losartan has been researched along with Pre-Eclampsia in 13 studies
Losartan: An antagonist of ANGIOTENSIN TYPE 1 RECEPTOR with antihypertensive activity due to the reduced pressor effect of ANGIOTENSIN II.
losartan : A biphenylyltetrazole where a 1,1'-biphenyl group is attached at the 5-position and has an additional trisubstituted imidazol-1-ylmethyl group at the 4'-position
Pre-Eclampsia: A complication of PREGNANCY, characterized by a complex of symptoms including maternal HYPERTENSION and PROTEINURIA with or without pathological EDEMA. Symptoms may range between mild and severe. Pre-eclampsia usually occurs after the 20th week of gestation, but may develop before this time in the presence of trophoblastic disease.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Considering the role of renin-angiotensin system (RAS) in maternal programming during PE, we investigated the hypothesis that gestational modulation of offensive (Angiotensin II, Ang II) and defensive (Ang 1-7) components of RAS alleviates cardiovascular hyperresponsiveness of weaning PE mothers to postpartum endotoxemia." | 4.12 | Dysregulated ACE/Ang II/Ang1-7 signaling provokes cardiovascular and inflammatory sequelae of endotoxemia in weaning preeclamptic rats. ( Abuiessa, SA; El-Gowelli, HM; El-Gowilly, SM; El-Mas, MM; Helmy, MM, 2022) |
| "In pregnancy there is an attenuated response to vasoconstrictors and pressor agents, including Angiotensin II (Ang II)." | 3.73 | Renal vascular responses in an experimental model of preeclampsia. ( Bobadilla Lugo, RA; López Sanchez, P; Pérez-Alvarez, VM; Robledo, LA, 2005) |
| "Optimal cardiovascular prevention after preeclampsia should be further explored." | 3.11 | Differential effects of renin-angiotensine-aldosteron system inhibition, sympathoinhibition and low sodium diet on blood pressure in women with a history of preeclampsia: A double-blind, placebo-controlled cross-over trial (the PALM study). ( Franx, A; Groenhof, TKJ; Paauw, ND; Spiering, W; Titia Lely, A; Veerbeek, JHW; Verhaar, MC; Zoet, GA, 2022) |
| "Co-treatment with losartan significantly attenuated the release of sEng and sEng mRNA expression in the trophoblast cells." | 1.42 | Autoantibodies isolated from patients with preeclampsia induce soluble endoglin production from trophoblast cells via interactions with angiotensin II type 1 receptor. ( Chishima, F; Kobayashi, Y; Suzuki, M; Takahashi, H; Yamamoto, T, 2015) |
| "Preeclampsia is a serious pathologic complication during pregnancy, and its pathogenesis remains poorly understood." | 1.35 | Autoantibody against AT1 receptor from preeclamptic patients induces vasoconstriction through angiotensin receptor activation. ( Chang, H; Cheng, X; Liu, H; Ma, XL; Wang, F; Wang, X; Yang, L; Yang, X; Zhang, M; Zhang, S, 2008) |
| "There is evidence that preeclampsia results from a breakdown in the balance between vasodilators such as prostacyclin and prostaglandin E2 and nitric oxide and the vasoconstrictors angiotensin II, thromboxane A2, serotonin, and endothelin." | 1.30 | The role of AT1 angiotensin receptor activation in the pathogenesis of preeclampsia. ( Doering, TP; Freeman, EJ; Haller, NA; Hopkins, MP; Montgomery, MA, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (7.69) | 18.2507 |
| 2000's | 5 (38.46) | 29.6817 |
| 2010's | 5 (38.46) | 24.3611 |
| 2020's | 2 (15.38) | 2.80 |
| Authors | Studies |
|---|---|
| Zoet, GA | 1 |
| Paauw, ND | 1 |
| Veerbeek, JHW | 1 |
| Groenhof, TKJ | 1 |
| Spiering, W | 1 |
| Verhaar, MC | 1 |
| Franx, A | 1 |
| Titia Lely, A | 1 |
| Abuiessa, SA | 1 |
| Helmy, MM | 1 |
| El-Gowelli, HM | 1 |
| El-Gowilly, SM | 1 |
| El-Mas, MM | 1 |
| Warrington, JP | 1 |
| Fan, F | 1 |
| Duncan, J | 1 |
| Cunningham, MW | 1 |
| LaMarca, BB | 1 |
| Dechend, R | 2 |
| Wallukat, G | 2 |
| Roman, RJ | 1 |
| Drummond, HA | 1 |
| Granger, JP | 1 |
| Ryan, MJ | 1 |
| Yang, X | 2 |
| Wang, F | 2 |
| Lau, WB | 1 |
| Zhang, S | 3 |
| Liu, H | 2 |
| Ma, XL | 2 |
| van der Graaf, AM | 1 |
| Wiegman, MJ | 1 |
| Plösch, T | 1 |
| Zeeman, GG | 1 |
| van Buiten, A | 1 |
| Henning, RH | 1 |
| Buikema, H | 1 |
| Faas, MM | 1 |
| Wang, HP | 1 |
| Zhang, WH | 1 |
| Wang, XF | 1 |
| Zhu, J | 1 |
| Zheng, YQ | 1 |
