losartan has been researched along with Hypertrophy in 40 studies
Losartan: An antagonist of ANGIOTENSIN TYPE 1 RECEPTOR with antihypertensive activity due to the reduced pressor effect of ANGIOTENSIN II.
losartan : A biphenylyltetrazole where a 1,1'-biphenyl group is attached at the 5-position and has an additional trisubstituted imidazol-1-ylmethyl group at the 4'-position
Hypertrophy: General increase in bulk of a part or organ due to CELL ENLARGEMENT and accumulation of FLUIDS AND SECRETIONS, not due to tumor formation, nor to an increase in the number of cells (HYPERPLASIA).
| Excerpt | Relevance | Reference |
|---|---|---|
| " In the present study, we tested the hypothesis that the B1 kinin receptor (B1R) contributes to vascular hypertrophy in angiotensin II (ANG II)-induced hypertension, through a mechanism involving reactive oxygen species (ROS) generation and extracellular signal-regulated kinase (ERK1/2) activation." | 7.80 | An interaction of renin-angiotensin and kallikrein-kinin systems contributes to vascular hypertrophy in angiotensin II-induced hypertension: in vivo and in vitro studies. ( Akamine, EH; Barreto-Chaves, ML; Carvalho, MH; Ceravolo, GS; Chopard, RP; Costa, TJ; Fernandes, DC; Fortes, ZB; Jordão, MT; Laurindo, FR; Montezano, AC; Takano, AP; Tostes, RC; Touyz, RM, 2014) |
| " Secondary objectives were to evaluate changes in components of the renin-angiotensin axis and the effects of administration of losartan on pregnancy outcome." | 7.72 | Insulin and losartan reduce proteinuria and renal hypertrophy in the pregnant diabetic rat. ( Boner, G; Erman, A; Gafter, U; Natif, N; Sclarovsky-Benjaminov, F; Sulkes, J; Van Dijk, DJ, 2003) |
| "To investigate the role of p27 and AT1 receptor in the hypertrophy of mesangial cell (MC) induced by angiotensin II (Ang II)." | 7.71 | [The role of AT1 receptor and cyclin kinase inhibitor p27 protein in angiotensin II-induced hypertrophy of mesangial cell]. ( Cui, R; Gao, C; Mei, X, 2001) |
| "We assessed the role of angiotensin (Ang) II type 1 receptor (AT1) and endothelin type A and B (ETA & ETB) receptor in cardiovascular hypertrophy associated with angiotensin II-induced hypertension (200 ng/kg." | 7.70 | [Cardiac and vascular hypertrophy in hypertension due to angiotensin II. Effect of losartan and bosentan]. ( Belabbas, H; Herizi, A; Jover, B; Mimran, A, 2000) |
| "To investigate the role of angiotensin II (Ang II) in cardiovascular hypertrophy in the Goldblatt one-kidney, one clip (1-K, 1C) renal hypertensive rat." | 7.69 | Cardiovascular hypertrophy in one-kidney, one clip renal hypertensive rats: a role for angiotensin II? ( Bertram, JF; Black, MJ; Bobik, A; O'Sullivan, JB, 1994) |
| "Juxtaglomerular (JG) cell hypertrophy and hyperplasia were investigated in rhesus monkeys given angiotensin II (AII) AT1 receptor antagonists L-158,338 and DUP 753 (MK-0954, losartan)." | 7.69 | Juxtaglomerular cell hypertrophy and hyperplasia induced in rhesus monkeys by angiotensin II receptor antagonists. ( Eydelloth, RS; Hubert, MF; Keenan, KP; Molon-Noblot, S; Owen, RA; Siegl, PK, 1994) |
