Page last updated: 2024-08-23

lovastatin and Acute Confusional Senile Dementia

lovastatin has been researched along with Acute Confusional Senile Dementia in 27 studies

Research

Studies (27)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	23 (85.19)	29.6817
2010's	4 (14.81)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Li, R; Ma, T; Xu, DE	1
Kuo, TF; Lee, CL; Pan, TM; Wang, JJ; Wu, CL	1
Guan, S; Huang, L; Jia, W; Liao, W; Liu, X; Xu, N; Yu, C; Zhao, S; Zhao, Z	1
Barone, E; Butterfield, DA; Mancuso, C	1
Catalano, R; Cordell, B; Naidu, A; Xu, Q	1
Austen, BM; Frears, E; Liu, C; Sidera, C	1
Lipton, AM; Lutjohann, D; Moore, C; Svetlik, D; Vega, GL; Von Bergmann, K; Weiner, MF	1
Baskin, F; Fang, X; Hynan, LS; Moore, CB; Rosenberg, RN; Vega, GL; Weiner, M	1
Bang, OY; Boo, JH; Hong, HS; Hwang, EM; Jung, MW; Kim, SU; Lee, J; Mook-Jung, I; Oh, SS; Park, IH	1
Distl, R; Glöckner, F; Meske, V; Ohm, TG; Schönheit, B; Tamanai, M; Treiber-Held, S	1
Baudry, M; Bi, X; Brucher, F; Fu, L; Liu, J; Lynch, G; Yao, Y	1
Austen, B; Parsons, R; Sidera, C	2
Decker, M; Fändrich, M; Gellermann, GP; Habicht, G; Horn, U; Hortschansky, P; Lehmann, J; Möllmann, U; Sauter, SR; Tannert, A; Ullrich, K; Unger, C	1
Chen, X; Dodel, R; Du, Y; Farlow, M; Fontanilla, C; Hampel, H; Liang, Z; Wei, X; Zhao, L	1
Kuo, TF; Lee, CL; Pan, TM; Wang, JJ	1
Arias, C; Ferrera, P; Mercado-Gómez, O; Silva-Aguilar, M; Valverde, M	1
Dolga, AM; Eisel, UL; Luiten, PG; Nijholt, IM; Ostroveanu, A; Ten Bosch, Q	1
Lee, CL; Pan, TM; Wang, JJ	1
Cordell, B; Cyras, C; Li, Y; Sanan, DA; Xu, Q	1
Celesia, GG; Kellman, W; Ruosseau, P; Siegel, G; Wolozin, B	1
Feinberg, AW	1
Bollen, EL; Buckley, BM; Gaw, A	1
Buxbaum, JD; Cullen, EI; Friedhoff, LT; Geoghagen, NS	1
Das, UN	1
Humphrey, J; Mullan, M; Obregon, DF; Paris, D; Townsend, KP; Yokota, K	1
Buxbaum, JD; Cullen, EI; Friedhoff, LT	1

Reviews

1 review(s) available for lovastatin and Acute Confusional Senile Dementia

Article	Year
Essential fatty acids as possible mediators of the actions of statins. Prostaglandins, leukotrienes, and essential fatty acids, 2001, Volume: 65, Issue:1 Topics: Alzheimer Disease; Animals; Anticholesteremic Agents; Arteriosclerosis; Cardiovascular Diseases; Drug Therapy, Combination; Fatty Acids, Essential; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin	2001

