losartan-potassium and Klinefelter-Syndrome

losartan-potassium has been researched along with Klinefelter-Syndrome* in 2 studies

Other Studies

2 other study(ies) available for losartan-potassium and Klinefelter-Syndrome

Article	Year
Erythropoietin-resistant anaemia in a predialysis patient with Klinefelter syndrome. Nephrology (Carlton, Vic.), 2005, Volume: 10, Issue:2 A diabetic predialysis patient who had significantly reduced sensitivity to erythropoietin therapy was admitted to Tsukuba University Hospital. Many factors that might have been the cause of the erythropoietin resistance were examined, and a diagnosis of refractory anaemia was made based on a bone marrow aspiration biopsy. A cytogenetic abnormality (47, XXY) was also detected in the bone marrow biopsy specimen, and hence the patient was also diagnosed with Klinefelter syndrome. It was suspected that the sex chromosome abnormality influenced glucose intolerance, renal insufficiency, and erythropoietin resistance due to myelodysplastic changes in the bone marrow. Topics: Anemia; Drug Resistance; Erythropoietin; Humans; Karyotyping; Klinefelter Syndrome; Male; Middle Aged; Renal Insufficiency	2005
[Effect of androgen on erythropoietin in patients with hypogonadism]. Zhonghua nan ke xue = National journal of andrology, 2003, Volume: 9, Issue:4 To observe the change of erythropoietin (EPO) in patients of hypogonadism who received androgen replacement treatment and explore the mechanism of androgen-induced increase of red blood cells and haemoglobin.. Eight patients with Klinefelter's syndrome, divided into two groups, received TU intramuscular injections of 500 mg or 1000 mg dose, respectively. After three months, seven patients received the second injection of crossover dose. Testosterone levels in serum were measured with RIA before and after the injections treatment. RBC count, impacted volume of blood cells and haemoglobin concentration were measured before treatment and 4, 8 weeks after treatment. At the same interval, EPO levels were measured with ELISA method.. Development of the secondary sex characters was improved in all patients after the TU injection. Serum testosterone levels raised significantly and reached the peak one week after the injections. Effective level of testosterone lasted for over 6 weeks. RBC count, impacted volume of blood cells and haemoglobin increased at different degrees after TU injections, but these changes were not significant in statistic(P < 0.05). The increased levels remained for 8 weeks. EPO levels were elevated significantly (P < 0.01 or 0.05) after the TU injection(Pbat > 0.05). The second injection could still make the EPO level go up.. Androgen replacement treatment can increase the EPO levels in patients of hypogonadism, which is one of the mechanism of RBC production increase. Topics: Adolescent; Adult; Enzyme-Linked Immunosorbent Assay; Erythropoietin; Humans; Injections, Intramuscular; Klinefelter Syndrome; Male; Radioimmunoassay; Testosterone	2003

Article

Year

Erythropoietin-resistant anaemia in a predialysis patient with Klinefelter syndrome.

Nephrology (Carlton, Vic.), 2005, Volume: 10, Issue:2

A diabetic predialysis patient who had significantly reduced sensitivity to erythropoietin therapy was admitted to Tsukuba University Hospital. Many factors that might have been the cause of the erythropoietin resistance were examined, and a diagnosis of refractory anaemia was made based on a bone marrow aspiration biopsy. A cytogenetic abnormality (47, XXY) was also detected in the bone marrow biopsy specimen, and hence the patient was also diagnosed with Klinefelter syndrome. It was suspected that the sex chromosome abnormality influenced glucose intolerance, renal insufficiency, and erythropoietin resistance due to myelodysplastic changes in the bone marrow.

Topics: Anemia; Drug Resistance; Erythropoietin; Humans; Karyotyping; Klinefelter Syndrome; Male; Middle Aged; Renal Insufficiency

2005

[Effect of androgen on erythropoietin in patients with hypogonadism].

Zhonghua nan ke xue = National journal of andrology, 2003, Volume: 9, Issue:4

To observe the change of erythropoietin (EPO) in patients of hypogonadism who received androgen replacement treatment and explore the mechanism of androgen-induced increase of red blood cells and haemoglobin.. Eight patients with Klinefelter's syndrome, divided into two groups, received TU intramuscular injections of 500 mg or 1000 mg dose, respectively. After three months, seven patients received the second injection of crossover dose. Testosterone levels in serum were measured with RIA before and after the injections treatment. RBC count, impacted volume of blood cells and haemoglobin concentration were measured before treatment and 4, 8 weeks after treatment. At the same interval, EPO levels were measured with ELISA method.. Development of the secondary sex characters was improved in all patients after the TU injection. Serum testosterone levels raised significantly and reached the peak one week after the injections. Effective level of testosterone lasted for over 6 weeks. RBC count, impacted volume of blood cells and haemoglobin increased at different degrees after TU injections, but these changes were not significant in statistic(P < 0.05). The increased levels remained for 8 weeks. EPO levels were elevated significantly (P < 0.01 or 0.05) after the TU injection(Pbat > 0.05). The second injection could still make the EPO level go up.. Androgen replacement treatment can increase the EPO levels in patients of hypogonadism, which is one of the mechanism of RBC production increase.

Topics: Adolescent; Adult; Enzyme-Linked Immunosorbent Assay; Erythropoietin; Humans; Injections, Intramuscular; Klinefelter Syndrome; Male; Radioimmunoassay; Testosterone

2003