losartan has been researched along with Hypertension, Portal in 24 studies
Losartan: An antagonist of ANGIOTENSIN TYPE 1 RECEPTOR with antihypertensive activity due to the reduced pressor effect of ANGIOTENSIN II.
losartan : A biphenylyltetrazole where a 1,1'-biphenyl group is attached at the 5-position and has an additional trisubstituted imidazol-1-ylmethyl group at the 4'-position
Hypertension, Portal: Abnormal increase of resistance to blood flow within the hepatic PORTAL SYSTEM, frequently seen in LIVER CIRRHOSIS and conditions with obstruction of the PORTAL VEIN.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We performed a longitudinal study that included 23 consecutive patients with cirrhosis and esophageal varices who received 25 mg/day of losartan during 12 wk." | 3.73 | A1166C angiotensin II type 1 receptor gene polymorphism may predict hemodynamic response to losartan in patients with cirrhosis and portal hypertension. ( Castaño, G; García, SI; González, C; Pirola, CJ; Sookoian, S; Viudez, P, 2005) |
| "Advanced stages of portal hypertension are characterized by generalized vasodilatation and a hyperdynamic syndrome that leads to complications such as hepatopulmonary syndrome." | 1.36 | Losartan prevents portal hypertension-induced, redox-mediated endothelial dysfunction in the mesenteric artery in rats. ( Boehm, N; Bronner, C; Chataigneau, T; Dal-Ros, S; Gény, B; Oswald-Mammosser, M; Pestrikova, T; Schini-Kerth, VB; Schott, C, 2010) |
| " We aimed to study both the systemic and portal hemodynamics, and tolerability after chronic administration of losartan, an ANG II receptor antagonist." | 1.32 | Chronic administration of losartan, an angiotensin II receptor antagonist, is not effective in reducing portal pressure in patients with preascitic cirrhosis. ( Hayes, PC; Johnston, N; Lui, HF; Therapondos, G; Tripathi, D; Webb, DJ, 2004) |
| " Higher dosage of losartan had deleterious effects in BDL rats." | 1.31 | Hemodynamic and antifibrotic effects of losartan in rats with liver fibrosis and/or portal hypertension. ( Calès, P; Chappard, D; Croquet, V; Douay, O; Gallois, Y; Moal, F; Oberti, F; Roux, J; Veal, N; Vuillemin, E; Wang, J, 2002) |
| "Portal hypertension was induced by partial portal vein ligation 3 weeks before study." | 1.29 | Loss of angiotensin-II receptors in portal hypertensive rabbits. ( Aguilera, G; Burns, RC; Cahill, PA; Sitzmann, JV; Wu, Y, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (12.50) | 18.2507 |
| 2000's | 15 (62.50) | 29.6817 |
| 2010's | 6 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| de Araújo, LJT | 1 |
| Nagaoka, MR | 1 |
| Borges, DR | 1 |
| Kouyoumdjian, M | 1 |
| Dal-Ros, S | 1 |
| Oswald-Mammosser, M | 1 |
| Pestrikova, T | 1 |
| Schott, C | 1 |
| Boehm, N | 1 |
| Bronner, C | 1 |
| Chataigneau, T | 1 |
| Gény, B | 1 |
| Schini-Kerth, VB | 1 |
| Huo, LJ | 1 |
| Han, XD | 1 |
| Tian, LL | 1 |
| Brooks, R | 1 |
| Huang, HC | 1 |
| Chang, CC | 1 |
| Wang, SS | 1 |
| Lee, FY | 2 |
| Teng, TH | 1 |
| Lee, JY | 1 |
| Lin, HC | 2 |
| Chuang, CL | 1 |
| Lee, SD | 2 |
| Agasti, AK | 1 |