| " We have shown that the hypertrophic agent angiotensin II stimulates superoxide production by activating the membrane-bound NADH/NADPH oxidase and that inhibition of this oxidase attenuates vascular hypertrophy." | 7.69 | p22phox is a critical component of the superoxide-generating NADH/NADPH oxidase system and regulates angiotensin II-induced hypertrophy in vascular smooth muscle cells. ( Fukui, T; Griendling, KK; Ishizaka, N; Ushio-Fukai, M; Zafari, AM, 1996) |
| " In the present study, we tested the hypothesis that the B1 kinin receptor (B1R) contributes to vascular hypertrophy in angiotensin II (ANG II)-induced hypertension, through a mechanism involving reactive oxygen species (ROS) generation and extracellular signal-regulated kinase (ERK1/2) activation." | 3.80 | An interaction of renin-angiotensin and kallikrein-kinin systems contributes to vascular hypertrophy in angiotensin II-induced hypertension: in vivo and in vitro studies. ( Akamine, EH; Barreto-Chaves, ML; Carvalho, MH; Ceravolo, GS; Chopard, RP; Costa, TJ; Fernandes, DC; Fortes, ZB; Jordão, MT; Laurindo, FR; Montezano, AC; Takano, AP; Tostes, RC; Touyz, RM, 2014) |
| " Secondary objectives were to evaluate changes in components of the renin-angiotensin axis and the effects of administration of losartan on pregnancy outcome." | 3.72 | Insulin and losartan reduce proteinuria and renal hypertrophy in the pregnant diabetic rat. ( Boner, G; Erman, A; Gafter, U; Natif, N; Sclarovsky-Benjaminov, F; Sulkes, J; Van Dijk, DJ, 2003) |
| "To investigate the role of p27 and AT1 receptor in the hypertrophy of mesangial cell (MC) induced by angiotensin II (Ang II)." | 3.71 | [The role of AT1 receptor and cyclin kinase inhibitor p27 protein in angiotensin II-induced hypertrophy of mesangial cell]. ( Cui, R; Gao, C; Mei, X, 2001) |
| "To separate the role of ANG II from pressure in hypertrophy of the vascular wall in one-kidney, one-clip (1K1C) hypertension, experimental and sham-operated rats were given the AT(1)-receptor antagonist losartan (20 mg x kg(-1) x day(-1)) or tap water for 14 days." | 3.70 | AT(1) receptor inhibition does not reduce arterial wall hypertrophy or PDGF-A expression in renal hypertension. ( Dobrian, AD; Parker, SB; Prewitt, RL; Wade, SS, 2000) |
| "We assessed the role of angiotensin (Ang) II type 1 receptor (AT1) and endothelin type A and B (ETA & ETB) receptor in cardiovascular hypertrophy associated with angiotensin II-induced hypertension (200 ng/kg." | 3.70 | [Cardiac and vascular hypertrophy in hypertension due to angiotensin II. Effect of losartan and bosentan]. ( Belabbas, H; Herizi, A; Jover, B; Mimran, A, 2000) |
| "To investigate the role of angiotensin II (Ang II) in cardiovascular hypertrophy in the Goldblatt one-kidney, one clip (1-K, 1C) renal hypertensive rat." | 3.69 | Cardiovascular hypertrophy in one-kidney, one clip renal hypertensive rats: a role for angiotensin II? ( Bertram, JF; Black, MJ; Bobik, A; O'Sullivan, JB, 1994) |
