Page last updated: 2024-08-23

lovastatin and Allergic Encephalomyelitis

lovastatin has been researched along with Allergic Encephalomyelitis in 15 studies

Research

Studies (15)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (6.67)18.2507
2000's12 (80.00)29.6817
2010's2 (13.33)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Choi, S; Samuvel, DJ; Saxena, N; Singh, AK; Singh, I; Won, J1
Paintlia, AS; Paintlia, MK; Singh, AK; Singh, I; Skoff, RB1
Paintlia, AS; Paintlia, MK; Singh, AK; Singh, I3
Hollis, BW; Paintlia, AS; Paintlia, MK; Singh, AK; Singh, I1
Gilg, AG; Singh, AK; Singh, I; Stanislaus, R1
Adamson, P; Baker, D; Beraud, E; Greenwood, J; Kanuga, N; Pryce, G; Walters, CE1
Blezer, EL; de Vries, HE; Dijkstra, CD; Döpp, E; Floris, S; Nicolay, K; Schadee-Eestermans, IL; Schreibelt, G; van der Pol, SM1
Giri, S; Nath, N; Prasad, R; Singh, AK; Singh, I1
Barbosa, E; Gilg, AG; Paintlia, AS; Paintlia, MK; Singh, AK; Singh, I; Stanislaus, R1
Contreras, MA; Haq, E; Khan, M; Paintlia, AS; Paintlia, MK; Singh, AK; Singh, I; Stanislaus, R1
Khan, M; Paintlia, AS; Paintlia, MK; Singh, AK; Singh, I; Vollmer, T1
Pahan, K; Singh, AK; Singh, I; Stanislaus, R1
Singh, AK; Singh, I; Stanislaus, R1

Other Studies

15 other study(ies) available for lovastatin and Allergic Encephalomyelitis

ArticleYear
Combination therapy of lovastatin and AMP-activated protein kinase activator improves mitochondrial and peroxisomal functions and clinical disease in experimental autoimmune encephalomyelitis model.
    Immunology, 2018, Volume: 154, Issue:3

    Topics: Adenosine Triphosphate; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Biomarkers; Cell Line; Cytokines; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Female; Gene Expression; Humans; Lovastatin; Mice; Mitochondria; Peroxisomes; rho-Associated Kinases; rhoA GTP-Binding Protein; Ribonucleotides; Spinal Cord

2018
Combination therapy of lovastatin and rolipram provides neuroprotection and promotes neurorepair in inflammatory demyelination model of multiple sclerosis.
    Glia, 2009, Jan-15, Volume: 57, Issue:2

    Topics: Animals; Central Nervous System; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Encephalomyelitis, Autoimmune, Experimental; Female; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immunologic Factors; Lovastatin; Nerve Fibers, Myelinated; Nerve Regeneration; Neuroprotective Agents; Phosphodiesterase Inhibitors; Rats; Rats, Inbred Lew; Rolipram; Treatment Outcome; Wallerian Degeneration

2009
Combined medication of lovastatin with rolipram suppresses severity of experimental autoimmune encephalomyelitis.
    Experimental neurology, 2008, Volume: 214, Issue:2

    Topics: Animals; Demyelinating Diseases; Drug Synergism; Drug Therapy, Combination; Encephalomyelitis, Autoimmune, Experimental; Female; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immune Tolerance; Lovastatin; Nerve Degeneration; Phosphodiesterase Inhibitors; Rats; Rats, Inbred Lew; Rolipram; Severity of Illness Index; T-Lymphocytes, Regulatory; Th1 Cells; Th2 Cells

2008
Interference with RhoA-ROCK signaling mechanism in autoreactive CD4+ T cells enhances the bioavailability of 1,25-dihydroxyvitamin D3 in experimental autoimmune encephalomyelitis.
    The American journal of pathology, 2012, Volume: 181, Issue:3

    Topics: 25-Hydroxyvitamin D3 1-alpha-Hydroxylase; Animals; Biological Availability; Biosynthetic Pathways; Calcitriol; CD4-Positive T-Lymphocytes; Encephalomyelitis, Autoimmune, Experimental; Female; Guinea Pigs; Immunosuppression Therapy; Inflammation; Lovastatin; Lymphoid Tissue; Mevalonic Acid; Protein Kinase Inhibitors; Rats; Rats, Inbred Lew; rho-Associated Kinases; rhoA GTP-Binding Protein; Signal Transduction; Spinal Cord; Steroid Hydroxylases; Vitamin D; Vitamin D3 24-Hydroxylase

2012
Immunomodulation of experimental autoimmune encephalomyelitis in the Lewis rats by Lovastatin.
    Neuroscience letters, 2002, Nov-29, Volume: 333, Issue:3

    Topics: Animals; Cell Culture Techniques; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Enzyme-Linked Immunosorbent Assay; Female; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Interferon-gamma; Interleukin-10; Interleukin-6; Lovastatin; Myelin Basic Protein; Nitrites; Phytohemagglutinins; Rats; Rats, Inbred Lew; Spleen

2002
Lovastatin inhibits brain endothelial cell Rho-mediated lymphocyte migration and attenuates experimental autoimmune encephalomyelitis.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2003, Volume: 17, Issue:8

    Topics: Animals; Brain; Cell Movement; Coculture Techniques; Dose-Response Relationship, Drug; Encephalomyelitis, Autoimmune, Experimental; Endothelium, Vascular; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Lymphocytes; Mice; Remission Induction; rho GTP-Binding Proteins; Secondary Prevention

2003
Blood-brain barrier permeability and monocyte infiltration in experimental allergic encephalomyelitis: a quantitative MRI study.
    Brain : a journal of neurology, 2004, Volume: 127, Issue:Pt 3

