losartan has been researched along with Delayed Effects, Prenatal Exposure in 14 studies
Losartan: An antagonist of ANGIOTENSIN TYPE 1 RECEPTOR with antihypertensive activity due to the reduced pressor effect of ANGIOTENSIN II.
losartan : A biphenylyltetrazole where a 1,1'-biphenyl group is attached at the 5-position and has an additional trisubstituted imidazol-1-ylmethyl group at the 4'-position
| Excerpt | Relevance | Reference |
|---|---|---|
| " This study determined the influence of maternal intake of high sucrose (HS) during pregnancy on vessel tone, intracellular Ca(2+) ([Ca(2+)](i)), K(+) channels, especially large-conductance Ca(2+)-activated K(+) channels (BK), in mesenteric arteries in the offspring rats exposed to prenatal HS." | 7.79 | Intake of high sucrose during pregnancy altered large-conductance Ca2+-activated K+ channels and vessel tone in offspring's mesenteric arteries. ( Cao, L; Fang, Q; Li, S; Liu, Y; Mao, C; Shi, A; Wu, L; Xu, Z; Zhou, A; Zhu, H, 2013) |
| " This study determined the influence of maternal intake of high sucrose (HS) during pregnancy on vessel tone, intracellular Ca(2+) ([Ca(2+)](i)), K(+) channels, especially large-conductance Ca(2+)-activated K(+) channels (BK), in mesenteric arteries in the offspring rats exposed to prenatal HS." | 3.79 | Intake of high sucrose during pregnancy altered large-conductance Ca2+-activated K+ channels and vessel tone in offspring's mesenteric arteries. ( Cao, L; Fang, Q; Li, S; Liu, Y; Mao, C; Shi, A; Wu, L; Xu, Z; Zhou, A; Zhu, H, 2013) |
| " Losartan abolished hypertension, suggesting that AT(1a)R plays a primary role in arterial pressure elevation." | 3.78 | Temporal alterations in vascular angiotensin receptors and vasomotor responses in offspring of protein-restricted rat dams. ( Balakrishnan, M; Chinnathambi, V; Gao, H; Sathishkumar, K; Yallampalli, C, 2012) |
| "Nicotine was administered to pregnant rats via subcutaneous osmotic minipumps throughout the gestation." | 1.35 | Prenatal gender-related nicotine exposure increases blood pressure response to angiotensin II in adult offspring. ( Huang, X; Longo, LD; Xiao, D; Xu, Z; Yang, S; Zhang, L, 2008) |
| "Body weights were 10% lower in the LO group at the start but remained unchanged relative to the CO group during the entire 8-day period of observation." | 1.31 | AT(1) receptor blockade with losartan during gestation in Wistar rats leads to an increase in thirst and sodium appetite in their adult female offspring. ( Butler, DG; Midgely, A; Nemati, B; Pak, SH, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 7 (50.00) | 29.6817 |
| 2010's | 5 (35.71) | 24.3611 |
| 2020's | 2 (14.29) | 2.80 |
| Authors | Studies |
|---|---|
| Barros, MAV | 1 |
| de Brito Alves, JL | 1 |
| Barros, RGN | 1 |
| Santana E Silva, M | 1 |
| Nasser, S | 1 |
| Tourneur, Y | 1 |
| Leandro, CVG | 1 |
| Vidal, H | 1 |
| Pirola, L | 1 |
| Costa-Silva, JH | 1 |
| Feng, X | 1 |
| Yu, T | 1 |
| Zhang, Y | 1 |
| Li, L | 1 |
| Qu, M | 1 |
| Wang, J | 1 |
| Dong, F | 1 |
| Zhang, L | 2 |
| Wang, F | 1 |
| Zhang, F | 1 |
| Zhou, X | 1 |
| Xu, Z | 4 |
| Man, D | 1 |
| Tao, H | 1 |
| Rui, C | 1 |
| Zheng, J | 1 |
| Tang, J | 1 |
| Wu, L | 2 |
| Shi, A | 2 |
| Chen, N | 1 |
| He, R | 1 |
| Wu, C | 1 |
| Li, J | 1 |
| Yin, X | 1 |
| Zhang, P | 1 |
| Zhu, Z | 1 |
| Tao, J | 1 |
| Xiao, J | 1 |
| Mao, C | 2 |
| Lengellé, C | 1 |
| Bejan-Angoulvant, T | 1 |
| Beau-Salinas, F | 1 |
| Jonville-Béra, AP | 1 |
| Gwathmey, TM | 1 |
| Shaltout, HA | 1 |
| Rose, JC | 1 |
| Diz, DI | 1 |
| Chappell, MC | 1 |
| Sathishkumar, K | 1 |
| Balakrishnan, M | 1 |
| Chinnathambi, V | 1 |
| Gao, H | 1 |
| Yallampalli, C | 1 |
| Li, S | 1 |
| Fang, Q | 1 |
| Zhou, A | 1 |
| Cao, L | 1 |
| Zhu, H | 1 |
| Liu, Y | 1 |
| Racasan, S | 1 |
| Hahnel, B | 1 |
| van der Giezen, DM | 1 |
| Blezer, EL | 1 |
| Goldschmeding, R | 1 |
| Braam, B | 1 |
| Kriz, W | 1 |
| Koomans, HA | 1 |
