losartan-potassium and Wilms-Tumor

Topics: Diagnosis, Differential; Erythropoietin; Hemangiopericytoma; Hormones, Ectopic; Humans; Hypertension, Renal; Hyperthyroidism; Kidney Neoplasms; Paraneoplastic Endocrine Syndromes; Renin; Syndrome; Wilms Tumor

Topics: Adenocarcinoma; Adrenal Gland Neoplasms; Animals; Brain Neoplasms; Carcinoma; Carcinoma, Hepatocellular; Cell Transformation, Neoplastic; Cells, Cultured; Cricetinae; Cysts; Erythropoietin; Esophageal Neoplasms; Female; Growth Substances; Haplorhini; Humans; In Vitro Techniques; Kidney Neoplasms; Leiomyoma; Leukemia; Leukemia, Experimental; Liver Neoplasms; Lymphoma; Male; Mice; Neoplasm Metastasis; Neoplasm Transplantation; Pheochromocytoma; Polycythemia; Rats; Sarcoma, Experimental; Skin Neoplasms; Time Factors; Wilms Tumor

Topics: Adult; Advance Directive Adherence; Erythropoietin; Female; Humans; Iron; Jehovah's Witnesses; Kidney Neoplasms; Nephrectomy; Wilms Tumor

Paraneoplastic erythrocytosis in patients with Wilms' tumors is exceedingly rare, with only three reported cases in the literature. We report a case of a young man with Wilms' tumor with a significant erythrocytosis but a normal serum erythropoietin level and a tumor that elaborated erythropoietin.

Topics: Adult; Erythropoietin; Humans; Kidney Neoplasms; Male; Paraneoplastic Syndromes; Polycythemia; Wilms Tumor

We report a 32-year-old white male with nephroblastoma induced erythrocytosis. Serum erythropoietin levels were elevated preoperatively and normalized after surgical eradication of the renal mass causing the complete disappearance of the erythrocytosis. The erythropoietic hormone was demonstrated in the neoplastic mass confirming the nephroblastoma as the site of hormone synthesis. After surgery, the patient underwent a course of chemotherapy with actinomycin D (AMD) and vincristine (VCR) and is currently free of disease.

Topics: Adult; Combined Modality Therapy; Erythropoietin; Humans; Kidney Neoplasms; Male; Polycythemia; Wilms Tumor

A Wilms' tumour was diagnosed in an 18-year-old male patient with erythrocytosis. After radical excision of the tumour and postoperative irradiation and chemotherapy, the erythrocytosis disappeared and did not recur during a 2-year observation period. The levels of erythropoiesis-stimulating activity in serum and in the renal mass suggest the tumour as the source of this activity. The rarity of the association is discussed and a review of the literature is given.

Topics: Adolescent; Erythropoiesis; Erythropoietin; Humans; Kidney; Kidney Neoplasms; Male; Polycythemia; Radiography; Renal Artery; Wilms Tumor

Erythropoietin (ESF) levels were assayed in rats bearing the Wistar-Furth Wilms' transplantable tumor. Sites of tumor inoculation varied from subcutaneous, intramuscular, intrarenal (subcapsular), to intraperitoneal. Two-thirds of the animals exhibited ESF elevations without polycythemia, or severe anemia (HCT less than 30.0 vol%). The elevations of ESF were not detectably related to the time of sacrifice (age of the animal), size of the primary tumor, or number of gross metastatic foci. The diminished ESF response noted to animals given intramuscular tumor implantations is believed to reflect differences in tumor blood and lymphatic supply at the various sites of inoculation. The pattern of ESF responses in the Wistar-Furth Wilms' tumor model is thus quite similar to that which we have observed in man, and appears to represent an animal model for tumor-related ectopic hormone release. The nature of the hormone is believed to differ from that seen in normal physiological states.

Topics: Animals; Erythropoietin; Hematocrit; Male; Neoplasm Metastasis; Neoplasm Transplantation; Neoplasms, Experimental; Rats; Rats, Inbred WF; Wilms Tumor

Ectopic tumor associated erythropoietin release was measured preoperatively and postoperatively in 36 Wilms' tumor patients followed for an average of three years. Erythropoietin assay results in plasma and urine were related independently to tumor stage as well as to the general clinical judgment following appropriate and exhaustive tests as to whether the disease was active or inactive at the time of the assay. Consistent erythropoietin plasma elevations were correlated with the presence of active disease in all stages of Wilms' tumor. Less consistent elevations were noted in urine specimens concomitantly obtained and assayed. This hormonal assay continues to be of consistent and long-term benefit in predicting or correlating disease recurrence or persistence in Wilms' tumor.

