Page last updated: 2024-08-25

losoxantrone and Benign Neoplasms

losoxantrone has been researched along with Benign Neoplasms in 6 studies

Research

Studies (6)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	3 (50.00)	18.2507
2000's	3 (50.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Guziec, FS; Guziec, LJ; Hasinoff, BB; Liang, H; Marshall, K; Wu, X; Yalowich, JC	1
Baker, SD; Burris, HA; Cobb, PW; Diab, SG; Drengler, R; Eckhardt, SG; Finizio, M; Hammond, L; Joshi, A; Kraynak, M; Rodriguez, GI; Rowinsky, EK; Villalona-Calero, MA; Von Hoff, DD; Weiss, GR	1
Chai, MF; Davidson, AF; Finizio, M; Joshi, AS; Pieniaszek, HJ; Ratain, MJ; Richards, LE; Vogelzang, NJ; Vokes, EE	1
Goh, BC; Joshi, A; Ratain, MJ; Vokes, EE	1
Calvert, AH; Foster, BJ; Graham, MA; Gumbrell, LA; Jenns, KE; Kaye, SB; Newell, DR	1
Calvert, AH; Foster, BJ; Graham, MA; Gumbrell, LA; Jenns, KE; Newell, DR	1

Trials

4 trial(s) available for losoxantrone and Benign Neoplasms

Article	Year
A phase I and pharmacokinetic study of losoxantrone and paclitaxel in patients with advanced solid tumors. Clinical cancer research : an official journal of the American Association for Cancer Research, 1999, Volume: 5, Issue:2 Topics: Adult; Aged; Anthraquinones; Antineoplastic Combined Chemotherapy Protocols; Dose-Response Relationship, Drug; Feasibility Studies; Follow-Up Studies; Heart Failure; Humans; Immunosuppression Therapy; Middle Aged; Nausea; Neoplasms; Paclitaxel; Pyrazoles; Pyrazolones; Treatment Outcome	1999
Phase I study of the combination of losoxantrone and cyclophosphamide in patients with refractory solid tumours. British journal of cancer, 2002, Feb-12, Volume: 86, Issue:4 Topics: Adult; Aged; Anthraquinones; Antineoplastic Combined Chemotherapy Protocols; Area Under Curve; Cyclophosphamide; Female; Granulocyte Colony-Stimulating Factor; Humans; Infusions, Intravenous; Male; Maximum Tolerated Dose; Middle Aged; Neoplasm Staging; Neoplasms; Neutropenia; Neutrophils; Pyrazoles; Pyrazolones	2002
Phase I trial of the anthrapyrazole CI-941: prospective evaluation of a pharmacokinetically guided dose-escalation. European journal of cancer (Oxford, England : 1990), 1992, Volume: 28, Issue:2-3 Topics: Adult; Aged; Anthraquinones; Antibiotics, Antineoplastic; Drug Administration Schedule; Drug Evaluation; Female; Humans; Leukopenia; Male; Middle Aged; Neoplasms; Prospective Studies; Pyrazoles; Pyrazolones	1992
Clinical pharmacokinetics of the anthrapyrazole CI-941: factors compromising the implementation of a pharmacokinetically guided dose escalation scheme. Cancer research, 1992, Feb-01, Volume: 52, Issue:3 Topics: Anthraquinones; Antineoplastic Agents; Blood Proteins; Carbon Radioisotopes; Drug Evaluation; Glomerular Filtration Rate; Humans; Metabolic Clearance Rate; Neoplasms; Orosomucoid; Protein Binding; Pyrazoles; Pyrazolones; Regression Analysis; Tissue Distribution	1992

Other Studies

2 other study(ies) available for losoxantrone and Benign Neoplasms

Article	Year
The structure-based design, synthesis and biological evaluation of DNA-binding bisintercalating bisanthrapyrazole anticancer compounds. Bioorganic & medicinal chemistry, 2008, Apr-01, Volume: 16, Issue:7 Topics: Anthracyclines; Antigens, Neoplasm; Antineoplastic Agents; Cell Line; Cell Survival; DNA; DNA Topoisomerases, Type II; DNA-Binding Proteins; Drug Design; Enzyme Inhibitors; Humans; Models, Molecular; Molecular Structure; Neoplasms; Nucleic Acid Denaturation; Plasmids; Protein Binding; Quantitative Structure-Activity Relationship; Temperature; Topoisomerase II Inhibitors	2008
Elimination pathways of [14C]losoxantrone in four cancer patients. Drug metabolism and disposition: the biological fate of chemicals, 2001, Volume: 29, Issue:2 Topics: Anthraquinones; Antineoplastic Agents; Carbon Radioisotopes; Feces; Humans; Infusions, Intravenous; Neoplasms; Pyrazoles; Pyrazolones	2001

Article

Year

The structure-based design, synthesis and biological evaluation of DNA-binding bisintercalating bisanthrapyrazole anticancer compounds.

Bioorganic & medicinal chemistry, 2008, Apr-01, Volume: 16, Issue:7

Topics: Anthracyclines; Antigens, Neoplasm; Antineoplastic Agents; Cell Line; Cell Survival; DNA; DNA Topoisomerases, Type II; DNA-Binding Proteins; Drug Design; Enzyme Inhibitors; Humans; Models, Molecular; Molecular Structure; Neoplasms; Nucleic Acid Denaturation; Plasmids; Protein Binding; Quantitative Structure-Activity Relationship; Temperature; Topoisomerase II Inhibitors

2008

Elimination pathways of [14C]losoxantrone in four cancer patients.

Drug metabolism and disposition: the biological fate of chemicals, 2001, Volume: 29, Issue:2

Topics: Anthraquinones; Antineoplastic Agents; Carbon Radioisotopes; Feces; Humans; Infusions, Intravenous; Neoplasms; Pyrazoles; Pyrazolones

2001