losartan-potassium has been researched along with Amyloid-Neuropathies* in 2 studies
1 trial(s) available for losartan-potassium and Amyloid-Neuropathies
| Article | Year |
|---|---|
Secondary hypoplastic anemia in patients with familial amyloidotic polyneuropathy.
The anemia of patients with familial amyloidotic polyneuropathy (FAP) was evaluated. Anemia was seen in 32 (91%) of the 35 FAP patients, more often with progression of the disease. The incidence of macrocytic hypochromic anemia was the most common type (40%). In 14 autopsied and 2 biopsied cases, no amyloid deposition was detected in the bone marrow. Thirteen (81%) of the 16 FAP patients showed hypoplastic bone marrow. Bone marrow aspiration of 2 patients revealed a decreased ratio of erythrocytic/myelocytic cells. The plasma levels of vitamin B12 and folate were within normal ranges. Neither oral nor intravenous administration of iron had any effect on the anemia of FAP patients. Intravenous erythropoietin elevated blood hemoglobin levels and blood pressure in 2 patients. Orthostatic hypotension, one of the most common symptoms of FAP, was unexpectedly improved. Secondary hypoplastic anemia is common in FAP, but treatment of anemia in this disease using erythropoietin is promising. Topics: Adult; Aged; Amyloid Neuropathies; Anemia, Aplastic; Biopsy, Needle; Bone Marrow; Erythropoietin; Female; Humans; Male; Middle Aged; Recombinant Proteins | 1993 |
1 other study(ies) available for losartan-potassium and Amyloid-Neuropathies
| Article | Year |
|---|---|
Autonomic dysfunction and anemia in neurologic disorders.
The effect of autonomic dysfunctions on anemia in various neurological disorders, such as familial amyloidotic polyneuropathy (FAP) Type I, pandysautonomia, and Shy-Drager syndrome was examined. As a control, hemograms of patients with amyotrophic lateral sclerosis (ALS), which is known to be free from autonomic dysfunction, was compared with patients with the above neurological disorders. FAP and pandysautonomia patients showed significant anemia comparable with the severity of the autonomic dysfunctions. Shy-Drager patients exhibited mild anemia. However, in ALS patients, no such anemia was recognized at all even in the end stage of this disease. In pandysautonomia patients, hypoplastic bone marrow was recognized, which was quite consistent with the data previously reported in FAP patients. Human recombinant erythropoietin improved orthostatic hypotension as well as anemia in 4 FAP patients. These results suggest that autonomic dysfunction may be deeply connected with erythropoiesis. Topics: Adult; Aged; Amyloid Neuropathies; Amyotrophic Lateral Sclerosis; Anemia; Biopsy, Needle; Bone Marrow; Erythropoietin; Female; Humans; Male; Middle Aged; Polyneuropathies; Recombinant Proteins; Shy-Drager Syndrome | 1996 |