losartan has been researched along with Ventricular Fibrillation in 9 studies
Losartan: An antagonist of ANGIOTENSIN TYPE 1 RECEPTOR with antihypertensive activity due to the reduced pressor effect of ANGIOTENSIN II.
losartan : A biphenylyltetrazole where a 1,1'-biphenyl group is attached at the 5-position and has an additional trisubstituted imidazol-1-ylmethyl group at the 4'-position
Ventricular Fibrillation: A potentially lethal cardiac arrhythmia that is characterized by uncoordinated extremely rapid firing of electrical impulses (400-600/min) in HEART VENTRICLES. Such asynchronous ventricular quivering or fibrillation prevents any effective cardiac output and results in unconsciousness (SYNCOPE). It is one of the major electrocardiographic patterns seen with CARDIAC ARREST.
| Excerpt | Relevance | Reference |
|---|---|---|
| "ASA, captopril or losartan were given at a concentration of 40 mg/kg/day in drinking water." | 5.32 | Comparative effects of aspirin with ACE inhibitor or angiotensin receptor blocker on myocardial infarction and vascular function. ( Browne, AE; Chatterjee, K; Grossman, W; Karliner, JS; Lee, RJ; Parmley, WW; Sievers, RE; Zhu, BQ, 2003) |
| " Losartan increased the threshold for ventricular fibrillation (p=0." | 3.71 | The renin-angiotensin system does not contribute to the endothelial dysfunction and increased infarct size in rats exposed to second hand smoke. ( Browne, AE; Chair, K; Chatterjee, K; Glantz, SA; Hillman, RT; Lee, RJ; Parmley, WW; Sievers, RE; Zhu, BQ, 2002) |
| "Fonsartan and losartan treatment totally abolished these effects." | 1.32 | Angiotensin II subtype AT1 receptor blockade prevents hypertension and renal insufficiency induced by chronic NO-synthase inhibition in rats. ( Grötsch, H; Hropot, M; Langer, KH; Linz, W; Wiemer, G, 2003) |
| "ASA, captopril or losartan were given at a concentration of 40 mg/kg/day in drinking water." | 1.32 | Comparative effects of aspirin with ACE inhibitor or angiotensin receptor blocker on myocardial infarction and vascular function. ( Browne, AE; Chatterjee, K; Grossman, W; Karliner, JS; Lee, RJ; Parmley, WW; Sievers, RE; Zhu, BQ, 2003) |
| " In dose-finding experiments in non-hypertrophied isolated perfused hearts, we performed dose-response curves of losartan and enalaprilat studying monophasic action potential duration at 90% repolarisation (MAPD(90%)) and ventricular fibrillation (VF) threshold." | 1.32 | Losartan but not enalaprilat acutely reduces reperfusion ventricular tachyarrhythmias in hypertrophied rat hearts after low-flow ischaemia. ( Beier, K; Bellahcene, M; Buser, PT; Butz, S; Driamov, S; Remondino, A; Zaugg, CE; Ziegler, A, 2004) |
| "Rats treated with losartan had significantly higher levels of angiotensin II in their plasma." | 1.31 | Comparative effects of pretreatment with captopril and losartan on cardiovascular protection in a rat model of ischemia-reperfusion. ( Browne, AE; Chatterjee, K; Chou, TM; Lee, RJ; Parmley, WW; Pulukurthy, S; Sievers, RE; Sudhir, K; Sun, Y; Zhu, B, 2000) |
| "The incidence of ventricular tachyarrhythmias during reperfusion was lower in the losartan group than in the control group (4/15 vs 6/15)." | 1.30 | Effects of an angiotensin II antagonist on reperfusion arrhythmias in dogs. ( Annoura, M; Arakawa, K; Handa, K; Hiroki, T; Kumagai, K; Matsuo, K; Nakashima, Y; Yamanouchi, Y, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (11.11) | 18.2507 |
