losartan has been researched along with Diabetic Retinopathy in 14 studies
Losartan: An antagonist of ANGIOTENSIN TYPE 1 RECEPTOR with antihypertensive activity due to the reduced pressor effect of ANGIOTENSIN II.
losartan : A biphenylyltetrazole where a 1,1'-biphenyl group is attached at the 5-position and has an additional trisubstituted imidazol-1-ylmethyl group at the 4'-position
Diabetic Retinopathy: Disease of the RETINA as a complication of DIABETES MELLITUS. It is characterized by the progressive microvascular complications, such as ANEURYSM, interretinal EDEMA, and intraocular PATHOLOGIC NEOVASCULARIZATION.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Captopril and losartan also inhibited hyperglycemia-induced leukostasis at 6 weeks and 1 week in the retinal vasculature, respectively." | 7.74 | Captopril inhibits capillary degeneration in the early stages of diabetic retinopathy. ( Gao, L; Kern, TS; Xi, X; Zhang, JZ, 2007) |
| "To study if the endogenous renin-angiotensin system affects diabetic retinal leukostasis, rats with streptozotocin-induced diabetes were treated with an ACE inhibitor (ramipril), an angiotensin II AT(1) receptor antagonist (losartan) and the Ca channel blocker, (nifedipine)." | 7.73 | Role of angiotensin II in retinal leukostasis in the diabetic rat. ( Chen, P; Dahl, D; Edwards, PA; Fenstermacher, JD; Guo, M; Scicli, AG; Scicli, GM, 2006) |
| "We conducted a multicenter, controlled trial involving 285 normotensive patients with type 1 diabetes and normoalbuminuria and who were randomly assigned to receive losartan (100 mg daily), enalapril (20 mg daily), or placebo and followed for 5 years." | 5.14 | Renal and retinal effects of enalapril and losartan in type 1 diabetes. ( Donnelly, S; Drummond, K; Gardiner, R; Goodyer, P; Gubler, MC; Klein, R; Mauer, M; Sinaiko, A; Strand, T; Suissa, S; Zinman, B, 2009) |
| " This investigation sought to determine whether hypertension exacerbates the oxidative stress, neurodegeneration, and mitochondrial dysfunction that exists in diabetic retinopathy and whether these changes could be minimized by the angiotensin II type 1 (AT(1)) receptor blocker (ARB) losartan." | 3.75 | Diabetic retinal neurodegeneration is associated with mitochondrial oxidative stress and is improved by an angiotensin receptor blocker in a model combining hypertension and diabetes. ( Biswas, SK; Lopes de Faria, JB; Lopes de Faria, JM; Rosales, MA; Silva, KC, 2009) |
| " Captopril and losartan also inhibited hyperglycemia-induced leukostasis at 6 weeks and 1 week in the retinal vasculature, respectively." | 3.74 | Captopril inhibits capillary degeneration in the early stages of diabetic retinopathy. ( Gao, L; Kern, TS; Xi, X; Zhang, JZ, 2007) |
| "To study if the endogenous renin-angiotensin system affects diabetic retinal leukostasis, rats with streptozotocin-induced diabetes were treated with an ACE inhibitor (ramipril), an angiotensin II AT(1) receptor antagonist (losartan) and the Ca channel blocker, (nifedipine)." | 3.73 | Role of angiotensin II in retinal leukostasis in the diabetic rat. ( Chen, P; Dahl, D; Edwards, PA; Fenstermacher, JD; Guo, M; Scicli, AG; Scicli, GM, 2006) |
| "Diabetic retinopathy was determined by masked grading of 30 degrees color stereoscopic fundus photographs of 7 standard fields using the Early Treatment Diabetic Retinopathy Study severity scale." | 2.72 | The relation of ambulatory blood pressure and pulse rate to retinopathy in type 1 diabetes mellitus: the renin-angiotensin system study. ( Donnelly, SM; Gardiner, R; Goodyer, P; Klein, R; Kramer, MS; Mauer, M; Moss, SE; Sinaiko, AR; Strand, T; Suissa, S; Zinman, B, 2006) |
| "The treatment with losartan ameliorated all of the above alterations." | 1.36 | Reduction of inducible nitric oxide synthase via angiotensin receptor blocker prevents the oxidative retinal damage in diabetic hypertensive rats. ( de Faria, JB; de Faria, JM; Rosales, MA; Silva, KC, 2010) |
| "Hypertension is an important risk factor associated with development and progression of diabetic retinopathy (DR)." | 1.34 | Prevention of hypertension abrogates early inflammatory events in the retina of diabetic hypertensive rats. ( Biswas, SK; de Faria, JB; de Faria, JM; Pinto, CC; Silva, KC; Souza, DS, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 10 (71.43) | 29.6817 |
| 2010's | 3 (21.43) | 24.3611 |
| 2020's | 1 (7.14) | 2.80 |
| Authors | Studies |
|---|---|
| Gao, D | 1 |
| Yu, P | 1 |
