losartan has been researched along with Stress Disorders, Post-Traumatic in 5 studies
Losartan: An antagonist of ANGIOTENSIN TYPE 1 RECEPTOR with antihypertensive activity due to the reduced pressor effect of ANGIOTENSIN II.
losartan : A biphenylyltetrazole where a 1,1'-biphenyl group is attached at the 5-position and has an additional trisubstituted imidazol-1-ylmethyl group at the 4'-position
Stress Disorders, Post-Traumatic: A class of traumatic stress disorders with symptoms that last more than one month.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Losartan (vs." | 3.01 | Randomized, Placebo-Controlled Trial of the Angiotensin Receptor Antagonist Losartan for Posttraumatic Stress Disorder. ( Benedek, DM; Bui, E; Cassano, P; Griffith, JL; He, F; Howlett, J; Jain, S; Malgaroli, M; Marvar, PJ; Melaragno, A; Ressler, KJ; Seligowski, AV; Shu, IW; Simon, NM; Song, S; Stein, MB; Szuhany, K; Taylor, CT; West, JC, 2021) |
| "With an animal model of PTSD and the selective angiotensin receptor type 1 (AT1) antagonist losartan, we investigated the acute and long-term effects of AT1 receptor inhibition on fear memory and baseline anxiety." | 1.40 | Angiotensin type 1 receptor inhibition enhances the extinction of fear memory. ( Banerjee, S; Choi, DC; Fuchs, S; Goodman, J; Marvar, PJ; Ressler, KJ, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (20.00) | 24.3611 |
| 2020's | 4 (80.00) | 2.80 |
| Authors | Studies |
|---|---|
| Torregrossa, MM | 1 |
| Shkreli, L | 1 |
| Woud, ML | 1 |
| Ramsbottom, R | 1 |
| Rupietta, AE | 1 |
| Waldhauser, GT | 1 |
| Kumsta, R | 1 |
| Reinecke, A | 1 |
| Hong, Y | 1 |
| Wu, W | 1 |
| Wang, S | 1 |
| Hao, Q | 1 |
| Zheng, H | 1 |
| Li, S | 1 |
| Zhang, X | 1 |
| Sun, R | 1 |
| Stein, MB | 1 |
| Jain, S | 1 |
| Simon, NM | 1 |
| West, JC | 1 |
| Marvar, PJ | 2 |
| Bui, E | 1 |
| He, F | 1 |
| Benedek, DM | 1 |
| Cassano, P | 1 |
| Griffith, JL | 1 |
| Howlett, J | 1 |
| Malgaroli, M | 1 |
| Melaragno, A | 1 |
| Seligowski, AV | 1 |
| Shu, IW | 1 |
| Song, S | 1 |
| Szuhany, K | 1 |
| Taylor, CT | 1 |
| Ressler, KJ | 2 |
| Goodman, J | 1 |
| Fuchs, S | 1 |
| Choi, DC | 1 |
| Banerjee, S | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Enhancing Fear Extinction Via Angiotensin Type 1 Receptor Inhibition: A Randomized Controlled Trial in Posttraumatic Stress Disorder[NCT02709018] | 149 participants (Actual) | Interventional | 2016-07-16 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
The Clinician-Administered PTSD Scale for DSM-5 (CAPS-5) as used here has 20 items, each scored 0-4, to yield a score with a possible range of 0-80. Higher scores mean worse outcome. (NCT02709018)
Timeframe: 10 weeks
| Intervention | score on a scale (Mean) |
|---|---|
| CC Homozygotes on Losartan | 16.7 |
| T Carriers on Losartan | 15.8 |
"Clinician-Administered PTSD Scale for DSM-5 also known as CAPS-5 is the gold standard in PTSD assessment. The CAPS-5 is a 30-item structured interview that can be used to, make current (past month) diagnosis of PTSD, make a lifetime diagnosis of PTSD and assess PTSD symptoms over the past week.~The CAPS-5 as used here has 20 items, each scored 0-4, to yield a score with a possible range of 0-80. Higher scores mean worse outcome." (NCT02709018)
Timeframe: 10 weeks
| Intervention | score on a scale (Mean) |
|---|---|
| Losartan | -15.96 |
| Placebo | -16.89 |
2 trials available for losartan and Stress Disorders, Post-Traumatic
| Article | Year |
|---|---|
Angiotensin involvement in trauma processing-exploring candidate neurocognitive mechanisms of preventing post-traumatic stress symptoms.
Topics: Adult; Angiotensin II Type 1 Receptor Blockers; Angiotensins; Cognition; Double-Blind Method; Female | 2020 |
Randomized, Placebo-Controlled Trial of the Angiotensin Receptor Antagonist Losartan for Posttraumatic Stress Disorder.
Topics: Angiotensin Receptor Antagonists; Double-Blind Method; Female; Humans; Losartan; Male; Stress Disord | 2021 |
3 other studies available for losartan and Stress Disorders, Post-Traumatic
| Article | Year |
|---|---|
Failure of Losartan in a Clinical Trial for Posttraumatic Stress Disorder: Lack of Efficacy or Spotlight on the Power of Placebo?
Topics: Double-Blind Method; Humans; Losartan; Stress Disorders, Post-Traumatic | 2021 |
Angiotensin II type 1 receptor blockade attenuates posttraumatic stress disorder-related chronic pain by inhibiting glial activation in the spinal cord.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Astrocytes; Chronic Pain; Hippocam | 2021 |
Angiotensin type 1 receptor inhibition enhances the extinction of fear memory.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Disease Models, Animal; Extinction, Psychological; | 2014 |