| "Juxtaglomerular (JG) cell hypertrophy and hyperplasia were investigated in rhesus monkeys given angiotensin II (AII) AT1 receptor antagonists L-158,338 and DUP 753 (MK-0954, losartan)." | 3.69 | Juxtaglomerular cell hypertrophy and hyperplasia induced in rhesus monkeys by angiotensin II receptor antagonists. ( Eydelloth, RS; Hubert, MF; Keenan, KP; Molon-Noblot, S; Owen, RA; Siegl, PK, 1994) |
| "0%) prevented by the protein synthesis inhibitor cycloheximide (10(-5)M), which supports the role of decreased protein degradation in the angiotensin-II-induced cell hypertrophy." | 3.69 | Angiotensin-II-induced cell hypertrophy: potential role of impaired proteolytic activity in cultured LLC-PK1 cells. ( Heidland, A; Ling, H; Schaefer, L; Schaefer, RM; Schnittler, HJ; Vamvakas, S, 1995) |
| " Therefore, we investigated the effect of AT1 or AT2 subtype receptor chronic blockade by losartan or PD123319 on the vascular hypertrophy in rats with Ang II-induced hypertension." | 3.69 | Chronic blockade of AT2-subtype receptors prevents the effect of angiotensin II on the rat vascular structure. ( Benessiano, J; Caputo, L; Duriez, M; Henrion, D; Heymes, C; Levy, BI; Poitevin, P; Samuel, JL, 1996) |
| " We have shown that the hypertrophic agent angiotensin II stimulates superoxide production by activating the membrane-bound NADH/NADPH oxidase and that inhibition of this oxidase attenuates vascular hypertrophy." | 3.69 | p22phox is a critical component of the superoxide-generating NADH/NADPH oxidase system and regulates angiotensin II-induced hypertrophy in vascular smooth muscle cells. ( Fukui, T; Griendling, KK; Ishizaka, N; Ushio-Fukai, M; Zafari, AM, 1996) |
| " The renin-angiotensin system has been implicated in vascular and cardiac hypertrophy, but the involvement of angiotensin II (ANG II) as a trophic factor in the lower urinary tract has not been investigated." | 3.69 | Angiotensin II and bladder obstruction in the rat: influence on hypertrophic growth and contractility. ( Andersson, KE; Pandita, RK; Persson, K; Waldeck, K, 1996) |
| "To examine the role played by angiotensin II (AII) in the development of prehypertensive vascular hypertrophy in the spontaneously hypertensive rat (SHR) and to determine whether normalization of prehypertensive vascular hypertrophy attenuates the development of hypertension." | 3.69 | Role of angiotensin II in early cardiovascular growth and vascular amplifier development in spontaneously hypertensive rats. ( Black, MJ; Bobik, A; Kanellakis, P, 1997) |
| " The AII receptors were characterized by means of the subtype-specific receptor antagonists DuP 753 (AII-1) and PD123177 (AII-2) using changes of [Ca2+]i (fura-2) as an indirect measurement of vasoconstriction and of [3H]leucine or [3H]thymidine incorporation as indices for hypertrophy and hyperplasia, respectively." | 3.68 | Angiotensin II-1 receptors mediate both vasoconstrictor and hypertrophic responses in rat aortic smooth muscle cells. ( Chiu, AT; McCall, DE; Roscoe, WA; Timmermans, PB, 1991) |
| "RV hypertrophy was also prevented, but LV hypertrophy only partially, and kidney hypertrophy not at all." | 1.35 | Prevention of salt-induced hypertension and fibrosis by AT1-receptor blockers in Dahl S rats. ( Leenen, FH; Liang, B, 2008) |
