losartan has been researched along with Pulmonary Fibrosis in 16 studies
Losartan: An antagonist of ANGIOTENSIN TYPE 1 RECEPTOR with antihypertensive activity due to the reduced pressor effect of ANGIOTENSIN II.
losartan : A biphenylyltetrazole where a 1,1'-biphenyl group is attached at the 5-position and has an additional trisubstituted imidazol-1-ylmethyl group at the 4'-position
Pulmonary Fibrosis: A process in which normal lung tissues are progressively replaced by FIBROBLASTS and COLLAGEN causing an irreversible loss of the ability to transfer oxygen into the bloodstream via PULMONARY ALVEOLI. Patients show progressive DYSPNEA finally resulting in death.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Paraquat (PQ) is one of the most widely used herbicides in the world and can cause pulmonary fibrosis in the cases with intoxication." | 7.81 | Losartan attenuates paraquat-induced pulmonary fibrosis in rats. ( Guo, F; Hu, XT; Li, J; Li, S; Liu, ZF; Su, L; Sun, YB, 2015) |
| "Twenty-four male Wistar rats were randomized into pulmonary fibrosis model, perindopril treatment, losartan treatment and control groups." | 7.74 | [Perindopril and losartan attenuate bleomycin A5-induced pulmonary fibrosis in rats]. ( Cai, SX; Cheng, YX; Li, X; Meng, Y; Tong, WC, 2008) |
| " This study aimed to explore the effect of losartan, an angiotensin II type 1 receptor antagonist, on lung fibrosis in neonatal rats with hyperoxia-induced chronic lung disease (CLD) and its possible mechanisms." | 7.74 | [Effect of losartan on lung fibrosis in neonatal rats with hyperoxia-induced chronic lung disease]. ( Chen, N; Li, JJ; Xue, XD, 2007) |
| "To study the effect of losartan, an angiotensin II antagonist, on bleomycin-induced pulmonary fibrosis in rats and its possible mechanism." | 7.73 | Losartan attenuates bleomycin-induced pulmonary fibrosis in rats. ( Lu, Y; Yao, HW; Zhao, MH; Zhu, JP, 2006) |
| "To study the effect of losartan on bleomycin-induced pulmonary fibrosis in rats and its possible mechanism." | 7.71 | [Losartan in the rat model of bleomycin-induced pulmonary fibrosis and its impact on the expression of monocyte chemoattractant protein-1 and basic fibroblast growth factor]. ( Fang, X; Hu, X; Liu, Y; Zhu, Y, 2002) |
| "Paraquat (PQ) is one of the most widely used herbicides in the world and can cause pulmonary fibrosis in the cases with intoxication." | 3.81 | Losartan attenuates paraquat-induced pulmonary fibrosis in rats. ( Guo, F; Hu, XT; Li, J; Li, S; Liu, ZF; Su, L; Sun, YB, 2015) |
| "Twenty-four male Wistar rats were randomized into pulmonary fibrosis model, perindopril treatment, losartan treatment and control groups." | 3.74 | [Perindopril and losartan attenuate bleomycin A5-induced pulmonary fibrosis in rats]. ( Cai, SX; Cheng, YX; Li, X; Meng, Y; Tong, WC, 2008) |
| " This study aimed to explore the effect of losartan, an angiotensin II type 1 receptor antagonist, on lung fibrosis in neonatal rats with hyperoxia-induced chronic lung disease (CLD) and its possible mechanisms." | 3.74 | [Effect of losartan on lung fibrosis in neonatal rats with hyperoxia-induced chronic lung disease]. ( Chen, N; Li, JJ; Xue, XD, 2007) |
| "To study the effect of losartan, an angiotensin II antagonist, on bleomycin-induced pulmonary fibrosis in rats and its possible mechanism." | 3.73 | Losartan attenuates bleomycin-induced pulmonary fibrosis in rats. ( Lu, Y; Yao, HW; Zhao, MH; Zhu, JP, 2006) |
