losartan-potassium and Adenoma

Topics: Adenoma; Adrenocorticotropic Hormone; Erythropoietin; Female; Glucagon-Like Peptides; Gonadotropins; Hormones, Ectopic; Humans; Hypercalcemia; Infant; Insulin; Insulin Secretion; Kidney Neoplasms; Male; Middle Aged; Parathyroid Hormone; Parathyroid Neoplasms; Placental Lactogen; Prolactin; Prostaglandins A; Renin

Erythropoietin (Epo) is glycoprotein hormone which binds on erythropoietin receptors (EpoR) promoting proliferation and differentiation. Studies have shown that EpoR, apart from erythrocyte precursors, is expressed on no hematopoietic tissue and various tumor cells. Despite the progress in modern medicine, colorectal carcinoma (CRC) is still the leading cause of increased morbidity and mortality between oncology patients worldwide. Its precursors are benign villous adenomas, which in certain percentage progress to cancer. Anemia of chronic disease is common finding in CRC patients. Some of them are treated with Epo. Epo/EpoR seems to correlate with tumor progression and metastasizing. Therefore, the identification of at-risk group remains a clinical challenge. Vascular endothelial growth factor (VEGF) is a signal protein that stimulates angiogenesis and concentration of VEGF is positive correlated with tumor growth in numerous tumors. The importance of Epo in tumor pathogenesis has led to a growing interest in the potential prognostic value. By our point of view there are many open questions about role of Epo/EpoR in CRC.

Topics: Adenoma; Animals; Biomarkers, Tumor; Colorectal Neoplasms; Erythropoietin; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Hematopoiesis; Humans; Immunohistochemistry; Models, Theoretical; Neoplasm Metastasis; Neovascularization, Pathologic; Receptors, Erythropoietin; Recombinant Proteins; Vascular Endothelial Growth Factor A

A 53-year-old woman with severe erythrocytosis (hemoglobin concentration 19.5 g/dl and hematocrit 0.59) was admitted to our hospital because of fatigue and headache. The serum erythropoietin (Epo) concentration was 68.6 U/l (reference range; 3.7-31.5). Further investigations excluded polycythemia vera or any lung or heart disease. Radiological examination showed a tumor in the left hepatic lobe. Needle biopsies were performed and the histopathological diagnosis was hepatocellular adenoma. Immunohistochemistry demonstrated erythropoietin expression in the adenomatous cells. Liver adenoma is a rare cause of erythrocytosis. For the first time, we report erythropoietin-positive immunoreactivity in liver adenomatous cells in a patient with erythrocytosis.

Topics: Adenoma; Biopsy, Needle; Erythropoietin; Female; Humans; Immunohistochemistry; Liver Neoplasms; Middle Aged; Polycythemia; Severity of Illness Index

This is the first report of direct evidence that metanephric adenoma cells produce erythropoietin and other types of cytokines, which may be the cause of the high incidence of erythrocytosis in patients with this tumor. The purpose of the study was to establish a metanephric adenoma cell line in vitro from nephrectomized tumor tissue in order to investigate the ability of metanephric adenoma cells to produce erythropoietin and other types of cytokines. The tumor tissue was obtained from a 16-year-old boy who had developed metanephric adenoma with erythrocytosis and was served for cell culture. Significantly high concentrations of erythropoietin, granulocyte-macrophage colony-stimulating factor (GM-CSF), granulocyte-colony-stimulating factor (G-CSF), interleukin-6 (IL-6), and IL-8 were detected in the cell culture supernatant. Southern hybridization showed specific positive signals for GM-CSF, G-CSF, IL-6, IL-8 and erythropoietin. The number of chromosomes was 46-XY without any structural abnormalities in cytogenetic analysis of the cultured cells.

Topics: Adenoma; Adolescent; Biomarkers, Tumor; Cell Nucleus; Cytokines; Erythropoietin; Gene Expression; Humans; Kidney Neoplasms; Male; Nephrectomy; Polycythemia; RNA, Messenger; Treatment Outcome; Tumor Cells, Cultured

Effects of erythropoietin on parathyroid cell function has not been studied before.. We aimed to demonstrate whether erythropoietin receptor present in parathyroid cells.. The specimens of normal parathyroid gland, parathyroid adenoma and hyperplasia were retrieved from our pathology archives. The sections were stained immunohistochemically. Quantitative gene expression study was performed for erythropoietin and erythropoietin receptor.. Erythropoietin receptors were detected by immunohistochemical staining and by its gene expression. Its density was higher in normal parathyroid, followed by parathyroid adenoma and hyperplasia.. Erythropoietin receptor is present in normal parathyroid, parathyroid adenoma, and hyperplasia.

