loteprednol-etabonate and Myopia

To review cases of central toxic keratopathy (CTK) occurring over a period of 46 days.. Moorfields Eye Hospital, London, United Kingdom.. Retrospective consecutive case series.. This was a review of patients with CTK after uneventful laser in situ keratomileusis (LASIK) performed by 1 of 5 surgeons at a single institute. The following parameters were analyzed: corrected distance visual acuity (CDVA), manifest refraction, and central corneal thickness from Scheimpflug pachymetry readings (Pentacam).. The cohort consisted of 15 eyes of 9 patients. Thirteen eyes were diagnosed within 7 days after LASIK, while the remaining 2 eyes developed CTK 12 days postoperatively. In 10 eyes, the time to resolution was 1 to 8 months. Five eyes still had residual signs at the last outpatient visit. At the final follow-up, 3 eyes (20%) had a CDVA worse than 0.0 logMAR.. Although a rare entity, CTK can occur in clusters. Although a cause was not fully isolated, ultimately each eye achieved excellent CDVA (all better than 0.2 logMAR) at the last follow-up.

Topics: Adult; Androstadienes; Anti-Allergic Agents; Corneal Stroma; Corneal Topography; Humans; Hyperopia; Keratitis; Keratomileusis, Laser In Situ; Lasers, Excimer; Loteprednol Etabonate; Male; Microscopy, Confocal; Myopia; Postoperative Complications; Refraction, Ocular; Retrospective Studies; Surgical Flaps; Visual Acuity