| "To study the effect of losartan on bleomycin-induced pulmonary fibrosis in rats and its possible mechanism." | 3.71 | [Losartan in the rat model of bleomycin-induced pulmonary fibrosis and its impact on the expression of monocyte chemoattractant protein-1 and basic fibroblast growth factor]. ( Fang, X; Hu, X; Liu, Y; Zhu, Y, 2002) |
| "Paricalcitol treatment suppressed the induction of these RAS components, whereas vitamin D deficiency enhanced the activation of the lung RAS." | 1.62 | Vitamin D suppresses bleomycin-induced pulmonary fibrosis by targeting the local renin-angiotensin system in the lung. ( Chang, J; Du, J; Ge, X; Li, X; Li, YC; Liu, W; Nie, H; Sun, Y; Wei, X; Xun, Z, 2021) |
| "Vitamin D deficiency is associated with pulmonary fibrosis and impaired lung function, but the underlying mechanism has not yet been fully elucidated." | 1.46 | Chronic vitamin D deficiency induces lung fibrosis through activation of the renin-angiotensin system. ( Fu, J; Liu, T; Shi, Y; Xing, Y; Xue, X; Yao, L; Zhao, X, 2017) |
| "Losartan (10 mg/kg) was administered by gavage daily, starting from 1 d before LPS stimulation." | 1.39 | Angiotensin-(1-7) attenuates lung fibrosis by way of Mas receptor in acute lung injury. ( Chen, Q; Huang, Y; Liu, L; Pan, C; Qiu, H; Yang, Y, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 11 (68.75) | 29.6817 |
| 2010's | 4 (25.00) | 24.3611 |
| 2020's | 1 (6.25) | 2.80 |
| Authors | Studies |
|---|---|
| Chang, J | 1 |
| Nie, H | 1 |
| Ge, X | 1 |
| Du, J | 1 |
| Liu, W | 1 |
| Li, X | 4 |
| Sun, Y | 1 |
| Wei, X | 1 |
| Xun, Z | 1 |
| Li, YC | 1 |
| Shi, Y | 1 |
| Liu, T | 1 |
| Yao, L | 1 |
| Xing, Y | 1 |
| Zhao, X | 1 |
| Fu, J | 1 |
| Xue, X | 1 |
| Chen, Q | 1 |
| Yang, Y | 1 |
| Huang, Y | 1 |
| Pan, C | 1 |
| Liu, L | 1 |
| Qiu, H | 1 |
| Guo, F | 1 |
| Sun, YB | 1 |
| Su, L | 1 |
| Li, S | 1 |
| Liu, ZF | 1 |
| Li, J | 2 |
| Hu, XT | 1 |
| Meng, Y | 2 |
| Cai, SX | 1 |
| Tong, WC | 1 |
| Cheng, YX | 1 |
| Chou, HC | 1 |
| Lang, YD | 1 |
| Wang, LF | 1 |
| Wu, TY | 1 |
| Hsieh, YF | 1 |
| Chen, CM | 1 |
| Fang, X | 1 |
| Zhu, Y | 1 |
| Hu, X | 1 |
| Liu, Y | 1 |
| Uhal, BD | 3 |
| Wang, R | 2 |
| Laukka, J | 1 |
| Zhuang, J | 2 |
| Soledad-Conrad, V | 1 |
| Filippatos, G | 1 |
| Marshall, RP | 1 |
| Gohlke, P | 1 |
| Chambers, RC | 1 |
| Howell, DC | 1 |
| Bottoms, SE | 1 |
| Unger, T | 1 |
| McAnulty, RJ | 1 |
| Laurent, GJ | 1 |
| Rayford, H | 1 |
| Keogh, KA | 1 |
| Standing, J | 1 |
| Kane, GC | 1 |
| Terzic, A | 1 |
| Limper, AH | 1 |
| Yao, HW | 1 |
| Zhu, JP | 1 |
| Zhao, MH | 1 |
| Lu, Y | 1 |
| Molina-Molina, M | 1 |
| Serrano-Mollar, A | 1 |
| Bulbena, O | 1 |
| Fernandez-Zabalegui, L | 1 |
| Closa, D | 1 |
| Marin-Arguedas, A | 1 |
| Torrego, A | 1 |
| Mullol, J | 1 |
| Picado, C | 1 |
| Xaubet, A | 1 |
| Long, X | 1 |
| Xiong, SD | 1 |
| Xiong, WN | 1 |
| Xu, YJ | 1 |
| Zhang, ZX | 1 |
| Cao, Y | 1 |
| Chen, J | 1 |
| Xu, XH | 1 |
| Chen, N | 1 |
| Li, JJ | 1 |
| Xue, XD | 1 |
| Papp, M | 1 |
16 other studies available for losartan and Pulmonary Fibrosis
| Article | Year |
|---|---|
Vitamin D suppresses bleomycin-induced pulmonary fibrosis by targeting the local renin-angiotensin system in the lung.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensinogen; Animals; Bleomycin; Diseas | 2021 |
Chronic vitamin D deficiency induces lung fibrosis through activation of the renin-angiotensin system.
