losartan-potassium and Granulomatosis-with-Polyangiitis

Anemia is commonly observed among patients with chronic kidney disease (CKD). No such information is available for patients with a history of systemic vasculitis.. We examined the prevalence of anemia, the response to therapy with erythropoiesis-stimulating agents (ESA), and the association of anemia with the kidney function in clinically stable patients with Wegener's granulomatosis in a retrospective, single-center study.. The mean hemoglobin concentration of 36 patients (mean age: 58 years; 15 female, 21 male; mean duration of disease: 4.6 years) was 13.0+/-2.1 g/dl, and the mean estimated glomerular filtration rate (eGFR) was 41+/-21 ml/min/1.73 m(2). 14 of 36 patients (38.8%) presented with anemia (hemoglobin concentration < 12 g/dl in women, < 13 g/dl in men, or ESA therapy). In patients with a CKD Stage 3 or 4, anemia was present about twice as much as compared to the Third National Health and Nutrition Examination Survey (NHANES III) population. The hemoglobin concentration, however, was not associated with a change of kidney function (p = 0.1578).. We found a higher prevalence of anemia in patients with Wegener's granulomatosis, as compared to the NHANES III population. The hemoglobin concentrations showed no association with changes of kidney function.

Topics: Anemia; Creatinine; Darbepoetin alfa; Drug Therapy, Combination; Erythropoietin; Female; Glomerular Filtration Rate; Granulomatosis with Polyangiitis; Hematinics; Hemoglobins; Humans; Kidney Failure, Chronic; Male; Middle Aged; Outpatients; Prevalence; Prognosis; Recombinant Proteins; Retrospective Studies; Severity of Illness Index

Topics: Anemia; Blood Transfusion; Erythropoietin; Female; Granulomatosis with Polyangiitis; Hemoglobins; Humans; Kidney Transplantation; Renal Dialysis

Topics: Aged; Anemia; Anticoagulants; Diagnosis, Differential; Erythropoietin; Granulomatosis with Polyangiitis; Humans; Leg Ulcer; Male; Recombinant Proteins; Renal Insufficiency; Thrombosis; Treatment Outcome; Warfarin