Page last updated: 2024-10-30

losartan and Glioma

losartan has been researched along with Glioma in 5 studies

Losartan: An antagonist of ANGIOTENSIN TYPE 1 RECEPTOR with antihypertensive activity due to the reduced pressor effect of ANGIOTENSIN II.
losartan : A biphenylyltetrazole where a 1,1'-biphenyl group is attached at the 5-position and has an additional trisubstituted imidazol-1-ylmethyl group at the 4'-position

Glioma: Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). Astrocytes may give rise to astrocytomas (ASTROCYTOMA) or glioblastoma multiforme (see GLIOBLASTOMA). Oligodendrocytes give rise to oligodendrogliomas (OLIGODENDROGLIOMA) and ependymocytes may undergo transformation to become EPENDYMOMA; CHOROID PLEXUS NEOPLASMS; or colloid cysts of the third ventricle. (From Escourolle et al., Manual of Basic Neuropathology, 2nd ed, p21)

Research Excerpts

ExcerptRelevanceReference
"Malignant gliomas have a highly immune suppressive tumor microenvironment (TME) which renders them largely unresponsive to conventional therapeutics."5.72Reprogramming the Canine Glioma Microenvironment with Tumor Vaccination plus Oral Losartan and Propranolol Induces Objective Responses. ( Ammons, DT; Boss, MK; Chow, L; Dow, S; Frank, C; Griffin, JF; Guth, A; Kurihara, J; MacQuiddy, B; Makii, R; Marolf, AJ; McGrath, S; Packer, RA; Regan, DP; Rozental, AJ, 2022)
"Malignant gliomas have a highly immune suppressive tumor microenvironment (TME) which renders them largely unresponsive to conventional therapeutics."1.72Reprogramming the Canine Glioma Microenvironment with Tumor Vaccination plus Oral Losartan and Propranolol Induces Objective Responses. ( Ammons, DT; Boss, MK; Chow, L; Dow, S; Frank, C; Griffin, JF; Guth, A; Kurihara, J; MacQuiddy, B; Makii, R; Marolf, AJ; McGrath, S; Packer, RA; Regan, DP; Rozental, AJ, 2022)

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's3 (60.00)18.2507
2000's1 (20.00)29.6817
2010's0 (0.00)24.3611
2020's1 (20.00)2.80

Authors

AuthorsStudies
Ammons, DT1
Guth, A1
Rozental, AJ1
Kurihara, J1
Marolf, AJ1
Chow, L1
Griffin, JF1
Makii, R1
MacQuiddy, B1
Boss, MK1
Regan, DP1
Frank, C1
McGrath, S1
Packer, RA1
Dow, S1
Moeller, I1
Albiston, AL1
Lew, RA1
Mendelsohn, FA1
Chai, SY1
Rivera, E1
Arrieta, O1
Guevara, P1
Duarte-Rojo, A1
Sotelo, J1
Leung, KH1
Chang, RS1
Lotti, VJ1
Roscoe, WA1
Smith, RD1
Timmermans, PB1
Chiu, AT1
Jaiswal, N1
Diz, DI1
Tallant, EA1
Khosla, MC1
Ferrario, CM1

Other Studies

5 other studies available for losartan and Glioma

ArticleYear
Reprogramming the Canine Glioma Microenvironment with Tumor Vaccination plus Oral Losartan and Propranolol Induces Objective Responses.
    Cancer research communications, 2022, Volume: 2, Issue:12

    Topics: Animals; Brain Neoplasms; Cancer Vaccines; Dogs; Glioma; Losartan; Propranolol; Prospective Studies;

2022
A globin fragment, LVV-hemorphin-7, induces [3H]thymidine incorporation in a neuronal cell line via the AT4 receptor.
    Journal of neurochemistry, 1999, Volume: 73, Issue:1

    Topics: Angiotensin II; Binding, Competitive; DNA; Glioma; Hemoglobins; Hybrid Cells; Losartan; Neuroblastom

1999
AT1 receptor is present in glioma cells; its blockage reduces the growth of rat glioma.
    British journal of cancer, 2001, Nov-02, Volume: 85, Issue:9

    Topics: Angiotensin II; Animals; Antihypertensive Agents; Brain Neoplasms; Cell Division; Glioma; Losartan;

2001
AT1 receptors mediate the release of prostaglandins in porcine smooth muscle cells and rat astrocytes.
    American journal of hypertension, 1992, Volume: 5, Issue:9

    Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Arachidonic Acids; Astrocytes; Biphenyl C

1992
Characterization of angiotensin receptors mediating prostaglandin synthesis in C6 glioma cells.
    The American journal of physiology, 1991, Volume: 260, Issue:5 Pt 2

    Topics: Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Glioma; Imidazoles; Losart

1991