lovastatin and Cancer of Prostate

Topics: Cell Line, Tumor; Cytochrome P-450 CYP2C8; Cytochrome P-450 CYP2C8 Inhibitors; Drug Resistance, Neoplasm; Drug Synergism; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Kaplan-Meier Estimate; Lovastatin; Male; Models, Biological; Paclitaxel; Prognosis; Prostatic Neoplasms

Topics: Coenzyme A; Humans; Lovastatin; Male; Monascus; Phosphatidylinositol 3-Kinases; Prostatic Neoplasms

Topics: Antigens, Surface; Cell Line, Tumor; Dutasteride; Glutamate Carboxypeptidase II; Humans; Lovastatin; Male; Prostate; Prostate-Specific Antigen; Prostatic Neoplasms

Topics: Androgens; Apoptosis; Biological Products; Cell Line, Tumor; Cell Proliferation; Humans; Lovastatin; Male; PC-3 Cells; Prostatic Neoplasms

Topics: Activating Transcription Factor 3; Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Blotting, Western; Breast Neoplasms; Carcinoma, Squamous Cell; Cell Membrane Permeability; Cell Proliferation; Cinnamates; Drug Resistance, Neoplasm; Drug Synergism; Embryo, Mammalian; Eukaryotic Initiation Factor-2; Female; Fibroblasts; Flow Cytometry; Head and Neck Neoplasms; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immunoenzyme Techniques; Lovastatin; Male; Membrane Potential, Mitochondrial; Mice; Phosphorylation; Prostatic Neoplasms; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; RNA, Small Interfering; Thiourea; Tumor Cells, Cultured

Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cholesterol; Coxsackie and Adenovirus Receptor-Like Membrane Protein; Dependovirus; Dose-Response Relationship, Drug; Genetic Therapy; Genetic Vectors; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Integrins; Lovastatin; Male; Membrane Microdomains; Oncolytic Virotherapy; Prostatic Neoplasms; Receptors, TNF-Related Apoptosis-Inducing Ligand; Signal Transduction; Time Factors; TNF-Related Apoptosis-Inducing Ligand; Transduction, Genetic; Xenograft Model Antitumor Assays

Topics: Adenocarcinoma; Aged; Aged, 80 and over; Anticholesteremic Agents; Case-Control Studies; Follow-Up Studies; Gastrointestinal Hemorrhage; Humans; Lovastatin; Male; Middle Aged; Prognosis; Prostatic Neoplasms; Radiation Injuries; Radiation Protection; Radiotherapy, Conformal; Rectum

Topics: Brachytherapy; Erectile Dysfunction; Follow-Up Studies; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Male; Middle Aged; Neoplasm Staging; Prognosis; Prostatic Neoplasms; Risk Factors

Topics: Aged; Atorvastatin; Biomarkers, Tumor; Cholesterol, HDL; Cholesterol, LDL; Early Diagnosis; Fatty Acids, Monounsaturated; Fluvastatin; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Incidence; Indoles; Linear Models; Longitudinal Studies; Lovastatin; Male; Middle Aged; Multivariate Analysis; Pravastatin; Prostate-Specific Antigen; Prostatic Neoplasms; Pyrroles; Risk Assessment; Simvastatin; Veterans

Topics: Androgens; Anticholesteremic Agents; Apoptosis; Biological Products; Cell Line, Tumor; Cell Proliferation; Gene Expression Regulation; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Male; Mevalonic Acid; Monascus; Prostate; Prostatic Neoplasms; Receptors, Androgen; Sterol Regulatory Element Binding Protein 2

Topics: 3-Oxo-5-alpha-Steroid 4-Dehydrogenase; Animals; Atorvastatin; Azetidines; Cell Line, Tumor; Ezetimibe; Gene Expression Regulation, Enzymologic; Heptanoic Acids; Hydroxymethylglutaryl CoA Reductases; Hypercholesterolemia; Liver; Lovastatin; Male; Mice; Promoter Regions, Genetic; Prostate; Prostatic Neoplasms; Pyrroles; Sterol Regulatory Element Binding Protein 2; Transfection

Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Humans; Lovastatin; Male; Prostatic Neoplasms

Topics: Animals; Antineoplastic Agents; Apoptosis; Biological Products; Cell Line, Tumor; Cell Proliferation; Cholesterol; Enzyme-Linked Immunosorbent Assay; Humans; Lovastatin; Male; Mice; Mice, SCID; Prostate-Specific Antigen; Prostatic Neoplasms; Reverse Transcriptase Polymerase Chain Reaction; Xenograft Model Antitumor Assays

Topics: Aged; Aged, 80 and over; Anticarcinogenic Agents; Anticholesteremic Agents; Antihypertensive Agents; Atorvastatin; Biomarkers, Tumor; Cholesterol; Confounding Factors, Epidemiologic; Fatty Acids, Monounsaturated; Fluvastatin; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Incidence; Indoles; Lipids; Lovastatin; Male; Middle Aged; Multivariate Analysis; New England; Pravastatin; Proportional Hazards Models; Prostatic Neoplasms; Pyrroles; Risk Assessment; Severity of Illness Index; Simvastatin; Veterans

Topics: Androgens; Caspase 3; Cell Line, Tumor; Gene Expression Regulation, Neoplastic; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immunoassay; Lovastatin; Lymphatic Metastasis; Male; Prostate-Specific Antigen; Prostatic Neoplasms; Proto-Oncogene Proteins c-akt; Receptors, Androgen; RNA, Small Interfering; Signal Transduction

Topics: Anticholesteremic Agents; CDC2-CDC28 Kinases; Cell Division; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinases; Enzyme Activation; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Male; Phosphorylation; Prostatic Neoplasms; Protein Serine-Threonine Kinases; Tumor Cells, Cultured

Topics: Animals; Apoptosis; Body Weight; Cell Cycle; Cell Division; Cell Transformation, Neoplastic; Female; Flow Cytometry; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Male; Mammary Neoplasms, Experimental; Mice; Mice, Transgenic; Prostatic Neoplasms

Topics: CDC2-CDC28 Kinases; Cell Cycle; Cell Division; Cell Line; Cell Line, Tumor; Colonic Neoplasms; Cyclin A; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinases; Cyclins; Flow Cytometry; G1 Phase; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immunoblotting; Lovastatin; Male; Microscopy, Fluorescence; Models, Biological; Phosphorylation; Precipitin Tests; Prostatic Neoplasms; Retinoblastoma Protein; RNA, Messenger; RNA, Small Interfering

Topics: Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Cell Survival; Chromans; Cyclin A; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase Inhibitor p27; Dose-Response Relationship, Drug; Drug Synergism; E2F1 Transcription Factor; Glioblastoma; HeLa Cells; Humans; Lovastatin; Lung Neoplasms; Male; Pancreatic Neoplasms; Phosphorylation; Prostatic Neoplasms; Retinoblastoma Protein; Thiazolidinediones; Troglitazone; Tumor Cells, Cultured

Topics: Antineoplastic Agents; Cell Cycle; Cell Line, Tumor; Cellular Senescence; Dose-Response Relationship, Drug; Gene Expression Regulation, Neoplastic; Humans; Lovastatin; Male; Prostatic Neoplasms; rhoA GTP-Binding Protein

Topics: Aged; Atorvastatin; Biopsy; Brachytherapy; Cause of Death; Chemotherapy, Adjuvant; Chi-Square Distribution; Disease-Free Survival; Fatty Acids, Monounsaturated; Fluvastatin; Follow-Up Studies; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Lovastatin; Male; Neoplasm Staging; Pravastatin; Proportional Hazards Models; Prostatic Neoplasms; Pyrroles; Retrospective Studies; Simvastatin; Survival Analysis

