losartan has been researched along with Colitis in 6 studies
Losartan: An antagonist of ANGIOTENSIN TYPE 1 RECEPTOR with antihypertensive activity due to the reduced pressor effect of ANGIOTENSIN II.
losartan : A biphenylyltetrazole where a 1,1'-biphenyl group is attached at the 5-position and has an additional trisubstituted imidazol-1-ylmethyl group at the 4'-position
Colitis: Inflammation of the COLON section of the large intestine (INTESTINE, LARGE), usually with symptoms such as DIARRHEA (often with blood and mucus), ABDOMINAL PAIN, and FEVER.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To evaluate the in vivo effect of losartan - an angiotensin II receptor antagonist - on the course of chronic colitis-associated fibrosis and on TGF-b1 expression." | 7.78 | Losartan reduces trinitrobenzene sulphonic acid-induced colorectal fibrosis in rats. ( Goldin, E; Israeli, E; Latella, G; Lysy, J; Metanes, I; Necozione, S; Papo, O; Pines, M; Wengrower, D; Zanninelli, G, 2012) |
| "We evaluated the direct effect of angiotensin II (AII) on the pathogenesis of immune mediated colitis using angiotensinogen deficient homozygous (Atg-/-) mice." | 7.73 | Amelioration of 2,4,6-trinitrobenzene sulphonic acid induced colitis in angiotensinogen gene knockout mice. ( Inokuchi, Y; Kawana, I; Kihara, M; Morohashi, T; Nagashima, Y; Umemura, S, 2005) |
| "To evaluate the in vivo effect of losartan - an angiotensin II receptor antagonist - on the course of chronic colitis-associated fibrosis and on TGF-b1 expression." | 3.78 | Losartan reduces trinitrobenzene sulphonic acid-induced colorectal fibrosis in rats. ( Goldin, E; Israeli, E; Latella, G; Lysy, J; Metanes, I; Necozione, S; Papo, O; Pines, M; Wengrower, D; Zanninelli, G, 2012) |
| "We evaluated the direct effect of angiotensin II (AII) on the pathogenesis of immune mediated colitis using angiotensinogen deficient homozygous (Atg-/-) mice." | 3.73 | Amelioration of 2,4,6-trinitrobenzene sulphonic acid induced colitis in angiotensinogen gene knockout mice. ( Inokuchi, Y; Kawana, I; Kihara, M; Morohashi, T; Nagashima, Y; Umemura, S, 2005) |
| "Treatment with aliskiren (a renin inhibitor), but not hydralazine (a smooth muscle relaxant), ameliorated colitis in RenTgMK mice, although both drugs normalized blood pressure." | 1.43 | Activation of the Renin-Angiotensin System Promotes Colitis Development. ( Adhikari, S; Alpert, L; Bissonnette, M; Chen, L; Deb, DK; Dougherty, U; Hart, J; He, L; Kwon, J; Li, YC; Liu, SQ; Liu, T; Liu, W; Pekow, J; Rubin, DT; Shi, Y; Wang, J; Zhao, Q; Zhou, G, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (16.67) | 29.6817 |
| 2010's | 5 (83.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Watts, MN | 1 |
| Eshaq, RS | 1 |
| Carter, PR | 1 |
| Harris, NR | 1 |
| Shi, Y | 1 |
| Liu, T | 1 |
| He, L | 1 |
| Dougherty, U | 1 |
| Chen, L | 1 |
| Adhikari, S | 1 |
| Alpert, L | 1 |
| Zhou, G | 1 |
| Liu, W | 1 |
| Wang, J | 1 |
| Deb, DK | 1 |
| Hart, J | 1 |
| Liu, SQ | 1 |
| Kwon, J | 1 |
| Pekow, J | 1 |
| Rubin, DT | 1 |
| Zhao, Q | 1 |
| Bissonnette, M | 1 |
| Li, YC | 1 |
| Okawada, M | 2 |
| Wilson, MW | 1 |
| Larsen, SD | 2 |
| Lipka, E | 2 |
| Hillfinger, J | 2 |
| Teitelbaum, DH | 2 |
| Koga, H | 1 |
| Showalter, HD | 1 |
| Turbiak, AJ | 1 |
| Jin, X | 1 |
| Lucas, PC | 1 |
| Kim, JS | 1 |
| Wengrower, D | 1 |
| Zanninelli, G | 1 |
| Latella, G | 1 |
| Necozione, S | 1 |
| Metanes, I | 1 |
| Israeli, E | 1 |
| Lysy, J | 1 |
| Pines, M | 1 |
| Papo, O | 1 |
| Goldin, E | 1 |
| Inokuchi, Y | 1 |
| Morohashi, T | 1 |
| Kawana, I | 1 |
| Nagashima, Y | 1 |
| Kihara, M | 1 |
| Umemura, S | 1 |
6 other studies available for losartan and Colitis
| Article | Year |
|---|---|
Decreased retinal blood flow in experimental colitis; improvement by eye drop administration of losartan.
Topics: Administration, Topical; Angiotensin II Type 1 Receptor Blockers; Angiotensins; Animals; Blood Flow | 2013 |
Activation of the Renin-Angiotensin System Promotes Colitis Development.
Topics: Amides; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Apoptosis; Colitis; Colon; | 2016 |
Blockade of the renin-angiotensin system prevents acute and immunologically relevant colitis in murine models.
Topics: Acute Disease; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; An | 2016 |
Use of enterally delivered angiotensin II type Ia receptor antagonists to reduce the severity of colitis.
Topics: Administration, Oral; Angiotensin II Type 1 Receptor Blockers; Animals; Benzimidazoles; Biphenyl Com | 2011 |
Losartan reduces trinitrobenzene sulphonic acid-induced colorectal fibrosis in rats.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Colitis; Disease Models, Animal; Disease Progressi | 2012 |
Amelioration of 2,4,6-trinitrobenzene sulphonic acid induced colitis in angiotensinogen gene knockout mice.
Topics: Angiotensin II Type 1 Receptor Blockers; Angiotensinogen; Animals; Colitis; Colon; Cytokines; Immuni | 2005 |