Page last updated: 2024-10-30

losartan and Hypoxia

losartan has been researched along with Hypoxia in 33 studies

Losartan: An antagonist of ANGIOTENSIN TYPE 1 RECEPTOR with antihypertensive activity due to the reduced pressor effect of ANGIOTENSIN II.
losartan : A biphenylyltetrazole where a 1,1'-biphenyl group is attached at the 5-position and has an additional trisubstituted imidazol-1-ylmethyl group at the 4'-position

Hypoxia: Sub-optimal OXYGEN levels in the ambient air of living organisms.

Research Excerpts

ExcerptRelevanceReference
"Obstructive sleep apnea is characterized by chronic intermittent hypoxia (CIH), which is a risk factor for renal peritubular capillary (PTC) loss, and angiotensin II receptor blockers can alleviate PTC loss."7.96Losartan protects against intermittent hypoxia-induced peritubular capillary loss by modulating the renal renin-angiotensin system and angiogenesis factors. ( Chu, Y; Jiang, Z; Wu, J; Yu, Q, 2020)
"Adult male Sprague Dawley rats were subjected to 8 h/day of intermittent hypoxia/normoxia, with or without losartan, a selective AT1R blocker, and/or U73122, a selective PLC inhibitor, for 8 weeks."7.85Losartan attenuates aortic endothelial apoptosis induced by chronic intermittent hypoxia partly via the phospholipase C pathway. ( Deng, Y; Jin, M; Li, GC; Liu, HG; Liu, W; Pan, YY; Ren, J; Xie, S, 2017)
" To test the role of the brain renin-angiotensin system (RAS) in CIH hypertension, rats were implanted with intracerebroventricular (icv) cannulae delivering losartan (1 μg/h) or vehicle (VEH) via miniosmotic pumps and telemetry devices for arterial pressure recording."7.79Central losartan attenuates increases in arterial pressure and expression of FosB/ΔFosB along the autonomic axis associated with chronic intermittent hypoxia. ( Cunningham, JT; Knight, WD; Mifflin, SW; Nedungadi, TP; Saxena, A; Shell, B, 2013)
" Then, lumbar sympathetic activity was recorded under anesthesia during 20-s apneas, isocapnic hypoxia, and potassium cyanide."7.76Chronic intermittent hypoxia augments chemoreflex control of sympathetic activity: role of the angiotensin II type 1 receptor. ( Bird, CE; Li, YL; Marcus, NJ; Morgan, BJ; Schultz, HD, 2010)
"Obstructive sleep apnea is characterized by chronic intermittent hypoxia (CIH), which is a risk factor for renal peritubular capillary (PTC) loss, and angiotensin II receptor blockers can alleviate PTC loss."3.96Losartan protects against intermittent hypoxia-induced peritubular capillary loss by modulating the renal renin-angiotensin system and angiogenesis factors. ( Chu, Y; Jiang, Z; Wu, J; Yu, Q, 2020)
"Adult male Sprague Dawley rats were subjected to 8 h/day of intermittent hypoxia/normoxia, with or without losartan, a selective AT1R blocker, and/or U73122, a selective PLC inhibitor, for 8 weeks."3.85Losartan attenuates aortic endothelial apoptosis induced by chronic intermittent hypoxia partly via the phospholipase C pathway. ( Deng, Y; Jin, M; Li, GC; Liu, HG; Liu, W; Pan, YY; Ren, J; Xie, S, 2017)
" To test the role of the brain renin-angiotensin system (RAS) in CIH hypertension, rats were implanted with intracerebroventricular (icv) cannulae delivering losartan (1 μg/h) or vehicle (VEH) via miniosmotic pumps and telemetry devices for arterial pressure recording."3.79Central losartan attenuates increases in arterial pressure and expression of FosB/ΔFosB along the autonomic axis associated with chronic intermittent hypoxia. ( Cunningham, JT; Knight, WD; Mifflin, SW; Nedungadi, TP; Saxena, A; Shell, B, 2013)
" Then, lumbar sympathetic activity was recorded under anesthesia during 20-s apneas, isocapnic hypoxia, and potassium cyanide."3.76Chronic intermittent hypoxia augments chemoreflex control of sympathetic activity: role of the angiotensin II type 1 receptor. ( Bird, CE; Li, YL; Marcus, NJ; Morgan, BJ; Schultz, HD, 2010)
"6 hamsters (DL) with losartan, an AT1 receptor blocker, affects D1 receptor density in the striatum and nucleus tractus solitarius (NTS) and normalizes ventilation during exposure to air, hypoxia, following hypoxia, and hypercapnia, Ventilation was evaluated using plethysmography."3.76In dystrophic hamsters losartan affects control of ventilation and dopamine D1 receptor density. ( Schlenker, EH, 2010)