Topics: Cell Cycle; Cell Line, Tumor; Cyclin E; Cyclin-Dependent Kinase 2; Fatty Acids, Monounsaturated; Fluvastatin; G1 Phase; Humans; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Lovastatin; Male; p21-Activated Kinases; Phosphorylation; Pravastatin; Proliferating Cell Nuclear Antigen; Prostatic Neoplasms; Protein Serine-Threonine Kinases; Simvastatin

Topics: Aged, 80 and over; Antineoplastic Agents; Chemical and Drug Induced Liver Injury; Drug Interactions; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Ketoconazole; Lovastatin; Male; Prostatic Neoplasms; Rhabdomyolysis; Treatment Outcome

Topics: Adenocarcinoma; Antineoplastic Agents; Apoptosis; Breast Neoplasms; Burkitt Lymphoma; Carcinoma; Cell Line, Tumor; Cisplatin; Colorectal Neoplasms; Concanavalin A; Cytotoxicity, Immunologic; Diphosphonates; Doxorubicin; Drug Screening Assays, Antitumor; Drug Synergism; Etoposide; Female; Genes, T-Cell Receptor delta; Genes, T-Cell Receptor gamma; Humans; Imidazoles; Interferon-gamma; Lovastatin; Lung Neoplasms; Male; Membrane Glycoproteins; Neoplasms; Perforin; Pore Forming Cytotoxic Proteins; Prostatic Neoplasms; Receptors, Antigen, T-Cell, gamma-delta; T-Lymphocyte Subsets; Urinary Bladder Neoplasms; Vincristine; Zoledronic Acid

Topics: beta-Cyclodextrins; Cell Line, Tumor; Cholesterol; Endocytosis; Humans; Lovastatin; Lysosomes; Male; Mevalonic Acid; Neoplasm Proteins; Prostatic Neoplasms; Secretory Vesicles

Topics: Animals; Apoptosis; Caspase 3; Cell Cycle; Cell Line, Tumor; Enzyme Activation; Glycerophosphates; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Inclusion Bodies; Lipids; Lovastatin; Male; Nuclear Magnetic Resonance, Biomolecular; Phenylbutyrates; Phosphorylcholine; Prostatic Neoplasms; Radiography

Topics: Antineoplastic Agents; Benzamides; Cell Death; Cell Line, Tumor; Diphosphonates; Drug Screening Assays, Antitumor; Drug Synergism; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Imidazoles; Lovastatin; Male; Methionine; Mitochondria; Prostatic Neoplasms; Vorinostat; Zoledronic Acid

Topics: Apoptosis; Blotting, Western; Cell Cycle; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Situ Nick-End Labeling; In Vitro Techniques; Lovastatin; Male; Prostatic Neoplasms; Simvastatin; Tumor Cells, Cultured

Topics: Animals; Caspase 3; Cell Line, Tumor; Cell Survival; Chorionic Gonadotropin; Combined Modality Therapy; Drug Interactions; Female; Humans; Ki-67 Antigen; Lovastatin; Male; Mice; Mice, Nude; Prostatic Neoplasms; Radiation-Sensitizing Agents; Radiation, Ionizing

Topics: Animals; Chorionic Gonadotropin; Drug Interactions; Humans; Lovastatin; Male; Mice; Prostatic Neoplasms; Radiation-Sensitizing Agents

Topics: Antineoplastic Agents; Aphidicolin; Apoptosis; Cell Cycle; Cell Division; Cycloheximide; DNA, Neoplasm; Humans; Lovastatin; Male; Microscopy, Electron; Nucleosomes; Prostatic Neoplasms; Tumor Cells, Cultured

Topics: Cell Line; Electrophoresis, Polyacrylamide Gel; Humans; Lovastatin; Male; Neoplasm Proteins; Polyisoprenyl Phosphates; Prostatic Neoplasms; Protein Prenylation; Protein Processing, Post-Translational; Radioisotope Dilution Technique; Sesquiterpenes; Tritium; Tumor Cells, Cultured

Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Dose-Response Relationship, Drug; Drug Synergism; Genes, ras; Humans; Lovastatin; Male; Mice; Neoplasm Transplantation; Paclitaxel; Prostatic Neoplasms; Quinacrine; Transplantation, Heterologous; Tumor Cells, Cultured

Topics: Anticholesteremic Agents; Antineoplastic Agents; Apoptosis; Blotting, Western; Caspase 7; Caspases; Cysteine Endopeptidases; DNA Fragmentation; Electrophoresis, Agar Gel; Enzyme Activation; Enzyme Inhibitors; Humans; Lovastatin; Male; Poly(ADP-ribose) Polymerases; Prostatic Neoplasms; RNA, Messenger; Tumor Cells, Cultured

Topics: Apoptosis; Base Sequence; Carrier Proteins; Cell Cycle Proteins; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinases; Cyclins; DNA-Binding Proteins; E2F Transcription Factors; E2F1 Transcription Factor; G1 Phase; Gene Expression Regulation, Neoplastic; Humans; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Male; Molecular Sequence Data; Phosphorylation; Promoter Regions, Genetic; Prostatic Neoplasms; Retinoblastoma Protein; Retinoblastoma-Binding Protein 1; RNA, Messenger; Transcription Factor DP1; Transcription Factors; Transcription, Genetic; Tumor Cells, Cultured; Tumor Suppressor Protein p53

Topics: Actin Cytoskeleton; Adenocarcinoma; Alkyl and Aryl Transferases; Animals; Antineoplastic Agents; Apoptosis; Cell Adhesion; Cell Division; Cell Size; Diterpenes; Drug Interactions; Enzyme Activation; Farnesol; G1 Phase; Genes, ras; GTP-Binding Proteins; Guanosine Triphosphate; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Male; Mevalonic Acid; Mice; Mice, Transgenic; Polyisoprenyl Phosphates; Prostatic Neoplasms; Protein Prenylation; Protein Processing, Post-Translational; Proto-Oncogene Proteins p21(ras); rac GTP-Binding Proteins; rhoA GTP-Binding Protein; Sesquiterpenes; Tumor Cells, Cultured

Topics: Acetylcysteine; Antineoplastic Agents; Blotting, Western; Calcium-Binding Proteins; Calpain; CDC2-CDC28 Kinases; Cell Cycle; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinases; Cysteine Proteinase Inhibitors; Humans; Lovastatin; Male; Nuclear Proteins; Proliferating Cell Nuclear Antigen; Prostatic Neoplasms; Protein Serine-Threonine Kinases; Retinoblastoma Protein; Retinoblastoma-Like Protein p107; Sarcoma, Ewing; Transfection; Tumor Cells, Cultured; Ubiquitins

Topics: Adenocarcinoma; Calcium-Calmodulin-Dependent Protein Kinases; Cholesterol; Diterpenes; Farnesol; Genes, ras; Heat-Shock Response; Humans; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hydroxymethylglutaryl-CoA-Reductases, NADP-dependent; Lovastatin; Male; Mevalonic Acid; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Prostatic Neoplasms; Protein Prenylation; ras Proteins; Sterols; Stress, Physiological

Topics: Apoptosis; Calpain; Cell Cycle Proteins; Cell Survival; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinase Inhibitor p27; Cyclins; Cysteine Proteinase Inhibitors; DNA-Binding Proteins; E2F Transcription Factors; E2F1 Transcription Factor; Humans; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Male; Oligopeptides; Prostatic Neoplasms; RNA, Messenger; Transcription Factors; Transcription, Genetic; Tumor Cells, Cultured; Tumor Suppressor Proteins

Topics: 17-Hydroxysteroid Dehydrogenases; Aged; Humans; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Male; Oxidoreductases; Prostatic Neoplasms; Simvastatin; Steroids; Testis; Testosterone