losartan-potassium and Leukocytosis

Topics: Adrenal Cortex Hormones; Alpha-Globulins; Androgens; Anemia, Aplastic; Animals; Base Sequence; Blood Proteins; Cell Division; Chemical Phenomena; Chemistry; Dogs; Drug Synergism; Endocrine Glands; Erythropoiesis; Erythropoietin; Glycoproteins; Hematopoiesis; Humans; Kidney; Leukocytes; Leukocytosis; Leukopenia; Mice; Polycythemia; Polycythemia Vera; Radiation Effects; Rats; Thrombopoietin; Thyroid Hormones

The study mainly aimed at investigating possible correlations between peripheral blood counts, erythropoietin (EPO), JAK2 V617F mutation, and vascular complications prior to diagnosis of a population-based cohort of newly diagnosed patients with myeloproliferative neoplasms (MPN).. The study comprises 1105 patients with polycythemia vera (PV) and 1284 patients with essential thrombocythemia (ET) registered in the Swedish MPN Registry.. We conclude that vascular complications among newly diagnosed patients had affected more than one-third of our study population. Risk factors for vascular complications prior to diagnosis were lower hemoglobin in PV, and the presence of JAK2 V617F mutation, higher age, and leukocytosis in ET.

Topics: Age Factors; Aged; Aged, 80 and over; Biomarkers, Tumor; Erythropoietin; Female; Hemoglobins; Humans; Janus Kinase 2; Leukocytosis; Male; Middle Aged; Mutation; Polycythemia Vera; Prospective Studies; Registries; Risk Factors; Sweden; Thrombocythemia, Essential; Venous Thromboembolism

To study levels of hepsidine (Hp), hypoxia-inducible factor-1alpha (HIF-1alpha), erythropoietin (EP) and ferritin in patients with acute leukemia (AL), effects of protein fractions of homogenate of blastic cells (BC) on regulatory proteins studied.. Depending on leukocyte count in the onset of AL, 70 patients with first ever diagnosed AL were divided into two groups: group 1 - 17 patients with leukocyte count > 30 x 10(9)/l, group 2 - 53 patients with leukocyte count < 30 x 10(9)/l. Serum and leukocyte parameters were studied before treatment, during the treatment with cytostatic drugs, in the course of myelotoxic agranulocytosis (MTA), after normalization of hemograms. EP was detected with enzyme immunoassay, serum and leukocyte ferritin - with radioimmunoassay; HIF-1alpha, Hp - sandwich enzyme immunoassay using monospecific antisera and monoclonal antibodies against relevant antigens. Leukocytes were isolated in ficol and verografin solutions density gradient. Chromatographic division of the protein fractions in 3 patients with leukocytosis in AL onset and leukocytes of 3 donors was made by the method of preparative isoelectrofocusing of BC and leukocytes on LKB colon (Sweden). Effects of these fractions were studied on 11 plasma samples from hematological patients and 4 plasma samples from patients with normal hemopoiesis.. Leukocytosis patients with initial AL have serum ferritin, Hp and HIF-1alpha levels about 2-5 times lower than patients without leukocytosis. Cytostatic treatment raises an HIF-1alpha level in BC about 15-fold (85.8 +/- 24.5 pg/ml), in the study group - 3-fold (15.2 +/- 3.3 pg/ml). The highest EP levels were seen in MTA. It is detected that protein fractions isolated from leukocytes of patients with leukocytosis in the disease onset raise HIF-1alpha content irrespective of HIF-1alpha presence in the fraction. Patients free of hematological diseases have no changes of the above proteins.. Great difficulties exist in ferritin and Hp levels between AL patients with leukocytosis in the onset of the disease and without of leukocytosis. The study of leukocytes suggests that tumor cells of such patients contain compounds which can regulate production of HIF-1alpha, Hp and ferritin.

Topics: Acute Disease; Erythropoietin; Ferritins; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Iron; Leukemia; Leukocytosis; Radioimmunoassay

Topics: Aged; Darbepoetin alfa; Drug Therapy, Combination; Erythropoietin; Filgrastim; Granulocyte Colony-Stimulating Factor; Humans; Leukocytosis; Male; Myelodysplastic Syndromes; Polyethylene Glycols; Recombinant Proteins

Chronic eosinophilic leukemia (CEL) is a rare myeloproliferative disease in which autonomous, clonal proliferation of eosinophilic precursors results in persistent increase of eosinophils in the blood and bone marrow. A case of CEL spontaneous oscillation of white blood cell (WBC) count is presented. The cycle of WBC variation comprised about 60 days. Similar cyclic variations were noted in his platelet count, hemoglobin level and bone marrow cellularity, as well as in the spleen size, which was directly correlated with the WBC count. The numbers of bone marrow erythroid colony-forming units (CFU-E), granulocyte-macrophage colony-forming units (CFU-GM) and the serum level of colony-stimulating factors (CSFs) were also regularly changed during the oscillation of WBC. Bone marrow hyperplasia was accompanied with the increase in peripheral WBC count, suggesting that the variation of cell production caused the cyclic oscillation.