| Joles, JA | 1 |
| Dodic, M | 1 |
| McAlinden, AT | 1 |
| Jefferies, AJ | 1 |
| Wintour, EM | 1 |
| Cock, ML | 1 |
| May, CN | 1 |
| Evans, RG | 1 |
| Moritz, KM | 1 |
| Ceravolo, GS | 1 |
| Franco, MC | 1 |
| Carneiro-Ramos, MS | 1 |
| Barreto-Chaves, ML | 1 |
| Tostes, RC | 1 |
| Nigro, D | 1 |
| Fortes, ZB | 1 |
| Carvalho, MH | 1 |
| Xiao, D | 1 |
| Huang, X | 1 |
| Longo, LD | 1 |
| Yang, S | 1 |
| Roghair, RD | 1 |
| Miller, FJ | 1 |
| Scholz, TD | 1 |
| Lamb, FS | 1 |
| Segar, JL | 1 |
| Sherman, RC | 1 |
| Langley-Evans, SC | 1 |
| Butler, DG | 1 |
| Pak, SH | 1 |
| Midgely, A | 1 |
| Nemati, B | 1 |
14 other studies available for losartan and Delayed Effects, Prenatal Exposure
| Article | Year |
|---|---|
Effects of maternal protein restriction on central and peripheral renin-angiotensin systems in male rat offspring.
Topics: Animals; Arterial Pressure; Diet, Protein-Restricted; Female; Heart Rate; Hypertension; Lactation; L | 2020 |
Prenatal High-Sucrose Diet Induced Vascular Dysfunction in Thoracic Artery of Fetal Offspring.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Body Weight; Dietary Sucrose; Endothelium, Vascula | 2021 |
Angiotensin II-mediated vascular changes in aged offspring rats exposed to perinatal nicotine.
Topics: Acetylcholine; Aging; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Aorta, Abdom | 2013 |
[Drugs news].
Topics: Adrenergic beta-Antagonists; Angiotensin II Type 1 Receptor Blockers; Anti-Obesity Agents; Anticonvu | 2015 |
Glucocorticoid-induced fetal programming alters the functional complement of angiotensin receptor subtypes within the kidney.
Topics: Analysis of Variance; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Betamethason | 2011 |
Temporal alterations in vascular angiotensin receptors and vasomotor responses in offspring of protein-restricted rat dams.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Biomarkers; Blood Pressure; Diet, Protein-Restrict | 2012 |
Intake of high sucrose during pregnancy altered large-conductance Ca2+-activated K+ channels and vessel tone in offspring's mesenteric arteries.
Topics: Angiotensin II; Animals; Animals, Newborn; Dietary Carbohydrates; Dose-Response Relationship, Drug; | 2013 |
Temporary losartan or captopril in young SHR induces malignant hypertension despite initial normotension.
Topics: Animals; Animals, Suckling; Antihypertensive Agents; Blood Pressure; Captopril; Female; Hypertension | 2004 |
Differential effects of prenatal exposure to dexamethasone or cortisol on circulatory control mechanisms mediated by angiotensin II in the central nervous system of adult sheep.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Anti-Inflammatory Agents; Blood Pr | 2006 |
Enalapril and losartan restored blood pressure and vascular reactivity in intrauterine undernourished rats.
Topics: Animals; Antihypertensive Agents; Arterioles; Blood Glucose; Blood Pressure; Drug Antagonism; Enalap | 2007 |
Prenatal gender-related nicotine exposure increases blood pressure response to angiotensin II in adult offspring.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Aorta; Blood Pressure; Body Weight; Calcium; Enzym | 2008 |
Coronary constriction to angiotensin II is enhanced by endothelial superoxide production in sheep programmed by dexamethasone.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin II Type 2 Receptor Blockers; An | 2008 |
Antihypertensive treatment in early postnatal life modulates prenatal dietary influences upon blood pressure in the rat.
Topics: Analysis of Variance; Angiotensin Receptor Antagonists; Animal Nutritional Physiological Phenomena; | 2000 |
AT(1) receptor blockade with losartan during gestation in Wistar rats leads to an increase in thirst and sodium appetite in their adult female offspring.
Topics: Aging; Angiotensin Receptor Antagonists; Animals; Appetite; Blood Pressure; Body Weight; Carotid Art | 2002 |