losartan and Glioma
losartan has been researched along with Glioma in 5 studies
Losartan: An antagonist of ANGIOTENSIN TYPE 1 RECEPTOR with antihypertensive activity due to the reduced pressor effect of ANGIOTENSIN II.
losartan : A biphenylyltetrazole where a 1,1'-biphenyl group is attached at the 5-position and has an additional trisubstituted imidazol-1-ylmethyl group at the 4'-position
Glioma: Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). Astrocytes may give rise to astrocytomas (ASTROCYTOMA) or glioblastoma multiforme (see GLIOBLASTOMA). Oligodendrocytes give rise to oligodendrogliomas (OLIGODENDROGLIOMA) and ependymocytes may undergo transformation to become EPENDYMOMA; CHOROID PLEXUS NEOPLASMS; or colloid cysts of the third ventricle. (From Escourolle et al., Manual of Basic Neuropathology, 2nd ed, p21)
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| "Malignant gliomas have a highly immune suppressive tumor microenvironment (TME) which renders them largely unresponsive to conventional therapeutics." | 5.72 | Reprogramming the Canine Glioma Microenvironment with Tumor Vaccination plus Oral Losartan and Propranolol Induces Objective Responses. ( Ammons, DT; Boss, MK; Chow, L; Dow, S; Frank, C; Griffin, JF; Guth, A; Kurihara, J; MacQuiddy, B; Makii, R; Marolf, AJ; McGrath, S; Packer, RA; Regan, DP; Rozental, AJ, 2022) |
| "Malignant gliomas have a highly immune suppressive tumor microenvironment (TME) which renders them largely unresponsive to conventional therapeutics." | 1.72 | Reprogramming the Canine Glioma Microenvironment with Tumor Vaccination plus Oral Losartan and Propranolol Induces Objective Responses. ( Ammons, DT; Boss, MK; Chow, L; Dow, S; Frank, C; Griffin, JF; Guth, A; Kurihara, J; MacQuiddy, B; Makii, R; Marolf, AJ; McGrath, S; Packer, RA; Regan, DP; Rozental, AJ, 2022) |
Research
Studies (5)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (60.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (20.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Ammons, DT | 1 |
| Guth, A | 1 |
| Rozental, AJ | 1 |
| Kurihara, J | 1 |
| Marolf, AJ | 1 |
| Chow, L | 1 |
| Griffin, JF | 1 |
| Makii, R | 1 |
| MacQuiddy, B | 1 |
| Boss, MK | 1 |
| Regan, DP | 1 |
| Frank, C | 1 |
| McGrath, S | 1 |
| Packer, RA | 1 |
| Dow, S | 1 |
| Moeller, I | 1 |
| Albiston, AL | 1 |
| Lew, RA | 1 |
| Mendelsohn, FA | 1 |
| Chai, SY | 1 |
| Rivera, E | 1 |
| Arrieta, O | 1 |
| Guevara, P | 1 |
| Duarte-Rojo, A | 1 |
| Sotelo, J | 1 |
| Leung, KH | 1 |
| Chang, RS | 1 |
| Lotti, VJ | 1 |
| Roscoe, WA | 1 |
| Smith, RD | 1 |
| Timmermans, PB | 1 |
| Chiu, AT | 1 |
| Jaiswal, N | 1 |
| Diz, DI | 1 |
| Tallant, EA | 1 |
| Khosla, MC | 1 |
| Ferrario, CM | 1 |
Other Studies
5 other studies available for losartan and Glioma
| Article | Year |
|---|---|
Reprogramming the Canine Glioma Microenvironment with Tumor Vaccination plus Oral Losartan and Propranolol Induces Objective Responses.
Topics: Animals; Brain Neoplasms; Cancer Vaccines; Dogs; Glioma; Losartan; Propranolol; Prospective Studies; | 2022 |
A globin fragment, LVV-hemorphin-7, induces [3H]thymidine incorporation in a neuronal cell line via the AT4 receptor.
Topics: Angiotensin II; Binding, Competitive; DNA; Glioma; Hemoglobins; Hybrid Cells; Losartan; Neuroblastom | 1999 |
AT1 receptor is present in glioma cells; its blockage reduces the growth of rat glioma.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Brain Neoplasms; Cell Division; Glioma; Losartan; | 2001 |
AT1 receptors mediate the release of prostaglandins in porcine smooth muscle cells and rat astrocytes.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Arachidonic Acids; Astrocytes; Biphenyl C | 1992 |
Characterization of angiotensin receptors mediating prostaglandin synthesis in C6 glioma cells.
Topics: Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Glioma; Imidazoles; Losart | 1991 |