"The pulmonary vasoconstriction induced by acute hypoxia was significantly attenuated during losartan infusion, while Psa, SVR, CO, pH, PaCO(2), PaO(2) and base excess did not differ between groups."3.74The role of angiotensin II receptor-1 blockade in the hypoxic pulmonary vasoconstriction response in newborn piglets. ( Bancalari, E; Camelo, JS; Camelo, SH; Devia, C; Hehre, D; Suguihara, C, 2008)
" Hypoxia-induced constriction of vessels from losartan-treated rats was inhibited by endothelium removal or indomethacin (1 microM)."3.72Chronic AT(1) receptor blockade alters mechanisms mediating responses to hypoxia in rat skeletal muscle resistance arteries. ( Drenjancevic-Peric, I; Frisbee, JC; Lombard, JH; Phillips, SA, 2004)
"Losartan could reduce pulmonary arterial collagen I expression, it may be one of the therapeutic mechanisms on hypoxic pulmonary hypertension of losartan."3.72[The effects of losartan on pulmonary arterial collagen and AT1 in chronic hypoxic rats]. ( Chen, XJ; Cheng, DY; Guan, J; Su, QL; Wang, H; Zhang, Y, 2004)
" Baroreflex curves were determined under conditions of normoxia and hypoxia (10% O2 + 3% CO2) before and after central administration of either Ringer solution, the ANG II receptor antagonist losartan (10 micrograms), or the angiotensin-converting enzyme inhibitor enalaprilat (500 ng) on separate days."3.70Role of central catecholaminergic pathways in the actions of endogenous ANG II on sympathetic reflexes. ( Gaudet, EA; Godwin, SJ; Head, GA, 1998)
" Normoxia (40 min) was followed by hypoxia (40 min, breathing 10% oxygen, arterial oxygen pressures 36 +/- 1 Torr) during both control (Con) and losartan experiments (Los; iv infusion of 100 microg."3.70Acute hypoxic pulmonary vasoconstriction in conscious dogs decreases renin and is unaffected by losartan. ( Boemke, W; Kaczmarczyk, G; Krebs, MO; Simon, S; Wenz, M, 1999)
"In the present study, the effects of chronic hypoxia on the expression and localization of angiotensin II (Ang II) receptors are investigated by semi-quantitative reverse transcription-polymerase chain reaction (RT-PCR) and by immunohistochemistry."3.70Chronic hypoxia upregulates the expression and function of AT(1) receptor in rat carotid body. ( Fung, ML; Lam, SY; Leung, PS, 2000)
"Pre-treatment with losartan, however, had no significant effect on systemic vascular resistance although losartan compared to placebo resulted in a significant (P < 0."2.68Acute hypoxic pulmonary vasoconstriction in man is attenuated by type I angiotensin II receptor blockade. ( Cargill, RI; Kiely, DG; Lipworth, BJ, 1995)
"Although some tumors had vessels with greater oxygen-carrying ability than those of normal skin, most tumors had inefficient vessels."1.72Multiphoton Phosphorescence Quenching Microscopy Reveals Kinetics of Tumor Oxygenation during Antiangiogenesis and Angiotensin Signaling Inhibition. ( Bawendi, MG; Brown, EB; Chauhan, VP; Duda, DG; Fukumura, D; Han, HS; Jain, RK; Kamoun, WS; Lanning, RM; Lee, H; Martin, JD; Martin, MR; Mousa, AS; Padera, TP; Stylianopoulos, T, 2022)
"Hypoxia produced right ventricular hypertrophy of about 100% after 3 wk, which reversed with normoxia recovery."1.31Modulation of angiotensin II receptor expression during development and regression of hypoxic pulmonary hypertension. ( Adamy, C; Adnot, S; Chassagne, C; Dubois-Randé, JL; Eddahibi, S; Marotte, F; Rideau, D; Samuel, JL; Teiger, E, 2000)
"These data suggest that postnatal hypoxemia is associated with an increased sensitivity of peripheral chemoreceptors in response to Ang II and an up-regulation of AT1a receptor-mediated [Ca2+]i activity of the chemoreceptors."1.31Postnatal hypoxemia increases angiotensin II sensitivity and up-regulates AT1a angiotensin receptors in rat carotid body chemoreceptors. ( Chen, Y; Dong, X; Lam, SY; Leung, PS, 2002)
" Meclofenamate and N omega-nitro-L-arginine methyl ester shifted the dose-response curve for ANG IV to the left in a manner similar to that observed with ANG II and ANG III."1.29Analysis of responses to ANG IV: effects of PD-123319 and DuP-753 in the pulmonary circulation of the rat. ( Feng, CJ; Kadowitz, PJ; Kaye, AD; Nossaman, BD, 1995)