| Jing, S | 1 |
| Yan, C | 1 |
| Ding, D | 1 |
| Qiao, Y | 1 |
| Wu, G | 1 |
| Silva, KC | 3 |
| Rosales, MA | 2 |
| Biswas, SK | 2 |
| Lopes de Faria, JB | 1 |
| Lopes de Faria, JM | 1 |
| Marshall, SM | 1 |
| Mauer, M | 3 |
| Zinman, B | 3 |
| Gardiner, R | 2 |
| Suissa, S | 2 |
| Sinaiko, A | 2 |
| Strand, T | 2 |
| Drummond, K | 1 |
| Donnelly, S | 1 |
| Goodyer, P | 2 |
| Gubler, MC | 1 |
| Klein, R | 3 |
| de Faria, JB | 2 |
| de Faria, JM | 2 |
| Sjølie, AK | 1 |
| Dodson, P | 1 |
| Hobbs, FR | 1 |
| Harindhanavudhi, T | 1 |
| Caramori, ML | 1 |
| Eguchi, K | 1 |
| Kario, K | 1 |
| Shimada, K | 1 |
| Knudsen, ST | 1 |
| Bek, T | 1 |
| Poulsen, PL | 1 |
| Hove, MN | 1 |
| Rehling, M | 1 |
| Mogensen, CE | 1 |
| Gleim, GW | 1 |
| Tressler, CS | 1 |
| Chen, P | 1 |
| Scicli, GM | 1 |
| Guo, M | 1 |
| Fenstermacher, JD | 1 |
| Dahl, D | 1 |
| Edwards, PA | 1 |
| Scicli, AG | 1 |
| Moss, SE | 1 |
| Sinaiko, AR | 1 |
| Donnelly, SM | 1 |
| Kramer, MS | 1 |
| Pinto, CC | 1 |
| Souza, DS | 1 |
| Zhang, JZ | 1 |
| Xi, X | 1 |
| Gao, L | 1 |
| Kern, TS | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Renin Angiotensin System Blockage-DN (RASS)[NCT00143949] | Phase 2 | 285 participants (Actual) | Interventional | 1997-03-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for losartan and Diabetic Retinopathy
| Article | Year |
|---|---|
Does renin-angiotensin system blockade have a role in preventing diabetic retinopathy? A clinical review.
Topics: Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Benzimidazoles; B | 2011 |
[What is a good marker for better antihypertensive therapy in diabetic patients when coexisting with hypertension].
Topics: Albuminuria; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Biomarkers; | 2002 |
4 trials available for losartan and Diabetic Retinopathy
| Article | Year |
|---|---|
Renal and retinal effects of enalapril and losartan in type 1 diabetes.
Topics: Adult; Albuminuria; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitor | 2009 |
Benefits of Renin-Angiotensin blockade on retinopathy in type 1 diabetes vary with glycemic control.
Topics: Adult; Angiotensin-Converting Enzyme Inhibitors; Blood Glucose; Diabetes Mellitus, Type 1; Diabetic | 2011 |
Effects of losartan on diabetic maculopathy in type 2 diabetic patients: a randomized, double-masked study.
Topics: Aged; Angiotensin Receptor Antagonists; Blood Pressure; Diabetes Mellitus, Type 2; Diabetic Retinopa | 2003 |
The relation of ambulatory blood pressure and pulse rate to retinopathy in type 1 diabetes mellitus: the renin-angiotensin system study.
Topics: Adult; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Blood Pres | 2006 |
8 other studies available for losartan and Diabetic Retinopathy
| Article | Year |
|---|---|
miR-193a as a potential mediator of WT-1/synaptopodin in the renoprotective effect of Losartan on diabetic kidney.
Topics: Adult; Aged; Albuminuria; Animals; Diabetic Retinopathy; Female; Gene Expression; Humans; Losartan; | 2022 |
Diabetic retinal neurodegeneration is associated with mitochondrial oxidative stress and is improved by an angiotensin receptor blocker in a model combining hypertension and diabetes.
Topics: Angiotensin Receptor Antagonists; Animals; Diabetes Mellitus, Experimental; Diabetic Retinopathy; DN | 2009 |
Intensive diabetes management for high-risk patients: how best to deliver?
Topics: Albuminuria; Angiotensin II Type 1 Receptor Blockers; Cardiovascular Diseases; Delivery of Health Ca | 2009 |
Reduction of inducible nitric oxide synthase via angiotensin receptor blocker prevents the oxidative retinal damage in diabetic hypertensive rats.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Administration, Oral; Angiotensin II Type 1 Receptor Blockers; Animals; | 2010 |
Effects of losartan on diabetic maculopathy in type 2 diabetic patients.
Topics: Diabetes Mellitus, Type 2; Diabetic Retinopathy; Humans; Losartan; Macula Lutea; Tomography; Treatme | 2004 |
Role of angiotensin II in retinal leukostasis in the diabetic rat.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; A | 2006 |
Prevention of hypertension abrogates early inflammatory events in the retina of diabetic hypertensive rats.
Topics: Administration, Oral; Animals; Antihypertensive Agents; Blood Pressure; Diabetic Retinopathy; Drug C | 2007 |
Captopril inhibits capillary degeneration in the early stages of diabetic retinopathy.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; A | 2007 |