| Mahajan, AU | 1 |
| Phadke, AY | 1 |
| Nathani, PJ | 1 |
| Sawant, P | 1 |
| Croquet, V | 1 |
| Moal, F | 2 |
| Veal, N | 2 |
| Wang, J | 2 |
| Oberti, F | 2 |
| Roux, J | 1 |
| Vuillemin, E | 2 |
| Gallois, Y | 1 |
| Douay, O | 1 |
| Chappard, D | 1 |
| Calès, P | 2 |
| Blendis, L | 1 |
| Lurie, Y | 1 |
| Oren, R | 1 |
| Blendis, LM | 1 |
| Wong, F | 1 |
| De, BK | 1 |
| Bandyopadhyay, K | 1 |
| Das, TK | 1 |
| Das, D | 1 |
| Biswas, PK | 1 |
| Majumdar, D | 1 |
| Mandal, SK | 1 |
| Ray, S | 1 |
| Dasgupta, S | 1 |
| Heller, J | 1 |
| Shiozawa, T | 1 |
| Trebicka, J | 1 |
| Hennenberg, M | 1 |
| Schepke, M | 1 |
| Neef, M | 1 |
| Sauerbruch, T | 1 |
| Tripathi, D | 1 |
| Therapondos, G | 1 |
| Lui, HF | 1 |
| Johnston, N | 1 |
| Webb, DJ | 1 |
| Hayes, PC | 1 |
| Castaño, G | 3 |
| Viudez, P | 3 |
| Sookoian, S | 3 |
| García, SI | 1 |
| González, C | 1 |
| Pirola, CJ | 1 |
| Spiering, W | 1 |
| Kroon, AA | 1 |
| de Leeuw, PW | 1 |
| Zhang, R | 1 |
| Liu, XY | 1 |
| Sitzmann, JV | 1 |
| Wu, Y | 1 |
| Aguilera, G | 1 |
| Cahill, PA | 1 |
| Burns, RC | 1 |
| Schneider, AW | 1 |
| Kalk, JF | 1 |
| Klein, CP | 1 |
| García-Tsao, G | 1 |
| González-Abraldes, J | 1 |
| Albillos, A | 1 |
| Bañares, R | 1 |
| Del Arbol, LR | 1 |
| Moitinho, E | 1 |
| Rodríguez, C | 1 |
| González, M | 1 |
| Escorsell, A | 1 |
| García-Pagán, JC | 1 |
| Bosch, J | 1 |
| Roy, E | 1 |
| Kaassis, M | 1 |
| Trouvé, R | 1 |
| Saumet, JL | 1 |
| Lebrec, D | 1 |
| Yang, YY | 1 |
| Huang, YT | 1 |
| Lee, TY | 1 |
| Hou, MC | 1 |
| Liu, RS | 1 |
| Chang, FY | 1 |
| Frider, B | 1 |
| Gustavo, C | 1 |
| Pedro, V | 1 |
| Bernardo, F | 1 |
| Silvia, S | 1 |
1 review available for losartan and Hypertension, Portal
| Article | Year |
|---|---|
[Angiotensin II receptor antagonists and portal hypertension].
Topics: Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; | 2002 |
4 trials available for losartan and Hypertension, Portal
| Article | Year |
|---|---|
Comparative randomized study on efficacy of losartan versus propranolol in lowering portal pressure in decompensated chronic liver disease.
Topics: Adult; Angiotensin II Type 1 Receptor Blockers; Antihypertensive Agents; Female; Follow-Up Studies; | 2013 |
Portal pressure response to losartan compared with propranolol in patients with cirrhosis.
Topics: Adrenergic beta-Antagonists; Adult; Angiotensin II; Antihypertensive Agents; Esophageal and Gastric | 2003 |
Effect of losartan, an angiotensin II receptor antagonist, on portal pressure in cirrhosis.
Topics: Adult; Aged; Angiotensin Receptor Antagonists; Antihypertensive Agents; Bilirubin; Female; Hemodynam | 1999 |
Randomized comparison of long-term losartan versus propranolol in lowering portal pressure in cirrhosis.
Topics: Adult; Antihypertensive Agents; Blood Pressure; Blood Urea Nitrogen; Creatinine; Female; Glomerular | 2001 |
19 other studies available for losartan and Hypertension, Portal
| Article | Year |
|---|---|
Participation of hepatic α/β-adrenoceptors and AT1 receptors in glucose release and portal hypertensive response induced by adrenaline or angiotensin II.