| " Chronic administration of Rut (10, 20, or 40 mg/kg/day, respectively) for 4 weeks caused a depressor effect and significantly regressed the lumen diameter and decreased the medium thickness of mesenteric arteries in hypertensive rats concomitantly with an increase in the plasma concentration of CGRP and the expression of CGRP mRNA in DRG." | 1.34 | Calcitonin gene-related Peptide-mediated depressor effect and inhibiting vascular hypertrophy of rutaecarpine in renovascular hypertensive rats. ( Chen, QQ; Deng, HW; Hu, GY; Li, D; Li, YJ; Luo, D; Qin, XP; Zeng, SY; Zhang, Z, 2007) |
| "Losartan treatments prevented EC training-induced increases in muscle wet and dry weights compared to untreated rats." | 1.33 | AT1 receptors are necessary for eccentric training-induced hypertrophy and strength gains in rat skeletal muscle. ( McBride, TA, 2006) |
| "Losartan treatment resulted in a dose-dependent reduction in the media thickness and mediato-lumen ratio in small arteries from the four vascular beds studied on the wire myograph and in pressurized mesenteric small arteries." | 1.30 | Effect of AT1 angiotensin-receptor blockade on structure and function of small arteries in SHR. ( Li, JS; Schiffrin, EL; Sharifi, AM, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 18 (45.00) | 18.2507 |
| 2000's | 16 (40.00) | 29.6817 |
| 2010's | 6 (15.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Piccolo, P | 1 |
| Mithbaokar, P | 1 |
| Sabatino, V | 1 |
| Tolmie, J | 1 |
| Melis, D | 1 |
| Schiaffino, MC | 1 |
| Filocamo, M | 1 |
| Andria, G | 1 |
| Brunetti-Pierri, N | 1 |
| Ceravolo, GS | 1 |
| Montezano, AC | 1 |
| Jordão, MT | 1 |
| Akamine, EH | 1 |
| Costa, TJ | 1 |
| Takano, AP | 1 |
| Fernandes, DC | 1 |
| Barreto-Chaves, ML | 2 |
| Laurindo, FR | 1 |
| Tostes, RC | 1 |
| Fortes, ZB | 1 |
| Chopard, RP | 1 |
| Touyz, RM | 1 |
| Carvalho, MH | 1 |
| Chen, S | 1 |
| Grover, M | 1 |
| Sibai, T | 1 |
| Black, J | 1 |
| Rianon, N | 1 |
| Rajagopal, A | 1 |
| Munivez, E | 1 |
| Bertin, T | 1 |
| Dawson, B | 1 |
| Chen, Y | 1 |
| Jiang, MM | 1 |
| Lee, B | 1 |
| Yang, T | 1 |
| Bae, Y | 1 |
| Qin, XP | 2 |
| Zeng, SY | 2 |
| Tian, HH | 1 |
| Deng, SX | 1 |
| Ren, JF | 1 |
| Zheng, YB | 1 |
| Li, D | 2 |
| Li, YJ | 2 |
| Liao, DF | 1 |
| Chen, SY | 1 |
| Diniz, GP | 1 |
| Carneiro-Ramos, MS | 1 |
| Cui, XL | 1 |
| Chang, B | 1 |
| Myatt, L | 1 |
| Sakuta, T | 1 |
| Morita, Y | 1 |
| Satoh, M | 1 |
| Fox, DA | 1 |
| Kashihara, N | 1 |
| Zhang, HG | 1 |
| Cheng, YQ | 1 |
| Liu, Y | 1 |
| Zhou, JZ | 1 |
| Jia, Y | 1 |
| Wang, XQ | 1 |
| Li, XH | 1 |
| Marchand, EL | 1 |
| Der Sarkissian, S | 1 |
| Hamet, P | 1 |
| deBlois, D | 1 |
| Park, SY | 1 |
| Song, CY | 1 |
| Kim, BC | 1 |
| Hong, HK | 1 |
| Lee, HS | 1 |
| Natif, N | 1 |
| Sclarovsky-Benjaminov, F | 1 |
| Van Dijk, DJ | 2 |
| Sulkes, J | 1 |
| Gafter, U | 2 |
| Boner, G | 2 |
| Erman, A | 2 |
| Aunapuu, M | 1 |
| Pechter, U | 1 |
| Arend, A | 1 |
| Suuroja, T | 1 |
| Ots, M | 1 |
| Veksler, S | 1 |
| Wittenberg, C | 1 |
| McBride, TA | 1 |
| Izquierdo, A | 1 |
| López-Luna, P | 1 |
| Ortega, A | 1 |
