losartan has been researched along with Memory Disorders in 7 studies
Losartan: An antagonist of ANGIOTENSIN TYPE 1 RECEPTOR with antihypertensive activity due to the reduced pressor effect of ANGIOTENSIN II.
losartan : A biphenylyltetrazole where a 1,1'-biphenyl group is attached at the 5-position and has an additional trisubstituted imidazol-1-ylmethyl group at the 4'-position
Memory Disorders: Disturbances in registering an impression, in the retention of an acquired impression, or in the recall of an impression. Memory impairments are associated with DEMENTIA; CRANIOCEREBRAL TRAUMA; ENCEPHALITIS; ALCOHOLISM (see also ALCOHOL AMNESTIC DISORDER); SCHIZOPHRENIA; and other conditions.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Losartan was unable to improve hippocampal BDNF and IL-10 levels as well as the retention trial in the MWM task and depressive-like behaviors." | 5.56 | Losartan modulates brain inflammation and improves mood disorders and memory impairment induced by innate immune activation: The role of PPAR-γ activation. ( Baghcheghi, Y; Hosseini, M; Mokhtari-Zaer, A; Moradi-Marjaneh, R; Salmani, H, 2020) |
| "Losartan treatment effectively prevented increase of the hypothalamic Ang II concentration and the development of depression-like behavior, and also reduced the impairment of learning and memory in the stressed animals." | 5.56 | Tactile stimulation of adult rats modulates hormonal responses, depression-like behaviors, and memory impairment induced by chronic mild stress: Role of angiotensin II. ( Casarini, DE; Costa, R; Cunha, TS; Marcondes, FK; Moreira, RP; Nogueira, MD; Sanches, A; Tamascia, ML, 2020) |
| " We tested the curative potential of the non brain-penetrant ACEi enalapril (3 mg/kg/day) administered for 3 months either alone or in combination with the brain penetrant ARB losartan (10 mg/kg/day) in aged (∼15 months) transgenic mice overexpressing a mutated form of the human amyloid-β protein precursor (AβPP, thereafter APP mice)." | 5.43 | Enalapril Alone or Co-Administered with Losartan Rescues Cerebrovascular Dysfunction, but not Mnemonic Deficits or Amyloidosis in a Mouse Model of Alzheimer's Disease. ( Aboulkassim, T; Hamel, E; Imboden, H; Nicolakakis, N; Ongali, B; Tong, XK, 2016) |
| "Losartan was unable to improve hippocampal BDNF and IL-10 levels as well as the retention trial in the MWM task and depressive-like behaviors." | 1.56 | Losartan modulates brain inflammation and improves mood disorders and memory impairment induced by innate immune activation: The role of PPAR-γ activation. ( Baghcheghi, Y; Hosseini, M; Mokhtari-Zaer, A; Moradi-Marjaneh, R; Salmani, H, 2020) |
| "Losartan treatment effectively prevented increase of the hypothalamic Ang II concentration and the development of depression-like behavior, and also reduced the impairment of learning and memory in the stressed animals." | 1.56 | Tactile stimulation of adult rats modulates hormonal responses, depression-like behaviors, and memory impairment induced by chronic mild stress: Role of angiotensin II. ( Casarini, DE; Costa, R; Cunha, TS; Marcondes, FK; Moreira, RP; Nogueira, MD; Sanches, A; Tamascia, ML, 2020) |
