lovastatin and Allergic Encephalomyelitis

Topics: Adenosine Triphosphate; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Biomarkers; Cell Line; Cytokines; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Female; Gene Expression; Humans; Lovastatin; Mice; Mitochondria; Peroxisomes; rho-Associated Kinases; rhoA GTP-Binding Protein; Ribonucleotides; Spinal Cord

Topics: Animals; Central Nervous System; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Encephalomyelitis, Autoimmune, Experimental; Female; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immunologic Factors; Lovastatin; Nerve Fibers, Myelinated; Nerve Regeneration; Neuroprotective Agents; Phosphodiesterase Inhibitors; Rats; Rats, Inbred Lew; Rolipram; Treatment Outcome; Wallerian Degeneration

Topics: Animals; Demyelinating Diseases; Drug Synergism; Drug Therapy, Combination; Encephalomyelitis, Autoimmune, Experimental; Female; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immune Tolerance; Lovastatin; Nerve Degeneration; Phosphodiesterase Inhibitors; Rats; Rats, Inbred Lew; Rolipram; Severity of Illness Index; T-Lymphocytes, Regulatory; Th1 Cells; Th2 Cells

Topics: 25-Hydroxyvitamin D3 1-alpha-Hydroxylase; Animals; Biological Availability; Biosynthetic Pathways; Calcitriol; CD4-Positive T-Lymphocytes; Encephalomyelitis, Autoimmune, Experimental; Female; Guinea Pigs; Immunosuppression Therapy; Inflammation; Lovastatin; Lymphoid Tissue; Mevalonic Acid; Protein Kinase Inhibitors; Rats; Rats, Inbred Lew; rho-Associated Kinases; rhoA GTP-Binding Protein; Signal Transduction; Spinal Cord; Steroid Hydroxylases; Vitamin D; Vitamin D3 24-Hydroxylase

Topics: Animals; Cell Culture Techniques; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Enzyme-Linked Immunosorbent Assay; Female; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Interferon-gamma; Interleukin-10; Interleukin-6; Lovastatin; Myelin Basic Protein; Nitrites; Phytohemagglutinins; Rats; Rats, Inbred Lew; Spleen

Topics: Animals; Brain; Cell Movement; Coculture Techniques; Dose-Response Relationship, Drug; Encephalomyelitis, Autoimmune, Experimental; Endothelium, Vascular; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Lymphocytes; Mice; Remission Induction; rho GTP-Binding Proteins; Secondary Prevention

Topics: Animals; Blood-Brain Barrier; Brain; Capillary Permeability; Cell Movement; Contrast Media; Dextrans; Encephalomyelitis, Autoimmune, Experimental; Ferrosoferric Oxide; Gadolinium DTPA; Image Processing, Computer-Assisted; Immunohistochemistry; Iron; Lovastatin; Magnetic Resonance Imaging; Magnetite Nanoparticles; Male; Microscopy, Electron; Monocytes; Oxides; Rats; Rats, Inbred Lew; Spinal Cord

Topics: Animals; Cell Differentiation; Cell Line; Cell Migration Inhibition; Cell Movement; DNA-Binding Proteins; Encephalomyelitis, Autoimmune, Experimental; Epitopes, T-Lymphocyte; Female; GATA3 Transcription Factor; Growth Inhibitors; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Injections, Intraperitoneal; Interphase; Lovastatin; Mice; Mice, Inbred Strains; Multiple Sclerosis; Myelin Proteolipid Protein; Neurons; Spinal Cord; T-Box Domain Proteins; T-Lymphocyte Subsets; Th1 Cells; Th2 Cells; Trans-Activators; Transcription Factors; Up-Regulation

Topics: Animals; Cytokines; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Female; Gene Expression Regulation; Genes, MHC Class II; Growth Substances; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Multiple Sclerosis; Oligonucleotide Array Sequence Analysis; Rats; Rats, Inbred Lew; RNA, Messenger; Severity of Illness Index; Spinal Cord; Transcription Factors; Up-Regulation

Topics: Acyl-CoA Oxidase; Acyltransferases; Adenosine Triphosphatases; Animals; Anticholesteremic Agents; ATP-Binding Cassette Transporters; ATPases Associated with Diverse Cellular Activities; Catalase; Central Nervous System; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Fatty Acids; Female; Freund's Adjuvant; Immunohistochemistry; Inflammation; Lovastatin; Membrane Proteins; Microarray Analysis; Peroxisomal Disorders; Peroxisomes; Rats; Rats, Inbred Lew; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger

Topics: Animals; Cell Differentiation; Cell Movement; Cell Proliferation; Cell Survival; Cells, Cultured; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Female; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Multiple Sclerosis; Myelin Sheath; Oligodendroglia; Rats; Rats, Inbred Lew; Stem Cells

Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Drug Therapy, Combination; Encephalomyelitis, Autoimmune, Experimental; Enzyme Activation; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypoglycemic Agents; Immunoglobulin G; Immunologic Factors; Lovastatin; Multienzyme Complexes; Multiple Sclerosis; Myelin Basic Protein; Protein Serine-Threonine Kinases; Rats; Rats, Inbred Lew; Ribonucleotides; Th1 Cells; Th2 Cells

Topics: Animals; Benzamides; Cell Differentiation; Cell Proliferation; Cells, Cultured; Cholesterol; Encephalomyelitis, Autoimmune, Experimental; Female; Hydroxymethylglutaryl CoA Reductases; Inflammation; Lovastatin; Methionine; Mevalonic Acid; Myelin Sheath; Nerve Growth Factors; Neuroglia; Oligodendroglia; Polyisoprenyl Phosphates; ras Proteins; Rats; Rats, Inbred Lew; Rats, Sprague-Dawley; rho GTP-Binding Proteins; Spinal Cord; Wound Healing

Topics: Animals; Encephalomyelitis, Autoimmune, Experimental; Female; Fluorescent Antibody Technique; Interferon-gamma; Lovastatin; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Rats; Rats, Inbred Lew; Tumor Necrosis Factor-alpha

Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Adhesion; Chemotaxis, Leukocyte; Cytokines; Demyelinating Diseases; Disease Models, Animal; Drug Evaluation, Preclinical; Encephalomyelitis, Autoimmune, Experimental; Endothelium, Vascular; Enzyme Induction; Female; Gene Expression Regulation; Intercellular Adhesion Molecule-1; Lovastatin; Lymphocyte Function-Associated Antigen-1; Monocytes; Multiple Sclerosis; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Rats; Rats, Inbred Lew; Spinal Cord