losartan has been researched along with Crohn Disease in 1 studies
Losartan: An antagonist of ANGIOTENSIN TYPE 1 RECEPTOR with antihypertensive activity due to the reduced pressor effect of ANGIOTENSIN II.
losartan : A biphenylyltetrazole where a 1,1'-biphenyl group is attached at the 5-position and has an additional trisubstituted imidazol-1-ylmethyl group at the 4'-position
Crohn Disease: A chronic transmural inflammation that may involve any part of the DIGESTIVE TRACT from MOUTH to ANUS, mostly found in the ILEUM, the CECUM, and the COLON. In Crohn disease, the inflammation, extending through the intestinal wall from the MUCOSA to the serosa, is characteristically asymmetric and segmental. Epithelioid GRANULOMAS may be seen in some patients.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Losartan was administered to male adult C57BL/6 J mice 2 weeks prior to the induction of colitis, and images of the whole colon were captured to record changes, scored according to a microscopic scoring system, and reverse transcription-quantitative polymerase chain reaction were performed in order to investigate colonic inflammation." | 1.43 | AT1R blocker losartan attenuates intestinal epithelial cell apoptosis in a mouse model of Crohn's disease. ( Liu, TJ; Shi, YY; Wang, EB; Zhao, Q; Zhu, T, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Liu, TJ | 1 |
| Shi, YY | 1 |
| Wang, EB | 1 |
| Zhu, T | 1 |
| Zhao, Q | 1 |
1 other study available for losartan and Crohn Disease
| Article | Year |
|---|---|
AT1R blocker losartan attenuates intestinal epithelial cell apoptosis in a mouse model of Crohn's disease.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Apoptosis; bcl-2-Associated X Protein; Caspase 3; | 2016 |