Page last updated: 2024-10-30

losartan and Status Epilepticus

losartan has been researched along with Status Epilepticus in 5 studies

Losartan: An antagonist of ANGIOTENSIN TYPE 1 RECEPTOR with antihypertensive activity due to the reduced pressor effect of ANGIOTENSIN II.
losartan : A biphenylyltetrazole where a 1,1'-biphenyl group is attached at the 5-position and has an additional trisubstituted imidazol-1-ylmethyl group at the 4'-position

Status Epilepticus: A prolonged seizure or seizures repeated frequently enough to prevent recovery between episodes occurring over a period of 20-30 minutes. The most common subtype is generalized tonic-clonic status epilepticus, a potentially fatal condition associated with neuronal injury and respiratory and metabolic dysfunction. Nonconvulsive forms include petit mal status and complex partial status, which may manifest as behavioral disturbances. Simple partial status epilepticus consists of persistent motor, sensory, or autonomic seizures that do not impair cognition (see also EPILEPSIA PARTIALIS CONTINUA). Subclinical status epilepticus generally refers to seizures occurring in an unresponsive or comatose individual in the absence of overt signs of seizure activity. (From N Engl J Med 1998 Apr 2;338(14):970-6; Neurologia 1997 Dec;12 Suppl 6:25-30)

Research Excerpts

ExcerptRelevanceReference
"Spontaneous seizures were video- and EEG-monitored in spontaneously hypertensive rats (SHRs) for a 16-week period after SE."5.43Long-Term Treatment with Losartan Attenuates Seizure Activity and Neuronal Damage Without Affecting Behavioral Changes in a Model of Co-morbid Hypertension and Epilepsy. ( Atanasova, D; Ivanova, N; Kortenska, L; Lazarov, N; Lozanov, V; Mitreva, R; Pechlivanova, DM; Stoynev, A; Tchekalarova, JD, 2016)
"Spontaneous seizures were video- and EEG-monitored in spontaneously hypertensive rats (SHRs) for a 16-week period after SE."1.43Long-Term Treatment with Losartan Attenuates Seizure Activity and Neuronal Damage Without Affecting Behavioral Changes in a Model of Co-morbid Hypertension and Epilepsy. ( Atanasova, D; Ivanova, N; Kortenska, L; Lazarov, N; Lozanov, V; Mitreva, R; Pechlivanova, DM; Stoynev, A; Tchekalarova, JD, 2016)

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's5 (100.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Bar-Klein, G1
Lublinsky, S1
Kamintsky, L1
Noyman, I1
Veksler, R1
Dalipaj, H1
Senatorov, VV1
Swissa, E1
Rosenbach, D1
Elazary, N1
Milikovsky, DZ1
Milk, N1
Kassirer, M1
Rosman, Y1
Serlin, Y1
Eisenkraft, A1
Chassidim, Y1
Parmet, Y1
Kaufer, D1
Friedman, A1
Hong, S1
JianCheng, H1
JiaWen, W1
ShuQin, Z1
GuiLian, Z1
HaiQin, W1
Ru, Z1
Zhen, G1
HongWei, R1
Sun, H1
Wu, H1
Yu, X1
Zhang, G1
Zhang, R1
Zhan, S1
Wang, H1
Bu, N1
Ma, X1
Li, Y1
Tchekalarova, JD1
Ivanova, N1
Atanasova, D1
Pechlivanova, DM1
Lazarov, N1
Kortenska, L1
Mitreva, R1
Lozanov, V1
Stoynev, A1
Tsai, CY1
Chan, JY1
Hsu, KS1
Chang, AY1
Chan, SH1

Other Studies

5 other studies available for losartan and Status Epilepticus

ArticleYear
Imaging blood-brain barrier dysfunction as a biomarker for epileptogenesis.
    Brain : a journal of neurology, 2017, Jun-01, Volume: 140, Issue:6

    Topics: Anesthesia, Inhalation; Anesthetics, Inhalation; Angiotensin II Type 1 Receptor Blockers; Animals; B

2017
Losartan inhibits development of spontaneous recurrent seizures by preventing astrocyte activation and attenuating blood-brain barrier permeability following pilocarpine-induced status epilepticus.
    Brain research bulletin, 2019, Volume: 149

    Topics: Animals; Astrocytes; Blood-Brain Barrier; Brain; Disease Models, Animal; Epilepsy; Losartan; Male; N

2019
Angiotensin II and its receptor in activated microglia enhanced neuronal loss and cognitive impairment following pilocarpine-induced status epilepticus.
    Molecular and cellular neurosciences, 2015, Volume: 65

    Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Cognition Disorders; Hippocampus;

2015
Long-Term Treatment with Losartan Attenuates Seizure Activity and Neuronal Damage Without Affecting Behavioral Changes in a Model of Co-morbid Hypertension and Epilepsy.
    Cellular and molecular neurobiology, 2016, Volume: 36, Issue:6

    Topics: Animals; Behavior, Animal; Disease Models, Animal; Hippocampus; Hypertension; Losartan; Male; Neuron

2016
Brain-derived neurotrophic factor ameliorates brain stem cardiovascular dysregulation during experimental temporal lobe status epilepticus.
    PloS one, 2012, Volume: 7, Issue:3

    Topics: Acetophenones; Animals; Antioxidants; Brain Stem; Brain-Derived Neurotrophic Factor; Cardiovascular

2012