Topics: Bone Marrow; Chronic Disease; Erythropoietin; Hemoglobins; Humans; Hypereosinophilic Syndrome; Hyperplasia; Interleukin-1; Interleukin-2; Interleukin-6; Leukocyte Count; Leukocytosis; Male; Middle Aged; Periodicity; Platelet Count; Thrombocytosis; Tumor Necrosis Factor-alpha; Tumor Stem Cell Assay

Tumoral calcinosis is a rare form of soft tissue calcifications, initially described as an idiopathic condition, which could occur in uremic patients. Despite its distinct clinical and morphologic presentations, the underlying pathogenesis is unknown. We present a dialysis patient who developed tumoral calcinosis over the right shoulder after receiving a misplaced injection of human recombinant erythropoietin probably into the periarticular tissue. This case serves as an example highlighting the importance of periarticular inflammatory reaction in precipitating the development of the lesion in predisposed patients.

Topics: Administration, Oral; Adult; Bursa, Synovial; Calcinosis; Calcium; Calcium Carbonate; Dialysis Solutions; Erythropoietin; Female; Glomerulonephritis, IGA; Humans; Hypercalcemia; Hyperplasia; Injections, Intramuscular; Kidney Failure, Chronic; Leukocytosis; Parathyroid Hormone; Patient Compliance; Peritoneal Dialysis, Continuous Ambulatory; Radiography; Recombinant Proteins; Shoulder Joint

Smoking is the most common cause of secondary polycythemia and may induce leukocytosis. We studied the relationship between hematopoietic growth factors and erythrocytosis and leukocytosis. Two sets of healthy male volunteers, consisting of 177 and 202 (age: 19-59 years) were each divided into four groups according to whether or not they smoked at least one package daily and their leukocyte count. Serum erythropoietin (Epo) concentration and granulocyte-colony stimulating factor (G-CSF) concentration were measured in the 177 and 202 volunteers, respectively. The mean serum Epo concentration was lower in smokers than in nonsmokers (p = 0.01 in the subjects without leukocytosis and p = 0.107 in those with leukocytosis, respectively). After 3 smokers stopped smoking, the Epo concentration increased 2 weeks later, and remained constant for 20 weeks. Smokers tended to have a higher mean serum G-CSF concentration than nonsmokers in the subjects without leukocytosis. Neither Epo nor G-CSF is the main etiology of smokers' polycythemia, and Epo production may be down-regulated by an elevated red-cell volume.

Topics: Adult; Erythropoietin; Granulocyte Colony-Stimulating Factor; Hematocrit; Hemoglobins; Humans; Leukocyte Count; Leukocytosis; Male; Middle Aged; Radioimmunoassay; Reference Values; Risk Factors; Smoking

Exposure to high levels of benzene commonly results in the suppression of hemopoiesis, although cases of leukocytosis and leukocytosis with thrombocytosis have been reported. No hematologic abnormalities have generally been found with exposure to low levels of benzene.. A pipe fitter exposed to low levels of benzene (time-weighted average 0.9 ppm) developed leukocytosis. His blood counts and growth of erythroid burst forming units (BFU-E) was followed with and without the addition of erythropoietin.. Erythropoietin-independent BFU-E colonies were increased to 40 per 4 x 10(4) cells (normal < 3 per 4 x 10(4) cells). Both the leukocyte count and the number of erythropoietin-independent BFU-E colonies decreased when exposure to benzene was terminated. On reexposure the white blood count again increased. After the work was terminated, the white blood count returned to normal, as did the number of erythropoietin-independent BFU-E colonies, over a period of 12 months.. Our findings suggest that even low levels of benzene can result in perturbations of the hemopoietic system. Further studies are warranted to determine whether these findings are idiosyncratic, coincidental, or a more general phenomenon.

