losartan has been researched along with Hyperinsulinism in 11 studies
Losartan: An antagonist of ANGIOTENSIN TYPE 1 RECEPTOR with antihypertensive activity due to the reduced pressor effect of ANGIOTENSIN II.
losartan : A biphenylyltetrazole where a 1,1'-biphenyl group is attached at the 5-position and has an additional trisubstituted imidazol-1-ylmethyl group at the 4'-position
Hyperinsulinism: A syndrome with excessively high INSULIN levels in the BLOOD. It may cause HYPOGLYCEMIA. Etiology of hyperinsulinism varies, including hypersecretion of a beta cell tumor (INSULINOMA); autoantibodies against insulin (INSULIN ANTIBODIES); defective insulin receptor (INSULIN RESISTANCE); or overuse of exogenous insulin or HYPOGLYCEMIC AGENTS.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Twenty patients with essential hypertension were included in a randomized, double-blind, placebo-controlled crossover study of 4 weeks' treatment with losartan, a selective type 1 angiotensin (AT1) receptor antagonist." | 9.08 | Circulating levels of endothelin-1 during acute hyperinsulinemia in patients with essential hypertension treated with type 1 angiotensin receptor antagonist or placebo. ( Arnesen, H; Aspelin, T; Kjeldsen, SE; Moan, A; Seljeflot, I; Tønnessen, T, 1998) |
| "To investigate the role of angiotensin II in the pathogenesis of hyperinsulinemia-induced hypertension in rats." | 7.70 | Role of angiotensin II in hyperinsulinemia-induced hypertension in rats. ( Fang, TC; Huang, WC, 1998) |
| "The purpose of this study was to evaluate the role of angiotensin II (AII) in fructose-treated rats by assessing the effects of acute and chronic losartan treatment on glucose tolerance and insulin sensitivity." | 7.69 | Effect of acute and chronic losartan treatment on glucose tolerance and insulin sensitivity in fructose-fed rats. ( Iyer, SN; Katovich, MJ, 1996) |
| " Twenty patients with essential hypertension were included in a randomized, double-blind, placebo-controlled crossover study of 4 weeks' treatment with losartan, a selective type 1 angiotensin (AT1) receptor antagonist." | 5.08 | Circulating levels of endothelin-1 during acute hyperinsulinemia in patients with essential hypertension treated with type 1 angiotensin receptor antagonist or placebo. ( Arnesen, H; Aspelin, T; Kjeldsen, SE; Moan, A; Seljeflot, I; Tønnessen, T, 1998) |
| "The study was conducted to examine the effects of the angiotensin subtype 1 and 2 receptor antagonists (losartan and PD123319, respectively) on blood pressure (BP) and renal excretory function in chronic hyperinsulinemia-induced hypertension in rats." | 3.70 | Angiotensin receptor blockade blunts hyperinsulinemia-induced hypertension in rats. ( Fang, TC; Huang, WC, 1998) |
| "To investigate the role of angiotensin II in the pathogenesis of hyperinsulinemia-induced hypertension in rats." | 3.70 | Role of angiotensin II in hyperinsulinemia-induced hypertension in rats. ( Fang, TC; Huang, WC, 1998) |
| "The purpose of this study was to evaluate the role of angiotensin II (AII) in fructose-treated rats by assessing the effects of acute and chronic losartan treatment on glucose tolerance and insulin sensitivity." | 3.69 | Effect of acute and chronic losartan treatment on glucose tolerance and insulin sensitivity in fructose-fed rats. ( Iyer, SN; Katovich, MJ, 1996) |
| "During both models of hyperinsulinemia, plasminogen activator inhibitor activity and antigen decreased significantly (both P<." | 2.68 | Effect of angiotensin II receptor blockade on fibrinolysis during acute hyperinsulinemia in patients with essential hypertension. ( Arnesen, H; Kjeldsen, S; Moan, A; Sandvik, E; Seljeflot, I, 1996) |
| "These findings suggest that hyperinsulinemia increases lumbar SNA by activation of a glutamatergic NMDA-dependent projection to the RVLM." | 1.36 | Glutamatergic receptor activation in the rostral ventrolateral medulla mediates the sympathoexcitatory response to hyperinsulinemia. ( Bardgett, ME; McCarthy, JJ; Stocker, SD, 2010) |
| "Losartan-treated (LOS group, n = 10) and untreated rats served as controls (n = 11)." | 1.35 | Hyperinsulinemic rats are normotensive but sensitized to angiotensin II. ( Alexanderson, C; Andersson, IJ; Bergström, G; Holmäng, A; Johansson, ME; Skøtt, O, 2008) |
