losartan has been researched along with Sclerosis in 4 studies
Losartan: An antagonist of ANGIOTENSIN TYPE 1 RECEPTOR with antihypertensive activity due to the reduced pressor effect of ANGIOTENSIN II.
losartan : A biphenylyltetrazole where a 1,1'-biphenyl group is attached at the 5-position and has an additional trisubstituted imidazol-1-ylmethyl group at the 4'-position
Sclerosis: A pathological process consisting of hardening or fibrosis of an anatomical structure, often a vessel or a nerve.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Neither losartan- nor atenolol-based antihypertensive regimens could prevent the progression of aortic valve (AV) sclerosis in elderly, high-risk hypertensive patients, and the regression of AV sclerosis did not translate into reduced cardiovascular risk." | 9.11 | Effect of losartan versus atenolol on aortic valve sclerosis (a LIFE substudy). ( Bella, JN; Boman, K; Dahlöf, B; Devereux, RB; Gerdts, E; Liu, JE; Nieminen, MS; Olsen, MH; Papademetriou, V; Rokkedal, J; Wachtell, K, 2004) |
| "Neither losartan- nor atenolol-based antihypertensive regimens could prevent the progression of aortic valve (AV) sclerosis in elderly, high-risk hypertensive patients, and the regression of AV sclerosis did not translate into reduced cardiovascular risk." | 5.11 | Effect of losartan versus atenolol on aortic valve sclerosis (a LIFE substudy). ( Bella, JN; Boman, K; Dahlöf, B; Devereux, RB; Gerdts, E; Liu, JE; Nieminen, MS; Olsen, MH; Papademetriou, V; Rokkedal, J; Wachtell, K, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (25.00) | 18.2507 |
| 2000's | 3 (75.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Olsen, MH | 2 |
| Wachtell, K | 2 |
| Bella, JN | 2 |
| Liu, JE | 1 |
| Boman, K | 1 |
| Gerdts, E | 2 |
| Papademetriou, V | 1 |
| Nieminen, MS | 2 |
| Rokkedal, J | 1 |
| Dahlöf, B | 2 |
| Devereux, RB | 2 |
| Palmieri, V | 1 |
| Smith, G | 1 |
| Ibsen, H | 1 |
| Wolf, G | 1 |
| Schneider, A | 1 |
| Wenzel, U | 1 |
| Helmchen, U | 1 |
| Stahl, RA | 1 |
| Ma, LJ | 1 |
| Nakamura, S | 1 |
| Whitsitt, JS | 1 |
| Marcantoni, C | 1 |
| Davidson, JM | 1 |
| Fogo, AB | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Triple-Blind, Parallel Study to Investigate the Effect of Losartan Versus Atenolol on the Reduction of Morbidity and Mortality in Hypertensive Patients With Left Ventricular Hypertrophy[NCT00338260] | Phase 3 | 496 participants (Actual) | Interventional | 1995-06-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 trials available for losartan and Sclerosis
| Article | Year |
|---|---|
Effect of losartan versus atenolol on aortic valve sclerosis (a LIFE substudy).
Topics: Aged; Aged, 80 and over; Aortic Valve; Atenolol; Female; Heart Valve Diseases; Humans; Losartan; Mal | 2004 |
Aortic valve sclerosis and albuminuria predict cardiovascular events independently in hypertension: a losartan intervention for endpoint-reduction in hypertension (LIFE) substudy.
Topics: Aged; Albuminuria; Antihypertensive Agents; Aortic Valve; Atenolol; Cardiovascular Diseases; Double- | 2005 |
2 other studies available for losartan and Sclerosis
| Article | Year |
|---|---|
Regulation of glomerular TGF-beta expression in the contralateral kidney of two-kidney, one-clip hypertensive rats.
Topics: Animals; Antihypertensive Agents; Drug Combinations; Hydralazine; Hydrochlorothiazide; Hypertension, | 1998 |
Regression of sclerosis in aging by an angiotensin inhibition-induced decrease in PAI-1.
Topics: Aging; Angiotensin Receptor Antagonists; Angiotensins; Animals; Antihypertensive Agents; Aorta, Thor | 2000 |