Topics: Adult; Benzene; Erythroid Precursor Cells; Erythropoietin; Humans; Leukocytosis; Male; Occupational Exposure

We studied ten patients with various types of cancer who were being treated with Interleukin-2 (IL-2) and lymphokine activated killer cells (LAK). All patients developed a reticulocytopenic, normochromic, normocytic anemia. We noted some variability but no significant suppression of circulating erythroid progenitors. The levels of erythropoietin were lower than expected for the hemoglobin/hematocrit values. We could not detect Interferon or Tumor Necrosis Factor (TNF) in the serum of these patients; however, the supernatant of LAK cells did contain Interferon and TNF which could be neutralized with appropriate antibodies. These results suggest that the etiology of this anemia is multi-factorial. Administration of recombinant erythropoietin (Ep) may be of benefit in some of these patients.

Topics: Anemia; Eosinophilia; Erythroid Precursor Cells; Erythropoiesis; Erythropoietin; Hematopoiesis; Humans; Immunotherapy; Interferon-gamma; Interleukin-2; Killer Cells, Natural; Leukocytosis; Neoplasms; Tumor Necrosis Factor-alpha

A spontaneous oscillation of the white blood cell count was observed in a 58 year old man with chronic myelogenous leukemia (CML). Similar cyclic variations were noted in the platelet and reticulocyte counts with no apparent alterations in marrow cellularity to account for such changes. Since direct correlation was noted between white blood cells, platelets, and reticulocyte counts versus spleen size, it suggests that splenic hemopoiesis may be responsible for these cyclic changes. A possible inverse relationship between colony-stimulating factor (CSF) activity and the white blood cell count was noted, suggesting that CSF may be the humoral agent controlling granulocyte production. A direct correlation between the white blood cell count and serum unsaturated vitamin B12 binding capacity (UBBC) and lysozyme was also noted and further supports the concept that the latter two are measures of the granulocyte pool and metabolism. An inverse relationship between CSF activity and the UBBC suggests that these may be two different entities. Finally a modified form of standard chemotherapy may be effective in inducing remission in cases of CML with marked cyclic leukocytosis-leukopenia.

Topics: Alkaline Phosphatase; Blood Cell Count; Blood Platelets; Bone Marrow Examination; Colony-Stimulating Factors; Erythropoietin; Hemoglobins; Humans; Karyotyping; Leukemia, Myeloid; Leukocyte Count; Leukocytosis; Leukopenia; Male; Middle Aged; Muramidase; Periodicity; Reticulocytes; Spleen; Vitamin B 12

Topics: Alpha-Globulins; Animals; Bone Marrow; Bone Marrow Cells; Bone Marrow Transplantation; Cell Differentiation; Cell Division; Erythropoiesis; Erythropoietin; Feedback; Half-Life; Hematopoiesis; Hematopoietic Stem Cells; Kinetics; Leukocytes; Leukocytosis; Mice; Radiation Chimera; Radiation Effects; Spleen; Thymidine; Tritium

Topics: Adult; Aged; Animals; Blood Cell Count; Blood Platelets; Blood Transfusion; Erythropoietin; Female; Hematocrit; Hematopoietic Stem Cells; Humans; Injections, Subcutaneous; Iron; Iron Radioisotopes; Leukemia, Myeloid; Leukocyte Count; Leukocytosis; Male; Mice; Middle Aged; Polycythemia Vera; Primary Myelofibrosis

Topics: Anemia; Animals; Autopsy; Bone Marrow Cells; Bone Marrow Transplantation; Erythropoiesis; Erythropoietin; Escherichia coli; Female; Haplorhini; Hematoma; Hematopoiesis; Hemorrhage; Iron Radioisotopes; Leukocyte Count; Leukocytes; Leukocytosis; Leukopenia; Macaca; Male; Mice; Nandrolone; Nitrogen Mustard Compounds; Polysaccharides, Bacterial; Radiation Injuries, Experimental; Time Factors; Transplantation, Autologous

Topics: Alkaline Phosphatase; Blood Viscosity; Bone Marrow Examination; Carrier Proteins; Erythropoietin; Female; Hematocrit; Hemoglobinopathies; Histamine; Humans; Hypoxia; Leukocytosis; Male; Plasma Volume; Polycythemia; Splenomegaly; Thrombocytosis; Uric Acid; Vitamin B 12

Topics: Cadaver; Erythropoietin; Graft Rejection; Histocompatibility Testing; Humans; Kidney Glomerulus; Kidney Transplantation; Leukocytosis; Renin; Transplantation Immunology; Transplantation, Homologous