Topics: Adrenergic beta-Antagonists; Angiotensin II Type 1 Receptor Blockers; Angiotensin Receptor Antagonis | 2018 |
Losartan prevents portal hypertension-induced, redox-mediated endothelial dysfunction in the mesenteric artery in rats.
Topics: Acetophenones; Angiotensin II Type 1 Receptor Blockers; Animals; Biological Factors; Connexins; Endo | 2010 |
[Effect of different doses of losartan on cirrhotic portal hypertensive colopathy in rats].
Topics: Animals; Colon; Colonic Diseases; Hemodynamics; Hepatic Veins; Hypertension, Portal; Intestinal Muco | 2010 |
Management of varices in cirrhosis.
Topics: Angiotensin II Type 1 Receptor Blockers; Esophageal and Gastric Varices; Humans; Hypertension, Porta | 2010 |
The roles of angiotensin II receptors in the portosystemic collaterals of portal hypertensive and cirrhotic rats.
Topics: Animals; Collateral Circulation; Down-Regulation; Guanidines; Hypertension, Portal; Imidazoles; Liga | 2012 |
Hemodynamic and antifibrotic effects of losartan in rats with liver fibrosis and/or portal hypertension.
Topics: Alanine Transaminase; Alkaline Phosphatase; Angiotensin Receptor Antagonists; Animals; Bile Ducts; B | 2002 |
"A la carte" treatment of portal hypertension or just "hors d'oeuvres".
Topics: Gastrointestinal Hemorrhage; Hemodynamics; Humans; Hypertension, Portal; Isosorbide Dinitrate; Losar | 2003 |
Does losartan work after all?
Topics: Antihypertensive Agents; Humans; Hypertension, Portal; Liver Cirrhosis; Losartan; Propranolol; Rando | 2003 |
Acute haemodynamic effects of losartan in anaesthetized cirrhotic rats.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Antihypertensive Agents; Blood Pressure; Cardiac O | 2003 |
Chronic administration of losartan, an angiotensin II receptor antagonist, is not effective in reducing portal pressure in patients with preascitic cirrhosis.
Topics: Angiotensin Receptor Antagonists; Antihypertensive Agents; Female; Hemodynamics; Humans; Hypertensio | 2004 |
Losartan in preascitic cirrhosis.
Topics: Angiotensin II Type 2 Receptor Blockers; Antihypertensive Agents; Female; Hepatic Veins; Humans; Hyp | 2004 |
A1166C angiotensin II type 1 receptor gene polymorphism may predict hemodynamic response to losartan in patients with cirrhosis and portal hypertension.
Topics: Adolescent; Adult; Aged; Angiotensin II Type 1 Receptor Blockers; Blood Pressure; Chromatography, Hi | 2005 |
A116C angiotensin II type 1 receptor gene polymorphism may predict hemodynamic response to losartan in patients with cirrhosis and portal hypertension.
Topics: Adenine; Alleles; Angiotensin II Type 1 Receptor Blockers; Antihypertensive Agents; Cytosine; Heart | 2005 |
[Effect of losartan on portal hypertensive gastropathy in rats].
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Gastric Mucosa; Hypertension, Port | 2007 |
Loss of angiotensin-II receptors in portal hypertensive rabbits.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Autoradiography; Biphenyl Compounds; Hype | 1995 |
Angiotensin II receptor antagonists in the pharmacological therapy of portal hypertension: a caution.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Antihypertensive Agents; Humans; Hypertension, Por | 1999 |
New method of cardiac output measurement using ultrasound velocity dilution in rats.
Topics: Animals; Antihypertensive Agents; Aorta; Blood Flow Velocity; Blood Pressure; Cardiac Output; Hypert | 2001 |
Effect of 1-week losartan administration on bile duct-ligated cirrhotic rats with portal hypertension.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Blotting, Western; Common Bile Duct; Enzyme Inhibi | 2002 |
Discussion on randomized comparison of long-term losartan versus propranolol in lowering portal pressure in cirrhosis.
Topics: Antihypertensive Agents; Female; Humans; Hypertension, Portal; Liver Cirrhosis; Losartan; Male; Prop | 2002 |