losartan-potassium and Emergencies

Because of the firm refusal of transfusion of blood and blood components by Jehovah's Witnesses, the management of Jehovah's Witness patients with severe bleeding is often complicated by medical, ethical, and legal concerns. Because of a rapidly growing and worldwide membership, physicians working in hospitals should be prepared to manage these patients. Appropriate management of a Jehovah's Witness patient with severe bleeding entails understanding of the legal and ethical issues involved, and meticulous medical management, including treatment of hypovolemic shock, local hemostatic interventions, and administration of prohemostatic agents, when appropriate. In addition, high-dose recombinant erythropoietin in combination with supplemental iron may enhance the speed of hemoglobin synthesis.

Topics: Acute Disease; Adult; Antifibrinolytic Agents; Blood Coagulation Disorders; Blood Coagulation Factors; Blood Transfusion; Contraindications; Emergencies; Erythropoietin; Hemorrhage; Hemostatic Techniques; Humans; Informed Consent; Jehovah's Witnesses; Phlebotomy; Recombinant Proteins; Shock; Treatment Refusal; Unconsciousness; Vitamin K

Multicytokine therapy may be useful to counteract radiation-induced myelosuppression. We assessed the stem cell factor + glycosylated erythropoietin + pegylated granulocyte colony-stimulating factor combination (SEG) as an emergency treatment. SEG in highly irradiated monkeys efficacy appeared to be restricted to granulopoiesis. Early administration of Erythropoietin did not prevent radiation-induced anemia.

Topics: Animals; Blood Transfusion; Cytokines; Drug Evaluation, Preclinical; Drug Therapy, Combination; Emergencies; Erythropoietin; Filgrastim; Granulocyte Colony-Stimulating Factor; Interleukin-3; Macaca fascicularis; Membrane Proteins; Pancytopenia; Polyethylene Glycols; Radiation Injuries, Experimental; Recombinant Proteins; Stem Cell Factor; Thrombopoietin

Topics: Aged; Clinical Trials as Topic; Emergencies; Erythropoietin; Fibrinolytic Agents; Germany; Humans; Intensive Care Units; Multicenter Studies as Topic; Placebos; Plasminogen Activators; Stroke; Thrombolytic Therapy

Topics: Adult; Blood Transfusion; Cesarean Section; Christianity; Emergencies; Erythropoietin; Female; Hemorrhage; Humans; Postoperative Complications; Pregnancy; Pregnancy Complications; Religion and Medicine