losartan has been researched along with Scleroderma, Systemic in 8 studies
Losartan: An antagonist of ANGIOTENSIN TYPE 1 RECEPTOR with antihypertensive activity due to the reduced pressor effect of ANGIOTENSIN II.
losartan : A biphenylyltetrazole where a 1,1'-biphenyl group is attached at the 5-position and has an additional trisubstituted imidazol-1-ylmethyl group at the 4'-position
Scleroderma, Systemic: A chronic multi-system disorder of CONNECTIVE TISSUE. It is characterized by SCLEROSIS in the SKIN, the LUNGS, the HEART, the GASTROINTESTINAL TRACT, the KIDNEYS, and the MUSCULOSKELETAL SYSTEM. Other important features include diseased small BLOOD VESSELS and AUTOANTIBODIES. The disorder is named for its most prominent feature (hard skin), and classified into subsets by the extent of skin thickening: LIMITED SCLERODERMA and DIFFUSE SCLERODERMA.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Most patients with systemic sclerosis (SSc) have Raynaud's phenomenon (RP), which is often more severe than idiopathic RP." | 2.41 | Calcium-channel blockers for Raynaud's phenomenon in systemic sclerosis. ( Fenlon, D; Pope, JE; Shea, B; Thompson, AE; Welch, V, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (37.50) | 18.2507 |
| 2000's | 5 (62.50) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Jego, C | 1 |
| Michaut, V | 1 |
| Graffin, B | 1 |
| Paris, JF | 1 |
| Carli, P | 1 |
| Rajendran, PR | 1 |
| Molitor, JA | 1 |
| Caskey, FJ | 1 |
| Thacker, EJ | 1 |
| Johnston, PA | 1 |
| Barnes, JN | 1 |
| Goldsmith, DJ | 1 |
| Dziadzio, M | 1 |
| Denton, CP | 1 |
| Smith, R | 1 |
| Howell, K | 1 |
| Blann, A | 1 |
| Bowers, E | 1 |
| Black, CM | 1 |
| Hasegawa, S | 1 |
| Iesato, K | 1 |
| Tsukahara, T | 1 |
| Yamamoto, S | 1 |
| Kondou, Y | 1 |
| Ogawa, M | 1 |
| Ueda, S | 1 |
| Thompson, AE | 1 |
| Shea, B | 1 |
| Welch, V | 1 |
| Fenlon, D | 1 |
| Pope, JE | 1 |
| Bridges, MJ | 1 |
| Kelly, CA | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Identification of Transient Receptor Potential (TRP) Channels as New Potential Therapeutic Targets in Primary and Secondary Raynaud's Phenomenon.[NCT03211325] | 29 participants (Actual) | Interventional | 2016-10-18 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for losartan and Scleroderma, Systemic
| Article | Year |
|---|---|
Calcium-channel blockers for Raynaud's phenomenon in systemic sclerosis.
Topics: Calcium Channel Blockers; Cross-Over Studies; Humans; Iloprost; Injections, Intravenous; Ischemia; L | 2001 |
1 trial available for losartan and Scleroderma, Systemic
| Article | Year |
|---|---|
Losartan therapy for Raynaud's phenomenon and scleroderma: clinical and biochemical findings in a fifteen-week, randomized, parallel-group, controlled trial.
Topics: Adult; Aged; Female; Humans; Losartan; Male; Middle Aged; Nifedipine; Pilot Projects; Raynaud Diseas | 1999 |
6 other studies available for losartan and Scleroderma, Systemic
| Article | Year |
|---|---|
[Scleroderma renal crisis following withdrawal of therapy with losartan].
Topics: Acute Disease; Anti-Inflammatory Agents; Antihypertensive Agents; Causality; Female; Humans; Hyperte | 2003 |
Resolution of hypertensive encephalopathy and scleroderma renal crisis with an angiotensin receptor blocker.
Topics: Acute Kidney Injury; Angiotensin II Type 1 Receptor Blockers; CADASIL; Female; Humans; Hypertensive | 2005 |
Failure of losartan to control blood pressure in scleroderma renal crisis.
Topics: Acute Kidney Injury; Adult; Angiotensin Receptor Antagonists; Antihypertensive Agents; Biphenyl Comp | 1997 |
Angiotensin receptor antagonists.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Antihype | 1997 |
[Successful use of angiotensin II receptor antagonist (losartan) in a patient with scleroderma renal crisis].
Topics: Acute Kidney Injury; Aged; Angiotensin Receptor Antagonists; Antihypertensive Agents; Humans; Hypert | 2000 |
Raynaud's phenomenon affecting the tongue of a patient with scleroderma.
Topics: Female; Humans; Losartan; Middle Aged; Raynaud Disease; Scleroderma, Systemic; Tongue Diseases; Vaso | 2002 |