losartan has been researched along with Seizures in 11 studies
Losartan: An antagonist of ANGIOTENSIN TYPE 1 RECEPTOR with antihypertensive activity due to the reduced pressor effect of ANGIOTENSIN II.
losartan : A biphenylyltetrazole where a 1,1'-biphenyl group is attached at the 5-position and has an additional trisubstituted imidazol-1-ylmethyl group at the 4'-position
Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The use of losartan with sodium valproate in epilepsy may prevent the cognitive and cardiac sequelae of seizures." | 7.91 | Effects of enalapril and losartan alone and in combination with sodium valproate on seizures, memory, and cardiac changes in rats. ( Arava, S; Gupta, YK; Joshi, D; Katyal, J, 2019) |
| "Spontaneous seizures were video- and EEG-monitored in spontaneously hypertensive rats (SHRs) for a 16-week period after SE." | 5.43 | Long-Term Treatment with Losartan Attenuates Seizure Activity and Neuronal Damage Without Affecting Behavioral Changes in a Model of Co-morbid Hypertension and Epilepsy. ( Atanasova, D; Ivanova, N; Kortenska, L; Lazarov, N; Lozanov, V; Mitreva, R; Pechlivanova, DM; Stoynev, A; Tchekalarova, JD, 2016) |
| "The use of losartan with sodium valproate in epilepsy may prevent the cognitive and cardiac sequelae of seizures." | 3.91 | Effects of enalapril and losartan alone and in combination with sodium valproate on seizures, memory, and cardiac changes in rats. ( Arava, S; Gupta, YK; Joshi, D; Katyal, J, 2019) |
| " The aim of the current study was to evaluate the effects of losartan (2-n-butyl-4-chloro-5-hydroxymethyl-1-[(2'(1H-tetrazol-5-yl)-biphenil-4-yl)methyl]imidazole) and telmisartan (49-[(1,49-dimethyl-29-propyl[2,69-bi-1H-benzimidazo]-19-yl)methyl]-[1,19-biphenyl]-2-carboxylic acid), the angiotensin AT1 receptor antagonists which are widely used in clinical practice, on the protective action of conventional antiepileptic drugs (carbamazepine, phenytoin, valproate and phenobarbital) against maximal electroshock-induced seizures in mice." | 3.76 | Angiotensin AT1 receptor antagonists enhance the anticonvulsant action of valproate in the mouse model of maximal electroshock. ( Czuczwar, SJ; Jakubus, T; Janowska, A; Tochman-Gawda, A; Łukawski, K, 2010) |
| "The effects of non-peptide AT1- and AT2-receptor antagonists DuP 753 (losartan) and PD 123319 on the intensity of pentylenetetrazol (PTZ)-kindled seizures in mice were studied." | 3.69 | Effects of non-peptide angiotensin II-receptor antagonists on pentylenetetrazol kindling in mice. ( Georgiev, VP; Kambourova, TS; Lazarova, MB, 1996) |
| "In this review, we intended to highlight the role of drug-drug interactions involving angiotensin II receptor antagonists with antiepileptic drugs accompanied by a brief characteristic of the role of RAS in neuroinflammation." | 2.66 | A review of clinically significant drug-drug interactions involving angiotensin II receptor antagonists and antiepileptic drugs. ( Czuczwar, SJ; Rusek, M, 2020) |
| "Spontaneous seizures were video- and EEG-monitored in spontaneously hypertensive rats (SHRs) for a 16-week period after SE." | 1.43 | Long-Term Treatment with Losartan Attenuates Seizure Activity and Neuronal Damage Without Affecting Behavioral Changes in a Model of Co-morbid Hypertension and Epilepsy. ( Atanasova, D; Ivanova, N; Kortenska, L; Lazarov, N; Lozanov, V; Mitreva, R; Pechlivanova, DM; Stoynev, A; Tchekalarova, JD, 2016) |
| "Prazosin potentiated the anti-seizure effect of Ang III against MTW, GNCL, and THE in non-stressed mice while it reversed the seizure threshold-decreasing effect of this heptapeptide on MTW and GNCL in stressed mice." | 1.33 | Ang II and Ang III modulate PTZ seizure threshold in non-stressed and stressed mice: possible involvement of noradrenergic mechanism. ( Georgiev, V; Tchekalarova, J, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (18.18) | 18.2507 |