Research

Studies (33)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's9 (27.27)18.2507
2000's10 (30.30)29.6817
2010's9 (27.27)24.3611
2020's5 (15.15)2.80

Authors

AuthorsStudies
Martin, JD1
Lanning, RM1
Chauhan, VP1
Martin, MR1
Mousa, AS1
Kamoun, WS1
Han, HS1
Lee, H1
Stylianopoulos, T2
Bawendi, MG1
Duda, DG1
Brown, EB1
Padera, TP1
Fukumura, D1
Jain, RK2
Shelke, V1
Dagar, N1
Gaikwad, AB1
Wu, J1
Chu, Y1
Jiang, Z1
Yu, Q1
Chiu, CZ1
Wang, BW1
Yu, YJ1
Shyu, KG1
Franzén, S1
Näslund, E1
Wang, H2
Frithiof, R1
Zhao, Y1
Cao, J1
Melamed, A1
Worley, M1
Gockley, A1
Jones, D1
Nia, HT1
Zhang, Y2
Kumar, AS1
Mpekris, F1
Datta, M1
Sun, Y1
Wu, L1
Gao, X1
Yeku, O1
Del Carmen, MG1
Spriggs, DR1
Xu, L1
Knight, WD1
Saxena, A1
Shell, B1
Nedungadi, TP1
Mifflin, SW1
Cunningham, JT1
Morgan, BJ3
Bates, ML1
Rio, RD1
Wang, Z1
Dopp, JM1
Ren, J1
Liu, W1
Deng, Y1
Li, GC1
Pan, YY1
Xie, S1
Jin, M1
Liu, HG1
Marcus, NJ2
Li, YL2
Bird, CE2
Schultz, HD2
Schlenker, EH1
Foster, GE2
Hanly, PJ2
Ahmed, SB2
Beaudin, AE2
Pialoux, V2
Poulin, MJ2
Philippi, NR1
Drenjancevic-Peric, I2
Lombard, JH2
Phillips, SA1
Frisbee, JC1
Guan, J1
Cheng, DY1
Chen, XJ1
Su, QL1
Zoccal, DB1
Bonagamba, LG1
Oliveira, FR1
Antunes-Rodrigues, J1
Machado, BH1
Wang, B1
Scott, RC1
Pattillo, CB1
Prabhakarpandian, B1
Sundaram, S1
Kiani, MF1
Camelo, JS1
Hehre, D1
Devia, C1
Camelo, SH1
Bancalari, E1
Suguihara, C1
Nossaman, BD1
Feng, CJ1
Kaye, AD1
Kadowitz, PJ1
Kiely, DG1
Cargill, RI1
Lipworth, BJ1
Neylon, M1
Marshall, J1
Johns, EJ1
Morrell, NW1
Bendle, RD1
Malpas, SC1
Head, GA2
Gaudet, EA1
Godwin, SJ1
Krebs, MO1
Boemke, W1
Simon, S1
Wenz, M1
Kaczmarczyk, G1
Fletcher, EC1
Bao, G1
Li, R1
Pape, D1
Goineau, S1
Guillo, P1
Durand-Castel, X1
Bellissant, E1
Chassagne, C1
Eddahibi, S1
Adamy, C1
Rideau, D1
Marotte, F1
Dubois-Randé, JL1
Adnot, S1
Samuel, JL1
Teiger, E1
Leung, PS2
Lam, SY2
Fung, ML1
Lonchampt, M1
Pennel, L1
Duhault, J1
Dong, X1
Chen, Y1

