losartan has been researched along with Chemical and Drug Induced Liver Injury in 15 studies
Losartan: An antagonist of ANGIOTENSIN TYPE 1 RECEPTOR with antihypertensive activity due to the reduced pressor effect of ANGIOTENSIN II.
losartan : A biphenylyltetrazole where a 1,1'-biphenyl group is attached at the 5-position and has an additional trisubstituted imidazol-1-ylmethyl group at the 4'-position
Chemical and Drug Induced Liver Injury: A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug metabolites, herbal and dietary supplements and chemicals from the environment.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To investigate the effect of iron overload on experimental immunological liver injury in rats and the roles of losartan (LOS), which is the selective antagonist of angiotensin II receptor subtype AT1." | 3.76 | [Effect of iron overload on experimental immunological liver injury in rats and the role of angiotensin]. ( Jiang, H; Liu, H; Wang, J; Zhang, W; Zhang, Y; Zhuang, J, 2010) |
| " Experiment lasted 11 days and dosing was via oral route." | 1.37 | Pharmacologic inhibition of the renin-angiotensin system did not attenuate hepatic toxicity induced by carbon tetrachloride in rats. ( Adesanoye, OA; Bamidele, TO; Ekor, M; Kale, OE; Odewabi, AO; Oritogun, KS, 2011) |
| " An understanding of structure-activity relationships (SARs) of chemicals can make a significant contribution to the identification of potential toxic effects early in the drug development process and aid in avoiding such problems." | 1.36 | Developing structure-activity relationships for the prediction of hepatotoxicity. ( Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ, 2010) |
| "Losartan treatment was able to reduce all these parameters." | 1.34 | Effect of angiotensin AT1 receptor antagonist on D-galactosamine-induced acute liver injury. ( Chan, H; Leung, PS; Tam, MS, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (13.33) | 18.2507 |
| 2000's | 2 (13.33) | 29.6817 |
| 2010's | 10 (66.67) | 24.3611 |
| 2020's | 1 (6.67) | 2.80 |
| Authors | Studies |
|---|---|
| Fourches, D | 1 |
| Barnes, JC | 1 |
| Day, NC | 1 |
| Bradley, P | 1 |
| Reed, JZ | 1 |
| Tropsha, A | 1 |
| Greene, N | 1 |
| Fisk, L | 1 |
| Naven, RT | 1 |
| Note, RR | 1 |
| Patel, ML | 1 |
| Pelletier, DJ | 1 |
| Ekins, S | 1 |
| Williams, AJ | 1 |
| Xu, JJ | 1 |
| Liu, Z | 1 |
| Shi, Q | 1 |
| Ding, D | 1 |
| Kelly, R | 1 |
| Fang, H | 1 |
| Tong, W | 2 |
| Sakatis, MZ | 1 |
| Reese, MJ | 1 |
| Harrell, AW | 1 |
| Taylor, MA | 1 |
| Baines, IA | 1 |
| Chen, L | 1 |
| Bloomer, JC | 1 |
| Yang, EY | 1 |
| Ellens, HM | 1 |
| Ambroso, JL | 1 |
| Lovatt, CA | 1 |
| Ayrton, AD | 1 |
| Clarke, SE | 1 |
| Warner, DJ | 1 |
| Chen, H | 1 |
| Cantin, LD | 1 |
| Kenna, JG | 1 |
| Stahl, S | 1 |
| Walker, CL | 1 |
| Noeske, T | 1 |
| Aleo, MD | 1 |
| Luo, Y | 1 |
| Swiss, R | 1 |
| Bonin, PD | 1 |
| Potter, DM | 1 |
| Will, Y | 1 |
| Chen, M | 1 |
| Suzuki, A | 1 |
| Thakkar, S | 1 |
| Yu, K | 1 |
| Hu, C | 1 |
| Norman, BH | 1 |
| Choi, JH | 1 |
| Shin, S | 1 |
| Park, D | 1 |
| Jeon, JH | 1 |
| Choi, BH | 1 |
| Jang, MJ | 1 |
| Joo, SS | 1 |
| Oh, KW | 1 |
| Hong, JT | 1 |
| Suh, KH | 1 |
| Kim, YB | 1 |
| Zhuang, J | 1 |
| Zhang, Y | 1 |
| Zhang, W | 1 |
| Jiang, H | 1 |
| Liu, H | 1 |
| Wang, J | 1 |
| Ekor, M | 1 |
| Odewabi, AO | 1 |
| Kale, OE | 1 |
| Oritogun, KS | 1 |
| Adesanoye, OA | 1 |
| Bamidele, TO | 1 |
| Chan, H | 1 |
| Leung, PS | 1 |
| Tam, MS | 1 |
| Bosch, X | 1 |
| Andrade, RJ | 1 |
| Lucena, MI | 1 |
| Santalla, F | 1 |
2 reviews available for losartan and Chemical and Drug Induced Liver Injury
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Pr | 2016 |
Drug Induced Liver Injury (DILI). Mechanisms and Medicinal Chemistry Avoidance/Mitigation Strategies.
Topics: Animals; Cell Line; Cell Survival; Chemical and Drug Induced Liver Injury; Drug Discovery; Drug Eval | 2020 |
13 other studies available for losartan and Chemical and Drug Induced Liver Injury
| Article | Year |
|---|---|
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLI | 2010 |
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; | 2010 |
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands | 2010 |
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Da | 2011 |
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme | 2012 |
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters | 2012 |
Human drug-induced liver injury severity is highly associated with dual inhibition of liver mitochondrial function and bile salt export pump.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters | 2014 |
Comparative antihypertensive activities of losartan and HM70186 in rats with hepatic dysfunction.
Topics: Administration, Oral; Angiotensin II; Animals; Antihypertensive Agents; Blood Pressure; Carbon Tetra | 2009 |
[Effect of iron overload on experimental immunological liver injury in rats and the role of angiotensin].
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Chemical and Drug Induced Liver In | 2010 |
Pharmacologic inhibition of the renin-angiotensin system did not attenuate hepatic toxicity induced by carbon tetrachloride in rats.
Topics: Alanine Transaminase; Alkaline Phosphatase; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Con | 2011 |
Effect of angiotensin AT1 receptor antagonist on D-galactosamine-induced acute liver injury.
Topics: Acute Disease; Alanine Transaminase; Angiotensin II Type 1 Receptor Blockers; Animals; Chemical and | 2007 |
Losartan-induced hepatotoxicity.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Antihypertensive Agents; Chemical and Drug Induced | 1997 |
Hepatic injury associated with losartan.
Topics: Aged; Antihypertensive Agents; Chemical and Drug Induced Liver Injury; Humans; Kidney Diseases; Losa | 1998 |