    Topics: Animals; Blood-Brain Barrier; Brain; Capillary Permeability; Cell Movement; Contrast Media; Dextrans; Encephalomyelitis, Autoimmune, Experimental; Ferrosoferric Oxide; Gadolinium DTPA; Image Processing, Computer-Assisted; Immunohistochemistry; Iron; Lovastatin; Magnetic Resonance Imaging; Magnetite Nanoparticles; Male; Microscopy, Electron; Monocytes; Oxides; Rats; Rats, Inbred Lew; Spinal Cord

2004
Potential targets of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor for multiple sclerosis therapy.
    Journal of immunology (Baltimore, Md. : 1950), 2004, Jan-15, Volume: 172, Issue:2

    Topics: Animals; Cell Differentiation; Cell Line; Cell Migration Inhibition; Cell Movement; DNA-Binding Proteins; Encephalomyelitis, Autoimmune, Experimental; Epitopes, T-Lymphocyte; Female; GATA3 Transcription Factor; Growth Inhibitors; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Injections, Intraperitoneal; Interphase; Lovastatin; Mice; Mice, Inbred Strains; Multiple Sclerosis; Myelin Proteolipid Protein; Neurons; Spinal Cord; T-Box Domain Proteins; T-Lymphocyte Subsets; Th1 Cells; Th2 Cells; Trans-Activators; Transcription Factors; Up-Regulation

2004
Regulation of gene expression associated with acute experimental autoimmune encephalomyelitis by Lovastatin.
    Journal of neuroscience research, 2004, Jul-01, Volume: 77, Issue:1

    Topics: Animals; Cytokines; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Female; Gene Expression Regulation; Genes, MHC Class II; Growth Substances; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Multiple Sclerosis; Oligonucleotide Array Sequence Analysis; Rats; Rats, Inbred Lew; RNA, Messenger; Severity of Illness Index; Spinal Cord; Transcription Factors; Up-Regulation

2004
Impaired peroxisomal function in the central nervous system with inflammatory disease of experimental autoimmune encephalomyelitis animals and protection by lovastatin treatment.
    Brain research, 2004, Oct-01, Volume: 1022, Issue:1-2

    Topics: Acyl-CoA Oxidase; Acyltransferases; Adenosine Triphosphatases; Animals; Anticholesteremic Agents; ATP-Binding Cassette Transporters; ATPases Associated with Diverse Cellular Activities; Catalase; Central Nervous System; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Fatty Acids; Female; Freund's Adjuvant; Immunohistochemistry; Inflammation; Lovastatin; Membrane Proteins; Microarray Analysis; Peroxisomal Disorders; Peroxisomes; Rats; Rats, Inbred Lew; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger

2004
HMG-CoA reductase inhibitor augments survival and differentiation of oligodendrocyte progenitors in animal model of multiple sclerosis.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2005, Volume: 19, Issue:11

    Topics: Animals; Cell Differentiation; Cell Movement; Cell Proliferation; Cell Survival; Cells, Cultured; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Female; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Multiple Sclerosis; Myelin Sheath; Oligodendroglia; Rats; Rats, Inbred Lew; Stem Cells

2005
Immunomodulatory effect of combination therapy with lovastatin and 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside alleviates neurodegeneration in experimental autoimmune encephalomyelitis.
    The American journal of pathology, 2006, Volume: 169, Issue:3

    Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Drug Therapy, Combination; Encephalomyelitis, Autoimmune, Experimental; Enzyme Activation; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypoglycemic Agents; Immunoglobulin G; Immunologic Factors; Lovastatin; Multienzyme Complexes; Multiple Sclerosis; Myelin Basic Protein; Protein Serine-Threonine Kinases; Rats; Rats, Inbred Lew; Ribonucleotides; Th1 Cells; Th2 Cells

2006
Inhibition of rho family functions by lovastatin promotes myelin repair in ameliorating experimental autoimmune encephalomyelitis.
    Molecular pharmacology, 2008, Volume: 73, Issue:5

    Topics: Animals; Benzamides; Cell Differentiation; Cell Proliferation; Cells, Cultured; Cholesterol; Encephalomyelitis, Autoimmune, Experimental; Female; Hydroxymethylglutaryl CoA Reductases; Inflammation; Lovastatin; Methionine; Mevalonic Acid; Myelin Sheath; Nerve Growth Factors; Neuroglia; Oligodendroglia; Polyisoprenyl Phosphates; ras Proteins; Rats; Rats, Inbred Lew; Rats, Sprague-Dawley; rho GTP-Binding Proteins; Spinal Cord; Wound Healing

2008
Amelioration of experimental allergic encephalomyelitis in Lewis rats by lovastatin.
    Neuroscience letters, 1999, Jul-09, Volume: 269, Issue:2

    Topics: Animals; Encephalomyelitis, Autoimmune, Experimental; Female; Fluorescent Antibody Technique; Interferon-gamma; Lovastatin; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Rats; Rats, Inbred Lew; Tumor Necrosis Factor-alpha

1999
Lovastatin treatment decreases mononuclear cell infiltration into the CNS of Lewis rats with experimental allergic encephalomyelitis.
    Journal of neuroscience research, 2001, Oct-15, Volume: 66, Issue:2

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Adhesion; Chemotaxis, Leukocyte; Cytokines; Demyelinating Diseases; Disease Models, Animal; Drug Evaluation, Preclinical; Encephalomyelitis, Autoimmune, Experimental; Endothelium, Vascular; Enzyme Induction; Female; Gene Expression Regulation; Intercellular Adhesion Molecule-1; Lovastatin; Lymphocyte Function-Associated Antigen-1; Monocytes; Multiple Sclerosis; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Rats; Rats, Inbred Lew; Spinal Cord

2001