losartan has been researched along with Malignant Melanoma in 5 studies
Losartan: An antagonist of ANGIOTENSIN TYPE 1 RECEPTOR with antihypertensive activity due to the reduced pressor effect of ANGIOTENSIN II.
losartan : A biphenylyltetrazole where a 1,1'-biphenyl group is attached at the 5-position and has an additional trisubstituted imidazol-1-ylmethyl group at the 4'-position
| Excerpt | Relevance | Reference |
|---|---|---|
| "Losartan, EMA401 and lisinopril stimulated MV3 melanoma cell migration and invasion in a coculture model with Huh7 cells while leaving proliferation and adhesion largely unaffected." | 8.12 | The ACE Inhibitor Lisinopril Stimulates Melanoma Cell Invasiveness by Inducing MMP2 Secretion. ( Becker, Y; Stock, C, 2022) |
| "Losartan inhibits NHE1 activity and the migration of human melanoma cells." | 7.88 | The Angiotensin II Type 1 Receptor Antagonist Losartan Affects NHE1-Dependent Melanoma Cell Behavior. ( Hofschröer, V; Nielsen, N; Olschewski, DN; Schwab, A; Seidler, DG; Stock, C, 2018) |
| "Losartan, EMA401 and lisinopril stimulated MV3 melanoma cell migration and invasion in a coculture model with Huh7 cells while leaving proliferation and adhesion largely unaffected." | 4.12 | The ACE Inhibitor Lisinopril Stimulates Melanoma Cell Invasiveness by Inducing MMP2 Secretion. ( Becker, Y; Stock, C, 2022) |
| "Losartan inhibits NHE1 activity and the migration of human melanoma cells." | 3.88 | The Angiotensin II Type 1 Receptor Antagonist Losartan Affects NHE1-Dependent Melanoma Cell Behavior. ( Hofschröer, V; Nielsen, N; Olschewski, DN; Schwab, A; Seidler, DG; Stock, C, 2018) |
| "We evaluated the involvement of angiotensin II (AngII)-dependent pathways in melanoma growth, through the pharmacological blockage of AT1 receptor by the anti-hypertensive drug losartan (LOS)." | 3.76 | Inhibition of angiotensin II receptor 1 limits tumor-associated angiogenesis and attenuates growth of murine melanoma. ( Chammas, R; Freitas, HC; Fujihara, CK; Machado, CM; Mattar, AL; Nonogaki, S; Otake, AH; Zatz, R, 2010) |
| "Melanoma is one of the most aggressive cancers of all solid tumors." | 1.37 | AT1 receptors activation enhances the expression of MMP-2, MMP-13 and VEGF but not MMP-9 in B16F10 melanoma cells. ( Akhavan, MM; Falahtpishe, H; Ghodrati, M; Karimi, M, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 4 (80.00) | 24.3611 |
| 2020's | 1 (20.00) | 2.80 |
| Authors | Studies |
|---|---|
| Becker, Y | 1 |
| Stock, C | 2 |
| Olschewski, DN | 1 |
| Hofschröer, V | 1 |
| Nielsen, N | 1 |
| Seidler, DG | 1 |
| Schwab, A | 1 |
| Liu, LH | 1 |
| Fan, X | 1 |
| Li, HT | 1 |
| An, XX | 1 |
| Yang, RY | 1 |
| Otake, AH | 1 |
| Mattar, AL | 1 |
| Freitas, HC | 1 |
| Machado, CM | 1 |
| Nonogaki, S | 1 |
| Fujihara, CK | 1 |
| Zatz, R | 1 |
| Chammas, R | 1 |
| Akhavan, MM | 1 |
| Karimi, M | 1 |
| Ghodrati, M | 1 |
| Falahtpishe, H | 1 |
5 other studies available for losartan and Malignant Melanoma
| Article | Year |
|---|---|
The ACE Inhibitor Lisinopril Stimulates Melanoma Cell Invasiveness by Inducing MMP2 Secretion.
Topics: Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Cyclooxygenase 2; Humans | 2022 |
The Angiotensin II Type 1 Receptor Antagonist Losartan Affects NHE1-Dependent Melanoma Cell Behavior.
Topics: Angiotensin II Type 1 Receptor Blockers; Cell Line, Tumor; Cell Movement; Humans; Losartan; Melanoma | 2018 |
Angiotensin II promotes melanogenesis via angiotensin II type 1 receptors in human melanocytes.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Carcinogenesis; Humans; Losartan; Melanins; | 2015 |
Inhibition of angiotensin II receptor 1 limits tumor-associated angiogenesis and attenuates growth of murine melanoma.
Topics: Angiogenic Proteins; Angiotensin II Type 1 Receptor Blockers; Animals; Cell Line, Tumor; Female; Hum | 2010 |
AT1 receptors activation enhances the expression of MMP-2, MMP-13 and VEGF but not MMP-9 in B16F10 melanoma cells.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Cell Line, Tumor; Humans; Losartan; Matrix Metallo | 2011 |