losartan has been researched along with Nephrosclerosis in 5 studies
Losartan: An antagonist of ANGIOTENSIN TYPE 1 RECEPTOR with antihypertensive activity due to the reduced pressor effect of ANGIOTENSIN II.
losartan : A biphenylyltetrazole where a 1,1'-biphenyl group is attached at the 5-position and has an additional trisubstituted imidazol-1-ylmethyl group at the 4'-position
Nephrosclerosis: Hardening of the KIDNEY due to infiltration by fibrous connective tissue (FIBROSIS), usually caused by renovascular diseases or chronic HYPERTENSION. Nephrosclerosis leads to renal ISCHEMIA.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We investigated the effects of dual renin-angiotensin system (RAS) blockade on angiotensin-converting enzyme-2 (Ace2) expression, hypertension, and renal proximal tubular cell (RPTC) apoptosis in type 1 diabetic Akita angiotensinogen (Agt)-transgenic (Tg) mice that specifically overexpress Agt in their RPTCs." | 7.78 | Dual RAS blockade normalizes angiotensin-converting enzyme-2 expression and prevents hypertension and tubular apoptosis in Akita angiotensinogen-transgenic mice. ( Chan, JS; Chenier, I; Filep, JG; Godin, N; Ingelfinger, JR; Liu, F; Lo, CS; Maachi, H; Shi, Y; Zhang, SL, 2012) |
| "We investigated the effects of dual renin-angiotensin system (RAS) blockade on angiotensin-converting enzyme-2 (Ace2) expression, hypertension, and renal proximal tubular cell (RPTC) apoptosis in type 1 diabetic Akita angiotensinogen (Agt)-transgenic (Tg) mice that specifically overexpress Agt in their RPTCs." | 3.78 | Dual RAS blockade normalizes angiotensin-converting enzyme-2 expression and prevents hypertension and tubular apoptosis in Akita angiotensinogen-transgenic mice. ( Chan, JS; Chenier, I; Filep, JG; Godin, N; Ingelfinger, JR; Liu, F; Lo, CS; Maachi, H; Shi, Y; Zhang, SL, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (60.00) | 29.6817 |
| 2010's | 2 (40.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ávila, VF | 1 |
| Foresto-Neto, O | 1 |
| Arias, SCA | 1 |
| Faustino, VD | 1 |
| Malheiros, DMAC | 1 |
| Camara, NOS | 1 |
| Zatz, R | 1 |
| Fujihara, CK | 1 |
| Yu, M | 1 |
| Wang, X | 1 |
| Du, Y | 1 |
| Chen, H | 1 |
| Guo, X | 1 |
| Xia, L | 1 |
| Chen, J | 1 |
| Lo, CS | 1 |
| Liu, F | 1 |
| Shi, Y | 1 |
| Maachi, H | 1 |
| Chenier, I | 1 |
| Godin, N | 1 |
| Filep, JG | 1 |
| Ingelfinger, JR | 1 |
| Zhang, SL | 1 |
| Chan, JS | 1 |
| Suzuki, H | 1 |
| Kanno, Y | 1 |
| Westhoff, JH | 1 |
| Hilgers, KF | 1 |
| Steinbach, MP | 1 |
| Hartner, A | 1 |
| Klanke, B | 1 |
| Amann, K | 1 |
| Melk, A | 1 |
1 review available for losartan and Nephrosclerosis
| Article | Year |
|---|---|
[Diagnosis of and therapy for renal hypertension].
Topics: Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Calcium Channel B | 2004 |
4 other studies available for losartan and Nephrosclerosis
| Article | Year |
|---|---|
Pathogenic role of angiotensin II and the NF-κB system in a model of malignant hypertensive nephrosclerosis.
Topics: Albuminuria; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Arterioles; Female; G | 2019 |
Comparative analysis of renal protein expression in spontaneously hypertensive rat.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Arterioles; Blotting, Western; Disease Models, Ani | 2008 |
Dual RAS blockade normalizes angiotensin-converting enzyme-2 expression and prevents hypertension and tubular apoptosis in Akita angiotensinogen-transgenic mice.
Topics: Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme 2; Angiotensin-Converting Enz | 2012 |
Hypertension induces somatic cellular senescence in rats and humans by induction of cell cycle inhibitor p16INK4a.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Animals, Genetically Modified; Antihypertensive Ag | 2008 |