| 2000's | 2 (18.18) | 29.6817 |
| 2010's | 6 (54.55) | 24.3611 |
| 2020's | 1 (9.09) | 2.80 |
| Authors | Studies |
|---|---|
| Rusek, M | 1 |
| Czuczwar, SJ | 3 |
| Joshi, D | 1 |
| Katyal, J | 1 |
| Arava, S | 1 |
| Gupta, YK | 1 |
| Hong, S | 1 |
| JianCheng, H | 1 |
| JiaWen, W | 1 |
| ShuQin, Z | 1 |
| GuiLian, Z | 1 |
| HaiQin, W | 1 |
| Ru, Z | 1 |
| Zhen, G | 1 |
| HongWei, R | 1 |
| Lukawski, K | 1 |
| Janowska, A | 2 |
| Jakubus, T | 2 |
| Raszewski, G | 1 |
| Tchekalarova, J | 3 |
| Ivanova, N | 2 |
| Pechlivanova, D | 2 |
| Ilieva, K | 1 |
| Atanasova, M | 1 |
| Tchekalarova, JD | 1 |
| Atanasova, D | 1 |
| Pechlivanova, DM | 1 |
| Lazarov, N | 1 |
| Kortenska, L | 1 |
| Mitreva, R | 1 |
| Lozanov, V | 1 |
| Stoynev, A | 1 |
| Łukawski, K | 1 |
| Tochman-Gawda, A | 1 |
| Kambourova, T | 1 |
| Matsoukas, J | 1 |
| Georgiev, V | 3 |
| Georgiev, VP | 1 |
| Lazarova, MB | 1 |
| Kambourova, TS | 1 |
| Opitz, M | 1 |
1 review available for losartan and Seizures
| Article | Year |
|---|---|
A review of clinically significant drug-drug interactions involving angiotensin II receptor antagonists and antiepileptic drugs.
Topics: Angiotensin Receptor Antagonists; Animals; Anticonvulsants; Drug Interactions; Humans; Losartan; Neu | 2020 |
10 other studies available for losartan and Seizures
| Article | Year |
|---|---|
Effects of enalapril and losartan alone and in combination with sodium valproate on seizures, memory, and cardiac changes in rats.
Topics: Animals; Anticonvulsants; Drug Therapy, Combination; Enalapril; Heart Diseases; Kindling, Neurologic | 2019 |
Losartan inhibits development of spontaneous recurrent seizures by preventing astrocyte activation and attenuating blood-brain barrier permeability following pilocarpine-induced status epilepticus.
Topics: Animals; Astrocytes; Blood-Brain Barrier; Brain; Disease Models, Animal; Epilepsy; Losartan; Male; N | 2019 |
Combined treatment with gabapentin and drugs affecting the renin-angiotensin system against electroconvulsions in mice.
Topics: Amines; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Animals; | 2013 |
Strain-dependent effects of sub-chronically infused losartan against kainic acid-induced seizures, oxidative stress, and heat shock protein 72 expression.
Topics: Animals; Cerebral Cortex; Cytosol; Hippocampus; HSP72 Heat-Shock Proteins; Infusions, Subcutaneous; | 2014 |
Long-Term Treatment with Losartan Attenuates Seizure Activity and Neuronal Damage Without Affecting Behavioral Changes in a Model of Co-morbid Hypertension and Epilepsy.
Topics: Animals; Behavior, Animal; Disease Models, Animal; Hippocampus; Hypertension; Losartan; Male; Neuron | 2016 |
Angiotensin AT1 receptor antagonists enhance the anticonvulsant action of valproate in the mouse model of maximal electroshock.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Anticonvulsants; Behavior, Animal; Benzimidazoles; | 2010 |
The effects of sarmesin, an Angiotensin II analogue on seizure susceptibility, memory retention and nociception.
Topics: Angiotensin II; Animals; Avoidance Learning; Disease Models, Animal; Drug Combinations; Imidazoles; | 2003 |
Ang II and Ang III modulate PTZ seizure threshold in non-stressed and stressed mice: possible involvement of noradrenergic mechanism.
Topics: Adrenergic alpha-Antagonists; Adrenergic Uptake Inhibitors; Angiotensin II; Angiotensin II Type 1 Re | 2006 |
Effects of non-peptide angiotensin II-receptor antagonists on pentylenetetrazol kindling in mice.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Anticonvulsants; Biphenyl Compounds; Conv | 1996 |
Participation of angiotensin receptors in acute hypoxia in mice. II. Effects of angiotensin II nonpeptide receptor ligands losartan (DuP-753) and PD-123319.
Topics: Acute Disease; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; D | 1999 |