losartan-potassium and Nasal-Polyps

losartan-potassium has been researched along with Nasal-Polyps* in 2 studies

Other Studies

2 other study(ies) available for losartan-potassium and Nasal-Polyps

Article	Year
Local tissue hypoxia and formation of nasal polyps. Chinese medical journal, 2003, Volume: 116, Issue:2 To explore the response of nasal mucosa epithelial cells to hypoxia in terms of formation of nasal polyps (NP).. Epithelial cells of NP and inferior turbinate (IT) were cultured serum-free under normal oxygen and hypoxic circumstances with stimulation of IL-1 beta and TNF alpha. The vascular endothelial growth factor (VEGF) mRNA and VEGF protein levels of the cultured cells were detected using in situ hybridization and ELISA, respectively.. The expression of VEGF mRNA was significantly higher in epithelial cells of NP than in IT exposed to pro-inflammatory cytokines or hypoxia (P < 0.01). VEGF levels were higher in NP epithelial cells than those of IT (P < 0.01) under hypoxia.. VEGF-induced by hypoxia is very important for the early stages of forming polyps. Topics: Cell Hypoxia; Cells, Cultured; Endothelial Growth Factors; Enzyme-Linked Immunosorbent Assay; Erythropoietin; Humans; Intercellular Signaling Peptides and Proteins; Interleukin-1; Lymphokines; Nasal Mucosa; Nasal Polyps; RNA, Messenger; Tumor Necrosis Factor-alpha; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors	2003
[Hypoxia effects on vascular endothelial growth factor derived epithelial cells of nasal polyps]. Zhonghua er bi yan hou ke za zhi, 2002, Volume: 37, Issue:1 To understand the role of nasal mucous epithelial cells to hypoxia in early stage of nasal polyps(NP) formation.. Epithelial cells of NP and inferior turbinate (IT) were cultured without serum under normal oxygen and hypoxia, and stimulus of inflammatory cytokines. Erythropoietin (EPO) was regarded as hypoxia mark, and expression of vascular endothelial growth factor(VEGF) mRNA and protein derived from epithelial cells were detected respectively by in situ hybridization and ELISA.. 1. Under hypoxia, EPO mRNA was expressed intensely in epithelial cells from NP and IT, and there was no significant difference between both of them. This result suggested that EPO might be regarded as a hypoxic mark. 2. The ability of producing VEGF mRNA increased with cytokines stimulation, especially under hypoxia. Protein level of VEGF from epithelial cells of NP and IT increased with cytokines stimulation, especially in hypoxia and was time-dependent.. Epithelial cells actively produce vast VEGF under hypoxia. The VEGF induced by hypoxia of the mucosa in middle meatus is of importance in the formation of nasal polyps(NP) in early stage, which may be the major cause of NP formation in middle meatus. Topics: Cell Hypoxia; Cells, Cultured; Epithelial Cells; Erythropoietin; Humans; Interleukin-1; Nasal Polyps; Turbinates; Vascular Endothelial Growth Factors	2002

Article

Year

Local tissue hypoxia and formation of nasal polyps.

Chinese medical journal, 2003, Volume: 116, Issue:2

To explore the response of nasal mucosa epithelial cells to hypoxia in terms of formation of nasal polyps (NP).. Epithelial cells of NP and inferior turbinate (IT) were cultured serum-free under normal oxygen and hypoxic circumstances with stimulation of IL-1 beta and TNF alpha. The vascular endothelial growth factor (VEGF) mRNA and VEGF protein levels of the cultured cells were detected using in situ hybridization and ELISA, respectively.. The expression of VEGF mRNA was significantly higher in epithelial cells of NP than in IT exposed to pro-inflammatory cytokines or hypoxia (P < 0.01). VEGF levels were higher in NP epithelial cells than those of IT (P < 0.01) under hypoxia.. VEGF-induced by hypoxia is very important for the early stages of forming polyps.

Topics: Cell Hypoxia; Cells, Cultured; Endothelial Growth Factors; Enzyme-Linked Immunosorbent Assay; Erythropoietin; Humans; Intercellular Signaling Peptides and Proteins; Interleukin-1; Lymphokines; Nasal Mucosa; Nasal Polyps; RNA, Messenger; Tumor Necrosis Factor-alpha; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors

2003

[Hypoxia effects on vascular endothelial growth factor derived epithelial cells of nasal polyps].

Zhonghua er bi yan hou ke za zhi, 2002, Volume: 37, Issue:1

To understand the role of nasal mucous epithelial cells to hypoxia in early stage of nasal polyps(NP) formation.. Epithelial cells of NP and inferior turbinate (IT) were cultured without serum under normal oxygen and hypoxia, and stimulus of inflammatory cytokines. Erythropoietin (EPO) was regarded as hypoxia mark, and expression of vascular endothelial growth factor(VEGF) mRNA and protein derived from epithelial cells were detected respectively by in situ hybridization and ELISA.. 1. Under hypoxia, EPO mRNA was expressed intensely in epithelial cells from NP and IT, and there was no significant difference between both of them. This result suggested that EPO might be regarded as a hypoxic mark. 2. The ability of producing VEGF mRNA increased with cytokines stimulation, especially under hypoxia. Protein level of VEGF from epithelial cells of NP and IT increased with cytokines stimulation, especially in hypoxia and was time-dependent.. Epithelial cells actively produce vast VEGF under hypoxia. The VEGF induced by hypoxia of the mucosa in middle meatus is of importance in the formation of nasal polyps(NP) in early stage, which may be the major cause of NP formation in middle meatus.

Topics: Cell Hypoxia; Cells, Cultured; Epithelial Cells; Erythropoietin; Humans; Interleukin-1; Nasal Polyps; Turbinates; Vascular Endothelial Growth Factors

2002