losartan has been researched along with Transposition of Great Vessels in 2 studies
Losartan: An antagonist of ANGIOTENSIN TYPE 1 RECEPTOR with antihypertensive activity due to the reduced pressor effect of ANGIOTENSIN II.
losartan : A biphenylyltetrazole where a 1,1'-biphenyl group is attached at the 5-position and has an additional trisubstituted imidazol-1-ylmethyl group at the 4'-position
Transposition of Great Vessels: A congenital cardiovascular malformation in which the AORTA arises entirely from the RIGHT VENTRICLE, and the PULMONARY ARTERY arises from the LEFT VENTRICLE. Consequently, the pulmonary and the systemic circulations are parallel and not sequential, so that the venous return from the peripheral circulation is re-circulated by the right ventricle via aorta to the systemic circulation without being oxygenated in the lungs. This is a potentially lethal form of heart disease in newborns and infants.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Dore, A | 1 |
| Houde, C | 1 |
| Chan, KL | 1 |
| Ducharme, A | 1 |
| Khairy, P | 1 |
| Juneau, M | 1 |
| Marcotte, F | 1 |
| Mercier, LA | 1 |
| Lester, SJ | 1 |
| McElhinney, DB | 1 |
| Viloria, E | 1 |
| Reddy, GP | 1 |
| Ryan, E | 1 |
| Tworetzky, W | 1 |
| Schiller, NB | 1 |
| Foster, E | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Prospective Comparison of ARNI Versus plAcebo in Patients With Congenital sYStemic Right Ventricle Heart Failure[NCT05117736] | 48 participants (Anticipated) | Interventional | 2022-03-15 | Active, not recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 trials available for losartan and Transposition of Great Vessels
| Article | Year |
|---|---|
Angiotensin receptor blockade and exercise capacity in adults with systemic right ventricles: a multicenter, randomized, placebo-controlled clinical trial.
Topics: Adult; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Cross-Over Studies; Double-Blind Met | 2005 |
Effects of losartan in patients with a systemically functioning morphologic right ventricle after atrial repair of transposition of the great arteries.
Topics: Adolescent; Angiotensin Receptor Antagonists; Cross-Over Studies; Hemodynamics; Humans; Losartan; Tr | 2001 |