| Xia, Q | 1 |
| Zhi, JM | 1 |
| Kobayashi, Y | 1 |
| Yamamoto, T | 1 |
| Chishima, F | 1 |
| Takahashi, H | 1 |
| Suzuki, M | 1 |
| Chang, H | 1 |
| Yang, L | 1 |
| Wang, X | 1 |
| Cheng, X | 1 |
| Zhang, M | 1 |
| Anton, L | 1 |
| Merrill, DC | 1 |
| Neves, LA | 1 |
| Diz, DI | 1 |
| Corthorn, J | 1 |
| Valdes, G | 1 |
| Stovall, K | 1 |
| Gallagher, PE | 1 |
| Moorefield, C | 1 |
| Gruver, C | 1 |
| Brosnihan, KB | 1 |
| Irani, RA | 1 |
| Zhang, Y | 1 |
| Blackwell, SC | 1 |
| Zhou, CC | 1 |
| Ramin, SM | 1 |
| Kellems, RE | 1 |
| Xia, Y | 1 |
| Bobadilla Lugo, RA | 1 |
| Pérez-Alvarez, VM | 1 |
| Robledo, LA | 1 |
| López Sanchez, P | 1 |
| Doering, TP | 1 |
| Haller, NA | 1 |
| Montgomery, MA | 1 |
| Freeman, EJ | 1 |
| Hopkins, MP | 1 |
| Homuth, V | 1 |
| Kreuzer, J | 1 |
| Park, JK | 1 |
| Theuer, J | 1 |
| Juepner, A | 1 |
| Gulba, DC | 1 |
| Mackman, N | 1 |
| Haller, H | 1 |
| Luft, FC | 1 |
1 trial available for losartan and Pre-Eclampsia
| Article | Year |
|---|---|
Differential effects of renin-angiotensine-aldosteron system inhibition, sympathoinhibition and low sodium diet on blood pressure in women with a history of preeclampsia: A double-blind, placebo-controlled cross-over trial (the PALM study).
Topics: Adult; Angiotensin II Type 1 Receptor Blockers; Blood Pressure; Cardiovascular Diseases; Cross-Over | 2022 |
12 other studies available for losartan and Pre-Eclampsia
| Article | Year |
|---|---|
Dysregulated ACE/Ang II/Ang1-7 signaling provokes cardiovascular and inflammatory sequelae of endotoxemia in weaning preeclamptic rats.
Topics: Angiotensin II; Animals; Endotoxemia; Female; Humans; Losartan; Peptidyl-Dipeptidase A; Pioglitazone | 2022 |
The angiotensin II type I receptor contributes to impaired cerebral blood flow autoregulation caused by placental ischemia in pregnant rats.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Cerebrovascular Circulation; Female; Homeostasis; | 2019 |
Autoantibodies isolated from preeclamptic patients induce endothelial dysfunction via interaction with the angiotensin II AT1 receptor.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Autoantibodies; Caspases; Cells, Cultured; Dose-Re | 2014 |
Endothelium-dependent relaxation and angiotensin II sensitivity in experimental preeclampsia.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Aorta; Cyclooxygenase 1; Cyclooxyg | 2013 |
Exposure to AT1 receptor autoantibodies during pregnancy increases susceptibility of the maternal heart to postpartum ischemia-reperfusion injury in rats.
Topics: Animals; Autoantibodies; Collagen; Female; Heart Ventricles; Losartan; Mitochondria, Heart; Pre-Ecla | 2014 |
Autoantibodies isolated from patients with preeclampsia induce soluble endoglin production from trophoblast cells via interactions with angiotensin II type 1 receptor.
Topics: Adult; Angiotensin II Type 1 Receptor Blockers; Antigens, CD; Autoantibodies; Case-Control Studies; | 2015 |
Autoantibody against AT1 receptor from preeclamptic patients induces vasoconstriction through angiotensin receptor activation.
Topics: Adult; Angiotensin II Type 1 Receptor Blockers; Animals; Aorta, Thoracic; Autoantibodies; Dose-Respo | 2008 |
The uterine placental bed Renin-Angiotensin system in normal and preeclamptic pregnancy.
Topics: Alanine; Angiotensin I; Angiotensin II; Angiotensin-Converting Enzyme 2; Down-Regulation; Female; Ge | 2009 |
The detrimental role of angiotensin receptor agonistic autoantibodies in intrauterine growth restriction seen in preeclampsia.
Topics: Adult; Angiotensin II Type 1 Receptor Blockers; Animals; Apoptosis; Autoantibodies; CHO Cells; Crice | 2009 |
Renal vascular responses in an experimental model of preeclampsia.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Aortic Coarctation; Blood Pressure | 2005 |
The role of AT1 angiotensin receptor activation in the pathogenesis of preeclampsia.
Topics: Albuminuria; Angiotensin Receptor Antagonists; Animals; Blood Pressure; Endotoxins; Female; Fetus; L | 1998 |
AT(1) receptor agonistic antibodies from preeclamptic patients cause vascular cells to express tissue factor.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antibodies; Cells, Cultured; CHO Cells; C | 2000 |