Trials

4 trial(s) available for lovastatin and Acute Confusional Senile Dementia

Article	Year
Reduction in levels of 24S-hydroxycholesterol by statin treatment in patients with Alzheimer disease. Archives of neurology, 2003, Volume: 60, Issue:4 Topics: Aged; Alzheimer Disease; Brain; Cholesterol 24-Hydroxylase; Female; Humans; Hydroxycholesterols; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Male; Middle Aged; Niacin; Pravastatin; Simvastatin; Steroid Hydroxylases; Treatment Outcome	2003
Correlation of statin-increased platelet APP ratios and reduced blood lipids in AD patients. Neurology, 2003, Jun-24, Volume: 60, Issue:12 Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Blood Platelets; Cholesterol; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Niacin; Pravastatin; Protein Processing, Post-Translational; Simvastatin; Single-Blind Method	2003
Treatment with controlled-release lovastatin decreases serum concentrations of human beta-amyloid (A beta) peptide. The international journal of neuropsychopharmacology, 2001, Volume: 4, Issue:2 Topics: Adult; Aged; Alzheimer Disease; Amyloid beta-Peptides; Analysis of Variance; Anticholesteremic Agents; Delayed-Action Preparations; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Male; Middle Aged; Treatment Outcome	2001
Pharmacological concentrations of the HMG-CoA reductase inhibitor lovastatin decrease the formation of the Alzheimer beta-amyloid peptide in vitro and in patients. Frontiers in bioscience : a journal and virtual library, 2002, Apr-01, Volume: 7 Topics: Adult; Aged; Alzheimer Disease; Amyloid beta-Peptides; Animals; Cell Line; CHO Cells; Cholesterol; Cricetinae; Dogs; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypercholesterolemia; Lovastatin; Male; Middle Aged; Peptide Fragments	2002

Other Studies

22 other study(ies) available for lovastatin and Acute Confusional Senile Dementia