Trials

3 trials available for losartan and Hypoxia

ArticleYear
Intermittent hypoxia increases arterial blood pressure in humans through a Renin-Angiotensin system-dependent mechanism.
    Hypertension (Dallas, Tex. : 1979), 2010, Volume: 56, Issue:3

    Topics: Adult; Analysis of Variance; Angiotensin II Type 1 Receptor Blockers; Blood Pressure; Cerebrovascula

2010
Losartan abolishes oxidative stress induced by intermittent hypoxia in humans.
    The Journal of physiology, 2011, Nov-15, Volume: 589, Issue:Pt 22

    Topics: 8-Hydroxy-2'-Deoxyguanosine; Angiotensin II Type 1 Receptor Blockers; Cross-Over Studies; Deoxyguano

2011
Acute hypoxic pulmonary vasoconstriction in man is attenuated by type I angiotensin II receptor blockade.
    Cardiovascular research, 1995, Volume: 30, Issue:6

    Topics: Adult; Angiotensin II; Angiotensin Receptor Antagonists; Biphenyl Compounds; Blood Pressure; Heart R

1995

Other Studies

30 other studies available for losartan and Hypoxia

ArticleYear
Multiphoton Phosphorescence Quenching Microscopy Reveals Kinetics of Tumor Oxygenation during Antiangiogenesis and Angiotensin Signaling Inhibition.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2022, 07-15, Volume: 28, Issue:14

    Topics: Angiotensins; Animals; Hypoxia; Losartan; Mice; Microscopy; Neoplasms; Oxygen; Receptors, Angiotensi

2022
Phloretin as an add-on therapy to losartan attenuates diabetes-induced AKI in rats: A potential therapeutic approach targeting TLR4-induced inflammation.
    Life sciences, 2023, Nov-01, Volume: 332

    Topics: Acute Kidney Injury; Animals; Diabetes Mellitus, Experimental; Hypoxia; Inflammation; Kidney; Losart

2023
Losartan protects against intermittent hypoxia-induced peritubular capillary loss by modulating the renal renin-angiotensin system and angiogenesis factors.
    Acta biochimica et biophysica Sinica, 2020, Jan-02, Volume: 52, Issue:1

    Topics: Angiogenesis Inducing Agents; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Body

2020
Hyperbaric oxygen activates visfatin expression and angiogenesis via angiotensin II and JNK pathway in hypoxic human coronary artery endothelial cells.
    Journal of cellular and molecular medicine, 2020, Volume: 24, Issue:4