| " We tested the curative potential of the non brain-penetrant ACEi enalapril (3 mg/kg/day) administered for 3 months either alone or in combination with the brain penetrant ARB losartan (10 mg/kg/day) in aged (∼15 months) transgenic mice overexpressing a mutated form of the human amyloid-β protein precursor (AβPP, thereafter APP mice)." | 1.43 | Enalapril Alone or Co-Administered with Losartan Rescues Cerebrovascular Dysfunction, but not Mnemonic Deficits or Amyloidosis in a Mouse Model of Alzheimer's Disease. ( Aboulkassim, T; Hamel, E; Imboden, H; Nicolakakis, N; Ongali, B; Tong, XK, 2016) |
| "Rats treated with losartan present memory deficits and decreases in spine-density." | 1.40 | Losartan-induced hypotension leads to tau hyperphosphorylation and memory deficit. ( Gong, CX; Hu, J; Liu, X; Luo, H; Wang, JZ; Wang, XC; Wang, Z; Xia, Y; Yu, G; Zeng, K; Zhou, XW, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (42.86) | 24.3611 |
| 2020's | 4 (57.14) | 2.80 |
| Authors | Studies |
|---|---|
| Nguyen, BT | 1 |
| Shin, EJ | 1 |
| Jeong, JH | 1 |
| Sharma, N | 1 |
| Nah, SY | 1 |
| Ko, SK | 1 |
| Byun, JK | 1 |
| Lee, Y | 1 |
| Lei, XG | 1 |
| Kim, DJ | 1 |
| Nabeshima, T | 1 |
| Kim, HC | 1 |
| Salmani, H | 1 |
| Hosseini, M | 1 |
| Baghcheghi, Y | 1 |
| Moradi-Marjaneh, R | 1 |
| Mokhtari-Zaer, A | 1 |
| Costa, R | 1 |
| Tamascia, ML | 1 |
| Sanches, A | 1 |
| Moreira, RP | 1 |
| Cunha, TS | 1 |
| Nogueira, MD | 1 |
| Casarini, DE | 1 |
| Marcondes, FK | 1 |
| Marshall, M | 1 |
| Ababei, DC | 1 |
| Bild, V | 1 |
| Ciobică, A | 1 |
| Lefter, RM | 1 |
| Rusu, RN | 1 |
| Bild, W | 1 |
| Liu, X | 1 |
| Wang, Z | 1 |
| Xia, Y | 1 |
| Yu, G | 1 |
| Zeng, K | 1 |
| Luo, H | 1 |
| Hu, J | 1 |
| Gong, CX | 1 |
| Wang, JZ | 1 |
| Zhou, XW | 1 |
| Wang, XC | 1 |
| Ongali, B | 1 |
| Nicolakakis, N | 1 |
| Tong, XK | 1 |
| Aboulkassim, T | 1 |
| Imboden, H | 1 |
| Hamel, E | 1 |
7 other studies available for losartan and Memory Disorders
| Article | Year |
|---|---|
Ginsenoside Re attenuates memory impairments in aged Klotho deficient mice via interactive modulations of angiotensin II AT1 receptor, Nrf2 and GPx-1 gene.
Topics: Angiotensin II; Animals; Antioxidants; Ginsenosides; Glutathione Peroxidase; Glutathione Peroxidase | 2022 |
Losartan modulates brain inflammation and improves mood disorders and memory impairment induced by innate immune activation: The role of PPAR-γ activation.
Topics: Amyloid beta-Peptides; Angiotensin Receptor Antagonists; Anilides; Animals; Anxiety; Behavior Rating | 2020 |
Tactile stimulation of adult rats modulates hormonal responses, depression-like behaviors, and memory impairment induced by chronic mild stress: Role of angiotensin II.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Behavior, Animal; Cognitive Dysfun | 2020 |
COVID and the brain: researchers zero in on how damage occurs.
Topics: Animals; Antibodies, Viral; Astrocytes; Autoantibodies; Autopsy; Brain; Capillaries; COVID-19; Crice | 2021 |
A Comparative Study on the Memory-Enhancing Actions of Oral Renin-Angiotensin System Altering Drugs in Scopolamine-Treated Mice.
Topics: Administration, Oral; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibit | 2019 |
Losartan-induced hypotension leads to tau hyperphosphorylation and memory deficit.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Avoidance Learning; Blood Pressure; Dendritic Spin | 2014 |
Enalapril Alone or Co-Administered with Losartan Rescues Cerebrovascular Dysfunction, but not Mnemonic Deficits or Amyloidosis in a Mouse Model of Alzheimer's Disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloidosis; Analysis of V | 2016 |