Article	Year
Lovastatin suppresses the aberrant tau phosphorylation from FTDP-17 mutation and okadaic acid-induction in rat primary neurons. Neuroscience, 2015, May-21, Volume: 294 Topics: Alzheimer Disease; Animals; Cells, Cultured; Frontotemporal Dementia; Lovastatin; Mutation; Neurons; Okadaic Acid; Phosphorylation; Rats, Sprague-Dawley; tau Proteins	2015
Red mold rice promotes neuroprotective sAPPalpha secretion instead of Alzheimer's risk factors and amyloid beta expression in hyperlipidemic Abeta40-infused rats. Journal of agricultural and food chemistry, 2010, Feb-24, Volume: 58, Issue:4 Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Animals; Brain; Cerebral Ventricles; Cholesterol; Fungi; Humans; Hyperlipidemias; Infusions, Intravenous; Learning Disabilities; Lovastatin; Male; Maze Learning; Memory Disorders; Monascus; Oryza; Peptide Fragments; Rats; Rats, Wistar; Reactive Oxygen Species; Thiobarbituric Acid Reactive Substances	2010
Lovastatin improves neurological outcome after nucleus basalis magnocellularis lesion in rats. Neuroscience, 2010, May-19, Volume: 167, Issue:3 Topics: Acetylcholine; Alzheimer Disease; Animals; Basal Nucleus of Meynert; Binding, Competitive; Cerebral Cortex; Choline O-Acetyltransferase; Denervation; Disease Models, Animal; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Ibotenic Acid; Lovastatin; Male; Neurotoxins; p38 Mitogen-Activated Protein Kinases; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Receptors, Muscarinic; Receptors, N-Methyl-D-Aspartate; Recovery of Function; Treatment Outcome	2010
Cholesterol-independent neuroprotective and neurotoxic activities of statins: perspectives for statin use in Alzheimer disease and other age-related neurodegenerative disorders. Pharmacological research, 2011, Volume: 64, Issue:3 Topics: Alzheimer Disease; Animals; Atorvastatin; Cholesterol; Fatty Acids, Monounsaturated; Fluorobenzenes; Fluvastatin; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Lovastatin; Neurodegenerative Diseases; Pyrimidines; Pyrroles; Quinolines; Rosuvastatin Calcium; Sulfonamides	2011
Secretion of apolipoprotein E by brain glia requires protein prenylation and is suppressed by statins. Brain research, 2002, Dec-20, Volume: 958, Issue:1 Topics: Alkyl and Aryl Transferases; Alzheimer Disease; Amyloid beta-Peptides; Animals; Animals, Newborn; Apolipoproteins E; Astrocytes; Brain; Cells, Cultured; Disease Models, Animal; Dose-Response Relationship, Drug; Farnesyltranstransferase; Hippocampus; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Mevalonic Acid; Mice; Mice, Transgenic; Microglia; Neuroglia; Polyisoprenyl Phosphates; Protein Prenylation	2002
The role of intracellular cholesterol on the processing of the beta-amyloid precursor protein. The journal of nutrition, health & aging, 2003, Volume: 7, Issue:1 Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Aspartic Acid Endopeptidases; Cells, Cultured; Cholesterol; Electrophoresis, Polyacrylamide Gel; Endopeptidases; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin	2003
Lovastatin enhances Abeta production and senile plaque deposition in female Tg2576 mice. Neurobiology of aging, 2003, Volume: 24, Issue:5 Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals; Anticholesteremic Agents; Aspartic Acid Endopeptidases; Blotting, Western; Body Weight; Cerebral Cortex; Cholesterol; Disease Models, Animal; Eating; Endopeptidases; Female; Hippocampus; Humans; Immunohistochemistry; Lovastatin; Male; Membrane Proteins; Mice; Mice, Transgenic; Plaque, Amyloid; Presenilin-1; Sex Factors; Time Factors	2003
Cholesterol and tau protein--findings in Alzheimer's and Niemann Pick C's disease. Pharmacopsychiatry, 2003, Volume: 36 Suppl 2 Topics: Acyl Coenzyme A; Alzheimer Disease; Analysis of Variance; Animals; Anticholesteremic Agents; Astrocytes; Blotting, Western; Brain Chemistry; Calcium; Cerebral Cortex; Cholesterol; Dextrans; Drug Interactions; Filipin; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Immunohistochemistry; In Situ Hybridization; Intracellular Signaling Peptides and Proteins; Lovastatin; Mevalonic Acid; Mice; Mice, Inbred BALB C; Mice, Transgenic; Microglia; Microtubules; Neurofibrillary Tangles; Neurons; Niemann-Pick C1 Protein; Niemann-Pick Diseases; Proteins; rho GTP-Binding Proteins; RNA, Messenger; tau Proteins; Tubulin	2003
Inhibition of geranylgeranylation mediates the effects of 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase inhibitors on microglia. The Journal of biological chemistry, 2004, Nov-12, Volume: 279, Issue:46 Topics: Alzheimer Disease; Animals; CD11b Antigen; Cell Proliferation; Cell Shape; Dose-Response Relationship, Drug; Extracellular Signal-Regulated MAP Kinases; Hippocampus; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Lovastatin; Mevalonic Acid; Microglia; Polyisoprenyl Phosphates; Rats; Rats, Sprague-Dawley; rho GTP-Binding Proteins; Simvastatin; Terpenes; Tumor Necrosis Factor-alpha	2004
The regulation of beta-secretase by cholesterol and statins in Alzheimer's disease. Journal of the neurological sciences, 2005, Mar-15, Volume: 229-230 Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Androstenes; Anticholesteremic Agents; Aspartic Acid Endopeptidases; Blotting, Western; Cells, Cultured; Cholesterol; Endopeptidases; Enzyme Inhibitors; Glycosylation; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin	2005
