lovastatin has been researched along with Astrocytoma, Grade IV in 7 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (14.29) | 18.2507 |
| 2000's | 4 (57.14) | 29.6817 |
| 2010's | 2 (28.57) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Cheng, SY; Kiang, KMY; Leung, GK; Li, N; Wong, VK; Zhang, P; Zhu, Z | 1 |
| Chan, TM; Deng, Y; Hu, X; Liu, PC; Lu, G; Poon, WS; Su, XW; Wang, CD; Zhou, JY | 1 |
| Barrett, GM; Cemeus, C; Dimitroulakos, J; Lorimer, IA; Zhao, TT | 1 |
| Higashikubo, R; Jiang, Z; Lytle, RA; Rich, KM; Zheng, X | 1 |
| Chan, CF; Cheng, AL; Chuang, SE; Lai, GM; Yang, YY; Yao, CJ | 1 |
| Chan, DY; Chen, GG; Liu, PC; Poon, WS | 1 |
| Jane, J; Larner, J; Laws, E; Myers, C; Packer, R; Shaffrey, M | 1 |
1 trial(s) available for lovastatin and Astrocytoma, Grade IV
| Article | Year |
|---|---|
A phase I-II trial of lovastatin for anaplastic astrocytoma and glioblastoma multiforme.
Topics: Adult; Antineoplastic Agents; Astrocytoma; Brain Neoplasms; Female; Glioblastoma; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Male; Middle Aged; Radiation-Sensitizing Agents; Radiotherapy, Adjuvant | 1998 |
6 other study(ies) available for lovastatin and Astrocytoma, Grade IV
| Article | Year |
|---|---|
Lovastatin Enhances Cytotoxicity of Temozolomide via Impairing Autophagic Flux in Glioblastoma Cells.
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Autophagy; Brain Neoplasms; Cell Line, Tumor; Cell Survival; Drug Resistance, Neoplasm; Dyneins; Glioblastoma; Humans; Lovastatin; Lysosomal-Associated Membrane Protein 2; Proto-Oncogene Proteins c-akt; Signal Transduction; Temozolomide; TOR Serine-Threonine Kinases; Tumor Stem Cell Assay | 2019 |
Inhibition of NF-κB Pathway and Modulation of MAPK Signaling Pathways in Glioblastoma and Implications for Lovastatin and Tumor Necrosis Factor-Related Apoptosis Inducing Ligand (TRAIL) Combination Therapy.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Line, Tumor; Cell Proliferation; Disease Models, Animal; Glioblastoma; HEK293 Cells; Humans; Lovastatin; MAP Kinase Signaling System; Mice, Inbred BALB C; Mice, Nude; Models, Biological; NF-kappa B; Receptors, TNF-Related Apoptosis-Inducing Ligand; Subcutaneous Tissue; TNF-Related Apoptosis-Inducing Ligand; Up-Regulation | 2017 |
Lovastatin enhances gefitinib activity in glioblastoma cells irrespective of EGFRvIII and PTEN status.
Topics: Antineoplastic Combined Chemotherapy Protocols; Blotting, Western; Brain Neoplasms; Cell Line, Tumor; Drug Resistance, Neoplasm; ErbB Receptors; Flow Cytometry; Gefitinib; Glioblastoma; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; PTEN Phosphohydrolase; Quinazolines | 2008 |
Lovastatin-induced up-regulation of the BH3-only protein, Bim, and cell death in glioblastoma cells.
Topics: Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; Bcl-2-Like Protein 11; Carrier Proteins; Cell Line, Tumor; Cell Survival; Dose-Response Relationship, Drug; Glioblastoma; Glioma; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; MAP Kinase Signaling System; Membrane Proteins; Polyisoprenyl Phosphates; Protein Prenylation; Protein Structure, Tertiary; Proto-Oncogene Proteins; Up-Regulation | 2004 |
Dramatic synergistic anticancer effect of clinically achievable doses of lovastatin and troglitazone.
Topics: Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Cell Survival; Chromans; Cyclin A; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase Inhibitor p27; Dose-Response Relationship, Drug; Drug Synergism; E2F1 Transcription Factor; Glioblastoma; HeLa Cells; Humans; Lovastatin; Lung Neoplasms; Male; Pancreatic Neoplasms; Phosphorylation; Prostatic Neoplasms; Retinoblastoma Protein; Thiazolidinediones; Troglitazone; Tumor Cells, Cultured | 2006 |
Lovastatin sensitized human glioblastoma cells to TRAIL-induced apoptosis.
Topics: Analysis of Variance; Anticholesteremic Agents; Apoptosis; Cell Cycle; Cell Line, Tumor; Cell Survival; Dose-Response Relationship, Drug; Drug Interactions; Gene Expression Regulation, Neoplastic; Glioblastoma; Humans; Lovastatin; Receptors, TNF-Related Apoptosis-Inducing Ligand; Tetrazolium Salts; Thiazoles; TNF-Related Apoptosis-Inducing Ligand | 2008 |