Topics: Erythropoietin; Follow-Up Studies; Hormones, Ectopic; Humans; Kidney Neoplasms; Neoplasm Recurrence, Local; Prognosis; Wilms Tumor

Measurement of erythropoietin levels was achieved in urine, plasma and tumor extract specimens in 27 Wilms tumor patients. Good correlation of the stage of the disease, the clinical judgment of inactive or responding tumor foci and erythropoietin levels was noted. Erythropoietin levels are believed to reflect ectopic hormone production by the primary or secondary tumor. Since the erythropoietin hormone assayed in these and other Wilms tumor patients was not associated with polycythemia, it is believed that Wilms tumor-associated erythropoietin differs in some manner from the hormone produced normally in man and possible in other states associated with secondary polycythemia. Etythropoietin assay with further purification and technical development can be of additional widespread assistance in the clinical classification and subsequent management of the tumor state. Our study confirms this biological potential.

Topics: Child; Child, Preschool; Erythropoietin; Humans; Infant; Wilms Tumor

Topics: Age Factors; Angiography; Aortography; Blood Sedimentation; Child; Child, Preschool; Erythropoietin; Gastrointestinal Diseases; Hematuria; Humans; Infant; Iron; Kidney Neoplasms; Physical Examination; Prognosis; Radiography, Abdominal; Radioisotopes; Tomography, X-Ray; Ultrasonography; Urography; Vena Cava, Inferior; Wilms Tumor

Topics: Adolescent; Child; Child, Preschool; Erythropoietin; Follow-Up Studies; Humans; Iron Isotopes; Kidney Neoplasms; Neoplasm Recurrence, Local; Neoplasms, Multiple Primary; Nephrectomy; Time Factors; Wilms Tumor

Topics: Adult; Child; Erythropoietin; Humans; Iron Isotopes; Kidney; Kidney Neoplasms; Neoplasm Metastasis; Nephrectomy; Wilms Tumor

Topics: Adenocarcinoma; Adolescent; Adult; Aged; Animals; Brain Neoplasms; Child; Child, Preschool; Dogs; Electric Stimulation; Erythropoiesis; Erythropoietin; Ethacrynic Acid; Haplorhini; Humans; Hydronephrosis; Hypertension; Hypothalamus; Infant; Iron Isotopes; Kidney Diseases; Kidney Neoplasms; Lung Neoplasms; Male; Mice; Middle Aged; Polycythemia Vera; Rats; Testicular Neoplasms; Testosterone; Urinary Calculi; Urologic Diseases; Wilms Tumor; Wounds and Injuries

Topics: Adult; Aged; Animals; Biological Assay; Electric Stimulation; Erythrocytes; Erythropoietin; Female; Haplorhini; Humans; Hypophysectomy; Hypothalamus; Hypoxia; Iron; Iron Isotopes; Kidney; Kidney Diseases; Kidney Diseases, Cystic; Male; Middle Aged; Neoplasms, Experimental; Polycythemia Vera; Rats; Wilms Tumor

Topics: Adolescent; Animals; Biological Assay; Blood Urea Nitrogen; Child; Child, Preschool; Erythropoietin; Female; Humans; Infant; Iron Isotopes; Male; Mice; Neoplasm Metastasis; Prognosis; Wilms Tumor

Topics: Erythropoietin; Humans; Infant; Male; Polycythemia; Wilms Tumor

Topics: Adolescent; Erythropoietin; Female; Humans; Nephrectomy; Polycythemia Vera; Wilms Tumor

Topics: Adolescent; Anemia, Aplastic; Anemia, Hemolytic, Autoimmune; Anemia, Hypochromic; Child; Child, Preschool; Erythroblastosis, Fetal; Erythropoietin; Female; Humans; Infant; Infant, Newborn; Kidney Diseases; Male; Pregnancy; Wilms Tumor