losartan has been researched along with Melanoma in 5 studies
Losartan: An antagonist of ANGIOTENSIN TYPE 1 RECEPTOR with antihypertensive activity due to the reduced pressor effect of ANGIOTENSIN II.
losartan : A biphenylyltetrazole where a 1,1'-biphenyl group is attached at the 5-position and has an additional trisubstituted imidazol-1-ylmethyl group at the 4'-position
Melanoma: A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Losartan, EMA401 and lisinopril stimulated MV3 melanoma cell migration and invasion in a coculture model with Huh7 cells while leaving proliferation and adhesion largely unaffected." | 8.12 | The ACE Inhibitor Lisinopril Stimulates Melanoma Cell Invasiveness by Inducing MMP2 Secretion. ( Becker, Y; Stock, C, 2022) |
| "Losartan inhibits NHE1 activity and the migration of human melanoma cells." | 7.88 | The Angiotensin II Type 1 Receptor Antagonist Losartan Affects NHE1-Dependent Melanoma Cell Behavior. ( Hofschröer, V; Nielsen, N; Olschewski, DN; Schwab, A; Seidler, DG; Stock, C, 2018) |
| "Losartan, EMA401 and lisinopril stimulated MV3 melanoma cell migration and invasion in a coculture model with Huh7 cells while leaving proliferation and adhesion largely unaffected." | 4.12 | The ACE Inhibitor Lisinopril Stimulates Melanoma Cell Invasiveness by Inducing MMP2 Secretion. ( Becker, Y; Stock, C, 2022) |
| "Losartan inhibits NHE1 activity and the migration of human melanoma cells." | 3.88 | The Angiotensin II Type 1 Receptor Antagonist Losartan Affects NHE1-Dependent Melanoma Cell Behavior. ( Hofschröer, V; Nielsen, N; Olschewski, DN; Schwab, A; Seidler, DG; Stock, C, 2018) |
| "We evaluated the involvement of angiotensin II (AngII)-dependent pathways in melanoma growth, through the pharmacological blockage of AT1 receptor by the anti-hypertensive drug losartan (LOS)." | 3.76 | Inhibition of angiotensin II receptor 1 limits tumor-associated angiogenesis and attenuates growth of murine melanoma. ( Chammas, R; Freitas, HC; Fujihara, CK; Machado, CM; Mattar, AL; Nonogaki, S; Otake, AH; Zatz, R, 2010) |
| "Melanoma is one of the most aggressive cancers of all solid tumors." | 1.37 | AT1 receptors activation enhances the expression of MMP-2, MMP-13 and VEGF but not MMP-9 in B16F10 melanoma cells. ( Akhavan, MM; Falahtpishe, H; Ghodrati, M; Karimi, M, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 4 (80.00) | 24.3611 |
| 2020's | 1 (20.00) | 2.80 |
| Authors | Studies |
|---|---|
| Becker, Y | 1 |
| Stock, C | 2 |
| Olschewski, DN | 1 |
| Hofschröer, V | 1 |
| Nielsen, N | 1 |
| Seidler, DG | 1 |
| Schwab, A | 1 |
| Liu, LH | 1 |
| Fan, X | 1 |
| Li, HT | 1 |
| An, XX | 1 |
| Yang, RY | 1 |
| Otake, AH | 1 |
| Mattar, AL | 1 |
| Freitas, HC | 1 |
| Machado, CM | 1 |
| Nonogaki, S | 1 |
| Fujihara, CK | 1 |
| Zatz, R | 1 |
| Chammas, R | 1 |
| Akhavan, MM | 1 |
| Karimi, M | 1 |
| Ghodrati, M | 1 |
| Falahtpishe, H | 1 |
5 other studies available for losartan and Melanoma
| Article | Year |
|---|---|
The ACE Inhibitor Lisinopril Stimulates Melanoma Cell Invasiveness by Inducing MMP2 Secretion.
Topics: Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Cyclooxygenase 2; Humans | 2022 |
The Angiotensin II Type 1 Receptor Antagonist Losartan Affects NHE1-Dependent Melanoma Cell Behavior.
Topics: Angiotensin II Type 1 Receptor Blockers; Cell Line, Tumor; Cell Movement; Humans; Losartan; Melanoma | 2018 |
Angiotensin II promotes melanogenesis via angiotensin II type 1 receptors in human melanocytes.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Carcinogenesis; Humans; Losartan; Melanins; | 2015 |
Inhibition of angiotensin II receptor 1 limits tumor-associated angiogenesis and attenuates growth of murine melanoma.
Topics: Angiogenic Proteins; Angiotensin II Type 1 Receptor Blockers; Animals; Cell Line, Tumor; Female; Hum | 2010 |
AT1 receptors activation enhances the expression of MMP-2, MMP-13 and VEGF but not MMP-9 in B16F10 melanoma cells.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Cell Line, Tumor; Humans; Losartan; Matrix Metallo | 2011 |