| 2000's | 7 (77.78) | 29.6817 |
| 2010's | 1 (11.11) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chorro, FJ | 1 |
| Canto, ID | 1 |
| Brines, L | 1 |
| Such-Miquel, L | 1 |
| Calvo, C | 1 |
| Soler, C | 1 |
| Zarzoso, M | 1 |
| Trapero, I | 1 |
| Tormos, Á | 1 |
| Such, L | 1 |
| Hropot, M | 1 |
| Langer, KH | 1 |
| Wiemer, G | 1 |
| Grötsch, H | 1 |
| Linz, W | 1 |
| Zhu, BQ | 2 |
| Sievers, RE | 3 |
| Browne, AE | 3 |
| Lee, RJ | 3 |
| Chatterjee, K | 3 |
| Grossman, W | 1 |
| Karliner, JS | 1 |
| Parmley, WW | 3 |
| Butz, S | 1 |
| Driamov, S | 1 |
| Remondino, A | 1 |
| Bellahcene, M | 1 |
| Beier, K | 1 |
| Ziegler, A | 1 |
| Buser, PT | 1 |
| Zaugg, CE | 1 |
| Pourdjabbar, A | 1 |
| Parker, TG | 1 |
| Nguyen, QT | 1 |
| Desjardins, JF | 1 |
| Lapointe, N | 1 |
| Tsoporis, JN | 1 |
| Rouleau, JL | 1 |
| Matsuo, K | 1 |
| Kumagai, K | 1 |
| Annoura, M | 1 |
| Yamanouchi, Y | 1 |
| Handa, K | 1 |
| Nakashima, Y | 1 |
| Hiroki, T | 1 |
| Arakawa, K | 1 |
| Zhu, B | 1 |
| Sun, Y | 1 |
| Pulukurthy, S | 1 |
| Sudhir, K | 1 |
| Chou, TM | 1 |
| López-Farré, A | 1 |
| Ferrario, CM | 1 |
| Hillman, RT | 1 |
| Chair, K | 1 |
| Glantz, SA | 1 |
9 other studies available for losartan and Ventricular Fibrillation
| Article | Year |
|---|---|
Experimental Study of the Effects of EIPA, Losartan, and BQ-123 on Electrophysiological Changes Induced by Myocardial Stretch.
Topics: Amiloride; Angiotensin II Type 1 Receptor Blockers; Animals; Endothelin Receptor Antagonists; Epithe | 2015 |
Angiotensin II subtype AT1 receptor blockade prevents hypertension and renal insufficiency induced by chronic NO-synthase inhibition in rats.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Antihypertensive Agents; Biphenyl Compounds; Glome | 2003 |
Comparative effects of aspirin with ACE inhibitor or angiotensin receptor blocker on myocardial infarction and vascular function.
Topics: Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhib | 2003 |
Losartan but not enalaprilat acutely reduces reperfusion ventricular tachyarrhythmias in hypertrophied rat hearts after low-flow ischaemia.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Dose-Response Relationship, Drug; Enalaprilat; H | 2004 |
Effects of pre-, peri-, and postmyocardial infarction treatment with losartan in rats: effect of dose on survival, ventricular arrhythmias, function, and remodeling.
Topics: Actins; Angiotensin II Type 1 Receptor Blockers; Animals; Atrial Natriuretic Factor; Blood Pressure; | 2005 |
Effects of an angiotensin II antagonist on reperfusion arrhythmias in dogs.
Topics: Aldosterone; Angiotensin Receptor Antagonists; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac | 1997 |
Comparative effects of pretreatment with captopril and losartan on cardiovascular protection in a rat model of ischemia-reperfusion.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; | 2000 |
[Vascular diseases and thrombosis].
Topics: Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Coronary Thrombosis; Humans; Losartan; Ris | 2000 |
The renin-angiotensin system does not contribute to the endothelial dysfunction and increased infarct size in rats exposed to second hand smoke.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Arrhythmias, Cardiac; Electrocardiography; Endothe | 2002 |