Topics: Adenoma; Erythropoietin; Gene Expression Regulation; Humans; Hyperplasia; Parathyroid Glands; Parathyroid Neoplasms; Receptors, Erythropoietin

Activation of the Wnt signaling pathway initiates the transformation of colorectal epithelial cells, although the transition to metastatic cancer requires angiogenesis. We have investigated the expression of the von Hippel-Lindau (VHL) tumor suppressor in the intestines from humans and mice. Here, we show that VHL expression is regulated by TCF4 and is restricted to the proliferative compartment at the bottom of intestinal crypts. Accordingly, VHL is completely absent from the proliferative intestinal pockets of Tcf4(-/-) perinatal mice. We observed complementary staining of the hypoxia-inducible factor (HIF) 1alpha to VHL in normal intestinal epithelium as well as in all stages of colorectal cancer (CRC). To the best of our knowledge, this is the first report demonstrating the presence of nuclear HIF1alpha in normoxic healthy adult tissue. Although we observed upregulated levels of VHL in very early CRC lesions from sporadic and familial adenomatous polyposis patients - presumably due to activated Wnt signaling - a clear reduction of VHL expression is observed in later stages of CRC progression, coinciding with stabilization of HIF1alpha. As loss of VHL in later stages of CRC progression results in stabilization of HIF, these data provide evidence that selection for VHL downregulation provides a proangiogenic impulse for CRC progression.

Topics: Adenocarcinoma; Adenoma; Adenomatous Polyposis Coli; Animals; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; beta Catenin; Cell Line; Cell Transformation, Neoplastic; Colon; Colonic Polyps; Colorectal Neoplasms; Disease Progression; Epithelial Cells; Erythropoietin; Gene Expression Regulation, Neoplastic; Genes, Reporter; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Intestinal Mucosa; Kidney; L Cells; Mice; Mice, Knockout; Neovascularization, Pathologic; Nerve Tissue Proteins; Precancerous Conditions; Promoter Regions, Genetic; Recombinant Fusion Proteins; Signal Transduction; TCF Transcription Factors; Transcription Factor 4; Transcription Factor 7-Like 2 Protein; Von Hippel-Lindau Tumor Suppressor Protein; Wnt Proteins; Wnt3 Protein

In two children, a 9 year-old boy and a 10 1/2 year-old girl, who presented with polycythaemia as the only symptom, the expected renal tumour was only found after exclusion of all other causes of polycythaemia. The delay in diagnosis was caused by technically inadequate intravenous urograms, which were erroneously passed as normal. In one child low kv X-ray exposition of the kidneys led to the diagnosis of a renal tumour. In the other child high-dose urography and tomography gave the indication for selective angiography. Normalization of the red blood count postoperatively verifies the connection between preoperative erythrocytosis and the renal tumour. Histologically both cases proved to be renal adenomas, which are extremely rare in childhood.

Topics: Adenoma; Child; Erythropoietin; Female; Humans; Kidney Neoplasms; Male; Polycythemia

Topics: Adenoma; Adult; Erythropoietin; Female; Humans; Kidney Neoplasms; Leiomyoma; Male; Meningioma; Middle Aged; Neoplasms; Polycythemia; Stomach Neoplasms; Uterine Neoplasms

Topics: Abdominal Neoplasms; Adenocarcinoma; Adenoma; Animals; Carcinogens; Carcinoma, Squamous Cell; Carcinoma, Transitional Cell; Erythropoietin; Esters; Female; Injections, Intraperitoneal; Lung Neoplasms; Male; Mediastinal Neoplasms; Methane; Neoplasms, Experimental; Nephrectomy; Pituitary Neoplasms; Rats; Sarcoma; Sex Factors; Sulfonic Acids; Thyroid Neoplasms; Time Factors