Post-translational processing of beta-secretase in Alzheimer's disease. Proteomics, 2005, Volume: 5, Issue:6 Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Anticholesteremic Agents; Aspartic Acid Endopeptidases; Cell Line; Cholesterol; Endopeptidases; Glycoside Hydrolases; Glycosylation; Humans; Lovastatin; Mass Spectrometry; Membrane Microdomains; Mutation; Palmitates; Protein Processing, Post-Translational; Recombinant Proteins	2005
Alzheimer-like plaque formation by human macrophages is reduced by fibrillation inhibitors and lovastatin. Journal of molecular biology, 2006, Jul-07, Volume: 360, Issue:2 Topics: Alzheimer Disease; Amyloid; Cell Culture Techniques; Drug Evaluation, Preclinical; Humans; Lovastatin; Macrophages; Plaque, Amyloid	2006
C/T conversion alters interleukin-1A promoter function in a human astrocyte cell line. Life sciences, 2007, Feb-27, Volume: 80, Issue:12 Topics: Alzheimer Disease; Astrocytes; Cell Line; Cytosine; Humans; Interleukin-1alpha; Lovastatin; Luciferases; Plasmids; Polymorphism, Genetic; Promoter Regions, Genetic; Salicylates; Thymine; Transfection	2007
Red mold rice ameliorates impairment of memory and learning ability in intracerebroventricular amyloid beta-infused rat by repressing amyloid beta accumulation. Journal of neuroscience research, 2007, Nov-01, Volume: 85, Issue:14 Topics: Alzheimer Disease; Amyloid beta-Peptides; Analysis of Variance; Animals; Avoidance Learning; Behavior, Animal; Brain; Disease Models, Animal; Drug Interactions; Injections, Intraventricular; Learning; Lovastatin; Male; Maze Learning; Memory Disorders; Nerve Tissue Proteins; Oryza; PC12 Cells; Peptide Fragments; Phytotherapy; Plant Extracts; Rats; Rats, Wistar	2007
Cholesterol potentiates beta-amyloid-induced toxicity in human neuroblastoma cells: involvement of oxidative stress. Neurochemical research, 2008, Volume: 33, Issue:8 Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Anticholesteremic Agents; Cell Line, Tumor; Cell Survival; Cholesterol; Filipin; Humans; Lipid Peroxidation; Lovastatin; Mice; Neuroblastoma; Oxidative Stress; Reactive Oxygen Species	2008
Lovastatin induces neuroprotection through tumor necrosis factor receptor 2 signaling pathways. Journal of Alzheimer's disease : JAD, 2008, Volume: 13, Issue:2 Topics: Aged; Alzheimer Disease; Animals; Anticholesteremic Agents; Disease Models, Animal; Glutamic Acid; Humans; Lovastatin; Mice; Mice, Inbred C57BL; Neurons; Neuroprotective Agents; NF-kappa B; Phosphorylation; Proto-Oncogene Proteins c-akt; Receptors, Tumor Necrosis Factor, Type II; Signal Transduction; Stroke; Tumor Necrosis Factor-alpha	2008
Red mold rice extract represses amyloid beta peptide-induced neurotoxicity via potent synergism of anti-inflammatory and antioxidative effect. Applied microbiology and biotechnology, 2008, Volume: 79, Issue:5 Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Anti-Inflammatory Agents; Anticholesteremic Agents; Antioxidants; Cell Survival; Drug Synergism; Drugs, Chinese Herbal; Humans; Inflammation; Lovastatin; Monascus; Oryza; Oxidative Stress; PC12 Cells; Rats; Signal Transduction	2008
Isolation and characterization of apolipoproteins from murine microglia. Identification of a low density lipoprotein-like apolipoprotein J-rich but E-poor spherical particle. The Journal of biological chemistry, 2000, Oct-13, Volume: 275, Issue:41 Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Apolipoproteins E; Blotting, Western; Cell Death; Cells, Cultured; Chromatography, Gel; Clusterin; Culture Media, Conditioned; Electrophoresis, Polyacrylamide Gel; Glycoproteins; Kinetics; Lipoproteins, LDL; Liposomes; Lovastatin; Mice; Microglia; Microscopy, Electron; Molecular Chaperones; Nerve Tissue Proteins; Neurons; Particle Size; Plaque, Amyloid; Protein Binding; Rats	2000
Decreased prevalence of Alzheimer disease associated with 3-hydroxy-3-methyglutaryl coenzyme A reductase inhibitors. Archives of neurology, 2000, Volume: 57, Issue:10 Topics: Aged; Aged, 80 and over; Alzheimer Disease; Cardiovascular Diseases; Cholesterol; Cross-Sectional Studies; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension; Hypolipidemic Agents; Lovastatin; Male; Middle Aged; Pravastatin; Prevalence; Retrospective Studies; Risk Factors; Treatment Outcome	2000
Statins & Alzheimer's. Health news (Waltham, Mass.), 2000, Volume: 6, Issue:12 Topics: Aged; Alzheimer Disease; Anticholesteremic Agents; Dementia; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Middle Aged; Pravastatin	2000
Statin therapy and the prevention of dementia. Archives of neurology, 2001, Volume: 58, Issue:6 Topics: Alzheimer Disease; Anticholesteremic Agents; Dementia, Vascular; Humans; Lovastatin; Pravastatin; Randomized Controlled Trials as Topic	2001
Statins inhibit A beta-neurotoxicity in vitro and A beta-induced vasoconstriction and inflammation in rat aortae. Atherosclerosis, 2002, Volume: 161, Issue:2 Topics: Alprostadil; Alzheimer Disease; Amyloid beta-Peptides; Analysis of Variance; Animals; Anticholesteremic Agents; Aorta; Cells, Cultured; Dinoprostone; Dose-Response Relationship, Drug; Lovastatin; Male; Models, Animal; Rats; Rats, Sprague-Dawley; Reference Values; Vasculitis; Vasoconstriction	2002