| Romero, M | 1 |
| Guitiérrez-Tarrés, MA | 1 |
| Arribas, I | 1 |
| Alvarez, MJ | 1 |
| Esbrit, P | 1 |
| Bosch, RJ | 1 |
| Tarsitano, CA | 1 |
| Paffaro, VA | 1 |
| Pauli, JR | 1 |
| da Silva, GH | 1 |
| Saad, MJ | 1 |
| Salgado, I | 1 |
| da Cruz-Höfling, MA | 1 |
| Hyslop, S | 1 |
| Chen, QQ | 1 |
| Luo, D | 1 |
| Zhang, Z | 1 |
| Hu, GY | 1 |
| Deng, HW | 1 |
| Liang, B | 1 |
| Leenen, FH | 1 |
| Fujihara, CK | 1 |
| De Nucci, G | 1 |
| Zatz, R | 1 |
| O'Sullivan, JB | 1 |
| Black, MJ | 2 |
| Bertram, JF | 1 |
| Bobik, A | 2 |
| Owen, RA | 1 |
| Molon-Noblot, S | 1 |
| Hubert, MF | 1 |
| Siegl, PK | 1 |
| Eydelloth, RS | 1 |
| Keenan, KP | 1 |
| Morishita, R | 1 |
| Gibbons, GH | 1 |
| Ellison, KE | 1 |
| Lee, W | 1 |
| Zhang, L | 1 |
| Yu, H | 1 |
| Kaneda, Y | 1 |
| Ogihara, T | 1 |
| Dzau, VJ | 1 |
| Natarajan, R | 1 |
| Gonzales, N | 1 |
| Lanting, L | 1 |
| Nadler, J | 1 |
| Smith, LJ | 1 |
| Rosenberg, ME | 1 |
| Hostetter, TH | 1 |
| Ling, H | 1 |
| Vamvakas, S | 1 |
| Schaefer, L | 1 |
| Schnittler, HJ | 1 |
| Schaefer, RM | 1 |
| Heidland, A | 1 |
| Levy, BI | 1 |
| Benessiano, J | 1 |
| Henrion, D | 1 |
| Caputo, L | 1 |
| Heymes, C | 1 |
| Duriez, M | 1 |
| Poitevin, P | 1 |
| Samuel, JL | 1 |
| Ushio-Fukai, M | 1 |
| Zafari, AM | 1 |
| Fukui, T | 1 |
| Ishizaka, N | 1 |
| Griendling, KK | 1 |
| Persson, K | 1 |
| Pandita, RK | 1 |
| Waldeck, K | 1 |
| Andersson, KE | 1 |
| Peiró, C | 1 |
| Llergo, JL | 1 |
| Angulo, J | 1 |
| López-Novoa, JM | 1 |
| Rodríguez-López, A | 1 |
| Rodríguez-Mañas, L | 1 |
| Sánchez-Ferrer, CF | 1 |
| Li, JS | 1 |
| Sharifi, AM | 1 |
| Schiffrin, EL | 1 |
| Kanellakis, P | 1 |
| Yotsumoto, T | 1 |
| Naitoh, T | 1 |
| Shikada, K | 1 |
| Tanaka, S | 1 |
| Price, RL | 1 |
| Carver, W | 1 |
| Simpson, DG | 1 |
| Fu, L | 1 |
| Zhao, J | 1 |
| Borg, TK | 1 |
| Terracio, L | 1 |
| Kobori, H | 1 |
| Ichihara, A | 1 |
| Miyashita, Y | 1 |
| Hayashi, M | 1 |
| Saruta, T | 1 |
| Parker, SB | 1 |
| Dobrian, AD | 1 |
| Wade, SS | 1 |
| Prewitt, RL | 1 |
| Herizi, A | 1 |
| Belabbas, H | 1 |
| Mimran, A | 1 |
| Jover, B | 1 |
| Zimpelmann, J | 1 |
| Kumar, D | 1 |
| Levine, DZ | 1 |
| Wehbi, G | 1 |
| Imig, JD | 1 |
| Navar, LG | 1 |
| Burns, KD | 1 |
| Mei, X | 1 |
| Gao, C | 1 |
| Cui, R | 1 |
| Chiu, AT | 1 |
| Roscoe, WA | 1 |
| McCall, DE | 1 |
| Timmermans, PB | 1 |
| Wolf, G | 1 |
| Neilson, EG | 1 |
| Goldfarb, S | 1 |
| Ziyadeh, FN | 1 |
40 other studies available for losartan and Hypertrophy
| Article | Year |
|---|---|
SMAD4 mutations causing Myhre syndrome result in disorganization of extracellular matrix improved by losartan.
Topics: Adolescent; Adult; Child; Cryptorchidism; Extracellular Matrix; Facies; Female; Fibroblasts; Growth | 2014 |
An interaction of renin-angiotensin and kallikrein-kinin systems contributes to vascular hypertrophy in angiotensin II-induced hypertension: in vivo and in vitro studies.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Aorta; Blood Pressure; Bradykinin B1 Receptor Anta | 2014 |
Losartan increases bone mass and accelerates chondrocyte hypertrophy in developing skeleton.