| "Captopril treatment partially reversed low insulin sensitivity in LSD rats, whereas losartan did not change it, which indicates that the effect of LSD on insulin sensitivity is angiotensin independent." | 1.31 | High- or low-salt diet from weaning to adulthood: effect on insulin sensitivity in Wistar rats. ( Dolnikoff, MS; Furukawa, LN; Heimann, JC; Machado, UF; Okamoto, MM; Prada, P, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (45.45) | 18.2507 |
| 2000's | 5 (45.45) | 29.6817 |
| 2010's | 1 (9.09) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bardgett, ME | 1 |
| McCarthy, JJ | 1 |
| Stocker, SD | 1 |
| Nielsen, S | 1 |
| Lihn, AS | 1 |
| ØStergaard, T | 1 |
| Mogensen, CE | 1 |
| Schmitz, O | 1 |
| Krusinová, E | 1 |
| Klementová, M | 1 |
| Kopecký, J | 1 |
| Wohl, P | 1 |
| Kazdová, L | 1 |
| Mlejnek, P | 1 |
| Pravenec, M | 1 |
| Hill, M | 1 |
| Pelikánová, T | 1 |
| Johansson, ME | 1 |
| Andersson, IJ | 1 |
| Alexanderson, C | 1 |
| Skøtt, O | 1 |
| Holmäng, A | 1 |
| Bergström, G | 1 |
| Seljeflot, I | 2 |
| Moan, A | 2 |
| Kjeldsen, S | 1 |
| Sandvik, E | 1 |
| Arnesen, H | 2 |
| Iyer, SN | 1 |
| Katovich, MJ | 1 |
| Aspelin, T | 1 |
| Tønnessen, T | 1 |
| Kjeldsen, SE | 1 |
| Fang, TC | 2 |
| Huang, WC | 2 |
| Prada, P | 1 |
| Okamoto, MM | 1 |
| Furukawa, LN | 1 |
| Machado, UF | 1 |
| Heimann, JC | 1 |
| Dolnikoff, MS | 1 |
| Frossard, M | 1 |
| Joukhadar, C | 1 |
| Steffen, G | 1 |
| Schmid, R | 1 |
| Eichler, HG | 1 |
| Müller, M | 1 |
4 trials available for losartan and Hyperinsulinism
| Article | Year |
|---|---|
Increased plasma adiponectin in losartan-treated type 1 diabetic patients. a mediator of improved insulin sensitivity?
Topics: Adiponectin; Adult; Angiotensin Receptor Antagonists; Blood Glucose; Cross-Over Studies; Diabetes Me | 2004 |
Effect of acute hyperinsulinaemia with and without angiotensin II type 1 receptor blockade on resistin and adiponectin concentrations and expressions in healthy subjects.
Topics: Adiponectin; Adult; Angiotensin II Type 1 Receptor Blockers; Drug Combinations; Gene Expression; Glu | 2007 |
Effect of angiotensin II receptor blockade on fibrinolysis during acute hyperinsulinemia in patients with essential hypertension.
Topics: Adult; Aged; Angiotensin Receptor Antagonists; Antihypertensive Agents; Biphenyl Compounds; Blood Gl | 1996 |
Circulating levels of endothelin-1 during acute hyperinsulinemia in patients with essential hypertension treated with type 1 angiotensin receptor antagonist or placebo.
Topics: Adult; Aged; Antihypertensive Agents; Cross-Over Studies; Double-Blind Method; Endothelin-1; Fasting | 1998 |
7 other studies available for losartan and Hyperinsulinism
| Article | Year |
|---|---|
Glutamatergic receptor activation in the rostral ventrolateral medulla mediates the sympathoexcitatory response to hyperinsulinemia.
Topics: Analysis of Variance; Animals; Blotting, Western; Disease Models, Animal; Excitatory Amino Acid Anta | 2010 |
Hyperinsulinemic rats are normotensive but sensitized to angiotensin II.
Topics: Acetylcholine; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Antihypertensive Ag | 2008 |
Effect of acute and chronic losartan treatment on glucose tolerance and insulin sensitivity in fructose-fed rats.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Biphenyl Compoun | 1996 |
Angiotensin receptor blockade blunts hyperinsulinemia-induced hypertension in rats.
Topics: Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Blood Glucose; Blood Pressure; H | 1998 |
Role of angiotensin II in hyperinsulinemia-induced hypertension in rats.
Topics: Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Blood Pr | 1998 |
High- or low-salt diet from weaning to adulthood: effect on insulin sensitivity in Wistar rats.
Topics: Aging; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Biological Transp | 2000 |
Paracrine effects of angiotensin-converting-enzyme- and angiotensin-II-receptor- inhibition on transcapillary glucose transport in humans.
Topics: Adult; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; B | 2000 |