losartan has been researched along with Loeys-Dietz Aortic Aneurysm Syndrome in 6 studies
Losartan: An antagonist of ANGIOTENSIN TYPE 1 RECEPTOR with antihypertensive activity due to the reduced pressor effect of ANGIOTENSIN II.
losartan : A biphenylyltetrazole where a 1,1'-biphenyl group is attached at the 5-position and has an additional trisubstituted imidazol-1-ylmethyl group at the 4'-position
Loeys-Dietz Aortic Aneurysm Syndrome: Loeys-Dietz Syndrome with aortic aneurysm or dissection.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In addition, recent studies show that angiotensin II type 1 receptor (AT1R) signaling enhances cardiovascular pathologies in MFS, and the angiotensin II receptor blocker losartan has the potential to inhibit aortic aneurysm formation." | 4.93 | Pathophysiology and Management of Cardiovascular Manifestations in Marfan and Loeys-Dietz Syndromes. ( Akazawa, H; Fujita, D; Fujiwara, T; Hara, H; Harada, M; Inuzuka, R; Komuro, I; Nawata, K; Takeda, N; Taniguchi, Y; Toko, H; Yagi, H, 2016) |
| "Losartan is an emerging therapy that may help slow down the rate of arterial dilatation." | 1.35 | Loeys-Dietz syndrome: a Marfan-like syndrome associated with aggressive vasculopathy. ( Choo, JT; Lai, AH; Tan, TH; Wong, KY, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (16.67) | 29.6817 |
| 2010's | 4 (66.67) | 24.3611 |
| 2020's | 1 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| Yokota, T | 1 |
| Koiwa, H | 1 |
| Matsushima, S | 1 |
| Tsujinaga, S | 1 |
| Naya, M | 1 |
| Morisaki, H | 1 |
| Morisaki, T | 1 |
| Mehta, P | 1 |
| Holder, SE | 1 |
| Fisher, B | 1 |
| Vincent, TL | 1 |
| Gallo, EM | 1 |
| Loch, DC | 1 |
| Habashi, JP | 1 |
| Calderon, JF | 1 |
| Chen, Y | 1 |
| Bedja, D | 1 |
| van Erp, C | 1 |
| Gerber, EE | 1 |
| Parker, SJ | 1 |
| Sauls, K | 1 |
| Judge, DP | 1 |
| Cooke, SK | 1 |
| Lindsay, ME | 1 |
| Rouf, R | 1 |
| Myers, L | 1 |
| ap Rhys, CM | 1 |
| Kent, KC | 1 |
| Norris, RA | 1 |
| Huso, DL | 1 |
| Dietz, HC | 1 |
| Sandor, GG | 1 |
| Alghamdi, MH | 1 |
| Raffin, LA | 1 |
| Potts, MT | 1 |
| Williams, LD | 1 |
| Potts, JE | 1 |
| Kiess, M | 1 |
| van Breemen, C | 1 |
| Takeda, N | 1 |
| Yagi, H | 1 |
| Hara, H | 1 |
| Fujiwara, T | 1 |
| Fujita, D | 1 |
| Nawata, K | 1 |
| Inuzuka, R | 1 |
| Taniguchi, Y | 1 |
| Harada, M | 1 |
| Toko, H | 1 |
| Akazawa, H | 1 |
| Komuro, I | 1 |
| Choo, JT | 1 |
| Tan, TH | 1 |
| Lai, AH | 1 |
| Wong, KY | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Randomized Double-blind Study Assessing the Effects of Losartan Versus Atenolol on Pulse Wave Velocity and the Biophysical Properties of the Aorta in Patients With Marfan Syndrome[NCT00593710] | Phase 2 | 17 participants (Actual) | Interventional | 2008-01-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for losartan and Loeys-Dietz Aortic Aneurysm Syndrome
| Article | Year |
|---|---|
Pathophysiology and Management of Cardiovascular Manifestations in Marfan and Loeys-Dietz Syndromes.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Aortic Aneurysm; Disease Management; Fibrillin-1; | 2016 |
1 trial available for losartan and Loeys-Dietz Aortic Aneurysm Syndrome
| Article | Year |
|---|---|
A randomized, double blind pilot study to assess the effects of losartan vs. atenolol on the biophysical properties of the aorta in patients with Marfan and Loeys-Dietz syndromes.
Topics: Adolescent; Adrenergic beta-1 Receptor Antagonists; Angiotensin II Type 1 Receptor Blockers; Aorta; | 2015 |
4 other studies available for losartan and Loeys-Dietz Aortic Aneurysm Syndrome
| Article | Year |
|---|---|
Loeys-Dietz Cardiomyopathy? Long-term Follow-up After Onset of Acute Decompensated Heart Failure.
Topics: Acute Disease; Bisoprolol; Cardiomegaly; Cardiomyopathies; Cardiovascular Agents; Echocardiography; | 2022 |
A late presentation of Loeys-Dietz syndrome: joint hypermobility is not always benign.
Topics: Angiotensin II Type 1 Receptor Blockers; Aortic Aneurysm, Abdominal; Comorbidity; Female; Humans; Jo | 2014 |
Angiotensin II-dependent TGF-β signaling contributes to Loeys-Dietz syndrome vascular pathogenesis.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Aorta; Aortic Aneurysm; Cells, Cul | 2014 |
Loeys-Dietz syndrome: a Marfan-like syndrome associated with aggressive vasculopathy.
Topics: Anti-Arrhythmia Agents; Aortic Aneurysm; Echocardiography; Female; Humans; Infant, Newborn; Loeys-Di | 2009 |