Topics: Angiotensins; Animals; Bone and Bones; Bone Density; Bone Development; Cartilage; Cell Differentiati | 2015 |
Involvement of prolylcarboxypeptidase in the effect of rutaecarpine on the regression of mesenteric artery hypertrophy in renovascular hypertensive rats.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Antihypertensive Agents; Blood Pre | 2009 |
Angiotensin type 1 receptor mediates thyroid hormone-induced cardiomyocyte hypertrophy through the Akt/GSK-3beta/mTOR signaling pathway.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Animals, Newborn; Blotting, Western; Flow Cytometr | 2009 |
Expression and distribution of NADPH oxidase isoforms in human myometrium--role in angiotensin II-induced hypertrophy.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Cell Line; Female; Gene Expression; Humans; | 2010 |
Involvement of the renin-angiotensin system in the development of vascular damage in a rat model of arthritis: effect of angiotensin receptor blockers.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Aorta, Thoracic; Arthritis, Experi | 2010 |
Gαq-protein carboxyl terminus imitation polypeptide GCIP-27 attenuates proliferation of vascular smooth muscle cells and vascular remodeling in spontaneously hypertensive rats.
Topics: 3T3 Cells; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Aorta; Blood Pressure; | 2011 |
Caspase-dependent cell death mediates the early phase of aortic hypertrophy regression in losartan-treated spontaneously hypertensive rats.
Topics: Amino Acid Chloromethyl Ketones; Animals; Antihypertensive Agents; Aorta; Apoptosis; bcl-2-Associate | 2003 |
Angiotensin II mediates LDL-induced superoxide generation in mesangial cells.
Topics: Adult; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Cell Division; Cells, Cultured; Enzy | 2003 |
Insulin and losartan reduce proteinuria and renal hypertrophy in the pregnant diabetic rat.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Diabetes Mellitus, Experimental; Drug Therapy, Com | 2003 |
Ultrastructural changes in the remnant kidney (after 5/6 nephrectomy) glomerulus after losartan and atenolol treatment.
Topics: Adrenergic beta-Antagonists; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Atenolol; Ba | 2003 |
Renin-angiotensin system blockade prevents the increase in plasma transforming growth factor beta 1, and reduces proteinuria and kidney hypertrophy in the streptozotocin-diabetic rat.
Topics: Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Animals; Diabetes | 2004 |
AT1 receptors are necessary for eccentric training-induced hypertrophy and strength gains in rat skeletal muscle.
Topics: Adaptation, Physiological; Angiotensin II Type 1 Receptor Blockers; Animals; Dose-Response Relations | 2006 |
The parathyroid hormone-related protein system and diabetic nephropathy outcome in streptozotocin-induced diabetes.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Blood Glucose; Blotting, Western; | 2006 |
Hepatic morphological alterations, glycogen content and cytochrome P450 activities in rats treated chronically with N(omega)-nitro-L-arginine methyl ester (L-NAME).
Topics: Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Animals; Chronic | 2007 |
Calcitonin gene-related Peptide-mediated depressor effect and inhibiting vascular hypertrophy of rutaecarpine in renovascular hypertensive rats.
Topics: Analysis of Variance; Angiotensin II Type 1 Receptor Blockers; Animals; Blood Vessels; Calcitonin Ge | 2007 |
Prevention of salt-induced hypertension and fibrosis by AT1-receptor blockers in Dahl S rats.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Aorta; Benzimidazoles; Benzoates; | 2008 |
Chronic nitric oxide synthase inhibition aggravates glomerular injury in rats with subtotal nephrectomy.
Topics: Amino Acid Oxidoreductases; Angiotensin Receptor Antagonists; Animals; Arginine; Biphenyl Compounds; | 1995 |
Cardiovascular hypertrophy in one-kidney, one clip renal hypertensive rats: a role for angiotensin II?
