losartan has been researched along with Decerebrate Posturing in 21 studies
Losartan: An antagonist of ANGIOTENSIN TYPE 1 RECEPTOR with antihypertensive activity due to the reduced pressor effect of ANGIOTENSIN II.
losartan : A biphenylyltetrazole where a 1,1'-biphenyl group is attached at the 5-position and has an additional trisubstituted imidazol-1-ylmethyl group at the 4'-position
| Excerpt | Relevance | Reference |
|---|---|---|
| " Dose-response curves to angiotensin II of blood pressure show a tenfold higher potency for HR 720 to compete for angiotensin II, thereby decreasing the maximum effects when compared with losartan." | 1.30 | Effects of the AT1 antagonist HR 720 in comparison to losartan on stimulated sympathetic outflow, blood pressure, and heart rate in pithed spontaneously hypertensive rats. ( Dendorfer, A; Dominiak, P; Häuser, W; Nguyen, T, 1998) |
| " Losartan, but not PD123177, shifted the dose-response curves for AII to the right in a parallel manner." | 1.29 | Hemodynamic effects of angiotensin II and the influence of angiotensin receptor antagonists in pithed rabbits. ( Pfaffendorf, M; van Zwieten, PA; Zhang, J, 1995) |
| "Losartan (10 mg/kg) was administered orally, either as a single dose or for 8 successive days." | 1.29 | Sympathoinhibitory effects of losartan in spontaneously hypertensive rats. ( Giudicelli, JF; Moreau, N; Richer, C; Vincent, MP, 1993) |
| " Losartan but not PD123177 caused parallel rightward shifts of the dose-response curve of angiotensin II for dP/dtmax in the aortic blood pressure controlled pithed rat without altering the maximal response." | 1.29 | Positive inotropic action of angiotensin II in the pithed rat. ( Pfaffendorf, M; van Zwieten, PA; Zhang, J, 1993) |
| " In spontaneously hypertensive rats (SHR), repeated daily oral dosing of XR510, losartan, and enalapril at 30 mg/kg/day decreased BP similarly." | 1.29 | Pharmacology of XR510, a potent orally active nonpeptide angiotensin II AT1 receptor antagonist with high affinity for the AT2 receptor subtype. ( Bernard, R; Crain, EJ; McCall, DE; Quan, ML; Saye, JM; Smith, RD; Watson, CA; Wexler, RR; Wong, PC; Zaspel, AM, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 18 (85.71) | 18.2507 |
| 2000's | 2 (9.52) | 29.6817 |
| 2010's | 1 (4.76) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Koba, S | 1 |
| Watanabe, R | 1 |
| Kano, N | 1 |
| Watanabe, T | 1 |
| Tabrizchi, R | 2 |
| Lupichuk, SM | 1 |
| Zhang, J | 2 |
| Pfaffendorf, M | 3 |
| van Zwieten, PA | 3 |
| Moreau, N | 1 |
| Richer, C | 3 |
| Vincent, MP | 2 |
| Giudicelli, JF | 3 |
| Rechtman, M | 1 |
| Majewski, H | 1 |
| Cazes, M | 1 |
| Provost, D | 1 |
| Versigny, A | 1 |
| Cloarec, A | 1 |
| Chauvin, B | 1 |
| Wong, PC | 3 |
| Quan, ML | 1 |
| Saye, JM | 1 |
| Bernard, R | 2 |
| Crain, EJ | 1 |
| McCall, DE | 1 |
| Watson, CA | 1 |
| Zaspel, AM | 1 |
| Smith, RD | 1 |
| Wexler, RR | 1 |
| Domergue, V | 1 |
| Alvarez-Guerra, M | 1 |
| Alda, O | 1 |
| Morin, E | 1 |
| Allard, M | 1 |
| Garay, RP | 1 |
| Shibasaki, M | 1 |
| Fujimori, A | 1 |
| Takanashi, M | 1 |
| Kusayama, T | 1 |
| Tokioka, T | 1 |
| Satoh, Y | 1 |
| Okazaki, T | 1 |
| Uchida, W | 1 |
| Inagaki, O | 1 |
| Yanagisawa, I | 1 |
| Ohlstein, EH | 2 |
| Brooks, DP | 2 |
| Feuerstein, GZ | 1 |
| Ruffolo, RR | 2 |
| Häuser, W | 1 |
| Dendorfer, A | 1 |
| Nguyen, T | 1 |
| Dominiak, P | 1 |
| Lee, SH | 1 |
| Jung, YS | 1 |
| Lee, BH | 1 |
| Yun, SI | 1 |
| Yoo, SE | 1 |
| Shin, HS | 1 |
| Balt, JC | 1 |
| Mathy, MJ | 1 |
| Takata, Y | 1 |
| Kurihara, J | 1 |
| Yoda, T | 1 |
| Suzuki, S | 1 |
| Matsuoka, Y | 1 |
| Okubo, Y | 1 |
| Kato, H | 1 |
| Christ, DD | 1 |
| Timmermans, PB | 2 |
| Gellai, M | 1 |
| Vickery, L | 1 |
| Jugus, J | 1 |
| Sulpizio, A | 1 |
| Weinstock, J | 1 |
| Edwards, RM | 1 |
21 other studies available for losartan and Decerebrate Posturing
| Article | Year |
|---|---|
Oxidative stress exaggerates skeletal muscle contraction-evoked reflex sympathoexcitation in rats with hypertension induced by angiotensin II.
