losartan-potassium and Hyperoxaluria--Primary

Primary hyperoxaluria is a rare autosomal recessive disorder. Type 1 PH is the most common form and develops due to a defect in a liver specific enzyme the alanine aminotransferase enzyme. As a result of the enzyme deficiency, there is an overproduction of oxalate and excessive urinary excretion. Recurrent urolithiasis and nephrocalcinosis are the most important findings of the disorder and often at the beginning end-stage renal disease develops. This report presents a case backed up by literature of a patient with end stage renal failure and erythropoietin-resistant anaemia whose bone marrow biopsy showed crystal deposition which received delayed diagnosis of oxalosis.

Topics: Adult; Anemia; Bone Marrow; Erythropoietin; Humans; Hyperoxaluria; Hyperoxaluria, Primary; Kidney Failure, Chronic; Male

We report a male patient with primary hyperoxaluria from childhood who survived more than 21 years on conventional haemodialysis. Despite the severity of his bone disease, he was married and actively employed up until 2 years before his death. His condition really worsened a few months before his death. He presented with only renal and bone involvement and had hardly any cardiovascular complications, that was probably a reason for his prolonged survival. Such an evolution is very unusual and we speculate that the length of haemodialysis sessions in addition to the large surface of the membrane probably contributed to such an outcome. During the time period on HD, anemia was transiently controlled by recombinant erythropoietin despite oxalate involvement of the marrow. He was refused a liver-kidney transplant and died from malnourishment at 43 years of age. To our knowledge, such an outcome has not yet been reported. It shows that careful prolonged hemodialysis sessions should be helped in admet patients without severe cardiovascular involvement.

Topics: Adult; Erythropoietin; Humans; Hyperoxaluria, Primary; Kidney Failure, Chronic; Male; Recombinant Proteins; Renal Dialysis; Time Factors

Topics: Biopsy; Bone Marrow; Child, Preschool; Drug Resistance; Erythropoietin; Humans; Hyperoxaluria, Primary; Kidney Failure, Chronic; Liver; Male; Recombinant Proteins

Topics: Adult; Drug Resistance; Erythropoietin; Humans; Hyperoxaluria, Primary; Male; Recombinant Proteins; Renal Dialysis