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; | 1994 |
Juxtaglomerular cell hypertrophy and hyperplasia induced in rhesus monkeys by angiotensin II receptor antagonists.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Dose-Response Relatio | 1994 |
Evidence for direct local effect of angiotensin in vascular hypertrophy. In vivo gene transfer of angiotensin converting enzyme.
Topics: Angiotensin I; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Blood Pressure; Caroti | 1994 |
Role of the lipoxygenase pathway in angiotensin II-induced vascular smooth muscle cell hypertrophy.
Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; Analysis of Variance; Angiotensin II; Angiotensin Recept | 1994 |
Effect of angiotensin II blockade on dietary protein-induced renal growth.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Dietary Proteins; Ena | 1993 |
Angiotensin-II-induced cell hypertrophy: potential role of impaired proteolytic activity in cultured LLC-PK1 cells.
Topics: Analysis of Variance; Angiotensin II; Animals; Biphenyl Compounds; Calcium; Calcium Channel Blockers | 1995 |
Chronic blockade of AT2-subtype receptors prevents the effect of angiotensin II on the rat vascular structure.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Aorta, Thoracic; | 1996 |
p22phox is a critical component of the superoxide-generating NADH/NADPH oxidase system and regulates angiotensin II-induced hypertrophy in vascular smooth muscle cells.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Biphenyl Compounds; Blood Vessels; Cytochrome b Gr | 1996 |
Angiotensin II and bladder obstruction in the rat: influence on hypertrophic growth and contractility.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Female; Hypertrophy; | 1996 |
Effects of captopril, losartan, and nifedipine on cell hypertrophy of cultured vascular smooth muscle from hypertensive Ren-2 transgenic rats.
Topics: Angiotensin II; Animals; Animals, Genetically Modified; Biphenyl Compounds; Captopril; Cells, Cultur | 1997 |
Effect of AT1 angiotensin-receptor blockade on structure and function of small arteries in SHR.
Topics: Angiotensin Receptor Antagonists; Animals; Aorta; Arteries; Biphenyl Compounds; Blood Pressure; Coro | 1997 |
Role of angiotensin II in early cardiovascular growth and vascular amplifier development in spontaneously hypertensive rats.
Topics: Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Animals, Newborn; Antihypertensiv | 1997 |
Effects of specific antagonists of angiotensin II receptors and captopril on diabetic nephropathy in mice.
Topics: Albuminuria; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; An | 1997 |
The effects of angiotensin II and specific angiotensin receptor blockers on embryonic cardiac development and looping patterns.
Topics: Actins; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Cardiomegaly; Fetal Heart; Fibrob | 1997 |
Mechanism of hyperthyroidism-induced renal hypertrophy in rats.
Topics: Analysis of Variance; Angiotensin II; Animals; Antihypertensive Agents; Gene Expression; Hyperthyroi | 1998 |
AT(1) receptor inhibition does not reduce arterial wall hypertrophy or PDGF-A expression in renal hypertension.
Topics: Angiotensin Receptor Antagonists; Animals; Aorta, Thoracic; Arteries; Blood Pressure; Bromodeoxyurid | 2000 |
[Cardiac and vascular hypertrophy in hypertension due to angiotensin II. Effect of losartan and bosentan].
Topics: Analysis of Variance; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Ag | 2000 |
Early diabetes mellitus stimulates proximal tubule renin mRNA expression in the rat.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Angiotensinogen; Animals; Antihypertensive Agents; | 2000 |
[The role of AT1 receptor and cyclin kinase inhibitor p27 protein in angiotensin II-induced hypertrophy of mesangial cell].
Topics: Angiotensin II; Animals; Antihypertensive Agents; Cell Cycle Proteins; Cells, Cultured; Cyclin-Depen | 2001 |
Angiotensin II-1 receptors mediate both vasoconstrictor and hypertrophic responses in rat aortic smooth muscle cells.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Aorta, Thoracic; Biphenyl Compounds; Cell | 1991 |
The influence of glucose concentration on angiotensin II-induced hypertrophy of proximal tubular cells in culture.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Cell Line; Cyclic AMP; Glucose; Hypertrop | 1991 |