volume: 255, Issue:1 Topics: Androstenes; Anticholesteremic Agents; Carcinoma, Hepatocellular; Cell Line; Enzyme Activation; Humans; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hydroxymethylglutaryl-CoA-Reductases, NADP-dependent; Immunoblotting; Lipoproteins, LDL; Liver Neoplasms; Lovastatin; Mevalonic Acid; RNA, Messenger; Tumor Cells, Cultured	1988
Regulation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase in human hepatoma cell line Hep G2. Effects of inhibitors of cholesterol synthesis on enzyme activity. The Biochemical journal, 1987, Jan-15, Volume: 241, Issue:2 Topics: Androstenes; Animals; Anticholesteremic Agents; Carcinoma, Hepatocellular; Cell Line; Cholesterol; Humans; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hydroxymethylglutaryl-CoA-Reductases, NADP-dependent; Imidoesters; Lipid Metabolism; Liver Neoplasms; Lovastatin; Mevalonic Acid; Naphthalenes; Triparanol	1987