Topics: 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt; Afferent Pathways; Angiotensin II; Angiotens | 2013 |
The effects of losartan and captopril on vasopressor actions of cirazoline in the absence and presence of SZL-49 and nifedipine.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Analysis of Variance; Animals; Antihyperten | 1995 |
Influence of nonpeptide angiotensin II receptor antagonist, losartan, on neurogenic vasoconstriction.
Topics: Adenosine Triphosphate; Analysis of Variance; Angiotensin II; Animals; Biphenyl Compounds; Blood Pre | 1995 |
Hemodynamic effects of angiotensin II and the influence of angiotensin receptor antagonists in pithed rabbits.
Topics: Analysis of Variance; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Benzimidazoles; Bip | 1995 |
Sympathoinhibitory effects of losartan in spontaneously hypertensive rats.
Topics: Adrenergic alpha-Agonists; Anesthetics; Animals; Antihypertensive Agents; Biphenyl Compounds; Decere | 1993 |
Positive inotropic action of angiotensin II in the pithed rat.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Angiotensin I; Angiotensin II; Angiotensi | 1993 |
A facilitatory effect of anti-angiotensin drugs on vagal bradycardia in the pithed rat and guinea-pig.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; | 1993 |
In vivo pharmacological characterization of UP 269-6, a novel nonpeptide angiotensin II receptor antagonist.
Topics: Administration, Oral; Angiotensin II; Angiotensin III; Angiotensin Receptor Antagonists; Animals; An | 1995 |
Lack of involvement of bradykinin in the vascular sympathoinhibitory effects of angiotensin converting enzyme inhibitors in spontaneously hypertensive rats.
Topics: Adrenergic beta-Antagonists; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Convertin | 1995 |
Pharmacology of XR510, a potent orally active nonpeptide angiotensin II AT1 receptor antagonist with high affinity for the AT2 receptor subtype.
Topics: 1-Sarcosine-8-Isoleucine Angiotensin II; Administration, Oral; Adrenal Glands; Angiotensin Receptor | 1995 |
Involvement of nitric oxide, but not prostaglandins, in the vascular sympathoinhibitory effects of losartan in the pithed spontaneously hypertensive rat.
Topics: Animals; Antihypertensive Agents; Biphenyl Compounds; Cyclooxygenase Inhibitors; Decerebrate State; | 1996 |
Reduction by (-)-cicletanine of the vascular reactivity to angiotensin II in rats.
Topics: Administration, Oral; Angiotensin II; Animals; Antihypertensive Agents; Aorta, Thoracic; Biphenyl Co | 1996 |
Pharmacological profile of YM358, a novel nonpeptide angiotensin AT1 receptor antagonist.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Azoles; Binding, | 1997 |
Inhibition of sympathetic outflow by the angiotensin II receptor antagonist, eprosartan, but not by losartan, valsartan or irbesartan: relationship to differences in prejunctional angiotensin II receptor blockade.
Topics: Acrylates; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Biphe | 1997 |
Effects of the AT1 antagonist HR 720 in comparison to losartan on stimulated sympathetic outflow, blood pressure, and heart rate in pithed spontaneously hypertensive rats.
Topics: Angiotensin I; Angiotensin II; Animals; Antihypertensive Agents; Biphenyl Compounds; Blood Pressure; | 1998 |
Characterization of angiotensin II antagonism displayed by SK-1080, a novel nonpeptide AT1-receptor antagonist.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Aorta, Thoracic; | 1999 |
Inhibition of angiotensin II-induced facilitation of sympathetic neurotransmission in the pithed rat: a comparison between losartan, irbesartan, telmisartan, and captopril.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; | 2001 |
KT3-671, an angiotensin AT1 receptor antagonist, attenuates vascular but not cardiac responses to sympathetic nerve stimulation in pithed rats.
Topics: Adrenalectomy; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; B | 2001 |
Enhancement of losartan (DuP 753)-induced angiotensin II receptor antagonism by PD123177 in rats.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Blood Pressure; Decer | 1992 |
The antihypertensive effect of the angiotensin II receptor antagonist DuP 753 may not be due solely to angiotensin II receptor antagonism.
Topics: Acrylates; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Biphe | 1992 |
Effect of blocking angiotensin II receptor subtype on rat sympathetic nerve function.
Topics: Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Blood Pressure; Cardiac Output; Decer | 1992 |