losartan-potassium and Dermatitis--Exfoliative

Topics: Alopecia; Cytokines; Dermatitis, Exfoliative; Drug Eruptions; Erythropoietin; Granulocyte Colony-Stimulating Factor; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Interferons; Interleukin-2; Tumor Necrosis Factor-alpha; Vasculitis; Vitiligo

The increasing use of new drugs in cancer therapy, especially growth factors, hormones, and chemotherapies resulted in several reports of unusual skin eruptions. We studied a patient with erythroderma who had received erythropoietin because of myeloma with tumor anemia. The histological features were characterized by a lichenoid, focally granulomatous infiltrate with predominance of histiocytes. It is important for dermatopathologists to recognize this interesting pattern induced by erythropoietin.

Topics: Anemia; Antigens, CD; Dermatitis, Exfoliative; Erythropoietin; Granuloma; Histiocytes; Humans; Lichenoid Eruptions; Male; Middle Aged; Multiple Myeloma; T-Lymphocytes

Topics: Dermatitis, Exfoliative; Drug Eruptions; Erythropoietin; Female; Humans; Kidney Failure, Chronic; Middle Aged; Recombinant Proteins

The change of cell-mediated immunity was studied in patients receiving open heart surgery with or without administration of recombinant erythropoietin (rEPO). Group I was not administered rEPO in 30 patients, and Group II was done intravenously with 200U/kg/day of rEPO for 6.4 +/- 2.4 days before operation and also for 7.2 +/- 3.6 days after operation in 20 patients. The ratio of reticulocyte increased in all patients receiving rEPO. In both groups the ratios of OKT3 and OKT4 positive T lymphocytes decreased significantly on postoperative day 1. However, the ratios in patients with rEPO increased more significantly than in those without rEPO. Lymphocyte blast formation which was indicated by PHA-SI (phytohemagglutinin stimulation index) increased after administration of rEPO. The postoperative PHA-SI in both groups showed similar changes. The level of interleukin-2 (IL-2) production increased after the administration similar to PHA-SI change. The level of it decreased on postoperative day 1 and increased on postoperative days 3 and 7. We administered 200U/kg/day of rEPO for 7 days in a patient with postoperative erythroderma after open heart surgery and the level of IL-2 production was found to also increase in patient according with recovery of symptom. In conclusion, our data suggested that the rEPO might effect on not only erythrocyte but also lymphocyte activation.

Topics: Adult; Aged; Dermatitis, Exfoliative; Erythrocyte Count; Erythropoietin; Heart Diseases; Humans; Immunity, Cellular; Interleukin-2; Lymphocyte Activation; Male; Middle Aged; Postoperative Complications; Recombinant Proteins; Reticulocytes