Topics: Amides; Animals; Blood Pressure; Chronic Disease; Extracellular Matrix; Female; Fumarates; Losartan; | 2017 |
Angiotensin-(1-7) attenuates lung fibrosis by way of Mas receptor in acute lung injury.
Topics: Acute Lung Injury; Angiotensin I; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; | 2013 |
Losartan attenuates paraquat-induced pulmonary fibrosis in rats.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Blotting, Western; Collagen; Herbicides; Hydroxypr | 2015 |
[Perindopril and losartan attenuate bleomycin A5-induced pulmonary fibrosis in rats].
Topics: Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Animals; Bleomyci | 2008 |
Angiotensin II type 1 receptor antagonist attenuates lung fibrosis in hyperoxia-exposed newborn rats.
Topics: Actins; Angiotensin II Type 1 Receptor Blockers; Animals; Animals, Newborn; Blotting, Western; Body | 2012 |
[Losartan in the rat model of bleomycin-induced pulmonary fibrosis and its impact on the expression of monocyte chemoattractant protein-1 and basic fibroblast growth factor].
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents; Antihypertensive Agents; Bleomycin; Chemoki | 2002 |
Inhibition of amiodarone-induced lung fibrosis but not alveolitis by angiotensin system antagonists.
Topics: Amiodarone; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Ant | 2003 |
Angiotensin II and the fibroproliferative response to acute lung injury.
Topics: Acute Disease; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Antibiotics, Antineoplastic | 2004 |
Essential roles for angiotensin receptor AT1a in bleomycin-induced apoptosis and lung fibrosis in mice.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Apoptosis; Bleomycin; Collagen; Gene Deletion; Los | 2003 |
Angiotensin II antagonism fails to ameliorate bleomycin-induced pulmonary fibrosis in mice.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Bleomycin; Losartan; Mice; Mice, Inbred C57BL; Pul | 2005 |
Losartan attenuates bleomycin-induced pulmonary fibrosis in rats.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Antibiotics, Antineoplastic; Bleomycin; Body Weigh | 2006 |
Losartan attenuates bleomycin induced lung fibrosis by increasing prostaglandin E2 synthesis.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Antimetabolites, Antineoplastic; Bleomycin; Cycloo | 2006 |
[Losartan inhibited angiotensin induced human lung fibroblast transformation and collagen synthesis].
Topics: Angiotensin II; Cell Differentiation; Cells, Cultured; Collagen; Fibroblasts; Humans; Losartan; Pulm | 2007 |
[Effect of losartan on lung fibrosis in neonatal rats with hyperoxia-induced chronic lung disease].
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Animals, Newborn; Bronchopulmonary Dysplasia; Huma | 2007 |
Angiotensin receptor subtype AT(1) mediates alveolar epithelial cell apoptosis in response to ANG II.
Topics: Adenocarcinoma; Angiotensin II; Angiotensin Receptor Antagonists; Antihypertensive Agents; Apoptosis | 2002 |