    Topics: Angiotensin II; Anthracenes; Cell Movement; Cells, Cultured; Coronary Vessels; Cytokines; Endothelia

2020
Prevention of hemorrhage-induced renal vasoconstriction and hypoxia by angiotensin II type 1 receptor antagonism in pigs.
    American journal of physiology. Regulatory, integrative and comparative physiology, 2021, 07-01, Volume: 321, Issue:1

    Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Disease Models, Animal; Hemodynamics; Hemorrhage;

2021
Losartan treatment enhances chemotherapy efficacy and reduces ascites in ovarian cancer models by normalizing the tumor stroma.
    Proceedings of the National Academy of Sciences of the United States of America, 2019, 02-05, Volume: 116, Issue:6

    Topics: Animals; Antineoplastic Agents; Ascites; Collagen; Disease Models, Animal; Drug Synergism; Extracell

2019
Central losartan attenuates increases in arterial pressure and expression of FosB/ΔFosB along the autonomic axis associated with chronic intermittent hypoxia.
    American journal of physiology. Regulatory, integrative and comparative physiology, 2013, Nov-01, Volume: 305, Issue:9

    Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Arterial Pressure; Autonomic Nervous System; Brain

2013
Oxidative stress augments chemoreflex sensitivity in rats exposed to chronic intermittent hypoxia.
    Respiratory physiology & neurobiology, 2016, Volume: 234

    Topics: Acetophenones; Allopurinol; Analysis of Variance; Animals; Anti-Arrhythmia Agents; Antioxidants; Bod

2016
Losartan attenuates aortic endothelial apoptosis induced by chronic intermittent hypoxia partly via the phospholipase C pathway.
    Sleep & breathing = Schlaf & Atmung, 2017, Volume: 21, Issue:3

    Topics: Animals; Aorta; Apoptosis; Endothelial Cells; Hypoxia; Losartan; Male; Rats; Rats, Sprague-Dawley; T

2017
Chronic intermittent hypoxia augments chemoreflex control of sympathetic activity: role of the angiotensin II type 1 receptor.
    Respiratory physiology & neurobiology, 2010, Apr-15, Volume: 171, Issue:1

    Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Apnea; Blood Pressure; Carotid Bod

2010
In dystrophic hamsters losartan affects control of ventilation and dopamine D1 receptor density.
    Respiratory physiology & neurobiology, 2010, Aug-31, Volume: 173, Issue:1

    Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Body Weight; Corpus Striatum; Cricetinae; Disease

2010
Effect of AT1 receptor blockade on intermittent hypoxia-induced endothelial dysfunction.
    Respiratory physiology & neurobiology, 2012, Aug-15, Volume: 183, Issue:2

    Topics: Acetylcholine; Angiotensin II Type 1 Receptor Blockers; Animals; Arteries; Endothelium, Vascular; Hy

2012
Introgression of chromosome 13 in Dahl salt-sensitive genetic background restores cerebral vascular relaxation.
    American journal of physiology. Heart and circulatory physiology, 2004, Volume: 287, Issue:2

    Topics: Acetylcholine; Angiotensin II Type 1 Receptor Blockers; Animals; Cerebral Arteries; Chromosomes; Die

2004
Chronic AT(1) receptor blockade alters mechanisms mediating responses to hypoxia in rat skeletal muscle resistance arteries.
    American journal of physiology. Heart and circulatory physiology, 2004, Volume: 287, Issue:2

    Topics: Acetylcholine; Angiotensin II Type 1 Receptor Blockers; Animals; Arteries; Cardiovascular Agents; En

2004
[The effects of losartan on pulmonary arterial collagen and AT1 in chronic hypoxic rats].
    Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition, 2004, Volume: 35, Issue:6

    Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Chronic Disease; Collagen; Hypertension, Pulmonary

2004
Increased sympathetic activity in rats submitted to chronic intermittent hypoxia.
    Experimental physiology, 2007, Volume: 92, Issue:1

    Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Blood Pressure; Chronic Disease; Disease Models, A

2007
Microvascular transport model predicts oxygenation changes in the infarcted heart after treatment.
    American journal of physiology. Heart and circulatory physiology, 2007, Volume: 293, Issue:6

    Topics: Angiogenesis Inducing Agents; Angiotensin II Type 1 Receptor Blockers; Animals; Computer Simulation;

2007
The role of angiotensin II receptor-1 blockade in the hypoxic pulmonary vasoconstriction response in newborn piglets.
    Neonatology, 2008, Volume: 93, Issue:4

    Topics: Angiotensin II Type 1 Receptor Blockers; Angiotensin Receptor Antagonists; Animals; Animals, Newborn

2008
Analysis of responses to ANG IV: effects of PD-123319 and DuP-753 in the pulmonary circulation of the rat.
    The American journal of physiology, 1995, Volume: 268, Issue:2 Pt 1

    Topics: Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals;

1995
The role of the renin-angiotensin system in the renal response to moderate hypoxia in the rat.
    The Journal of physiology, 1996, Mar-01, Volume: 491 ( Pt 2)

    Topics: Animals; Biphenyl Compounds; Blood Pressure; Hypoxia; Imidazoles; Kidney; Losartan; Rats; Rats, Wist

1996
Use of pulsed-wave Doppler echocardiography to measure changes in MPAP. Is further validation required?
    Chest, 1997, Volume: 111, Issue:5

    Topics: Acute Disease; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhib

1997
Role of endogenous angiotensin II on sympathetic reflexes in conscious rabbits.
    The American journal of physiology, 1997, Volume: 272, Issue:6 Pt 2

    Topics: Angiotensin II; Animals; Antihypertensive Agents; Baroreflex; Biphenyl Compounds; Blood Pressure; Ca

1997
Role of central catecholaminergic pathways in the actions of endogenous ANG II on sympathetic reflexes.
    The American journal of physiology, 1998, Volume: 275, Issue:4

    Topics: Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals;

1998
Acute hypoxic pulmonary vasoconstriction in conscious dogs decreases renin and is unaffected by losartan.
    Journal of applied physiology (Bethesda, Md. : 1985), 1999, Volume: 86, Issue:6

    Topics: Angiotensin II; Animals; Antihypertensive Agents; Bicarbonates; Blood Gas Analysis; Blood Pressure;

1999
Renin activity and blood pressure in response to chronic episodic hypoxia.
    Hypertension (Dallas, Tex. : 1979), 1999, Volume: 34, Issue:2

    Topics: Adrenal Medulla; Angiotensin II; Animals; Antihypertensive Agents; Blood Pressure; Body Weight; Chem

1999
Endothelin, but not angiotensin II, contributes to the hypoxic contractile response of large isolated pulmonary arteries in the rat.
    Fundamental & clinical pharmacology, 1999, Volume: 13, Issue:4

    Topics: Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhib

1999
Modulation of angiotensin II receptor expression during development and regression of hypoxic pulmonary hypertension.
    American journal of respiratory cell and molecular biology, 2000, Volume: 22, Issue:3

    Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Antihypertensive Agents

2000
Chronic hypoxia upregulates the expression and function of AT(1) receptor in rat carotid body.
    The Journal of endocrinology, 2000, Volume: 167, Issue:3

    Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Carotid Body; Chemoreceptor Cells; Chroni

2000
Hyperoxia/normoxia-driven retinal angiogenesis in mice: a role for angiotensin II.
    Investigative ophthalmology & visual science, 2001, Volume: 42, Issue:2

    Topics: Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals;

2001
Postnatal hypoxemia increases angiotensin II sensitivity and up-regulates AT1a angiotensin receptors in rat carotid body chemoreceptors.
    The Journal of endocrinology, 2002, Volume: 173, Issue:2

    Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Animals, Newborn; Calcium; Carotid Body;

2002